ES8403114A1 - 2-Heterocyclyl oxy-alkyl-4(1H)-pyrimidone derivs. - Google Patents
2-Heterocyclyl oxy-alkyl-4(1H)-pyrimidone derivs.Info
- Publication number
- ES8403114A1 ES8403114A1 ES519787A ES519787A ES8403114A1 ES 8403114 A1 ES8403114 A1 ES 8403114A1 ES 519787 A ES519787 A ES 519787A ES 519787 A ES519787 A ES 519787A ES 8403114 A1 ES8403114 A1 ES 8403114A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- pyrimidone
- derivs
- nr3r4
- cpds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
2-Heterocyclyloxyalkyl- 4(1H)-pyrimidone derivs. of formula (I) and their salts are new. (R1 is H, 1-10C alkyl, 2-5C alkenyl, 2-5C alkynyl, Ph, cycloalkylmethyl, opt. substd. aralkyl or A-NR3R4; A is 1-5C alkylene; R3 and R4 are 1-5C alkyl; or NR3R4 is piperidino or pyrrolidino; R2 is H, 1-5C alkyl or CF3; Y is 5-dimethylamino-2-furyl, m-(N-piperidinomethyl)phenyl or a heterocyclic gp. of formula (II); R is H or 1-5C alkyl; B is O or S; m is 0-3; and n is 1-3). Intermediates of formulae (II) and (III) are new (sic.). (R5 is 1-5C alkyl). (I) are inhibitors of gastric acid secretion, anti-inflammatory agents and agents for treating cardiovascular and stomach diseases. (I; R1 is 4-9C alkyl) have a cytoprotective action as well as histamine H2-receptor blocking activity. Dose is 0.1-0.8 g daily in 1-4 doses. Specifically claimed are 8 cpds. (I), including 5-(p-t-butyl-benzyl)-2- 2-(((2- ((diaminomethylene) amino)-4-thiazolyl) methyl)thio)ethyl)-6-methyl-4(1H)-pyrimidone and the corresp. 5-n-butyl and 5-n-pentyl cpds.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57022280A JPS58140088A (en) | 1982-02-15 | 1982-02-15 | Novel pyrimidine derivative and its preparation |
| JP14812382A JPS5939877A (en) | 1982-08-26 | 1982-08-26 | Novel pyrimidone derivative and its preparation |
| JP14896782A JPS5939892A (en) | 1982-08-27 | 1982-08-27 | Novel pyrimidone derivative and its preparation |
| JP15199782A JPS5942381A (en) | 1982-09-01 | 1982-09-01 | Novel pyrimidone derivative and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES519787A0 ES519787A0 (en) | 1984-03-01 |
| ES8403114A1 true ES8403114A1 (en) | 1984-03-01 |
Family
ID=27457738
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES519787A Expired ES8403114A1 (en) | 1982-02-15 | 1983-02-14 | 2-Heterocyclyl oxy-alkyl-4(1H)-pyrimidone derivs. |
| ES525857A Expired ES8503341A1 (en) | 1982-02-15 | 1983-09-22 | 2-Heterocyclyl oxy-alkyl-4(1H)-pyrimidone derivs. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES525857A Expired ES8503341A1 (en) | 1982-02-15 | 1983-09-22 | 2-Heterocyclyl oxy-alkyl-4(1H)-pyrimidone derivs. |
Country Status (1)
| Country | Link |
|---|---|
| ES (2) | ES8403114A1 (en) |
-
1983
- 1983-02-14 ES ES519787A patent/ES8403114A1/en not_active Expired
- 1983-09-22 ES ES525857A patent/ES8503341A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES525857A0 (en) | 1985-02-16 |
| ES8503341A1 (en) | 1985-02-16 |
| ES519787A0 (en) | 1984-03-01 |
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