ES8501765A1 - Procedimiento para preparar 6-aril-1,2,4,-triazolo (4,3-b) piridazinas substituidas - Google Patents

Procedimiento para preparar 6-aril-1,2,4,-triazolo (4,3-b) piridazinas substituidas

Info

Publication number
ES8501765A1
ES8501765A1 ES531084A ES531084A ES8501765A1 ES 8501765 A1 ES8501765 A1 ES 8501765A1 ES 531084 A ES531084 A ES 531084A ES 531084 A ES531084 A ES 531084A ES 8501765 A1 ES8501765 A1 ES 8501765A1
Authority
ES
Spain
Prior art keywords
carbon atoms
formula
chlorine
alkyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES531084A
Other languages
English (en)
Other versions
ES531084A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES8501765A1 publication Critical patent/ES8501765A1/es
Publication of ES531084A0 publication Critical patent/ES531084A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR 6-ARIL-1,2,4-TRIAZOLO 4,3-B PIRIDAZINAS SUSTITUIDAS.CONSISTE EN PREPARAR COMPONENTES DE FORMULA GENERAL (I) Y SUS SALES, CON UN ACIDO FISIOLOGICAMENTE COMPATIBLE EN DONDE R Y R SON IGUALES O DISTINTOS Y REPRESENTAN HIDROGENO, CLORO U OTROS, R HIDROGENO Y OTROS, R ALQUILO DE CADENA LINEAL O RAMIFICADO U OTROS Y AR REPRESENTA RADICALES AROMATICAS TALES COMO FENILO, BIFENILO U OTROS, Y COMPRENDE LAS ETAPAS DE: A) SE CICLIZA UN COMPUESTO DE FORMULA (II) EN DONDE AR, R, R, R Y R TIENEN LOS SIGNIFICADOS ANTERIORES Y POR CALENTAMIENTO Y EVENTUALMENTE CON LA ADICION DE UN AGENTE CONDENSADO SE FORMA EL COMPUESTO DE FORMULA (I); Y B) SE HACE REACCIONAR EL COMPUESTO DE FORMULA (III) EN DONDE R SIGNIFICA CLORO U OTROS Y AR, R Y R LOS SIGNIFICADOS ANTERIORES CON AMINAS DE FORMULA (IV) EN DONDE R Y R TIENEN LOS SIGNIFICADOS ANTERIORES.
ES531084A 1983-03-31 1984-03-29 Procedimiento para preparar 6-aril-1,2,4,-triazolo (4,3-b) piridazinas substituidas Granted ES531084A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833311753 DE3311753A1 (de) 1983-03-31 1983-03-31 Substituierte 6-aryl-1,2,4-triazolo(4,3-b)pyridazine - ihre herstellung und verwendung -

Publications (2)

Publication Number Publication Date
ES8501765A1 true ES8501765A1 (es) 1984-12-01
ES531084A0 ES531084A0 (es) 1984-12-01

Family

ID=6195196

Family Applications (1)

Application Number Title Priority Date Filing Date
ES531084A Granted ES531084A0 (es) 1983-03-31 1984-03-29 Procedimiento para preparar 6-aril-1,2,4,-triazolo (4,3-b) piridazinas substituidas

Country Status (19)

Country Link
EP (1) EP0121490B1 (es)
JP (1) JPS59184179A (es)
KR (1) KR840008361A (es)
AT (1) ATE32723T1 (es)
AU (1) AU563556B2 (es)
CA (1) CA1246568A (es)
DE (2) DE3311753A1 (es)
DK (1) DK144884A (es)
ES (1) ES531084A0 (es)
FI (1) FI841238A (es)
GR (1) GR81812B (es)
HU (1) HU189076B (es)
IL (1) IL71412A (es)
MA (1) MA20080A1 (es)
NO (1) NO841270L (es)
NZ (1) NZ207691A (es)
PH (1) PH20465A (es)
PT (1) PT78343B (es)
ZA (1) ZA842389B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4654343A (en) * 1985-10-31 1987-03-31 American Cyanamid Company N-substituted-N[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]alkanamides, carbamates and ureas
WO2008021781A1 (en) 2006-08-07 2008-02-21 Incyte Corporation Triazolotriazines as kinase inhibitors
EP3443958A1 (en) 2006-11-22 2019-02-20 Incyte Holdings Corporation Imidazotriazines and imidazopyrimidines as kinase inhibitors
PL2300455T3 (pl) 2008-05-21 2018-02-28 Incyte Holdings Corporation Sole 2-fluoro-N-metylo-4-[7-(chinolin-6-ylometylo)imidazo[1,2-b][1, 2,4)triazyn-2-ylo)benzamidu i procesy związane z ich wytworzeniem
JP5714030B2 (ja) 2010-02-03 2015-05-07 インサイト コーポレーションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ Ｃ−Ｍｅｔ阻害剤としてのイミダゾ［１，２−ｂ］［１，２，４］トリアジン
WO2012148775A1 (en) * 2011-04-29 2012-11-01 Amgen Inc. Bicyclic pyridazine compounds as pim inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL128809C (es) * 1966-06-18
DE2113438A1 (de) * 1971-03-19 1972-09-21 Boehringer Mannheim Gmbh Nitrofuryl-triazolo[4,3-b]pyridazinderivate
US3915968A (en) * 1973-09-21 1975-10-28 Lepetit Spa Triazolopyridazines
DE3217325A1 (de) * 1982-05-08 1983-11-10 Hoechst Ag, 6230 Frankfurt 3-amino-6-aryl-1,2,4-triazolo(4,3-b)-pyridazine, ihre herstellung und ihre verwendung
DE3222342A1 (de) * 1982-06-14 1983-12-15 Hoechst Ag, 6230 Frankfurt 6-aryl-1,2,4-triazolo (4,3-b) pyridazin-3-carbaminate, ihre herstellung und sie enthaltende arzneimittel

Also Published As

Publication number Publication date
PT78343B (de) 1986-07-14
DK144884D0 (da) 1984-02-29
FI841238A0 (fi) 1984-03-28
AU2634684A (en) 1984-10-04
PT78343A (de) 1984-04-01
HU189076B (en) 1986-06-30
IL71412A0 (en) 1984-06-29
ES531084A0 (es) 1984-12-01
DE3469530D1 (en) 1988-04-07
CA1246568A (en) 1988-12-13
HUT34193A (en) 1985-02-28
JPS59184179A (ja) 1984-10-19
AU563556B2 (en) 1987-07-16
MA20080A1 (fr) 1984-10-01
EP0121490A1 (de) 1984-10-10
ZA842389B (en) 1984-11-28
FI841238A (fi) 1984-10-01
EP0121490B1 (de) 1988-03-02
GR81812B (es) 1984-12-12
PH20465A (en) 1987-01-14
NO841270L (no) 1984-10-01
NZ207691A (en) 1986-07-11
IL71412A (en) 1988-05-31
DE3311753A1 (de) 1984-10-04
DK144884A (da) 1984-10-01
ATE32723T1 (de) 1988-03-15
KR840008361A (ko) 1984-12-14

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