ES8304578A1 - New ergoline derivatives,preparation thereof and pharmaceutical compositions thereof - Google Patents
New ergoline derivatives,preparation thereof and pharmaceutical compositions thereofInfo
- Publication number
- ES8304578A1 ES8304578A1 ES509825A ES509825A ES8304578A1 ES 8304578 A1 ES8304578 A1 ES 8304578A1 ES 509825 A ES509825 A ES 509825A ES 509825 A ES509825 A ES 509825A ES 8304578 A1 ES8304578 A1 ES 8304578A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- alkyl
- pharmaceutical compositions
- ergoline derivatives
- new ergoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The compounds have the formula I (FORMULA) wherein R<u1>u is H, a C<u1-4>u alkyl or their precursors, R<u2>u is a C<u1-4>u alkyl, R<u3>u and R<u4>u independently of each other are H, a C alkyl or together are a C alkylene, R<u5>u is H or alkyl and A and B are each H or together represent a bond, providing that, when R<u1>u and R<u2>u = CH<u3>u, R<u3>u and R<u4>u = C<u2>uH<u5>u, A and B = H, R<u5>u is alkyl. Are also concerned the acid addition salts of those compounds. The compounds are used for the treatment of hypertonus, and cardiac insufficiencies.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH121081A CH645894A5 (en) | 1981-02-24 | 1981-02-24 | Ergoline derivatives, their preparation and use |
CH121181A CH645895A5 (en) | 1981-02-24 | 1981-02-24 | Ergoline derivatives, their preparation and use |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8304578A1 true ES8304578A1 (en) | 1983-03-01 |
ES509825A0 ES509825A0 (en) | 1983-03-01 |
Family
ID=25687002
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES509825A Granted ES509825A0 (en) | 1981-02-24 | 1982-02-23 | PROCEDURE FOR PREPARING ERGOLINE DERIVATIVES. |
Country Status (16)
Country | Link |
---|---|
AU (1) | AU8068282A (en) |
CA (1) | CA1178582A (en) |
DE (1) | DE3205169A1 (en) |
DK (1) | DK77082A (en) |
ES (1) | ES509825A0 (en) |
FI (1) | FI820526L (en) |
FR (1) | FR2500454A1 (en) |
GB (1) | GB2093452B (en) |
HU (1) | HU187650B (en) |
IL (1) | IL65074A0 (en) |
NL (1) | NL8200694A (en) |
NZ (1) | NZ199795A (en) |
PH (1) | PH17494A (en) |
PT (1) | PT74468B (en) |
SE (1) | SE8201098L (en) |
WO (1) | WO1982002892A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3309493A1 (en) * | 1983-03-14 | 1984-09-20 | Schering AG, 1000 Berlin und 4709 Bergkamen | NEW ERGOLIN DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND USE AS A MEDICINAL PRODUCT |
DE3402392A1 (en) * | 1984-01-25 | 1985-08-01 | Sandoz-Patent-GmbH, 7850 Lörrach | NEW ERGOL DERIVATIVES, THEIR PRODUCTION AND THEIR USE |
DE3445784A1 (en) * | 1984-12-13 | 1986-06-26 | Schering AG, Berlin und Bergkamen, 1000 Berlin | METHOD FOR PRODUCING ERGOLIN DERIVATIVES |
DE3528584A1 (en) * | 1985-08-06 | 1987-02-19 | Schering Ag | NEW 1-ALKYL-ERGOLIN-THIOURINE DERIVATIVES |
DE3528576A1 (en) * | 1985-08-06 | 1987-02-19 | Schering Ag | METHOD FOR THE PRODUCTION OF ERGOLIN THIOUROS |
DE3533672A1 (en) * | 1985-09-19 | 1987-03-26 | Schering Ag | NEW 12- AND 13-SUBSTITUTED ERGOL DERIVATIVES |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1191099A (en) * | 1968-03-07 | 1970-05-06 | Farmaceutici Italia | Ergoline Derivatives |
DK140596B (en) * | 1971-05-19 | 1979-10-08 | Sandoz Ag | Analogous process for the preparation of 8beta- (ureidomethyl) -ergolene derivatives. |
CH628049A5 (en) * | 1977-03-25 | 1982-02-15 | Sandoz Ag | Process for the preparation of ergolene derivatives |
FR2421176A1 (en) * | 1978-03-29 | 1979-10-26 | Sandoz Sa | 2,3-Di:hydro-ergolenyl-methyl urea derivs. - useful as antihypertensives |
-
1982
- 1982-02-13 DE DE19823205169 patent/DE3205169A1/en not_active Withdrawn
- 1982-02-17 FI FI820526A patent/FI820526L/en not_active Application Discontinuation
- 1982-02-19 WO PCT/CH1982/000025 patent/WO1982002892A1/en unknown
- 1982-02-19 FR FR8202991A patent/FR2500454A1/en active Granted
- 1982-02-22 DK DK77082A patent/DK77082A/en not_active Application Discontinuation
- 1982-02-22 IL IL65074A patent/IL65074A0/en unknown
- 1982-02-22 NL NL8200694A patent/NL8200694A/en not_active Application Discontinuation
- 1982-02-22 SE SE8201098A patent/SE8201098L/en not_active Application Discontinuation
- 1982-02-22 NZ NZ199795A patent/NZ199795A/en unknown
- 1982-02-22 AU AU80682/82A patent/AU8068282A/en not_active Abandoned
- 1982-02-22 PT PT74468A patent/PT74468B/en unknown
- 1982-02-22 GB GB8205176A patent/GB2093452B/en not_active Expired
- 1982-02-22 CA CA000396775A patent/CA1178582A/en not_active Expired
- 1982-02-23 ES ES509825A patent/ES509825A0/en active Granted
- 1982-02-23 HU HU82544A patent/HU187650B/en unknown
- 1982-02-23 PH PH26900A patent/PH17494A/en unknown
Also Published As
Publication number | Publication date |
---|---|
PT74468A (en) | 1982-03-01 |
IL65074A0 (en) | 1982-04-30 |
FR2500454B1 (en) | 1984-11-09 |
HU187650B (en) | 1986-02-28 |
GB2093452A (en) | 1982-09-02 |
DE3205169A1 (en) | 1982-10-14 |
GB2093452B (en) | 1984-11-07 |
WO1982002892A1 (en) | 1982-09-02 |
NL8200694A (en) | 1982-09-16 |
FI820526L (en) | 1982-08-25 |
PH17494A (en) | 1984-09-04 |
DK77082A (en) | 1982-08-25 |
CA1178582A (en) | 1984-11-27 |
NZ199795A (en) | 1985-08-30 |
FR2500454A1 (en) | 1982-08-27 |
PT74468B (en) | 1984-08-01 |
AU8068282A (en) | 1982-09-02 |
ES509825A0 (en) | 1983-03-01 |
SE8201098L (en) | 1982-08-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20010402 |