ES8206445A1 - Procedimiento de preparacion de amidas del acido 4-aminobu- tirico - Google Patents
Procedimiento de preparacion de amidas del acido 4-aminobu- tiricoInfo
- Publication number
- ES8206445A1 ES8206445A1 ES505004A ES505004A ES8206445A1 ES 8206445 A1 ES8206445 A1 ES 8206445A1 ES 505004 A ES505004 A ES 505004A ES 505004 A ES505004 A ES 505004A ES 8206445 A1 ES8206445 A1 ES 8206445A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- alkyl group
- carbon atoms
- integer
- linear
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE AMIDAS DE ACIDO 4-AMINKOBUTIRICO DE FORMULA (I), ENLA QUE R ES ALQUILO C1-7 O CICLOALQUILO, M VALE 0-3 Y N VALE 0-2, DE MODO QUE M+N>0, Y X, R1 Y R2 PUENDEN SER VARIOS RADIALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN CLORURO DE ACIDO DE FORMULA R-COCI, EN LAS QUE R'' ES HIDROGENO O ALQUILO INERIOR Y LOS DEMAS SIMBOLOS TIENE EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), EN UN DISOLVENTE INERTE, EN PRESENCIA DE UNA BASE COMO ACEPTOR DE ACIDO Y A UNA TEMPERATURA ENTRE 0 Y 50 C., SEGUIDA DE LA AMIDFICACION POR REACCION CON UNA AMINA DE FORMULA R1,NHR2. ESTOS COMPUESTOS TIENE APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD SOBRE EL SISTEMA NERVIOSO CENTRAL.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8018609A FR2489319A1 (fr) | 1980-08-27 | 1980-08-27 | Derives de l'acide amino-4 butyrique et les medicaments, actifs notamment sur le systeme nerveux central, en contenant |
Publications (2)
Publication Number | Publication Date |
---|---|
ES505004A0 ES505004A0 (es) | 1982-08-16 |
ES8206445A1 true ES8206445A1 (es) | 1982-08-16 |
Family
ID=9245433
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES505004A Expired ES8206445A1 (es) | 1980-08-27 | 1981-08-26 | Procedimiento de preparacion de amidas del acido 4-aminobu- tirico |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0046707B1 (es) |
JP (1) | JPS5772949A (es) |
AT (1) | ATE21099T1 (es) |
AU (1) | AU547392B2 (es) |
CA (1) | CA1208230A (es) |
DE (1) | DE3175030D1 (es) |
DK (1) | DK378781A (es) |
ES (1) | ES8206445A1 (es) |
FR (1) | FR2489319A1 (es) |
GR (1) | GR75299B (es) |
IE (1) | IE52415B1 (es) |
NO (1) | NO156608C (es) |
NZ (1) | NZ198110A (es) |
PT (1) | PT73558B (es) |
ZA (1) | ZA815662B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1340902C (en) * | 1985-02-15 | 2000-02-22 | Harold L. Kohn | Amino acid derivative anticonvulsant |
US5654301A (en) * | 1985-02-15 | 1997-08-05 | Research Corporation Technologies, Inc. | Amino acid derivative anticonvulsant |
US5378729A (en) * | 1985-02-15 | 1995-01-03 | Research Corporation Technologies, Inc. | Amino acid derivative anticonvulsant |
CA1320734C (en) * | 1986-02-04 | 1993-07-27 | Suntory Limited | Pyrrolidineamide derivative of acylamino acid and pharmaceutical composition containing the same |
US5198458A (en) * | 1986-02-04 | 1993-03-30 | Suntory Limited | Pyrrolidineamide derivatives of acylamino acid and pharmaceutical composition containing the same |
NZ222045A (en) * | 1986-08-21 | 1989-10-27 | Res Corp Technologies Inc | From diamides up to tetrapeptides for use as anticanvulsants |
US4992472A (en) * | 1987-06-16 | 1991-02-12 | The United States Of America As Represented By The Department Of Health And Human Services | Chemical differentiating agents |
US5770625A (en) * | 1988-02-08 | 1998-06-23 | The Trustees Of Columbia University In The City Of New York | Butyryl-tyrosinyl spermine, analogs thereof and methods of preparing and using same |
DE3915755A1 (de) * | 1989-05-13 | 1990-11-29 | Bayer Ag | Fungizide mittel sowie substituierte aminosaeureamid-derivate und deren herstellung |
DE3915756A1 (de) * | 1989-05-13 | 1990-11-29 | Bayer Ag | Cyclopropanoylaminosaeureamid-derivate |
JPH03506045A (ja) * | 1989-05-19 | 1991-12-26 | リサーチ・コーポレイション・テクノロジーズ・インコーポレイテッド | アミノ酸誘導体抗けいれん薬 |
DE4102042A1 (de) * | 1991-01-24 | 1992-07-30 | Bayer Ag | Substituierte aminosaeureamid-derivate deren herstellung und verwendung als fungizide |
US5585358A (en) * | 1993-07-06 | 1996-12-17 | Yissum Research Development Corporation Of The Hebrew University Of Jerusalem | Derivatives of valproic acid amides and 2-valproenoic acid amides, method of making and use thereof as anticonvulsant agents |
US6037472A (en) * | 1993-11-04 | 2000-03-14 | Syntex (U.S.A.) Inc. | Matrix metalloprotease inhibitors |
IL114483A0 (en) * | 1994-07-12 | 1995-11-27 | Yissum Res Dev Co | Glycinamide derivatives pharmaceutical compositions containing the same and methods utilizing the same |
CA2378955A1 (en) * | 1999-08-10 | 2001-02-15 | Uab Research Foundation | Use of gaba agonists for treatment of spastic disorders, convulsions, and epilepsy |
CZ2004266A3 (cs) | 2000-07-21 | 2005-02-16 | Teva Pharmaceutical Industries, Ltd. | Použití derivátů amidů kyseliny valproové a kyseliny 2-valproenové pro léčbu mánie při bipolární poruše |
EP1604656A1 (en) | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating amyotrophic lateral sclerosis (ALS) |
US7632836B2 (en) * | 2006-11-30 | 2009-12-15 | Cenerx Biopharma, Inc. | Dialkylamino alkyl esters of pivagabine as medicaments for the treatment of central nervous system disorders |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB732415A (en) * | 1952-07-12 | 1955-06-22 | Ruhrchemie Ag | Process for the production of aroylated aminocarboxylic acids |
US3022314A (en) * | 1955-06-20 | 1962-02-20 | Upjohn Co | Alpha-phenyl-omega-amino-alkanamides |
IE33790B1 (en) * | 1968-06-04 | 1974-10-30 | Beecham Group Ltd | Derivatives of n-acylaminoacid amides |
-
1980
- 1980-08-27 FR FR8018609A patent/FR2489319A1/fr active Granted
-
1981
- 1981-08-11 GR GR65767A patent/GR75299B/el unknown
- 1981-08-11 IE IE1835/81A patent/IE52415B1/en unknown
- 1981-08-13 DE DE8181401299T patent/DE3175030D1/de not_active Expired
- 1981-08-13 EP EP81401299A patent/EP0046707B1/fr not_active Expired
- 1981-08-13 AT AT81401299T patent/ATE21099T1/de not_active IP Right Cessation
- 1981-08-17 ZA ZA815662A patent/ZA815662B/xx unknown
- 1981-08-18 AU AU74259/81A patent/AU547392B2/en not_active Ceased
- 1981-08-20 NZ NZ198110A patent/NZ198110A/en unknown
- 1981-08-21 CA CA000384370A patent/CA1208230A/en not_active Expired
- 1981-08-24 PT PT73558A patent/PT73558B/pt unknown
- 1981-08-26 DK DK378781A patent/DK378781A/da not_active Application Discontinuation
- 1981-08-26 JP JP56132669A patent/JPS5772949A/ja active Pending
- 1981-08-26 ES ES505004A patent/ES8206445A1/es not_active Expired
- 1981-08-26 NO NO812890A patent/NO156608C/no unknown
Also Published As
Publication number | Publication date |
---|---|
NO156608B (no) | 1987-07-13 |
ZA815662B (en) | 1982-08-25 |
CA1208230A (en) | 1986-07-22 |
JPS5772949A (en) | 1982-05-07 |
IE811835L (en) | 1982-02-27 |
ES505004A0 (es) | 1982-08-16 |
EP0046707B1 (fr) | 1986-07-30 |
DE3175030D1 (en) | 1986-09-04 |
DK378781A (da) | 1982-02-28 |
IE52415B1 (en) | 1987-10-28 |
GR75299B (es) | 1984-07-13 |
PT73558A (fr) | 1981-09-01 |
NO156608C (no) | 1987-10-21 |
AU547392B2 (en) | 1985-10-17 |
NZ198110A (en) | 1984-12-14 |
FR2489319A1 (fr) | 1982-03-05 |
AU7425981A (en) | 1982-03-04 |
FR2489319B1 (es) | 1984-04-06 |
PT73558B (fr) | 1982-11-03 |
NO812890L (no) | 1982-03-01 |
ATE21099T1 (de) | 1986-08-15 |
EP0046707A1 (fr) | 1982-03-03 |
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