ES8303375A1 - Procedimiento para la fabricacion de derivados 2 substitui- dos del feniltiazol. - Google Patents

Procedimiento para la fabricacion de derivados 2 substitui- dos del feniltiazol.

Info

Publication number
ES8303375A1
ES8303375A1 ES507001A ES507001A ES8303375A1 ES 8303375 A1 ES8303375 A1 ES 8303375A1 ES 507001 A ES507001 A ES 507001A ES 507001 A ES507001 A ES 507001A ES 8303375 A1 ES8303375 A1 ES 8303375A1
Authority
ES
Spain
Prior art keywords
phenyl
substituted
peptic ulcer
thiazole derivatives
derivatives suitable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES507001A
Other languages
English (en)
Other versions
ES507001A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jureha Kagaku Kogyo KK
Kureha Corp
Original Assignee
Jureha Kagaku Kogyo KK
Kureha Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jureha Kagaku Kogyo KK, Kureha Corp filed Critical Jureha Kagaku Kogyo KK
Publication of ES8303375A1 publication Critical patent/ES8303375A1/es
Publication of ES507001A0 publication Critical patent/ES507001A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS 2-SUSTITUIDOS DEL FENILTIAZOL, DE FORMULA (I), EN LA QUE R ES ALQUILO C <- ; R ES HIDROGENO O ALQUILO C <- ; Y N VALE 1-3. CONSISTE EN LA REACCION DE AMONOLISIS DE UN ESTER ALQUILICO INFERIOR DEL ACIDO FENIL-4-METILTIAZOL-5-CARBOXILICO 2-SUSTITUIDO, DE FORMULA (II), EN LA QUE R ES UN ALQUILO C <- Y R Y N SON LOS MISMOS QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE A UNA TEMPERATURA COMPRENDIDA ENTRE -30 C Y 150 C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LA ULCERA PEPTICA.
ES507001A 1980-10-24 1981-10-20 Procedimiento para la fabricacion de derivados 2 substitui- dos del feniltiazol. Granted ES507001A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55149200A JPS5772975A (en) 1980-10-24 1980-10-24 2-substituted phenylthiazole derviative, and medicine for peptic ulcer containing said derivative as active component

Publications (2)

Publication Number Publication Date
ES8303375A1 true ES8303375A1 (es) 1983-02-01
ES507001A0 ES507001A0 (es) 1983-02-01

Family

ID=15470005

Family Applications (1)

Application Number Title Priority Date Filing Date
ES507001A Granted ES507001A0 (es) 1980-10-24 1981-10-20 Procedimiento para la fabricacion de derivados 2 substitui- dos del feniltiazol.

Country Status (7)

Country Link
US (1) US4558059A (es)
EP (1) EP0051409B1 (es)
JP (1) JPS5772975A (es)
KR (1) KR850001933B1 (es)
CA (1) CA1163636A (es)
DE (1) DE3162824D1 (es)
ES (1) ES507001A0 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879295A (en) * 1986-09-27 1989-11-07 Sawai Pharmaceutical Co., Ltd. N-tetrazolyl thiazolecarboxyamide derivatives and their use
EP0321115B1 (en) * 1987-12-14 1991-08-14 Sawai Pharmaceutical Co., Ltd. Carboxamide derivatives having tetrazole and thiazole rings and their use
WO1992009279A1 (en) * 1990-11-30 1992-06-11 Teijin Limited 2-arylthiazole derivative and pharmaceutical composition containing the same
US6083966A (en) * 1998-08-31 2000-07-04 University Of Florida Thiazoline acid derivatives
CA2344913A1 (en) * 1998-09-21 2000-03-30 University Of Florida Research Foundation, Inc. Antimalarial agents
US20040044220A1 (en) * 2002-08-22 2004-03-04 University Of Florida Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin
US20040132789A1 (en) * 2002-08-22 2004-07-08 University Of Florida Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin
AU2003270473A1 (en) * 2003-09-09 2005-04-27 University Of Florida Desferrithiocin derivatives and their use as iron chelators
DK3190106T3 (da) 2005-04-04 2019-07-15 Univ Florida Desferrithiocinpolyether-analoger
NZ579994A (en) * 2007-03-15 2011-09-30 Univ Florida Desferrithiocin polyether analogues useful in the treatment of pathological conditions responsive to chelation or sequestration of trivalent metal
BR112014014544A2 (pt) 2011-12-16 2017-06-13 Univ Florida usos de análogos de 4'-desferritiocina
CA2930966A1 (en) 2013-11-22 2015-05-28 University Of Florida Research Foundation, Inc. Desferrithiocin analogs and uses thereof
CN107708693A (zh) 2015-04-27 2018-02-16 佛罗里达大学研究基金会 代谢程序化的金属螯合剂及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1546183A (fr) * 1966-12-07 1968-11-15 Uniroyal Inc Carboxamidothiazoles, leurs substituants et dérivés, leurs procédés de fabrication ainsi que leurs applications et procédés d'application agriculturaux
US3794636A (en) * 1971-09-03 1974-02-26 Uniroyal Ltd Process for preparation of thiazole hydrohalides
US4336389A (en) * 1978-05-15 1982-06-22 Monsanto Company 2-Substituted-4-aryl-5-thiazolecarboxylic acids and their derivatives as safening agents
US4199506A (en) * 1978-05-15 1980-04-22 Monsanto Company 2,4-Disubstituted-5-thiazolecarboxylic acids and derivatives
US4363813A (en) * 1979-07-09 1982-12-14 Kureha Kagaku Kogyo Kabushiki Kaisha 2-(3,4,5-Trimethoxyphenyl)-4,5-disubstituted thiazoles
JPS5657776A (en) * 1979-10-17 1981-05-20 Kumiai Chem Ind Co Ltd Thiazole derivative and fungicide comprising it

Also Published As

Publication number Publication date
EP0051409A1 (en) 1982-05-12
JPS6148834B2 (es) 1986-10-25
JPS5772975A (en) 1982-05-07
US4558059A (en) 1985-12-10
CA1163636A (en) 1984-03-13
KR830007603A (ko) 1983-11-04
DE3162824D1 (en) 1984-04-26
ES507001A0 (es) 1983-02-01
KR850001933B1 (ko) 1985-12-31
EP0051409B1 (en) 1984-03-21

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603