ES8405009A1 - Un procedimiento para la preparacion de imidazodiacepinas. - Google Patents

Un procedimiento para la preparacion de imidazodiacepinas.

Info

Publication number
ES8405009A1
ES8405009A1 ES518263A ES518263A ES8405009A1 ES 8405009 A1 ES8405009 A1 ES 8405009A1 ES 518263 A ES518263 A ES 518263A ES 518263 A ES518263 A ES 518263A ES 8405009 A1 ES8405009 A1 ES 8405009A1
Authority
ES
Spain
Prior art keywords
hydrogen
imidazodiazepines
benzodiazepines
trifluoromethyl
cyano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES518263A
Other languages
English (en)
Other versions
ES518263A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES8405009A1 publication Critical patent/ES8405009A1/es
Publication of ES518263A0 publication Critical patent/ES518263A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE IMIDAZODIACEPINAS.CONSISTE EN CONVERTIR EL GRUPO CARBONILICO DE UN COMPUESTO DE FORMULA (II) EN UN GRUPO TIOCARBONILICO POR TRATAMIENTO CON UN AGENTE SULFURIZANTE TAL COMO PENTASULFURO DE FOSFORO, 24-BIS (P-METOXIFENIL) 1,3,2,4-DITIADIFOSFETAN-2,4-DISULFURO, EN PRESENCIA DE UN DISOLVENTE INERTE TAL COMO DIOXANO, TOLUENO O XILENO, Y A TEMPERATURA ENTRE 50JC Y LA TEMPERATURA DE REFLUJO, PARA OBTENER COMPUESTOS DE FORMULA (I) Y SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES, DONDE A JUNTO CON LOS DOS ATOMOS DESIGNADOSCOMO ALFA Y BETA SE REPRESENTAN EN LA FORMULA (III); R ES HIDROGENO O ALQUILO INFERIOR; R ES HIDROGENO, TRIFLUOROMETILO, HALOGENO, CIANO O NITRO; R ES HIDROGENO.TIENE APLICACION EN LA PREVENCION DE ENFERMEDADES.
ES518263A 1981-02-27 1982-12-16 Un procedimiento para la preparacion de imidazodiacepinas. Granted ES518263A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH134081 1981-02-27

Publications (2)

Publication Number Publication Date
ES8405009A1 true ES8405009A1 (es) 1984-06-01
ES518263A0 ES518263A0 (es) 1984-06-01

Family

ID=4208189

Family Applications (3)

Application Number Title Priority Date Filing Date
ES509924A Granted ES509924A0 (es) 1981-02-27 1982-02-26 "un procedimiento para la preparacion de imidazodiacepinas".
ES518262A Expired ES8405008A1 (es) 1981-02-27 1982-12-16 Un procedimiento para la preparacion de imidazodiacepinas.
ES518263A Granted ES518263A0 (es) 1981-02-27 1982-12-16 Un procedimiento para la preparacion de imidazodiacepinas.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES509924A Granted ES509924A0 (es) 1981-02-27 1982-02-26 "un procedimiento para la preparacion de imidazodiacepinas".
ES518262A Expired ES8405008A1 (es) 1981-02-27 1982-12-16 Un procedimiento para la preparacion de imidazodiacepinas.

Country Status (27)

Country Link
US (1) US4352817A (es)
EP (1) EP0059389B1 (es)
JP (1) JPS57156488A (es)
KR (1) KR830009104A (es)
AT (1) ATE10745T1 (es)
AU (1) AU551811B2 (es)
BR (1) BR8200949A (es)
CA (1) CA1184176A (es)
DE (1) DE3261496D1 (es)
DK (1) DK87182A (es)
ES (3) ES509924A0 (es)
FI (1) FI73431C (es)
GB (1) GB2093842B (es)
GR (1) GR76032B (es)
HU (1) HU185089B (es)
IE (1) IE52696B1 (es)
IL (1) IL65072A (es)
MC (1) MC1441A1 (es)
NO (1) NO157377C (es)
NZ (1) NZ199796A (es)
OA (1) OA07010A (es)
PH (1) PH18255A (es)
PT (1) PT74505B (es)
YU (1) YU25282A (es)
ZA (1) ZA821129B (es)
ZM (1) ZM482A1 (es)
ZW (1) ZW3082A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MC1528A1 (fr) * 1982-07-21 1984-04-13 Hoffmann La Roche Imidazobenzodiazepines
DK151808C (da) * 1982-11-16 1988-06-20 Ferrosan As Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
IL74070A (en) * 1984-01-19 1988-12-30 Hoffmann La Roche Imidazodiazepine derivatives,their manufacture and pharmaceutical compositions containing them
EP0212825B1 (en) * 1985-07-09 1993-09-29 Nippon Petrochemicals Company, Limited Flame-retardant olefin polymer composition
CA1281168C (en) * 1986-03-03 1991-03-12 Toyoaki Ueno Vertical die casting machine
ZA881538B (en) * 1987-03-10 1988-09-12 F. Hoffmann-La Roche & Co. Aktiengesellschaft Imidazodiazepine derivatives
CA1327008C (en) * 1988-01-15 1994-02-15 Walter Merz Anti-psychotic imidazobenzodiazepine
EP0353754B1 (de) * 1988-08-05 1992-12-02 F. Hoffmann-La Roche Ag Radioaktiv markierte Benzodiazepinderivate
US5096695A (en) * 1988-08-05 1992-03-17 Hoffmann-Laroche Inc. Radioiodine benzodiazepines as brain imaging agents
CA1327572C (en) * 1988-08-31 1994-03-08 F. Hoffmann-La Roche Ag Imidazodiazepine derivatives
CA2015336A1 (en) * 1989-05-19 1990-11-19 F. Hoffmann-La Roche Ag Imidazodiazepines for the treatment of neurological symptoms
US5109013A (en) * 1990-06-06 1992-04-28 A. H. Robins Company, Incorporated 2-(2-substituted aminoethyl)-1,4-dialkyl-3,4-dihydro-1H-1,3,5]triazepino[3,2-a]benzimidazol-5(2H)-ones as muscle relaxants
US5438035A (en) * 1994-06-24 1995-08-01 American Cyanamid Company Methods for controlling undesirable plant species with benzodiazepine compounds
JO2259B1 (en) * 1999-05-12 2004-10-07 اف. هوفمان- لاروش أيه جي‏ Method for the manufacture of diazapine derivatives
AU2006276998A1 (en) * 2005-05-16 2007-02-15 Wisys Technology Foundation, Inc. Gabaergic agents to treat memory deficits
US20090054412A1 (en) * 2007-08-20 2009-02-26 John Alan Kemp Treatment of Sleep Disorders
EP2190435B1 (en) 2007-08-20 2018-05-30 Evotec International GmbH Treatment of sleep disorders
CN113087713B (zh) * 2021-03-29 2022-10-04 中国人民解放军军事科学院军事医学研究院 一类苯并二氮䓬衍生物及其制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT361486B (de) * 1975-08-07 1981-03-10 Hoffmann La Roche Verfahren zur herstellung von neuen imidazo(1,5 -a) (1,4)diazepinverbindungen, ihren salzen und optisch aktiven formen
GB1600600A (en) * 1977-03-10 1981-10-21 Diamond Shamrock Chem Plasticiser compositions for use with synthetic resin polymers
US4118386A (en) * 1977-04-04 1978-10-03 Hoffmann-La Roche Inc. Synthesis of imidazo[1,5-a]diazepine-3-carboxylates
CA1143728A (en) * 1979-10-04 1983-03-29 Max Gerecke Imidazodiazepine derivatives

Also Published As

Publication number Publication date
IE52696B1 (en) 1988-01-20
ZA821129B (en) 1983-01-26
GB2093842B (en) 1984-10-17
AU8066682A (en) 1982-09-02
PH18255A (en) 1985-05-13
JPS57156488A (en) 1982-09-27
EP0059389A1 (de) 1982-09-08
OA07010A (fr) 1983-08-31
NO157377C (no) 1988-03-05
FI73431C (fi) 1987-10-09
NO157377B (no) 1987-11-30
US4352817A (en) 1982-10-05
KR830009104A (ko) 1983-12-17
DE3261496D1 (en) 1985-01-24
IE820420L (en) 1982-08-27
GB2093842A (en) 1982-09-08
YU25282A (en) 1989-08-31
ZW3082A1 (en) 1982-09-29
ZM482A1 (en) 1982-11-22
AU551811B2 (en) 1986-05-15
GR76032B (es) 1984-08-03
EP0059389B1 (de) 1984-12-12
HU185089B (en) 1984-11-28
NZ199796A (en) 1985-10-11
ATE10745T1 (de) 1984-12-15
PT74505B (en) 1984-11-26
ES518262A0 (es) 1984-06-01
DK87182A (da) 1982-08-28
BR8200949A (pt) 1983-01-04
ES8304982A1 (es) 1983-04-01
ES509924A0 (es) 1983-04-01
IL65072A (en) 1985-12-31
IL65072A0 (en) 1982-04-30
ES8405008A1 (es) 1984-06-01
MC1441A1 (fr) 1982-12-06
CA1184176A (en) 1985-03-19
NO820623L (no) 1982-08-30
FI73431B (fi) 1987-06-30
FI820199L (fi) 1982-08-28
PT74505A (en) 1982-03-01
ES518263A0 (es) 1984-06-01

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