ES8306377A1 - Un procedimiento para la preparacion de cefalosporina bis-tetrazolmetil sustituidas. - Google Patents

Un procedimiento para la preparacion de cefalosporina bis-tetrazolmetil sustituidas.

Info

Publication number
ES8306377A1
ES8306377A1 ES505550A ES505550A ES8306377A1 ES 8306377 A1 ES8306377 A1 ES 8306377A1 ES 505550 A ES505550 A ES 505550A ES 505550 A ES505550 A ES 505550A ES 8306377 A1 ES8306377 A1 ES 8306377A1
Authority
ES
Spain
Prior art keywords
bis
preparation
tetrazoylmethyl
pharmaceutical formulations
formulations containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES505550A
Other languages
English (en)
Other versions
ES505550A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES505550A0 publication Critical patent/ES505550A0/es
Publication of ES8306377A1 publication Critical patent/ES8306377A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE CEFALOSPORINAS BIS-TETRAZOLMETIL SUSTUITUIDAS DE FORMULA GENERAL (I), EN LA QUE R ES HIDROGENO, UN GRUPO ACILO O UN GRUPO AROILO; R ES HIDROGENO O UN GRUPO PROTECTOR DEL CARBOXILO FACILMENTE ELIMINABLE; R ES HIDROGENO O METOXILO; Y R ES UN RADICAL, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), DONDE R , R Y R TIENEN LOS SIGNIFICADOS YA INDICADOS; Y R ES ACILOXILO DE C -C O HALO, CON UN COMPUESTO DE BIS-TETRAZOLMETIL TIOL DE FORMULA (III), DONDE R ES HIDROGENO O ALQUILO DE C -C , EN PRESENCIA DE UN DISOLVENTE ORGANICO INERTE. DE APLICACION COMO ANTIBIOTICOS.
ES505550A 1980-09-17 1981-09-16 Un procedimiento para la preparacion de cefalosporina bis-tetrazolmetil sustituidas. Expired ES8306377A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/187,859 US4346076A (en) 1980-09-17 1980-09-17 Bis-tetrazoylmethyl substituted cephalosporin antibiotics

Publications (2)

Publication Number Publication Date
ES505550A0 ES505550A0 (es) 1983-05-16
ES8306377A1 true ES8306377A1 (es) 1983-05-16

Family

ID=22690789

Family Applications (1)

Application Number Title Priority Date Filing Date
ES505550A Expired ES8306377A1 (es) 1980-09-17 1981-09-16 Un procedimiento para la preparacion de cefalosporina bis-tetrazolmetil sustituidas.

Country Status (22)

Country Link
US (1) US4346076A (es)
EP (1) EP0048169A3 (es)
JP (1) JPS5781492A (es)
KR (1) KR830007688A (es)
AU (1) AU7528481A (es)
CA (1) CA1174668A (es)
CS (1) CS686781A2 (es)
DD (1) DD201142A5 (es)
DK (1) DK412181A (es)
ES (1) ES8306377A1 (es)
FI (1) FI812782L (es)
GB (1) GB2084144B (es)
GR (1) GR74671B (es)
HU (1) HU185954B (es)
IL (1) IL63770A0 (es)
PH (1) PH16985A (es)
PL (1) PL132001B1 (es)
PT (1) PT73680B (es)
RO (1) RO82970B (es)
SU (2) SU1087076A3 (es)
YU (1) YU222681A (es)
ZA (1) ZA816224B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR850001206B1 (ko) * 1984-04-27 1985-08-20 한국과학기술원 세펨 유도체의 제조 방법
IT1181672B (it) * 1984-10-25 1987-09-30 Upjohn Co Cefalosporina alogenidrato cristallino
US4868193A (en) * 1986-09-24 1989-09-19 Rorer Pharmaceutical Corporation Styryl tetrazoles and anti-allergic use thereof
EP0333082A3 (en) * 1988-03-15 1991-05-02 Takeda Chemical Industries, Ltd. Cephem compounds, their production and use

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ176206A (en) * 1973-12-25 1978-03-06 Takeda Chemical Industries Ltd Cephalosporins
US4286089A (en) * 1974-12-27 1981-08-25 Smithkline Corporation 7-Acyl-3-(substituted tetrazolyl thiomethyl)cephalosporins
JPS525787A (en) * 1975-06-27 1977-01-17 Bristol Myers Co Antiibacterial agent
US4121040A (en) * 1976-02-17 1978-10-17 Pfizer Inc. 4-(Tetrazol-5-yl)-Δ3 -cephem compounds
US4109083A (en) * 1976-02-17 1978-08-22 Pfizer Inc. 4-(Tetrazol-5-yl)-Δ3 -cephem compounds
US4278670A (en) * 1976-07-12 1981-07-14 Smithkline Corporation 7-Alpha-oxyiminoacylcephalosporins
US4129732A (en) * 1977-04-27 1978-12-12 Pfizer Inc. 4(Tetrazol-5-yl)-Δ3 -cephem compounds
FR2387235A1 (fr) * 1978-01-23 1978-11-10 Fujisawa Pharmaceutical Co Procede de preparation de composes d'acide 3,7-disubstitue-3-cephem-4-carboxylique et nouveaux produits ainsi obtenus, ayant une forte activite antibacterienne

Also Published As

Publication number Publication date
PT73680A (en) 1981-10-01
PT73680B (en) 1982-11-26
AU7528481A (en) 1982-03-25
SU1119607A3 (ru) 1984-10-15
CS686781A2 (en) 1985-06-13
SU1087076A3 (ru) 1984-04-15
HU185954B (en) 1985-04-28
KR830007688A (ko) 1983-11-04
PL233058A1 (es) 1982-10-11
EP0048169A2 (en) 1982-03-24
GR74671B (es) 1984-07-02
US4346076A (en) 1982-08-24
IL63770A0 (en) 1981-12-31
YU222681A (en) 1983-10-31
PH16985A (en) 1984-05-04
FI812782L (fi) 1982-03-18
ES505550A0 (es) 1983-05-16
ZA816224B (en) 1983-04-27
GB2084144B (en) 1985-02-06
DD201142A5 (de) 1983-07-06
CA1174668A (en) 1984-09-18
JPS5781492A (en) 1982-05-21
EP0048169A3 (en) 1983-01-19
DK412181A (da) 1982-04-21
PL132001B1 (en) 1985-01-31
GB2084144A (en) 1982-04-07
RO82970B (ro) 1984-01-30
RO82970A (ro) 1984-01-14

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