ES8501765A1 - Procedimiento para preparar 6-aril-1,2,4,-triazolo (4,3-b) piridazinas substituidas - Google Patents
Procedimiento para preparar 6-aril-1,2,4,-triazolo (4,3-b) piridazinas substituidasInfo
- Publication number
- ES8501765A1 ES8501765A1 ES531084A ES531084A ES8501765A1 ES 8501765 A1 ES8501765 A1 ES 8501765A1 ES 531084 A ES531084 A ES 531084A ES 531084 A ES531084 A ES 531084A ES 8501765 A1 ES8501765 A1 ES 8501765A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- formula
- chlorine
- alkyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR 6-ARIL-1,2,4-TRIAZOLO 4,3-B PIRIDAZINAS SUSTITUIDAS.CONSISTE EN PREPARAR COMPONENTES DE FORMULA GENERAL (I) Y SUS SALES, CON UN ACIDO FISIOLOGICAMENTE COMPATIBLE EN DONDE R Y R SON IGUALES O DISTINTOS Y REPRESENTAN HIDROGENO, CLORO U OTROS, R HIDROGENO Y OTROS, R ALQUILO DE CADENA LINEAL O RAMIFICADO U OTROS Y AR REPRESENTA RADICALES AROMATICAS TALES COMO FENILO, BIFENILO U OTROS, Y COMPRENDE LAS ETAPAS DE: A) SE CICLIZA UN COMPUESTO DE FORMULA (II) EN DONDE AR, R, R, R Y R TIENEN LOS SIGNIFICADOS ANTERIORES Y POR CALENTAMIENTO Y EVENTUALMENTE CON LA ADICION DE UN AGENTE CONDENSADO SE FORMA EL COMPUESTO DE FORMULA (I); Y B) SE HACE REACCIONAR EL COMPUESTO DE FORMULA (III) EN DONDE R SIGNIFICA CLORO U OTROS Y AR, R Y R LOS SIGNIFICADOS ANTERIORES CON AMINAS DE FORMULA (IV) EN DONDE R Y R TIENEN LOS SIGNIFICADOS ANTERIORES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19833311753 DE3311753A1 (de) | 1983-03-31 | 1983-03-31 | Substituierte 6-aryl-1,2,4-triazolo(4,3-b)pyridazine - ihre herstellung und verwendung - |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8501765A1 true ES8501765A1 (es) | 1984-12-01 |
ES531084A0 ES531084A0 (es) | 1984-12-01 |
Family
ID=6195196
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES531084A Granted ES531084A0 (es) | 1983-03-31 | 1984-03-29 | Procedimiento para preparar 6-aril-1,2,4,-triazolo (4,3-b) piridazinas substituidas |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0121490B1 (es) |
JP (1) | JPS59184179A (es) |
KR (1) | KR840008361A (es) |
AT (1) | ATE32723T1 (es) |
AU (1) | AU563556B2 (es) |
CA (1) | CA1246568A (es) |
DE (2) | DE3311753A1 (es) |
DK (1) | DK144884A (es) |
ES (1) | ES531084A0 (es) |
FI (1) | FI841238A (es) |
GR (1) | GR81812B (es) |
HU (1) | HU189076B (es) |
IL (1) | IL71412A (es) |
MA (1) | MA20080A1 (es) |
NO (1) | NO841270L (es) |
NZ (1) | NZ207691A (es) |
PH (1) | PH20465A (es) |
PT (1) | PT78343B (es) |
ZA (1) | ZA842389B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4654343A (en) * | 1985-10-31 | 1987-03-31 | American Cyanamid Company | N-substituted-N[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]alkanamides, carbamates and ureas |
WO2008021781A1 (en) | 2006-08-07 | 2008-02-21 | Incyte Corporation | Triazolotriazines as kinase inhibitors |
EP3443958A1 (en) | 2006-11-22 | 2019-02-20 | Incyte Holdings Corporation | Imidazotriazines and imidazopyrimidines as kinase inhibitors |
PL2300455T3 (pl) | 2008-05-21 | 2018-02-28 | Incyte Holdings Corporation | Sole 2-fluoro-N-metylo-4-[7-(chinolin-6-ylometylo)imidazo[1,2-b][1, 2,4)triazyn-2-ylo)benzamidu i procesy związane z ich wytworzeniem |
JP5714030B2 (ja) | 2010-02-03 | 2015-05-07 | インサイト コーポレーションIncyte Corporation | C−Met阻害剤としてのイミダゾ[1,2−b][1,2,4]トリアジン |
WO2012148775A1 (en) * | 2011-04-29 | 2012-11-01 | Amgen Inc. | Bicyclic pyridazine compounds as pim inhibitors |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL128809C (es) * | 1966-06-18 | |||
DE2113438A1 (de) * | 1971-03-19 | 1972-09-21 | Boehringer Mannheim Gmbh | Nitrofuryl-triazolo[4,3-b]pyridazinderivate |
US3915968A (en) * | 1973-09-21 | 1975-10-28 | Lepetit Spa | Triazolopyridazines |
DE3217325A1 (de) * | 1982-05-08 | 1983-11-10 | Hoechst Ag, 6230 Frankfurt | 3-amino-6-aryl-1,2,4-triazolo(4,3-b)-pyridazine, ihre herstellung und ihre verwendung |
DE3222342A1 (de) * | 1982-06-14 | 1983-12-15 | Hoechst Ag, 6230 Frankfurt | 6-aryl-1,2,4-triazolo (4,3-b) pyridazin-3-carbaminate, ihre herstellung und sie enthaltende arzneimittel |
-
1983
- 1983-03-31 DE DE19833311753 patent/DE3311753A1/de not_active Withdrawn
-
1984
- 1984-02-29 DK DK144884A patent/DK144884A/da not_active Application Discontinuation
- 1984-03-26 HU HU841204A patent/HU189076B/hu unknown
- 1984-03-28 DE DE8484710009T patent/DE3469530D1/de not_active Expired
- 1984-03-28 FI FI841238A patent/FI841238A/fi not_active Application Discontinuation
- 1984-03-28 EP EP84710009A patent/EP0121490B1/de not_active Expired
- 1984-03-28 AT AT84710009T patent/ATE32723T1/de not_active IP Right Cessation
- 1984-03-29 KR KR1019840001627A patent/KR840008361A/ko not_active Application Discontinuation
- 1984-03-29 ES ES531084A patent/ES531084A0/es active Granted
- 1984-03-29 PH PH30469A patent/PH20465A/en unknown
- 1984-03-29 NZ NZ207691A patent/NZ207691A/en unknown
- 1984-03-29 GR GR74257A patent/GR81812B/el unknown
- 1984-03-30 IL IL71412A patent/IL71412A/xx unknown
- 1984-03-30 PT PT78343A patent/PT78343B/pt not_active IP Right Cessation
- 1984-03-30 JP JP59061286A patent/JPS59184179A/ja active Pending
- 1984-03-30 NO NO841270A patent/NO841270L/no unknown
- 1984-03-30 ZA ZA842389A patent/ZA842389B/xx unknown
- 1984-03-30 AU AU26346/84A patent/AU563556B2/en not_active Ceased
- 1984-03-30 CA CA000451005A patent/CA1246568A/en not_active Expired
- 1984-03-31 MA MA20302A patent/MA20080A1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
PT78343B (de) | 1986-07-14 |
DK144884D0 (da) | 1984-02-29 |
FI841238A0 (fi) | 1984-03-28 |
AU2634684A (en) | 1984-10-04 |
PT78343A (de) | 1984-04-01 |
HU189076B (en) | 1986-06-30 |
IL71412A0 (en) | 1984-06-29 |
ES531084A0 (es) | 1984-12-01 |
DE3469530D1 (en) | 1988-04-07 |
CA1246568A (en) | 1988-12-13 |
HUT34193A (en) | 1985-02-28 |
JPS59184179A (ja) | 1984-10-19 |
AU563556B2 (en) | 1987-07-16 |
MA20080A1 (fr) | 1984-10-01 |
EP0121490A1 (de) | 1984-10-10 |
ZA842389B (en) | 1984-11-28 |
FI841238A (fi) | 1984-10-01 |
EP0121490B1 (de) | 1988-03-02 |
GR81812B (es) | 1984-12-12 |
PH20465A (en) | 1987-01-14 |
NO841270L (no) | 1984-10-01 |
NZ207691A (en) | 1986-07-11 |
IL71412A (en) | 1988-05-31 |
DE3311753A1 (de) | 1984-10-04 |
DK144884A (da) | 1984-10-01 |
ATE32723T1 (de) | 1988-03-15 |
KR840008361A (ko) | 1984-12-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR940005338B1 (en) | Process for phosphorylation | |
ES8501765A1 (es) | Procedimiento para preparar 6-aril-1,2,4,-triazolo (4,3-b) piridazinas substituidas | |
ES499378A0 (es) | Procedimiento para la preparacion de nuevos benzoxazoles y benzotiazoles | |
ATE12039T1 (de) | Substituierte azolyl-glykolsulfonate, diese enthaltende fungizide und verfahren zu ihrer herstellung. | |
ES8604096A1 (es) | Procedimiento para la obtencion de derivados de acido feno- xifenilpropionico sustituidos | |
DE3061105D1 (en) | Pyrazolin-5-on-yl-methyl-(di)thiophosphoric acid esters, process for their preparation and their use as pesticides |