ES8405803A1 - Oxabicyclopeptane derivative and related compounds - Google Patents
Oxabicyclopeptane derivative and related compoundsInfo
- Publication number
- ES8405803A1 ES8405803A1 ES517189A ES517189A ES8405803A1 ES 8405803 A1 ES8405803 A1 ES 8405803A1 ES 517189 A ES517189 A ES 517189A ES 517189 A ES517189 A ES 517189A ES 8405803 A1 ES8405803 A1 ES 8405803A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- substd
- opt
- aryl
- vinylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
EP--79694 A 7-Oxabicycloheptane derivs. of formula (I) are new. In (I), A' is vinylene or (CH2)2 B' is vinylene, ethynylene or (CH2)2 m is 1-8 X is OH, 1H-tetrazol-5-yl, COOH, (1-12C)alkoxycarbonyl CONHZ Z is H, 1-12C alkyl, aryl, SO2Q, COQ or OH Q is 1-12C alkyl or aryl Y is alkyl (provided that at least one of A' and B' is other than vinylene and X is other than COOH or alkoxycarbonyl), substd. alkyl, aryl-(1-12C)alkyl, alkenyl, alkynyl, aryl, pyridinyl-(1-12C)alkyl, opt. substd. pyridinyl, thienylalkyl, opt. substd. thienyl, opt. substd. cycloalkyl or opt. substd. cycloalkylalkyl and the broken bond is an opt. double bond, provided that when it is a double bond, A is vinylene and B is vinylene or (CH2)2 and Y is not alkenyl or alkynyl. - (I) are cardiovascular agents esp. inhibitors of blood platelet aggregation for treating thrombolytic diseases, and they are selective inhibitors of thromboxane A2 synthetase e.g. they have a vasodilatory effect for treatment of myocardial ischemic disease such as angina pectoris. Dose is 1-100 mg/kg daily in mammals. EPAB- EP--79694 B 7-Oxabicycloheptane derivs. of formula (I) are new. In (I), A' is vinylene or (CH2)2 B' is vinylene, ethynylene or (CH2)2 m is 1-8 X is OH, 1H-tetrazol-5-yl, COOH, (1-12C)alkoxycarbonyl CONHZ Z is H, 1-12C alkyl, aryl, SO2Q, COQ or OH Q is 1-12C alkyl or aryl Y is alkyl (provided that at least one of A' and B' is other than vinylene and X is other than COOH or alkoxycarbonyl), substd. alkyl, aryl-(1-12C)alkyl, alkenyl, alkynyl, aryl, pyridinyl-(1-12C)alkyl, opt. substd. pyridinyl, thienylalkyl, opt. substd. thienyl, opt. substd. cycloalkyl or opt. substd. cycloalkylalkyl and the broken bond is an opt. double bond, provided that when it is a double bond, A is vinylene and B is vinylene or (CH2)2 and Y is not alkenyl or alkynyl. - (I) are cardiovascular agents esp. inhibitors of blood platelet aggregation for treating thrombolytic diseases, and they are selective inhibitors of thromboxane A2 synthetase e.g. they have a vasodilatory effect for treatment of myocardial ischemic disease such as angina pectoris. Dose is 1-100 mg/kg daily in mammals. (164pp) - EP--79694 B A compound having the structural formula (I) and including all stereoisomers thereof wherein A and B may be the same or different and A is CH=CH or (CH2)2, B is CH=CH, C triple bond C or (CH2)2 m is 1 to 8, the group (CH2)m being optionally substituted with 1 or more lower alkyl radicals X is CO2R1 wherein R1 is H or C1-C12 alkyl Y is phenyl phenyl-lower alkyl substituted phenyl-lower alkyl wherein the substituent is lower alkyl, halogen, (Cl, Br or F) or lower alkoxy cycloalkyl cycloalkylalkyl or substituted cycloalkyl or substituted cyclo alkylalkyl wherein the substituent is 1 or 2 halogen, lower alkyl and/or lower alkoxy radicals the lower alkyl and lower alkoxy groups having up to 12 carbon atoms, and the cycloalkyl groups having from 3 to 12 carbon atoms and (i) represents a single or double bond. (43pp) USAB- US4537904 A 7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogues of formula (I) are new. IN (I), A is CH=CH or (CH2)2 B is CH=CH C=C or (CH2)2 m is 1-8 X is OH, COOR1 where R1 is H or 1-12C alkyl or O-CNH-Z where Z is H, 1-12Calkyl or aryl, SO2=Q where Q is 1-12C-alkyl or aryl, O=C-Q or OR2 where R2 is H Y is alkyl substd. halo, alkoxy, alkyl-aryl, haloalkyl, cycloalkyl or alkylaryl, alkylcycloalkyl, 3-6C-alkenyl or -alkynyl aryl opt. substd. cycloalkyl opt. substd. cycloalkylalkyl or PhOMe and dotted line is single or double bond. (I) are prepd. from alkylester (VI) by reaction scheme involving Collins oxidn.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31951181A | 1981-11-09 | 1981-11-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES517189A0 ES517189A0 (en) | 1984-06-16 |
ES8405803A1 true ES8405803A1 (en) | 1984-06-16 |
Family
ID=23242551
Family Applications (8)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES517189A Expired ES8405803A1 (en) | 1981-11-09 | 1982-11-08 | Oxabicyclopeptane derivative and related compounds |
ES529307A Expired ES8504784A1 (en) | 1981-11-09 | 1984-01-31 | Oxabicyclopeptane derivative and related compounds |
ES529306A Granted ES529306A0 (en) | 1981-11-09 | 1984-01-31 | PROCEDURE FOR PREPARING COMPOUNDS OF 7-OXABICICLOHEPTANO AND 7-OXIBICICLOHEPTENO |
ES529305A Granted ES529305A0 (en) | 1981-11-09 | 1984-01-31 | PROCEDURE FOR PREPARING COMPOUNDS OF 7-OXABICICLOHEPTANO AND 7-OXABICICLOHEPTENO |
ES529304A Expired ES8600302A1 (en) | 1981-11-09 | 1984-01-31 | Oxabicyclopeptane derivative and related compounds |
ES529308A Expired ES8504809A1 (en) | 1981-11-09 | 1984-01-31 | Oxabicyclopeptane derivative and related compounds |
ES543329A Expired ES8603856A1 (en) | 1981-11-09 | 1985-05-21 | Oxabicyclopeptane derivative and related compounds |
ES544172A Expired ES8604595A1 (en) | 1981-11-09 | 1985-06-14 | Oxabicyclopeptane derivative and related compounds |
Family Applications After (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES529307A Expired ES8504784A1 (en) | 1981-11-09 | 1984-01-31 | Oxabicyclopeptane derivative and related compounds |
ES529306A Granted ES529306A0 (en) | 1981-11-09 | 1984-01-31 | PROCEDURE FOR PREPARING COMPOUNDS OF 7-OXABICICLOHEPTANO AND 7-OXIBICICLOHEPTENO |
ES529305A Granted ES529305A0 (en) | 1981-11-09 | 1984-01-31 | PROCEDURE FOR PREPARING COMPOUNDS OF 7-OXABICICLOHEPTANO AND 7-OXABICICLOHEPTENO |
ES529304A Expired ES8600302A1 (en) | 1981-11-09 | 1984-01-31 | Oxabicyclopeptane derivative and related compounds |
ES529308A Expired ES8504809A1 (en) | 1981-11-09 | 1984-01-31 | Oxabicyclopeptane derivative and related compounds |
ES543329A Expired ES8603856A1 (en) | 1981-11-09 | 1985-05-21 | Oxabicyclopeptane derivative and related compounds |
ES544172A Expired ES8604595A1 (en) | 1981-11-09 | 1985-06-14 | Oxabicyclopeptane derivative and related compounds |
Country Status (4)
Country | Link |
---|---|
JP (1) | JPS5890588A (en) |
ES (8) | ES8405803A1 (en) |
HU (1) | HU190817B (en) |
ZA (1) | ZA827529B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5066480A (en) * | 1988-04-11 | 1991-11-19 | E. R. Squibb & Sons, Inc. | Method of preventing or reducing adverse reactions to protamine using a thromboxane a2 receptor antagonist |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4187236A (en) * | 1977-11-04 | 1980-02-05 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane compounds |
US4143054A (en) * | 1977-11-04 | 1979-03-06 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane- and 7-oxabicycloheptene compounds |
-
1982
- 1982-10-14 ZA ZA827529A patent/ZA827529B/en unknown
- 1982-11-08 HU HU358582A patent/HU190817B/en not_active IP Right Cessation
- 1982-11-08 JP JP57196706A patent/JPS5890588A/en active Granted
- 1982-11-08 ES ES517189A patent/ES8405803A1/en not_active Expired
-
1984
- 1984-01-31 ES ES529307A patent/ES8504784A1/en not_active Expired
- 1984-01-31 ES ES529306A patent/ES529306A0/en active Granted
- 1984-01-31 ES ES529305A patent/ES529305A0/en active Granted
- 1984-01-31 ES ES529304A patent/ES8600302A1/en not_active Expired
- 1984-01-31 ES ES529308A patent/ES8504809A1/en not_active Expired
-
1985
- 1985-05-21 ES ES543329A patent/ES8603856A1/en not_active Expired
- 1985-06-14 ES ES544172A patent/ES8604595A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES8504808A1 (en) | 1985-04-16 |
ES8604595A1 (en) | 1986-02-01 |
JPS5890588A (en) | 1983-05-30 |
ZA827529B (en) | 1983-09-28 |
ES529307A0 (en) | 1985-04-16 |
ES529304A0 (en) | 1985-10-01 |
ES529308A0 (en) | 1985-04-16 |
ES8602006A1 (en) | 1985-11-16 |
JPH0378398B2 (en) | 1991-12-13 |
ES529306A0 (en) | 1985-04-16 |
ES517189A0 (en) | 1984-06-16 |
ES8600302A1 (en) | 1985-10-01 |
ES8504809A1 (en) | 1985-04-16 |
ES529305A0 (en) | 1985-11-16 |
ES543329A0 (en) | 1986-01-01 |
ES8504784A1 (en) | 1985-04-16 |
HU190817B (en) | 1986-11-28 |
ES544172A0 (en) | 1986-02-01 |
ES8603856A1 (en) | 1986-01-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970505 |