ES8403482A1 - Procedimiento para la preparacion de nuevas piridobenzodiazepinonas. - Google Patents
Procedimiento para la preparacion de nuevas piridobenzodiazepinonas.Info
- Publication number
- ES8403482A1 ES8403482A1 ES519605A ES519605A ES8403482A1 ES 8403482 A1 ES8403482 A1 ES 8403482A1 ES 519605 A ES519605 A ES 519605A ES 519605 A ES519605 A ES 519605A ES 8403482 A1 ES8403482 A1 ES 8403482A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- methyl
- pyridobenzodiazepinones
- pharmaceutical compositions
- compositions containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE PIRIDOBENZODIAZEPINONA S, DE SUS FORMAS DIASTEREOISOMERAS Y ENANTIOMERAS Y DE SUS SALES DE ADICION DE ACIDOS, DE FORMULA (I), EN LA QUE X Y R PUEDEN SER VARIOS RADICALES.CONSISTE EN LA REACCION DE UNA PIRIDOBENZODIAZEPINONA, DE FORMULA (II), CON UN COMPUESTO DE FORMULA H-X-R O M-X-R, EN LAS QUE M ES UN METAL ALCALINO O UN EQUIVALENTE DE METAL ALCALINOTERREO Y X Y R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE EFECTUA EN UN DISOLVENTE INERTE, A UNA TEMPERATURA COMPRENDIDA ENTRE 0JC Y LA DE EBULLICION DE LA MEZCLA.ESTOSCOMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS EFECTOS ANTIULCEROGENOS Y ANTISECRETORIOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823204401 DE3204401A1 (de) | 1982-02-09 | 1982-02-09 | Pyridobenzodiazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8403482A1 true ES8403482A1 (es) | 1984-03-16 |
| ES519605A0 ES519605A0 (es) | 1984-03-16 |
Family
ID=6155156
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES519605A Granted ES519605A0 (es) | 1982-02-09 | 1983-02-08 | Procedimiento para la preparacion de nuevas piridobenzodiazepinonas. |
| ES526556A Expired ES8405794A1 (es) | 1982-02-09 | 1983-10-19 | Procedimiento para la preparacion de nuevas piridobenzodiazepinonas |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES526556A Expired ES8405794A1 (es) | 1982-02-09 | 1983-10-19 | Procedimiento para la preparacion de nuevas piridobenzodiazepinonas |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4424222A (es) |
| EP (1) | EP0085893B1 (es) |
| JP (1) | JPS58148883A (es) |
| AT (1) | ATE19777T1 (es) |
| AU (1) | AU556962B2 (es) |
| DE (2) | DE3204401A1 (es) |
| ES (2) | ES519605A0 (es) |
| NZ (1) | NZ203216A (es) |
| PH (1) | PH24504A (es) |
| ZA (1) | ZA83857B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3683217D1 (de) * | 1985-06-27 | 1992-02-13 | Thomae Gmbh Dr K | In 11-stellung substituierte 5,11-dihydro-6h-pyrido-(2,3-b)(1,4)benzodiazepin-6-one, verfahren zur ihrer herstellung und diese verbindungen enthaltende arzneimittel. |
| DE3643666A1 (de) * | 1986-12-20 | 1988-06-30 | Thomae Gmbh Dr K | Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3820347A1 (de) * | 1988-06-15 | 1989-12-21 | Thomae Gmbh Dr K | Verwendung von in 11-stellung substituierten 5,11-dihydro-6h-pyrido(2,3-b) (1,4)benzodiazepin-6-onen zur behandlung von bradycardien und bradyarrhythmien in der human- und veterinaermedizin |
| AU2005263577C1 (en) | 2004-07-16 | 2010-08-26 | Proteosys Ag | Muscarinic antagonists with PARP and SiR modulating activity as cytoprotective agents |
| EP2379080A1 (en) | 2009-01-13 | 2011-10-26 | ProteoSys AG | Pirenzepine as otoprotective agent |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1795183B1 (de) | 1968-08-20 | 1972-07-20 | Thomae Gmbh Dr K | 5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-on-derivate und Arzneimittel |
| DE2644121A1 (de) * | 1976-09-30 | 1978-04-06 | Thomae Gmbh Dr K | Neue pyridobenzodiazepinone, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| DE2724434A1 (de) * | 1977-05-31 | 1979-02-22 | Thomae Gmbh Dr K | Neue, in 11-stellung substituierte 5,11-dihydro-6h-pyrido eckige klammer auf 2,3-b eckige klammer zu eckige klammer auf 1,4 eckige klammer zu benzodiazepin-6-one, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
-
1982
- 1982-02-09 DE DE19823204401 patent/DE3204401A1/de not_active Withdrawn
-
1983
- 1983-01-26 EP EP83100679A patent/EP0085893B1/de not_active Expired
- 1983-01-26 DE DE8383100679T patent/DE3363450D1/de not_active Expired
- 1983-01-26 AT AT83100679T patent/ATE19777T1/de active
- 1983-01-31 US US06/462,183 patent/US4424222A/en not_active Expired - Fee Related
- 1983-02-07 PH PH28500A patent/PH24504A/en unknown
- 1983-02-08 AU AU11231/83A patent/AU556962B2/en not_active Ceased
- 1983-02-08 NZ NZ203216A patent/NZ203216A/en unknown
- 1983-02-08 ES ES519605A patent/ES519605A0/es active Granted
- 1983-02-08 ZA ZA83857A patent/ZA83857B/xx unknown
- 1983-02-08 JP JP58019521A patent/JPS58148883A/ja active Granted
- 1983-10-19 ES ES526556A patent/ES8405794A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS58148883A (ja) | 1983-09-05 |
| JPH0373550B2 (es) | 1991-11-22 |
| EP0085893B1 (de) | 1986-05-14 |
| AU556962B2 (en) | 1986-11-27 |
| US4424222A (en) | 1984-01-03 |
| ES526556A0 (es) | 1984-06-16 |
| DE3363450D1 (en) | 1986-06-19 |
| ES519605A0 (es) | 1984-03-16 |
| NZ203216A (en) | 1985-09-13 |
| DE3204401A1 (de) | 1983-08-11 |
| ATE19777T1 (de) | 1986-05-15 |
| AU1123183A (en) | 1983-08-18 |
| ES8405794A1 (es) | 1984-06-16 |
| ZA83857B (en) | 1984-10-31 |
| EP0085893A2 (de) | 1983-08-17 |
| EP0085893A3 (en) | 1984-03-21 |
| PH24504A (en) | 1990-07-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19960603 |