ES8506686A1 - Procedimiento para la obtencion de benzofuranonas - Google Patents

Procedimiento para la obtencion de benzofuranonas

Info

Publication number
ES8506686A1
ES8506686A1 ES531103A ES531103A ES8506686A1 ES 8506686 A1 ES8506686 A1 ES 8506686A1 ES 531103 A ES531103 A ES 531103A ES 531103 A ES531103 A ES 531103A ES 8506686 A1 ES8506686 A1 ES 8506686A1
Authority
ES
Spain
Prior art keywords
formula
salt
benzofuranonas
rent
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES531103A
Other languages
English (en)
Other versions
ES531103A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8506686A1 publication Critical patent/ES8506686A1/es
Publication of ES531103A0 publication Critical patent/ES531103A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE BENZOFURANONAS.CONSISTE EN HACER REACCIONAR A TEMPERATURA ENTRE 80 Y 200JC, UN COMPUESTO DE FORMULA (II) CON UNA AMINA DE FORMULA R2-H O UNA SAL DE ADICION DE ACIDO DE LA MISMA Y/O, SI SE DESEA, TRANSFORMAR LA SAL EN EL COMPUESTO LIBRE O EN OTRA SAL, O SI SE DESEA, SEPARAR LOS COMPONENTES DE LA MEZCLA DE ISOMEROS OBTENIBLE, PARA FORMAR BENZOFURANONAS DE FORMULA (I), DONDE R1 SIGNIFICA METILO, R2 SIGNIFICA UN GRUPO AMINO DISUSTITUIDO POR DOS RESTOS HIDROCARBUROS MONOVALENTES; Y RA, RB Y RC, EN CADA CASO, SIGNIFICAN H O ALQUILO INFERIOR, O RA Y RB JUNTOS REPRESENTAN ALQUILO DE 3 A 4 MIEMBROS.TIENEN UTILIDAD FARMACEUTICA POR SUS PROPIEDADES ANTIINFLAMATORIAS.
ES531103A 1981-10-28 1984-03-29 Procedimiento para la obtencion de benzofuranonas Granted ES531103A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH688181 1981-10-28

Publications (2)

Publication Number Publication Date
ES8506686A1 true ES8506686A1 (es) 1985-07-16
ES531103A0 ES531103A0 (es) 1985-07-16

Family

ID=4316522

Family Applications (3)

Application Number Title Priority Date Filing Date
ES516841A Granted ES516841A0 (es) 1981-10-28 1982-10-26 Procedimiento para la obtencion de benzofuranonas
ES527515A Expired ES8608502A1 (es) 1981-10-28 1983-11-24 Procedimiento para la obtencion de benzofuranonas
ES531103A Granted ES531103A0 (es) 1981-10-28 1984-03-29 Procedimiento para la obtencion de benzofuranonas

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES516841A Granted ES516841A0 (es) 1981-10-28 1982-10-26 Procedimiento para la obtencion de benzofuranonas
ES527515A Expired ES8608502A1 (es) 1981-10-28 1983-11-24 Procedimiento para la obtencion de benzofuranonas

Country Status (15)

Country Link
US (1) US4514415A (es)
EP (1) EP0078240A3 (es)
JP (1) JPS5888374A (es)
AU (1) AU8982282A (es)
DD (1) DD206376A5 (es)
DK (1) DK475882A (es)
ES (3) ES516841A0 (es)
FI (1) FI823639L (es)
GB (1) GB2110664B (es)
GR (1) GR77708B (es)
IL (1) IL67063A0 (es)
NO (1) NO823587L (es)
NZ (1) NZ202298A (es)
PT (1) PT75748B (es)
ZA (1) ZA827846B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2611713B1 (fr) * 1987-02-27 1990-11-30 Adir Nouveaux derives de l'acide (dihydro-2,3 oxo-2 benzofurannyl-3)-2 acetique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
US4849428A (en) * 1987-11-23 1989-07-18 The Procter & Gamble Company Cyclic anti-inflammatory derivatives of di-tert-butylphenol compounds, compositions and use
EP0336886B1 (de) * 1988-03-16 1992-08-26 Ciba-Geigy Ag Thioverbindungen
FR2686880B1 (fr) * 1992-02-04 1994-05-13 Hoechst Ste Francaise Procede de preparation de la chloro-5 3h-benzofuranone-2 et son application a l'obtention de l'acide chloro-5 hydroxy-2 phenylacetique.
ES2138902B1 (es) * 1997-05-19 2000-09-16 Salvat Lab Sa "5-ariltio-6-sulfonamido-3(2h)-benzofuranonas como inhibidores de la cox-2".
EP1007037A4 (en) 1997-06-26 2004-10-06 Lilly Co Eli ANTITHROMBOTIC AGENTS
CN1179962C (zh) 1999-07-30 2004-12-15 全药工业株式会社 氮杂吲哚嗪酮衍生物和以其为有效成分的脑功能改善剂
EP2147679B1 (en) 2001-07-25 2014-06-25 Raptor Pharmaceutical, Inc. Compositions for blood-brain barrier transport
DK1889198T3 (da) 2005-04-28 2015-02-09 Proteus Digital Health Inc Farma-informatiksystem
WO2008036682A2 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
DK2398500T3 (da) 2009-02-20 2019-05-13 2 Bbb Medicines B V Glutathion-baseret lægemiddelafgivelsessystem
IL255113B (en) 2009-05-06 2022-09-01 Laboratory Skin Care Inc Preparations for administration through the skin that include complexes of an active substance with calcium phosphate and methods of using them
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
GB201415329D0 (en) 2014-07-21 2014-10-15 Ge Healthcare Bio Sciences Parallel cell processing method and facility

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3424796A (en) * 1965-03-30 1969-01-28 Sandoz Ag Preparation of 4-aminodibenzo(a,d) cycloalken-5-ones
US3615521A (en) * 1968-10-01 1971-10-26 Eastman Kodak Co Photographic compositions and processes-a
DE2160136C3 (de) * 1971-12-03 1975-01-02 International Flavors & Fragrances Inc., New York, N.Y. (V.St.A.) Sonnenschutzmittel
US3862133A (en) * 1973-04-30 1975-01-21 Goodrich Co B F Gamma-lactones of o-hydroxyphenylacetic acids
DE2503223A1 (de) * 1974-02-05 1975-08-07 Sandoz Ag Verfahren zur herstellung neuer carbocyclischer verbindungen
US4013690A (en) * 1974-02-05 1977-03-22 Sandoz Ltd. Organic compounds
JPS5938268B2 (ja) * 1974-03-22 1984-09-14 カンザキセイシ カブシキガイシヤ 新規フタリド化合物の製造法
DK137274B (da) * 1975-03-12 1978-02-13 Sandoz Ag Analogifremgangsmåde til fremstilling af 2,3-dihydrobenzofuranon-2-derivater.
DE2652034A1 (de) * 1976-11-15 1978-05-24 Basf Ag Lichtschutzmittel
CA1113486A (en) * 1977-04-01 1981-12-01 Alfred Halpern Ultra-violet filtration with certain aminosalicylic acid esters

Also Published As

Publication number Publication date
PT75748A (de) 1982-11-01
JPS5888374A (ja) 1983-05-26
GB2110664A (en) 1983-06-22
EP0078240A2 (de) 1983-05-04
IL67063A0 (en) 1983-02-23
DD206376A5 (de) 1984-01-25
GR77708B (es) 1984-09-25
AU8982282A (en) 1983-05-05
FI823639A0 (fi) 1982-10-25
US4514415A (en) 1985-04-30
EP0078240A3 (de) 1984-03-28
ES8608502A1 (es) 1986-06-16
DK475882A (da) 1983-04-29
ZA827846B (en) 1983-08-31
NZ202298A (en) 1985-11-08
ES527515A0 (es) 1986-06-16
NO823587L (no) 1983-04-29
FI823639L (fi) 1983-04-29
PT75748B (de) 1985-12-03
GB2110664B (en) 1985-03-20
ES8406461A1 (es) 1984-08-01
ES516841A0 (es) 1984-08-01
ES531103A0 (es) 1985-07-16

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