ES8505411A1 - Un metodo para producir interferon - Google Patents

Un metodo para producir interferon

Info

Publication number
ES8505411A1
ES8505411A1 ES532173A ES532173A ES8505411A1 ES 8505411 A1 ES8505411 A1 ES 8505411A1 ES 532173 A ES532173 A ES 532173A ES 532173 A ES532173 A ES 532173A ES 8505411 A1 ES8505411 A1 ES 8505411A1
Authority
ES
Spain
Prior art keywords
novel vectors
interferon expression
interferon
expression
vectors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES532173A
Other languages
English (en)
Other versions
ES532173A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES532173A0 publication Critical patent/ES532173A0/es
Publication of ES8505411A1 publication Critical patent/ES8505411A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

METODO PARA LA PRODUCCION MICROBICA DE INTERFERON.COMPRENDE: A) TRANSFORMAR UN ORGANISMO HUESPED COMO SACCHAROMYCES CEREVISIAE CON UN VECTOR DE EXPRESION QUE CONTIENE EL GEN ESTRUCTURAL PARA UN INTERFERON HUMANO ENLAZADO DE FORMA OPERATIVA CON UN PROMOTOR/REGULADOR PRO5; B) DESARROLLAR EL ORGANISMO TRANSFORMADO EN UN MEDIO DE CULTIVO QUE CONTIENE FOSFATO INORGANICO Y NUTRIENTES; C) DISMINUIR LOS NIVELES DE FOSFATO INORGANICO PRESENTES EN EL MEDIO DE CULTIVO, PARA CONDUCIR AL ORGANISMO TRANSFORMADOY DESARROLLADO Y PRODUCIR INTERFERON; D) LISAR AL ORGANISMO TRANSFORMADO Y DESARROLLADO Y E) RECUPERAR AL INTERFERON DEL LISADO RESULTANTE.SE UTILIZA COMO ELEMENTO REGULADOR DE CONTROL DEL CRECIMIENTO DE LEVADURAS.
ES532173A 1983-05-05 1984-05-04 Un metodo para producir interferon Expired ES8505411A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49167283A 1983-05-05 1983-05-05

Publications (2)

Publication Number Publication Date
ES532173A0 ES532173A0 (es) 1985-06-01
ES8505411A1 true ES8505411A1 (es) 1985-06-01

Family

ID=23953166

Family Applications (2)

Application Number Title Priority Date Filing Date
ES532173A Expired ES8505411A1 (es) 1983-05-05 1984-05-04 Un metodo para producir interferon
ES540038A Expired ES8606887A1 (es) 1983-05-05 1985-02-01 Un metodo para la produccion microbica de interferon.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES540038A Expired ES8606887A1 (es) 1983-05-05 1985-02-01 Un metodo para la produccion microbica de interferon.

Country Status (14)

Country Link
EP (1) EP0124874A3 (es)
JP (1) JPS60186288A (es)
AU (1) AU2767684A (es)
DK (1) DK224684A (es)
ES (2) ES8505411A1 (es)
FI (1) FI841787A (es)
GR (1) GR79963B (es)
HU (1) HUT34239A (es)
IL (1) IL71745A0 (es)
MC (1) MC1598A1 (es)
NO (1) NO841811L (es)
NZ (1) NZ208046A (es)
PT (1) PT78552B (es)
ZA (1) ZA843275B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0214638A3 (en) * 1985-09-09 1988-08-31 G.D. Searle & Co. Yeast promoters
JPH0655146B2 (ja) * 1985-12-27 1994-07-27 財団法人化学及血清療法研究所 シヤトルベクタ−
US5013652A (en) * 1986-10-14 1991-05-07 Genex Corporation Composite yeast vectors
DE3635867A1 (de) * 1986-10-22 1988-05-11 Boehringer Ingelheim Int Neue hefeexpressionsvektoren fuer ifn-omega, verfahren zu ihrer herstellung und deren verwendung
KR100374307B1 (ko) * 1995-07-21 2003-07-07 주식회사 엘지생명과학 재조합효모로부터발현된감마인터페론의정제방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
AU561343B2 (en) * 1981-10-19 1987-05-07 Genentech Inc. Human immune interferon by recombinant dna
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
GB2125047B (en) * 1982-08-09 1986-02-19 Ciba Geigy Ag Yeast hybrid vectors and their use for the production of polypeptides
IL72773A0 (en) * 1983-08-29 1984-11-30 Meloy Lab Production of immune interferon and its mrna

Also Published As

Publication number Publication date
DK224684D0 (da) 1984-05-04
ES540038A0 (es) 1986-05-16
PT78552A (en) 1984-06-01
EP0124874A3 (en) 1987-03-25
DK224684A (da) 1984-11-06
ES532173A0 (es) 1985-06-01
HUT34239A (en) 1985-02-28
MC1598A1 (fr) 1985-05-09
FI841787A (fi) 1984-11-06
NZ208046A (en) 1988-04-29
ES8606887A1 (es) 1986-05-16
PT78552B (en) 1986-09-15
IL71745A0 (en) 1984-09-30
GR79963B (es) 1984-10-31
FI841787A0 (fi) 1984-05-04
JPS60186288A (ja) 1985-09-21
ZA843275B (en) 1984-12-24
AU2767684A (en) 1984-11-08
EP0124874A2 (en) 1984-11-14
NO841811L (no) 1984-11-06

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