ES8503945A1 - Un procedimiento para la preparacion de derivados de pirazolona utiles como inhibidores de lipoxigenasa. - Google Patents

Un procedimiento para la preparacion de derivados de pirazolona utiles como inhibidores de lipoxigenasa.

Info

Publication number
ES8503945A1
ES8503945A1 ES530432A ES530432A ES8503945A1 ES 8503945 A1 ES8503945 A1 ES 8503945A1 ES 530432 A ES530432 A ES 530432A ES 530432 A ES530432 A ES 530432A ES 8503945 A1 ES8503945 A1 ES 8503945A1
Authority
ES
Spain
Prior art keywords
atoms
radical
alkyl
image
son
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES530432A
Other languages
English (en)
Other versions
ES530432A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19833308881 external-priority patent/DE3308881A1/de
Priority claimed from DE19833342628 external-priority patent/DE3342628A1/de
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES8503945A1 publication Critical patent/ES8503945A1/es
Publication of ES530432A0 publication Critical patent/ES530432A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE PIRAZOLONA UTILES COMO INHIBIDORES DE LIPOXIGENASA.CONSISTE EN HACER REACCIONAR A HIDRAZINAS DE FORMULA (II) CON DERIVADOS DEL ACIDO BBB-CETONICO DE FORMULA (III), EN DISOLVENTE INERTES, EN PRESENCIA DE CATALIZADORES BASICOS O ACIDOS COMO HIDROXIDOS ALCALINOS E HIDRACIDOS HALOGENADOS Y A UNA TEMPERATURA ENTRE 10 Y 200JC, PARA OBTENER LOS DERIVADOS DE PIRAZOLONA DE FORMULA (I). SIENDO R UN RESTO ARILO O HETEROARILO DE C 6 A 12, QUE CONTIENE DE 1 A 3 SUSTITUYENTES DEL GRUPO TRIFLUORMETILO, ALQUILO Y OTROS; R, H O UN RESTO HIDROCARBONADO DE C 1 A 18, QUE CONTIENE GRUPOS HIDROXI, ETER Y OTROS; R, R O UN RADICAL DE FORMULA (IV); R, H; X, -(CH2)3, -O-CH2-CH2- Y OTROS, E Y, HIDROXI, ALCOXI Y OTROS.SE UTILIZAN COMO INHIBIDORES DE LIPOXIGENASA EN LA TERAPIA DE ISQUEMIAS.
ES530432A 1983-03-12 1984-03-09 Un procedimiento para la preparacion de derivados de pirazolona utiles como inhibidores de lipoxigenasa. Granted ES530432A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19833308881 DE3308881A1 (de) 1983-03-12 1983-03-12 Verwendung von pyrazolonderivaten als lipoxygenasehemmer, bei der therapie von ischaemien und herzrhythmusstoerungen sowie von rheumatischen, allergischen und asthmatischen erkrankungen, oedemen, lungenembolien, pulmonaler hypertension, sauerstoffintoxikation und ulcerationen, arzneimittel hierfuer und verfahren zu deren herstellung
DE19833342628 DE3342628A1 (de) 1983-11-25 1983-11-25 Verwendung von pyrazolonderivaten als lipoxygenasehemmer bei der therapie von ischaemien und herzrhythmusstoerungen, haut- und augenentzuendungen, sowie von rheumatischen, allergischen und asthmatischen erkrankungen, oedemen, lungenembolien, pulmonaler hypertension, schocklunge, sauerstoffintoxikation und ulcerationen, arzneimittel hierfuer und verfahren zu deren herstellung

Publications (2)

Publication Number Publication Date
ES8503945A1 true ES8503945A1 (es) 1985-04-16
ES530432A0 ES530432A0 (es) 1985-04-16

Family

ID=25808986

Family Applications (1)

Application Number Title Priority Date Filing Date
ES530432A Granted ES530432A0 (es) 1983-03-12 1984-03-09 Un procedimiento para la preparacion de derivados de pirazolona utiles como inhibidores de lipoxigenasa.

Country Status (10)

Country Link
US (1) US4670460A (es)
EP (1) EP0125406A2 (es)
DK (1) DK143684A (es)
ES (1) ES530432A0 (es)
FI (1) FI840954A (es)
GR (1) GR81867B (es)
HU (1) HUT34123A (es)
IL (1) IL71202A0 (es)
NO (1) NO840869L (es)
PT (1) PT78239B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE35801E (en) * 1985-05-20 1998-05-19 Mitsubishi Chemical Corporation Prophylactic and therapeutic composition for circulatory disorders and method of treatment
DK169672B1 (da) * 1985-05-20 1995-01-09 Mitsubishi Chem Ind Farmaceutiske præparater indeholdende pyrazolonderivater som aktiv bestanddel og anvendelsen af pyrazolonderivater til fremstilling af farmaceutiske præparater
JPH0737990B2 (ja) * 1990-10-12 1995-04-26 寳酒造株式会社 糖類の標識方法及び糖類標識用キット
US5183825A (en) * 1992-04-07 1993-02-02 American Home Products Corporation 4-arylmethyl-5-alkyl-3H-pyrazol-3-ones and hypoglycemic use
JPH0725765A (ja) * 1993-07-07 1995-01-27 Mitsubishi Chem Corp 眼疾患用薬剤
GB0011095D0 (en) * 2000-05-08 2000-06-28 Black James Foundation astrin and cholecystokinin receptor ligands (III)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3147276A (en) * 1964-09-01 Pyrazolones
DE2427272C3 (de) * 1974-06-06 1981-10-01 Bayer Ag, 5090 Leverkusen 1-(2-(β-Naphthyloxy)-äthyl)-3-methyl -pyrazolon-(5), Verfahren sowie Verwendung als Antithrombotikum
DE2526469A1 (de) * 1975-06-13 1976-12-30 Bayer Ag 1-substituierte pyrazolderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2526467A1 (de) * 1975-06-13 1976-12-30 Bayer Ag 4-substituierte pyrazolderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
CA1151164A (en) * 1978-01-13 1983-08-02 Atsuyuki Kojima Conjugated ketone compounds and their production and use
US4472428A (en) * 1980-12-09 1984-09-18 Teijin Limited Halogenated prostacyclins pharmaceutical use thereof and hydroxy intermediates therefore
JPS5846079A (ja) * 1981-09-12 1983-03-17 Santen Pharmaceut Co Ltd ベンゾチアゾリン環を有するエ−テル類
US4478842A (en) * 1981-11-19 1984-10-23 Ciba-Geigy Corporation N-Substituted-2-pyridylindoles

Also Published As

Publication number Publication date
IL71202A0 (en) 1984-06-29
DK143684D0 (da) 1984-02-29
US4670460A (en) 1987-06-02
PT78239B (en) 1986-04-24
NO840869L (no) 1984-09-13
ES530432A0 (es) 1985-04-16
FI840954A (fi) 1984-09-13
FI840954A0 (fi) 1984-03-08
HUT34123A (en) 1985-02-28
GR81867B (es) 1984-12-12
EP0125406A2 (de) 1984-11-21
DK143684A (da) 1984-09-13
PT78239A (en) 1984-04-01

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