ES8400416A1 - Procedimiento para la fabricacion de acil-2 hexahidro-1,3,4,6,7,11b-2h-piracino (2,1-a) isoquinoleinonas-4 e intermediarios. - Google Patents
Procedimiento para la fabricacion de acil-2 hexahidro-1,3,4,6,7,11b-2h-piracino (2,1-a) isoquinoleinonas-4 e intermediarios.Info
- Publication number
- ES8400416A1 ES8400416A1 ES518241A ES518241A ES8400416A1 ES 8400416 A1 ES8400416 A1 ES 8400416A1 ES 518241 A ES518241 A ES 518241A ES 518241 A ES518241 A ES 518241A ES 8400416 A1 ES8400416 A1 ES 8400416A1
- Authority
- ES
- Spain
- Prior art keywords
- acyl
- pyrazino
- hexahydro
- intermediates
- isoquinolinones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cosmetics (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
PROCEDIMIENTO PARA LA FABRICACION DE ACIL-2-HEXAHIDRO-1,3,4,6,7,11B-2H-PIRACINO (2,1-A) ISOQUINOLEINONAS-4 E INTERMEDIARIOS.SE TRATA UNA ACIL-4 DIOXO-2,6 PINERACINA (II) CON UN AGENTE ALQUILANTE (III) EN QUE X ES CLORO, BROMO, YODO O UN GRUPO NUCLEOFUGO, EN PRESENCIA DE UN AGENTE DE CONDENSACION ALCALINO, EN UN DISOLVENTE ORGANICO INERTE, DONDE SE REDUCE SELECTIVAMENTE UNO DE LOS CARBONILOS IMIDICOS DEL COMPUESTO INTERMEDIO OBTENIDO, POR UN HIDRURO METALICO COMPLEJO EN PRESENCIA DE UN CLORURO METALICO CATALIZADOR; EL INTERMEDIO OBTENIDO SE ACIDIFICA POR ACCION DE UN ACIDO MINERALU ORGANICO FUERTE A UNA TEMPERATURA DE 0 A 25JC. SE OBTIENE EL COMPUESTO (I) EN QUE R ES UN GRUPO ALQUILO INFERIOR, CICLOALQUILO O UN GRUPO FENILO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8201758A FR2520740A1 (fr) | 1982-01-29 | 1982-01-29 | Procede pour la preparation d'acyl-2-hexahydro-1,3,4,6,7,11b-2h-pyrazino (2,1-a) isoquinoleinones-4 et intermediaires |
Publications (2)
Publication Number | Publication Date |
---|---|
ES518241A0 ES518241A0 (es) | 1983-10-16 |
ES8400416A1 true ES8400416A1 (es) | 1983-10-16 |
Family
ID=9270646
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES518241A Expired ES8400416A1 (es) | 1982-01-29 | 1982-12-15 | Procedimiento para la fabricacion de acil-2 hexahidro-1,3,4,6,7,11b-2h-piracino (2,1-a) isoquinoleinonas-4 e intermediarios. |
Country Status (18)
Country | Link |
---|---|
US (1) | US4523013A (es) |
EP (1) | EP0086678B1 (es) |
JP (1) | JPS58134091A (es) |
KR (1) | KR840003252A (es) |
AT (1) | ATE14126T1 (es) |
CA (1) | CA1202629A (es) |
CS (1) | CS235304B2 (es) |
DE (1) | DE3360328D1 (es) |
DK (1) | DK30183A (es) |
ES (1) | ES8400416A1 (es) |
FI (1) | FI75346C (es) |
FR (1) | FR2520740A1 (es) |
HU (1) | HU187848B (es) |
IL (1) | IL67547A (es) |
NZ (1) | NZ202981A (es) |
OA (1) | OA07301A (es) |
SG (1) | SG62385G (es) |
ZA (1) | ZA83166B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0134984B1 (en) * | 1983-07-16 | 1988-07-13 | Beecham Group Plc | Benzazepine and benzoxazepine derivatives |
GB8509435D0 (en) * | 1985-04-12 | 1985-05-15 | Beecham Group Plc | Intermediates & process |
HU208311B (en) * | 1989-11-02 | 1993-09-28 | Alkaloida Vegyeszeti Gyar | Resolving process for producing enantiomers of 2-/4-(5-trifluoromethyl-2-pyridyloxy)-phenoxy/-propanoic acid |
CN100503582C (zh) * | 2005-03-01 | 2009-06-24 | 江苏工业学院 | 吡喹酮合成工艺 |
WO2012081036A2 (en) * | 2010-12-13 | 2012-06-21 | Sequent Scientific Limited | A process for preparation of 4,4'-(1-methyl-1,2-ethandiyl)-bis-(2,6-piperazinedione) |
CN102786519B (zh) * | 2011-05-17 | 2017-04-19 | 中国医学科学院药物研究所 | 吡喹酮晶b型物质及制备方法与在药品和保健品中应用 |
CN102786520A (zh) * | 2011-05-17 | 2012-11-21 | 中国医学科学院药物研究所 | 吡喹酮晶a型物质及制备方法与在药品和保健品中应用 |
US9175321B2 (en) * | 2011-10-26 | 2015-11-03 | Suzhou Tongli Biomedical Co., Ltd | R-praziquantel preparation method |
CN115466261A (zh) * | 2022-09-15 | 2022-12-13 | 诚弘制药(威海)有限责任公司 | 一种吡喹酮的新制备方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE624686A (es) * | ||||
US3239582A (en) * | 1958-05-21 | 1966-03-08 | Dow Chemical Co | Blend of polycarbonate resin and alkenylaromatic resin |
GB912946A (en) * | 1959-11-28 | 1962-12-12 | Nl Combinatie Chem Ind | Improvements in or relating to new substituted 2,6-diketopiperazines, intermediates in the production thereof and processes for their production |
NL273690A (es) * | 1961-01-19 | 1900-01-01 | ||
DE1189553B (de) * | 1962-08-09 | 1965-03-25 | Degussa | Verfahren zur Herstellung von racemischen und optisch aktiven Piperazinderivaten |
US3171837A (en) * | 1963-01-07 | 1965-03-02 | American Home Prod | 4-aroylalkyl-2-keto-and 2, 6-diketopiperazines |
US3969316A (en) * | 1973-07-12 | 1976-07-13 | Ciba-Geigy Corporation | 3,5-Dialkyl-4-hydroxyphenylalkyl substituted piperazine diones and polymeric compositions stabilized thereby |
DE2362539C2 (de) * | 1973-12-17 | 1986-05-07 | Merck Patent Gmbh, 6100 Darmstadt | 2-Acyl-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isochinoline, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
DE2441261A1 (de) * | 1974-08-28 | 1976-03-18 | Merck Patent Gmbh | Ringsubstituierte pyrazino-isochinolin-derivat und verfahren zu ihrer herstellung |
DE2457971A1 (de) * | 1974-12-07 | 1976-06-10 | Merck Patent Gmbh | Verfahren zur herstellung von 2-acyl4-oxo-pyrazino-isochinolin-derivaten |
DE2504250A1 (de) * | 1975-02-01 | 1976-08-05 | Merck Patent Gmbh | Tetrahydroisochinolin-derivate und verfahren zu ihrer herstellung |
-
1982
- 1982-01-29 FR FR8201758A patent/FR2520740A1/fr active Granted
- 1982-12-15 ES ES518241A patent/ES8400416A1/es not_active Expired
- 1982-12-22 IL IL67547A patent/IL67547A/xx unknown
-
1983
- 1983-01-07 AT AT83400044T patent/ATE14126T1/de not_active IP Right Cessation
- 1983-01-07 DE DE8383400044T patent/DE3360328D1/de not_active Expired
- 1983-01-07 EP EP83400044A patent/EP0086678B1/fr not_active Expired
- 1983-01-10 NZ NZ202981A patent/NZ202981A/en unknown
- 1983-01-11 ZA ZA83166A patent/ZA83166B/xx unknown
- 1983-01-11 FI FI830096A patent/FI75346C/fi not_active IP Right Cessation
- 1983-01-14 OA OA57895A patent/OA07301A/xx unknown
- 1983-01-20 KR KR1019830000205A patent/KR840003252A/ko not_active IP Right Cessation
- 1983-01-24 CA CA000420124A patent/CA1202629A/en not_active Expired
- 1983-01-26 CS CS83511A patent/CS235304B2/cs unknown
- 1983-01-26 DK DK30183A patent/DK30183A/da not_active Application Discontinuation
- 1983-01-28 HU HU83292A patent/HU187848B/hu not_active IP Right Cessation
- 1983-01-28 JP JP58013634A patent/JPS58134091A/ja active Pending
- 1983-01-31 US US06/462,397 patent/US4523013A/en not_active Expired - Fee Related
-
1985
- 1985-08-24 SG SG623/85A patent/SG62385G/en unknown
Also Published As
Publication number | Publication date |
---|---|
ES518241A0 (es) | 1983-10-16 |
FR2520740A1 (fr) | 1983-08-05 |
FR2520740B1 (es) | 1984-03-09 |
DE3360328D1 (en) | 1985-08-08 |
ATE14126T1 (de) | 1985-07-15 |
KR840003252A (ko) | 1984-08-20 |
DK30183D0 (da) | 1983-01-26 |
EP0086678A1 (fr) | 1983-08-24 |
CA1202629A (en) | 1986-04-01 |
DK30183A (da) | 1983-07-30 |
ZA83166B (en) | 1983-10-26 |
CS235304B2 (en) | 1985-05-15 |
JPS58134091A (ja) | 1983-08-10 |
HU187848B (en) | 1986-02-28 |
IL67547A (en) | 1985-07-31 |
FI830096A0 (fi) | 1983-01-11 |
FI75346C (fi) | 1988-06-09 |
FI75346B (fi) | 1988-02-29 |
SG62385G (en) | 1986-11-21 |
US4523013A (en) | 1985-06-11 |
NZ202981A (en) | 1985-07-12 |
OA07301A (fr) | 1984-08-31 |
FI830096L (fi) | 1983-07-30 |
EP0086678B1 (fr) | 1985-07-03 |
IL67547A0 (en) | 1983-05-15 |
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