ES8404671A1 - Un procedimiento para la preparacion de derivados del acido fenoxialquilcarboxilico. - Google Patents

Un procedimiento para la preparacion de derivados del acido fenoxialquilcarboxilico.

Info

Publication number
ES8404671A1
ES8404671A1 ES521337A ES521337A ES8404671A1 ES 8404671 A1 ES8404671 A1 ES 8404671A1 ES 521337 A ES521337 A ES 521337A ES 521337 A ES521337 A ES 521337A ES 8404671 A1 ES8404671 A1 ES 8404671A1
Authority
ES
Spain
Prior art keywords
phenoxycarboxylic acids
formula
phenoxycarboxylic
acids
anaphylaxis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES521337A
Other languages
English (en)
Other versions
ES521337A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES521337A0 publication Critical patent/ES521337A0/es
Publication of ES8404671A1 publication Critical patent/ES8404671A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DEL ACIDO FENOXIALQUILCARBOXILICO Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R Y R1 SON HIDROGENO O ALQUILO INFERIOR; R2 ES ALCANOILO INFERIOR; R3 ES HIDROGENO O METILO; R5 Y Z PUEDEN SER VARIOS RADICALES; Y S, T Y N VALEN 1-3, 1-3 Y 1-7 RESPECTIVAMENTE.CONSISTE EN LA REACCION DE HIDROLISIS DE UN COMPUESTO DE FORMULA (II), EN LA QUE R4 ES ALQUILO INFERIOR Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO POR TRATAMIENTO CON UN HIDROXIDO DE METALALCALINO, EN UNA MEZCLA DE AGUA Y UN ALCOHOL MISCIBLE CON AGUA A UNA TEMPERATURA ENTRE LA AMBIENTE Y LA DE REFLUJO.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ESTADOS ALERGICOS.
ES521337A 1982-04-09 1983-04-08 Un procedimiento para la preparacion de derivados del acido fenoxialquilcarboxilico. Expired ES8404671A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36689682A 1982-04-09 1982-04-09
US06/460,719 US4507498A (en) 1982-04-09 1983-01-24 Phenoxycarboxylic acids

Publications (2)

Publication Number Publication Date
ES521337A0 ES521337A0 (es) 1984-05-16
ES8404671A1 true ES8404671A1 (es) 1984-05-16

Family

ID=27003568

Family Applications (1)

Application Number Title Priority Date Filing Date
ES521337A Expired ES8404671A1 (es) 1982-04-09 1983-04-08 Un procedimiento para la preparacion de derivados del acido fenoxialquilcarboxilico.

Country Status (23)

Country Link
US (1) US4507498A (es)
AU (1) AU554354B2 (es)
BE (1) BE896416A (es)
CA (1) CA1247126A (es)
CH (1) CH652116A5 (es)
DE (1) DE3312675A1 (es)
DK (1) DK155783A (es)
ES (1) ES8404671A1 (es)
FI (1) FI831190L (es)
FR (1) FR2527204B1 (es)
GB (2) GB2118184B (es)
GR (1) GR82300B (es)
IE (1) IE54752B1 (es)
IL (1) IL68323A (es)
IT (1) IT1173663B (es)
LU (1) LU84737A1 (es)
MC (1) MC1512A1 (es)
NL (1) NL8301241A (es)
NO (1) NO158534C (es)
NZ (1) NZ203816A (es)
PH (1) PH18476A (es)
PT (1) PT76523B (es)
SE (2) SE454985B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5135940A (en) * 1982-09-23 1992-08-04 Merck Frosst Canada, Inc. Leukotriene antagonists
US4661505A (en) * 1982-11-03 1987-04-28 Eli Lilly And Company Leukotriene antagonists
US4550190A (en) * 1983-03-21 1985-10-29 Hoffmann-La Roche Inc. Naphthalenyloxy carboxylic acids
US4539419A (en) * 1983-05-02 1985-09-03 Hoffmann-La Roche Inc. Naphthalenyloxy substituted carboxylic acids
US4918092A (en) * 1983-12-21 1990-04-17 Merck Frosst Canada, Inc. Leukotriene antagonists
US4717736A (en) * 1984-01-23 1988-01-05 Merck Frosst Canada, Inc. Antagonists of slow reacting substances of anaphylaxis
US4628115A (en) * 1985-03-25 1986-12-09 Hoffmann-La Roche Inc. Substituted 4-acetyl-3-hydroxyphenoxy alkanoic acids
DE3515278A1 (de) * 1985-04-27 1986-10-30 Grünenthal GmbH, 5190 Stolberg Neue benzoesaeurederivate, diese enthaltende arzneimittel und verfahren zur herstellung dieser verbindungen und arzneimittel
PT81492B (pt) * 1985-09-17 1988-03-03 Ciba Geigy Ag Processo para a preparacao de novos eteres de resorcina fluorados
US4808604A (en) * 1985-10-03 1989-02-28 Ciba-Geigy Corporation N-(substituted phenyl) tetrazol-5-yl carboxamides and anti-allergic use thereof
US5294613A (en) * 1987-01-12 1994-03-15 Eli Lilly And Company Method of treating endotoxic shock in mammals
CA1315279C (en) * 1987-01-12 1993-03-30 Nancy Grace Bollinger Anti-inflammatory agents
US4945099A (en) * 1987-01-12 1990-07-31 Eli Lilly And Company Anti-inflammatory agents
US5098613A (en) * 1987-01-12 1992-03-24 Eli Lilly And Company Anti-inflammatory agents
JPH0819041B2 (ja) * 1987-09-10 1996-02-28 杏林製薬株式会社 フェノキシアルキルカルボン酸誘導体及びその製造法
US4985585A (en) * 1988-03-07 1991-01-15 Kyorin Pharmaceutical Co., Ltd. Phenoxyalkylcarboxylic acid derivatives and process for their preparations
DE3942574A1 (de) * 1989-12-22 1991-06-27 Basf Ag Polytetrahydrofuranderivate mit endstaendigen aromatischen gruppen
PH30449A (en) * 1991-11-25 1997-05-28 Lilly Co Eli Substituted phenyl phenol leukotriene antagonists

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE7897T1 (de) * 1979-09-05 1984-06-15 Glaxo Group Limited Phenol-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
GB2058785B (en) * 1979-09-05 1983-05-25 Glaxo Group Ltd Phenol derivatives
EP0056172B1 (en) * 1981-01-09 1985-04-03 FISONS plc Phenoxy- and thiophenoxy compounds, methods for their preparation and pharmaceutical formulations containing them
US4661505A (en) * 1982-11-03 1987-04-28 Eli Lilly And Company Leukotriene antagonists

Also Published As

Publication number Publication date
ES521337A0 (es) 1984-05-16
SE454985B (sv) 1988-06-13
NL8301241A (nl) 1983-11-01
IT1173663B (it) 1987-06-24
AU554354B2 (en) 1986-08-21
GB8506022D0 (en) 1985-04-11
NO158534C (no) 1988-09-28
FI831190L (fi) 1983-10-10
GB2118184B (en) 1985-10-09
IL68323A0 (en) 1983-07-31
BE896416A (fr) 1983-10-10
SE8700506L (sv) 1987-02-10
DE3312675A1 (de) 1983-10-13
LU84737A1 (de) 1984-05-10
IE54752B1 (en) 1990-01-31
IL68323A (en) 1987-02-27
GB2154586A (en) 1985-09-11
AU1324983A (en) 1983-10-13
NZ203816A (en) 1985-03-20
FR2527204A1 (fr) 1983-11-25
IE830807L (en) 1983-10-09
DK155783D0 (da) 1983-04-07
CH652116A5 (de) 1985-10-31
MC1512A1 (fr) 1984-02-10
FR2527204B1 (fr) 1987-10-23
GB2154586B (en) 1986-03-05
SE8700506D0 (sv) 1987-02-10
SE8301899L (sv) 1983-10-10
GB8309679D0 (en) 1983-05-11
GB2118184A (en) 1983-10-26
DK155783A (da) 1983-10-10
SE8301899D0 (sv) 1983-04-07
FI831190A0 (fi) 1983-04-08
CA1247126A (en) 1988-12-20
PH18476A (en) 1985-07-18
PT76523B (en) 1986-02-06
NO158534B (no) 1988-06-20
PT76523A (en) 1983-05-01
US4507498A (en) 1985-03-26
GR82300B (es) 1984-12-13
NO831248L (no) 1983-10-10
IT8320505A0 (it) 1983-04-08

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19991102