ES8300726A1 - "procedimiento para la preparacion de 3,1-benzoxazin-2-onas". - Google Patents

"procedimiento para la preparacion de 3,1-benzoxazin-2-onas".

Info

Publication number
ES8300726A1
ES8300726A1 ES508654A ES508654A ES8300726A1 ES 8300726 A1 ES8300726 A1 ES 8300726A1 ES 508654 A ES508654 A ES 508654A ES 508654 A ES508654 A ES 508654A ES 8300726 A1 ES8300726 A1 ES 8300726A1
Authority
ES
Spain
Prior art keywords
group
hydrogen
alkyl
methyl
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES508654A
Other languages
English (en)
Other versions
ES508654A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of ES508654A0 publication Critical patent/ES508654A0/es
Publication of ES8300726A1 publication Critical patent/ES8300726A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 3,1-BENZOXAZIN-2-ONAS Y DE SUS SALES DE ADICION DE ACIDOS, EN FORMA DE RACEMATOS, ANTIPODAS DIASTEREOISOMEROS Y ENANTIOMEROS, DE FORMULA (I), EN LA QUE R Y R SON HIDROGENO O ALCOHILO C <003> ; R Y R SON HIDROGENO O METILO; R , R Y R PUEDEN SER VARIOS RADICALES; Y N VALE DE 1 A 3. CONSISTE EN LA REACCION DE SEPARACION DEL GRUPO PROTECTOR R A PARTIR DEL COMPUESTO DE FORMULA (II), EN LA QUE R , R P Y R PUEDEN SER VARIOS RADICALES; R ES HIDROGENO O ALCOHILO C <003> ; Y N Y R <024>R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO POR HIDROGENACION CATALITICA EN PRESENCIA DE PLATINO, PALADIO O NIQUEL COMO CATALIZADORES. >ESTOS COMPUESTOS TIENEN APLICACIONES FAMACOLOGICAS POR SU EFECTO HIPOTENSOR Y TOCOLITICO, Y COMO BRONCOLITICOS, VASODILATADORES Y AGENTES CARDIACOS.
ES508654A 1980-07-12 1982-01-12 "procedimiento para la preparacion de 3,1-benzoxazin-2-onas". Expired ES8300726A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803026534 DE3026534A1 (de) 1980-07-12 1980-07-12 3,1-benzoxazin-2-one, ihre herstellung und verwendung

Publications (2)

Publication Number Publication Date
ES508654A0 ES508654A0 (es) 1982-11-01
ES8300726A1 true ES8300726A1 (es) 1982-11-01

Family

ID=6107085

Family Applications (4)

Application Number Title Priority Date Filing Date
ES503837A Granted ES503837A0 (es) 1980-07-12 1981-07-10 Procedimiento para la preparacion de 3,1-benzoxazin-2-onas
ES508653A Granted ES508653A0 (es) 1980-07-12 1982-01-12 "procedimiento para la preparacion de 3,1-benzoxazin-2-onas".
ES508654A Expired ES8300726A1 (es) 1980-07-12 1982-01-12 "procedimiento para la preparacion de 3,1-benzoxazin-2-onas".
ES508655A Granted ES508655A0 (es) 1980-07-12 1982-01-12 "procedimiento para la preparacion de 3,1-benzoxazin-2-onas".

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES503837A Granted ES503837A0 (es) 1980-07-12 1981-07-10 Procedimiento para la preparacion de 3,1-benzoxazin-2-onas
ES508653A Granted ES508653A0 (es) 1980-07-12 1982-01-12 "procedimiento para la preparacion de 3,1-benzoxazin-2-onas".

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES508655A Granted ES508655A0 (es) 1980-07-12 1982-01-12 "procedimiento para la preparacion de 3,1-benzoxazin-2-onas".

Country Status (25)

Country Link
US (1) US4341778A (es)
EP (1) EP0043940B1 (es)
JP (1) JPS5748975A (es)
KR (1) KR850000755B1 (es)
AT (1) ATE9336T1 (es)
AU (1) AU540916B2 (es)
CA (1) CA1165317A (es)
DD (1) DD202018A5 (es)
DE (2) DE3026534A1 (es)
DK (1) DK149851C (es)
ES (4) ES503837A0 (es)
FI (1) FI74703C (es)
GB (1) GB2080296B (es)
GR (1) GR74333B (es)
HK (1) HK98286A (es)
HU (1) HU183515B (es)
IE (1) IE52508B1 (es)
IL (1) IL63285A (es)
NO (1) NO158578C (es)
NZ (1) NZ197678A (es)
PH (1) PH17425A (es)
PT (1) PT73338B (es)
SG (1) SG77686G (es)
YU (1) YU170181A (es)
ZA (1) ZA814687B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4446319A (en) * 1981-04-28 1984-05-01 Takeda Chemical Industries, Ltd. Aminocyclitols and their production
JPS62238288A (ja) * 1986-04-04 1987-10-19 Nippon Tokushu Noyaku Seizo Kk 環状カルバメ−ト及び農園芸用殺菌剤
FR2636065B1 (fr) * 1988-09-08 1993-05-07 Fabre Sa Pierre Nouveaux derives de dihydro-2,3 arylacoylaminoalcoyl-3 4h-benzoxazine-1,3 ones-4, leur preparation et leur application en tant que medicaments utiles en therapeutique
JP2807577B2 (ja) * 1990-06-15 1998-10-08 エーザイ株式会社 環状アミド誘導体
FR2680172B1 (fr) * 1991-08-05 1993-11-19 Fabre Medicament Pierre Nouvelles piperazinylalcoyl-3 dihydro-2,3 4h-benzoxazine-1,3 ones-4 substituees, leur preparation et leur application en therapeutique.
EP0805681A4 (en) * 1995-01-24 1998-05-06 Merck & Co Inc TOCOLYTIC ANTAGONISTS OF OXYTOCIN RECEPTORS
US5874430A (en) * 1996-10-02 1999-02-23 Dupont Pharmaceuticals Company 4,4-disubstitued-1,4-dihydro-2H-3,1-benzoxazin-2-ones useful as HIV reverse transcriptase inhibitors and intermediates and processes for making the same
DE102004003428A1 (de) 2004-01-23 2005-08-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue langwirksame Beta-2-Agonisten, und deren Verwendung als Arzneimittel
JPWO2006077821A1 (ja) * 2005-01-19 2008-06-19 大日本住友製薬株式会社 アルドステロン受容体調節剤としての芳香族スルホン化合物
DE102005008921A1 (de) * 2005-02-24 2006-08-31 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittel zur Behandlung von Atemwegserkrankungen
US7423146B2 (en) * 2005-11-09 2008-09-09 Boehringer Ingelheim International Gmbh Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
PE20080610A1 (es) * 2006-08-22 2008-07-15 Boehringer Ingelheim Int Nuevos beta-agonistas enantiomericamente puros, procedimientos para su preparacion y uso como medicamentos
PE20080425A1 (es) * 2006-08-22 2008-06-16 Boehringer Ingelheim Int Formulacion aerosol para la inhalacion de beta-agonistas
WO2008023001A1 (en) * 2006-08-22 2008-02-28 Boehringer Ingelheim International Gmbh Powder formulations for inhalation containing enantiomerically pure beta-agonists
UY30552A1 (es) * 2006-08-22 2008-03-31 Boehringer Ingelheim Int Combinaciones farmacologiicas en base a derivados sustituidos de la n-(5-{2-[1,1-dimetil-propilamino]-1-hidroxi-metil}-2-hidroxi-fenil)-metansulfonamida y aplicaciones
EP2093219A1 (de) 2008-02-22 2009-08-26 Boehringer Ingelheim International Gmbh Kristalline, enantiomerenreine Salzform eines Betamimetikums und dessen Verwendung als Arzneimittel

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3526621A (en) * 1966-08-03 1970-09-01 Farmaceutical Italia Soc Substituted 3,1-benzoxazin-2-one
DE2609645A1 (de) * 1976-03-09 1977-09-15 Boehringer Sohn Ingelheim Aminoalkylheterocyclen
US4163053A (en) * 1977-12-27 1979-07-31 Schering Corporation Anti-hypertensive 5-[2-(substituted anilinoalkylamino)-1-hydroxyalkyl]salicylamides
FI791727A (fi) * 1978-06-05 1979-12-06 Ciba Geigy Ag Foerfarande foer framstaellning av n-alkylerade aminoalkoholer
DE2833140A1 (de) * 1978-07-28 1980-02-07 Boehringer Sohn Ingelheim Neue n-substituierte heterocyclen

Also Published As

Publication number Publication date
EP0043940B1 (de) 1984-09-12
PT73338A (de) 1981-08-01
IE52508B1 (en) 1987-11-25
DD202018A5 (de) 1983-08-24
US4341778A (en) 1982-07-27
EP0043940A1 (de) 1982-01-20
ES8300727A1 (es) 1982-11-01
DE3026534A1 (de) 1982-03-18
GB2080296A (en) 1982-02-03
ES8205402A1 (es) 1982-06-01
IE811567L (en) 1982-01-12
DK149851C (da) 1987-05-04
NO158578C (no) 1988-10-05
HK98286A (en) 1986-12-24
CA1165317A (en) 1984-04-10
IL63285A0 (en) 1981-10-30
NO812355L (no) 1982-01-13
KR850000755B1 (en) 1985-05-25
PT73338B (en) 1983-06-20
NZ197678A (en) 1984-12-14
YU170181A (en) 1983-10-31
ES503837A0 (es) 1982-06-01
GB2080296B (en) 1983-09-28
ES508655A0 (es) 1982-11-01
ES508654A0 (es) 1982-11-01
AU540916B2 (en) 1984-12-06
ATE9336T1 (de) 1984-09-15
NO158578B (no) 1988-06-27
PH17425A (en) 1984-08-08
ES8300725A1 (es) 1982-11-01
DK149851B (da) 1986-10-13
FI74703B (fi) 1987-11-30
FI812183L (fi) 1982-01-13
ES508653A0 (es) 1982-11-01
HU183515B (en) 1984-05-28
JPS5748975A (en) 1982-03-20
KR830006248A (ko) 1983-09-20
FI74703C (fi) 1988-03-10
ZA814687B (en) 1983-03-30
DE3166003D1 (en) 1984-10-18
GR74333B (es) 1984-06-25
SG77686G (en) 1987-02-27
DK306781A (da) 1982-01-13
IL63285A (en) 1985-03-31
AU7273181A (en) 1982-09-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19950921