ES8504665A1 - Metodo de preparar derivados de p-acilaminofenol - Google Patents

Metodo de preparar derivados de p-acilaminofenol

Info

Publication number
ES8504665A1
ES8504665A1 ES526647A ES526647A ES8504665A1 ES 8504665 A1 ES8504665 A1 ES 8504665A1 ES 526647 A ES526647 A ES 526647A ES 526647 A ES526647 A ES 526647A ES 8504665 A1 ES8504665 A1 ES 8504665A1
Authority
ES
Spain
Prior art keywords
derivatives
therapeutical effect
preparation
active ingredients
pharmacologically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES526647A
Other languages
English (en)
Other versions
ES526647A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cermol SA
Original Assignee
Cermol SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cermol SA filed Critical Cermol SA
Publication of ES526647A0 publication Critical patent/ES526647A0/es
Publication of ES8504665A1 publication Critical patent/ES8504665A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)

Abstract

METODO PARA LA PREPARACION DE DERIVADOS DE P-ACILAMINOFENOL, DE FORMULA GENERAL (I), EN LA QUE R REPRESENTA UN RADICAL ACILO; N ES 0, 1, 2 O 3; R1 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO METILO; Y R2 Y R3 REPRESENTAN CADA UNO DE ELLOS UN GRUPO ALQUILO LINEAL O RAMIFICADO, Y SUS SALES DE ADICION FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN HACER REACCIONAR UN CLORURO DE ACIDO CORRESPONDIENTE CON UN FENOL DE FORMULA GENERAL (II), EN PRESENCIA DE UNA BASE TERCIARIA.DE APLICACION EN LA PREPARACION DE COMPOSICIONES CON EFECTO TERAPEUTICO, EN PARTICULAR, ANALGESICO O ANTIINFLAMATORIO.
ES526647A 1981-11-02 1983-10-21 Metodo de preparar derivados de p-acilaminofenol Expired ES8504665A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH700081 1981-11-02
CH250782 1982-04-26

Publications (2)

Publication Number Publication Date
ES526647A0 ES526647A0 (es) 1985-05-16
ES8504665A1 true ES8504665A1 (es) 1985-05-16

Family

ID=25690624

Family Applications (2)

Application Number Title Priority Date Filing Date
ES516880A Expired ES8401929A1 (es) 1981-11-02 1982-10-27 Procedimiento de preparar derivados de p-acilaminofenol.
ES526647A Expired ES8504665A1 (es) 1981-11-02 1983-10-21 Metodo de preparar derivados de p-acilaminofenol

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES516880A Expired ES8401929A1 (es) 1981-11-02 1982-10-27 Procedimiento de preparar derivados de p-acilaminofenol.

Country Status (7)

Country Link
US (1) US4532249A (es)
EP (1) EP0078765B1 (es)
CA (1) CA1211105A (es)
DE (1) DE3269449D1 (es)
ES (2) ES8401929A1 (es)
GR (1) GR77703B (es)
PT (1) PT75767B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849737A (en) * 1995-04-14 1998-12-15 The Regents Of The University Of California Compositions and methods for treating pain
US6166085A (en) * 1995-04-14 2000-12-26 The Regents Of The University Of California Method of producing analgesia
EP0915834A1 (en) * 1996-03-15 1999-05-19 Elan Pharmaceuticals, Inc. Method and compositions for producing analgesia
US7718692B2 (en) * 2004-02-13 2010-05-18 Carson John R Hetero-substituted acetanilide derivatives as analgesic agents
BRPI0404222A (pt) * 2004-06-07 2006-02-07 Fundacao Oswaldo Cruz Compostos derivados da lidocaìna, composições farmacêuticas contendo os mesmos, uso das respectivas composições farmacêuticas no tratamento, prevenção ou inibição de doenças bem como o método de tratamento, prevenção ou inibição de doenças com as ditas composições farmacêuticas

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE940828C (de) * 1953-08-20 1956-03-29 Leo Pharm Prod Ltd Verfahren zur Herstellung von Estern des Penicillins mit Phenolen und Thiophenolen
GB888664A (en) * 1959-02-18 1962-01-31 May & Baker Improvements in or relating to acylamidophenol derivatives
FR2043489B1 (es) * 1969-05-29 1973-07-13 Orsymonde
DE2625195A1 (de) * 1976-06-04 1977-12-22 Hoechst Ag 1-methyl-2-(4-aminophenyl-substit.- methyl)-5-nitro-imidazole und verfahren zu ihrer herstellung
GB1587070A (en) * 1977-06-02 1981-03-25 Sterwin Ag Pharmacologically-active 4-acetamidophenyl a-(2-methyl-ind(en/ol)-3-yl)-acetates processes for their preparation and pharmaceutical composition incorporating them

Also Published As

Publication number Publication date
ES516880A0 (es) 1984-01-16
CA1211105A (fr) 1986-09-09
PT75767B (fr) 1985-07-26
ES8401929A1 (es) 1984-01-16
EP0078765B1 (fr) 1986-02-26
PT75767A (fr) 1982-11-01
ES526647A0 (es) 1985-05-16
EP0078765A1 (fr) 1983-05-11
DE3269449D1 (en) 1986-04-03
GR77703B (es) 1984-09-25
US4532249A (en) 1985-07-30

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612