ES8506591A1 - Un procedimiento para la preparacion de nuevas 1,2,3,4--tetrahidro-2-naftilaminas. - Google Patents
Un procedimiento para la preparacion de nuevas 1,2,3,4--tetrahidro-2-naftilaminas.Info
- Publication number
- ES8506591A1 ES8506591A1 ES529311A ES529311A ES8506591A1 ES 8506591 A1 ES8506591 A1 ES 8506591A1 ES 529311 A ES529311 A ES 529311A ES 529311 A ES529311 A ES 529311A ES 8506591 A1 ES8506591 A1 ES 8506591A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- group
- alkyl
- alkyl group
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE 1,2,3,4-TETRAHIDRO-2-NAFTILAMINAS, DE FORMULA GENERAL (I), EN LA QUE R3 Y EL GRUPO NR1R2 ESTAN EN UNA POSICION CIS, UNO CON RESPECTO AL OTRO, Y EN LA QUE Y ESTA POSICION 5 O 7, Y ES OH, Y SUS BASES Y SALES DE ADICION DE ACIDO, FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN CONVERTIR UN COMPUESTO DE FORMULA GENERAL (II) EN UN COMPUESTO DE FORMULA GENERAL (I), MEDIANTE LA ALCOHILACION DEL ATOMO DE NITROGENO CON UN AGENTE ALCOHILANTE. DE LA MEZCLA ISOMERICA OBTENIDA SE PUEDE SEPARAR UN ISOMERO PURO.DE APLICACION EN TERAPEUTICA, ESPECIALMENTE DEL SISTEMA NERVIOSO CENTRAL.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8102908 | 1981-05-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES529311A0 ES529311A0 (es) | 1985-08-01 |
ES8506591A1 true ES8506591A1 (es) | 1985-08-01 |
Family
ID=20343779
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES511986A Granted ES511986A0 (es) | 1981-05-08 | 1982-05-07 | "un procedimiento para la preparacion de nuevas 1,2,3,4 tetrahidro 2 naftilaminas". |
ES519615A Expired ES8504666A1 (es) | 1981-05-08 | 1983-02-08 | Un procedimiento para la preparacion de nuevas 1,2,3,4-tetrahidro-2-naftilaminas. |
ES529311A Expired ES8506591A1 (es) | 1981-05-08 | 1984-01-31 | Un procedimiento para la preparacion de nuevas 1,2,3,4--tetrahidro-2-naftilaminas. |
ES535882A Expired ES8602603A1 (es) | 1981-05-08 | 1984-09-13 | Un procedimiento para la preparacion de nuevas 1,2,3,4-tetrahidro-2-naftilaminas |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES511986A Granted ES511986A0 (es) | 1981-05-08 | 1982-05-07 | "un procedimiento para la preparacion de nuevas 1,2,3,4 tetrahidro 2 naftilaminas". |
ES519615A Expired ES8504666A1 (es) | 1981-05-08 | 1983-02-08 | Un procedimiento para la preparacion de nuevas 1,2,3,4-tetrahidro-2-naftilaminas. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES535882A Expired ES8602603A1 (es) | 1981-05-08 | 1984-09-13 | Un procedimiento para la preparacion de nuevas 1,2,3,4-tetrahidro-2-naftilaminas |
Country Status (16)
Country | Link |
---|---|
US (1) | US4876284A (es) |
EP (1) | EP0064964B1 (es) |
JP (1) | JPS57192344A (es) |
AT (1) | ATE8874T1 (es) |
AU (2) | AU554206B2 (es) |
CA (1) | CA1236113A (es) |
DE (1) | DE3260529D1 (es) |
DK (1) | DK164937C (es) |
ES (4) | ES511986A0 (es) |
FI (1) | FI78067C (es) |
GR (1) | GR77121B (es) |
IE (1) | IE53143B1 (es) |
IL (1) | IL65501A (es) |
NO (1) | NO152902C (es) |
NZ (1) | NZ200526A (es) |
PH (2) | PH18065A (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL65501A (en) * | 1981-05-08 | 1986-04-29 | Astra Laekemedel Ab | 1-alkyl-2-aminotetralin derivatives,process for their preparation and pharmaceutical compositions containing them |
US4657925A (en) * | 1984-08-13 | 1987-04-14 | Nelson Research & Development Co. | Method and compositions for reducing the intraocular pressure of mammals |
US4722933A (en) * | 1985-12-20 | 1988-02-02 | Nelson Research & Development Co. | Substituted 2-aminotetralins |
US4743618A (en) * | 1983-01-03 | 1988-05-10 | Nelson Research & Development Co. | Substituted 2-aminotetralins |
GB2157950B (en) * | 1984-05-04 | 1988-11-02 | Nelson Res & Dev | Selective d-2 dopamine receptor agonist |
AU573828B2 (en) * | 1984-05-17 | 1988-06-23 | E.R. Squibb & Sons, Inc. | Tetrahydronaphthalenols |
DE3479314D1 (en) * | 1984-05-22 | 1989-09-14 | Nelson Res & Dev | Substituted 2-aminotetralins and processes for synthesis |
DE3718317A1 (de) * | 1986-12-10 | 1988-06-16 | Bayer Ag | Substituierte basische 2-aminotetraline |
HUT58035A (en) * | 1988-07-29 | 1992-01-28 | Schering Corp | Process for enanthiospecific synthesis of intermediates of hexahydrobenzo(d)naphtno(2,1-b)azepines |
US5091526A (en) * | 1988-07-29 | 1992-02-25 | Schering Corporation | Process for the enantiospecific synthesis of intermediates for hexahydro-benzo[d]-naphtho[2,1-b]azepines |
CA1335106C (en) * | 1989-02-27 | 1995-04-04 | John Mehnert Schaus | Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes |
SE8901889D0 (sv) * | 1989-05-26 | 1989-05-26 | Astra Ab | Novel 8-substituted-2-aminotetralines |
ATE172712T1 (de) * | 1989-05-31 | 1998-11-15 | Upjohn Co | Zns-wirksame 8-heterocyclyl-2-aminotetralin derivate |
IT1232160B (it) * | 1989-07-31 | 1992-01-25 | Sigma Tau Ind Farmaceuti | 2-(n-acil)ammino-6,7-dimetossi tetraline, procedimento per la loro preparazione e composizioni farmaceutiche ad attivita' antiipertensiva che le contengono |
EP0507863A4 (en) * | 1989-12-28 | 1993-07-07 | Virginia Commonwealth University | Sigma receptor ligands and the use thereof |
ES2100211T3 (es) * | 1990-08-15 | 1997-06-16 | Lilly Co Eli | 2-amino-1,2,3,4-tetrahidronaftalenos, 3-aminocromanos y 3-aminotiocromanos sustituidos en el anillo. |
CA2106197A1 (en) * | 1991-04-26 | 1992-10-27 | Montford F. Piercey | Method of treating/preventing substance abuse |
CA2111957A1 (en) * | 1991-06-27 | 1993-01-07 | Richard A. Glennon | Sigma receptor ligands and the use thereof |
IT1251877B (it) * | 1991-09-26 | 1995-05-26 | Zambon Spa | Processo per la preparazione di 2-ammino-5,6 dimetossi-tetralina |
EP0697894A4 (en) * | 1993-03-31 | 1996-05-01 | Univ Pennsylvania | DOPAMINE D-3 AND SEROTONIN (5-HT 1A) RECEPTOR LIGANDS AND IMAGING AGENTS |
ZA944513B (en) * | 1993-06-23 | 1996-01-16 | Cambridge Neuroscience Inc | Sigma receptor ligands |
GB9315566D0 (en) * | 1993-07-28 | 1993-09-08 | Smithkline Beecham Plc | Medicaments |
AU5147196A (en) * | 1995-03-27 | 1996-10-16 | Smithkline Beecham Plc | Bicyclic amine derivatives and their use as anti-psychotic a gents |
US5646188A (en) * | 1995-07-05 | 1997-07-08 | Teva Pharmaceutical Industries, Ltd. | Polyamine derivatives of 1-aminoindan |
CN1329589A (zh) | 1998-10-07 | 2002-01-02 | 奥索-麦克尼尔药品公司 | 用作神经肽yy5受体的配体的n-芳烷基氨基1,2,3,4-四氢萘 |
AU2003241453A1 (en) | 2002-05-17 | 2003-12-02 | Janssen Pharmaceutica N.V. | Aminotetralin-derived urea modulators of vanilloid vr1 receptor |
EP2098511A1 (en) | 2008-03-07 | 2009-09-09 | Solvias AG | Process for preparing compounds containing a hydronaphtalene structure with an unsymmetrically substituted benzene ring |
DE102010020553A1 (de) | 2010-05-14 | 2011-11-17 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 8-Alkoxy-2-aminotetralin-Derivate und ihre Verwendung |
CN104703964B (zh) | 2012-07-20 | 2017-04-12 | 拜耳制药股份公司 | 取代氨基茚满‑和氨基萘满甲酸及其用途 |
ME02603B (me) | 2012-07-20 | 2017-06-20 | Bayer Pharma AG | Nove 5 - aminotetrahidrohinolin-2-karbonske kiseline i njihova upotreba |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1017359A (en) * | 1972-07-03 | 1977-09-13 | Frederic P. Hauck | Substituted cyclic polymethylene phenols |
JPS5124508B2 (es) * | 1972-08-14 | 1976-07-24 | ||
DE2752659A1 (de) * | 1976-12-07 | 1978-06-08 | Sandoz Ag | Neue tetralinderivate, ihre herstellung und verwendung |
EP0026848B1 (de) * | 1979-09-14 | 1983-05-04 | Sandoz Ag | Tetralinderivate, ihre Herstellung und Heilmittel, welche diese Verbindungen enthalten |
AU7179781A (en) * | 1980-05-29 | 1981-12-21 | Astra Lakemedel Aktiebolag | Therapeutically useful tetralin derivatives |
IL65501A (en) * | 1981-05-08 | 1986-04-29 | Astra Laekemedel Ab | 1-alkyl-2-aminotetralin derivatives,process for their preparation and pharmaceutical compositions containing them |
FR2512814A1 (fr) * | 1981-09-16 | 1983-03-18 | Synthelabo | Derives d'amino-2 tetrahydro-1,2,3,4 naphtalene, leur preparation et leur application en therapeutique |
-
1982
- 1982-04-15 IL IL65501A patent/IL65501A/xx not_active IP Right Cessation
- 1982-04-28 CA CA000401881A patent/CA1236113A/en not_active Expired
- 1982-05-05 NZ NZ200526A patent/NZ200526A/en unknown
- 1982-05-05 PH PH27236A patent/PH18065A/en unknown
- 1982-05-05 AU AU83409/82A patent/AU554206B2/en not_active Ceased
- 1982-05-06 NO NO821494A patent/NO152902C/no unknown
- 1982-05-06 AT AT82850102T patent/ATE8874T1/de active
- 1982-05-06 DE DE8282850102T patent/DE3260529D1/de not_active Expired
- 1982-05-06 DK DK202882A patent/DK164937C/da not_active IP Right Cessation
- 1982-05-06 FI FI821598A patent/FI78067C/fi not_active IP Right Cessation
- 1982-05-06 IE IE1076/82A patent/IE53143B1/en not_active IP Right Cessation
- 1982-05-06 EP EP82850102A patent/EP0064964B1/en not_active Expired
- 1982-05-07 GR GR68101A patent/GR77121B/el unknown
- 1982-05-07 ES ES511986A patent/ES511986A0/es active Granted
- 1982-05-07 JP JP57075554A patent/JPS57192344A/ja active Granted
-
1983
- 1983-02-08 ES ES519615A patent/ES8504666A1/es not_active Expired
-
1984
- 1984-01-31 ES ES529311A patent/ES8506591A1/es not_active Expired
- 1984-03-19 AU AU25879/84A patent/AU572497B2/en not_active Ceased
- 1984-06-08 PH PH30792A patent/PH19585A/en unknown
- 1984-09-13 ES ES535882A patent/ES8602603A1/es not_active Expired
-
1988
- 1988-01-11 US US07/143,260 patent/US4876284A/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8504666A1 (es) | Un procedimiento para la preparacion de nuevas 1,2,3,4-tetrahidro-2-naftilaminas. | |
ES8400730A1 (es) | Un procedimiento para preparar derivados de tetralina | |
ES8601915A1 (es) | Un procedimiento para preparar derivados de piridazinona | |
GB2251616B (en) | Therapeutic benzazapine compounds | |
ATE152708T1 (de) | (1,2n) und (3,2n)-karbozyklische-2-amino- tetralinderivate | |
ES8403857A1 (es) | Procedimiento de preparacion de dederivados de amino-2--tetrahidro-1 2 3 4-naftaleno | |
ES8707530A1 (es) | Un procedimiento para la preparacion de una octahidroindolizina | |
FR2415637A1 (fr) | Nouveaux carbamates de 8b-(hydroxyethyl)ergolines, utiles notamment pour le traitement des affections des systemes circulatoire, respiratoire et nerveux central, et leur procede de preparation | |
ES8707247A1 (es) | Un procedimiento para preparar un derivado de ergolina | |
MY108455A (en) | Therapeutic benzazapine compounds. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19990201 |