ES8304105A1 - Procedimiento de preparacion de la (2,6-dimetoxi-4-hidroxifenil)-(3-piperidinopropil)-cetona. - Google Patents
Procedimiento de preparacion de la (2,6-dimetoxi-4-hidroxifenil)-(3-piperidinopropil)-cetona.Info
- Publication number
- ES8304105A1 ES8304105A1 ES511431A ES511431A ES8304105A1 ES 8304105 A1 ES8304105 A1 ES 8304105A1 ES 511431 A ES511431 A ES 511431A ES 511431 A ES511431 A ES 511431A ES 8304105 A1 ES8304105 A1 ES 8304105A1
- Authority
- ES
- Spain
- Prior art keywords
- dimethoxy
- formula
- piperidinopropyl
- hydroxyphenyl
- ketone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- MVDBGZOSRSXNHU-UHFFFAOYSA-N 1-(4-hydroxy-2,6-dimethoxyphenyl)-4-piperidin-1-ylbutan-1-one Chemical compound COC1=CC(O)=CC(OC)=C1C(=O)CCCN1CCCCC1 MVDBGZOSRSXNHU-UHFFFAOYSA-N 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 abstract 2
- ZNDKGZTXFLTQKE-UHFFFAOYSA-N 2-piperidin-1-ylbutanenitrile Chemical compound CCC(C#N)N1CCCCC1 ZNDKGZTXFLTQKE-UHFFFAOYSA-N 0.000 abstract 1
- XQDNFAMOIPNVES-UHFFFAOYSA-N 3,5-Dimethoxyphenol Chemical compound COC1=CC(O)=CC(OC)=C1 XQDNFAMOIPNVES-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 150000004658 ketimines Chemical class 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 239000012429 reaction media Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
_(PROCEDIMIENTO DE PREPARACION DE LA (2,6-DIMETOXI-4-HIDROXIFENIL)-(3-PIPERIDINOPROPIL)-CETONA . SE HACE REACCIONAR ESTEQUIOMETRICAMENTE EL 1,5-DIMETOXI-3-HIDROXIBENCENO CON PIPERIDINOBUTIRONITRILO EN PRESENCIA DE ALCL HACIENDO PASAR POR EL MEDIO DE REACCION DURANTE AL MENOS HORAS, A TEMPERATURA DE 10 A 20 C, UNA CORRIENTE GASEOSA DE HCL Y LUEGO HIDROLIZAR EL DERIVADO CETIMINA FORMADO. PUEDEN OBTENERSE LAS SALES DE ADICION CORRESPONDIENTES MEDIANTE LA REACCION DE LA BASE LIBRE CON EL ACIDO MINERAL U ORGANICO, Y LAS SALES DE AMONIO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8107597A FR2504136A1 (fr) | 1981-04-15 | 1981-04-15 | (2,6-dimethoxy-4-hydroxyphenyl)-(3-piperidinopropyl)-cetone et ses sels d'addition, utilisation en therapeutique et procede de preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8304105A1 true ES8304105A1 (es) | 1983-02-16 |
| ES511431A0 ES511431A0 (es) | 1983-02-16 |
Family
ID=9257449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES511431A Granted ES511431A0 (es) | 1981-04-15 | 1982-04-14 | Procedimiento de preparacion de la (2,6-dimetoxi-4-hidroxifenil)-(3-piperidinopropil)-cetona. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0063075B1 (es) |
| JP (1) | JPS57181073A (es) |
| AT (1) | ATE8258T1 (es) |
| CA (1) | CA1183853A (es) |
| DE (1) | DE3260320D1 (es) |
| DK (1) | DK156002C (es) |
| ES (1) | ES511431A0 (es) |
| FR (1) | FR2504136A1 (es) |
| GR (1) | GR75918B (es) |
| IE (1) | IE52871B1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2534912B1 (fr) * | 1982-10-26 | 1985-06-28 | Lafon Labor | Nouveaux derives de (2,4,6-trimethoxyphenyl) - (3-piperidinopropyl) -cetone, utilisation en therapeutique et procede de preparation |
| FR2597864B1 (fr) * | 1986-04-28 | 1990-11-16 | Lafon Labor | Nouveaux derives de la n-((trimethoxy-2,4,6-benzoyl)-3 propyl) piperidine, leurs procedes de preparation et leur application en therapeutique |
| JP2569940Y2 (ja) * | 1992-02-14 | 1998-04-28 | 株式会社ヨシコー | 摩擦クラッチ |
| HUT74870A (en) * | 1993-05-26 | 1997-02-28 | Syntex Inc | Process for producing 1-phenylalkanone 5-ht4 receptor ligands and pharmaceutical compositions containing them |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2092133B1 (es) * | 1970-05-06 | 1974-03-22 | Orsymonde | |
| FR2134218A1 (en) * | 1971-04-27 | 1972-12-08 | Penciolelli Madeleine | Phloroglucinol aminoketones - vasodilators and antispasmodics |
| GB2004883B (en) * | 1977-09-26 | 1982-03-17 | Lafon Labor | Phloroglucinol derivatives their method of preparation and their use as pharmaceuticals |
| FR2404003A1 (fr) * | 1977-09-26 | 1979-04-20 | Lafon Labor | Nouveaux derives de phloroglucinol, leur procede de preparation et leur application en therapeutique |
-
1981
- 1981-04-15 FR FR8107597A patent/FR2504136A1/fr active Granted
-
1982
- 1982-03-29 IE IE742/82A patent/IE52871B1/en unknown
- 1982-03-30 DE DE8282400577T patent/DE3260320D1/de not_active Expired
- 1982-03-30 AT AT82400577T patent/ATE8258T1/de not_active IP Right Cessation
- 1982-03-30 EP EP82400577A patent/EP0063075B1/fr not_active Expired
- 1982-04-05 CA CA000400489A patent/CA1183853A/en not_active Expired
- 1982-04-06 GR GR67826A patent/GR75918B/el unknown
- 1982-04-14 DK DK167782A patent/DK156002C/da not_active IP Right Cessation
- 1982-04-14 JP JP57063198A patent/JPS57181073A/ja active Granted
- 1982-04-14 ES ES511431A patent/ES511431A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DK156002B (da) | 1989-06-12 |
| EP0063075B1 (fr) | 1984-07-04 |
| JPH039112B2 (es) | 1991-02-07 |
| GR75918B (es) | 1984-08-02 |
| ATE8258T1 (de) | 1984-07-15 |
| DK167782A (da) | 1982-10-16 |
| EP0063075A1 (fr) | 1982-10-20 |
| JPS57181073A (en) | 1982-11-08 |
| FR2504136A1 (fr) | 1982-10-22 |
| ES511431A0 (es) | 1983-02-16 |
| IE52871B1 (en) | 1988-03-30 |
| DK156002C (da) | 1989-11-06 |
| DE3260320D1 (en) | 1984-08-09 |
| CA1183853A (en) | 1985-03-12 |
| IE820742L (en) | 1982-10-15 |
| FR2504136B1 (es) | 1984-02-10 |
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