ES8402285A1 - Un procedimiento para la preparacion de nuevos derivados de 1-bencil-4-(4-(2-pirimidinilamino)bencil)-2,3-dioxopiperazina o sus sales. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de 1-bencil-4-(4-(2-pirimidinilamino)bencil)-2,3-dioxopiperazina o sus sales.

Info

Publication number
ES8402285A1
ES8402285A1 ES518304A ES518304A ES8402285A1 ES 8402285 A1 ES8402285 A1 ES 8402285A1 ES 518304 A ES518304 A ES 518304A ES 518304 A ES518304 A ES 518304A ES 8402285 A1 ES8402285 A1 ES 8402285A1
Authority
ES
Spain
Prior art keywords
benzyl
dioxopiperazine derivatives
dioxopiperazine
derivatives
pyrimidinylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES518304A
Other languages
English (en)
Other versions
ES518304A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of ES8402285A1 publication Critical patent/ES8402285A1/es
Publication of ES518304A0 publication Critical patent/ES518304A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 1-BENCIL-4-[4-(2-PIRIMIDINILAMINO) BENCIL]-2,3-DIOXOPIPERAZINA Y DE SUS ALES, DE FORMULA (I); X ES OXIGENO O AZUFRE; R ELEVADO 2 ES HIDROGENO O ALQUILO Y R ELEVADO 1 PUEDE SER VARIOS RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO, DE FORMULA (II), CON UN COMPUESTO DE FORMULA H-X-R ELEVADO 1, EN LA QUE R ELEVADO 3 PUEDE SER UNO DE VARIOS TIPOS DE RADICALES Y X, R ELEVADO 1 Y R ELEVADO 2 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN AUSENCIA O EN PRESENCIA DE UN DISOLVENTE ORGANICO INERTE, A UNA TEMPERATURA COMPRENDIDA ENTRE 0GC Y 150GC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD CARCINOSTATICA. *FORMULA*.
ES518304A 1981-02-06 1982-12-16 Un procedimiento para la preparacion de nuevos derivados de 1-bencil-4-(4-(2-pirimidinilamino)bencil)-2,3-dioxopiperazina o sus sales. Granted ES518304A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56015837A JPS57140783A (en) 1981-02-06 1981-02-06 1-benzyl-4-(4-(2-pyrimidinylamino)benzyl)-2, 3-dioxopiperazine derivative and its salt, their preparation, and carcinostatic agent containing the same

Publications (2)

Publication Number Publication Date
ES8402285A1 true ES8402285A1 (es) 1984-01-16
ES518304A0 ES518304A0 (es) 1984-01-16

Family

ID=11899943

Family Applications (2)

Application Number Title Priority Date Filing Date
ES509391A Granted ES509391A0 (es) 1981-02-06 1982-02-05 Un procedimiento para la preparacion de nuevos derivados de 1-bencil-4(4-(2-pirimidinilamino)bencil-2,3-dioxopiperazina o sus sales.
ES518304A Granted ES518304A0 (es) 1981-02-06 1982-12-16 Un procedimiento para la preparacion de nuevos derivados de 1-bencil-4-(4-(2-pirimidinilamino)bencil)-2,3-dioxopiperazina o sus sales.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES509391A Granted ES509391A0 (es) 1981-02-06 1982-02-05 Un procedimiento para la preparacion de nuevos derivados de 1-bencil-4(4-(2-pirimidinilamino)bencil-2,3-dioxopiperazina o sus sales.

Country Status (12)

Country Link
JP (1) JPS57140783A (es)
KR (1) KR880001105B1 (es)
AU (1) AU537512B2 (es)
BE (1) BE892032A (es)
CH (1) CH651036A5 (es)
DE (1) DE3204074A1 (es)
ES (2) ES509391A0 (es)
FR (1) FR2499569A1 (es)
GB (1) GB2094296B (es)
IT (1) IT1154274B (es)
NL (1) NL8200451A (es)
SE (1) SE449101B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL334304A1 (en) * 1996-12-24 2000-02-14 Chugai Pharmaceutical Co Ltd Derivatives of aromatic amines acting as nos inhibitors
JP7371622B2 (ja) * 2018-04-11 2023-10-31 三菱瓦斯化学株式会社 ジシアノアルカンおよびビス（アミノメチル）アルカンの製造方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5618969A (en) * 1979-07-24 1981-02-23 Toyama Chem Co Ltd Novel 1-(4-aminobenzyl)-2,3-dioxopiperazine derivative, its acid addition salt, and their preparation

Also Published As

Publication number Publication date
GB2094296A (en) 1982-09-15
IT8247729A0 (it) 1982-02-05
AU537512B2 (en) 1984-06-28
GB2094296B (en) 1985-02-13
DE3204074C2 (es) 1987-12-23
KR830009090A (ko) 1983-12-17
IT1154274B (it) 1987-01-21
FR2499569B1 (es) 1985-02-22
BE892032A (fr) 1982-08-05
JPS57140783A (en) 1982-08-31
DE3204074A1 (de) 1982-10-28
ES8304970A1 (es) 1983-03-16
KR880001105B1 (ko) 1988-06-29
NL8200451A (nl) 1982-09-01
AU8024082A (en) 1982-08-12
FR2499569A1 (fr) 1982-08-13
ES509391A0 (es) 1983-03-16
SE8200679L (sv) 1982-09-22
SE449101B (sv) 1987-04-06
JPS6366319B2 (es) 1988-12-20
ES518304A0 (es) 1984-01-16
CH651036A5 (de) 1985-08-30

Similar Documents

Publication Publication Date Title
GR3005315T3 (es)
PL292101A1 (en) Method of obtaining novel derivatives of cyclopentylpurine and cyclopentylpyrimidine
EP0705833A4 (en) DC-89 DERIVATIVES
ZA911502B (en) A pharmaceutical solution
ES2001341A6 (es) Un procedimiento de producir un derivado de acido guanidinometilbenzoico.
SE9003476L (sv) Novel isoindole derivatives and salts thereof, process for producing the same and antitumor agent comprising the same
IL68937A0 (en) Hydroxyalkinyl-azolyl derivatives,their preparation and their use as fungicides
ES8401930A1 (es) Un procedimiento para preparar derivados de amida del acido nitrobenzoico.
ES468170A1 (es) Un procedimiento para la preparacion de un nuevo derivado demorfina
ES8800920A1 (es) Un procedimiento para preparar un derivado de 1,5-benzotiazepina
AU562253B2 (en) Thiazolothienoazepine or pyridiue derivatives
ES8304970A1 (es) Un procedimiento para la preparacion de nuevos derivados de 1-bencil-4(4-(2-pirimidinilamino)bencil-2,3-dioxopiperazina o sus sales.
AU560734B2 (en) Hydroxyethylazolyl - oxime derivatives
CA2092919A1 (en) Epoxysuccinamic acid derivatives
ES8401761A1 (es) Un procedimiento para la preparacion de derivados de 1-(3,4,5-trimetoxicinamoil)-4-aminocarboniletil-piperazina sustituidos.
ES2093051T3 (es) Purinil- y pirimidil-tetrahidrofuranos.
EP0055907A3 (en) Cis-c3",c4"-carbonate derivatives of oleandomycin-y, pharmaceutical compositions containing them, and intermediates therefor
ES2014041A6 (es) Un procedimiento para preparar un derivado de amina.
ES8405781A1 (es) Metodo de obtencion de derivados n-metilcarbamaticos utiles para insecticidas.
TW221988B (es)
IL78748A (en) Phosphorimidates,their preparation and their use as pesticides