ES8206445A1 - Procedimiento de preparacion de amidas del acido 4-aminobu- tirico - Google Patents

Procedimiento de preparacion de amidas del acido 4-aminobu- tirico

Info

Publication number
ES8206445A1
ES8206445A1 ES505004A ES505004A ES8206445A1 ES 8206445 A1 ES8206445 A1 ES 8206445A1 ES 505004 A ES505004 A ES 505004A ES 505004 A ES505004 A ES 505004A ES 8206445 A1 ES8206445 A1 ES 8206445A1
Authority
ES
Spain
Prior art keywords
group
alkyl group
carbon atoms
integer
linear
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES505004A
Other languages
English (en)
Other versions
ES505004A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of ES505004A0 publication Critical patent/ES505004A0/es
Publication of ES8206445A1 publication Critical patent/ES8206445A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE AMIDAS DE ACIDO 4-AMINKOBUTIRICO DE FORMULA (I), ENLA QUE R ES ALQUILO C1-7 O CICLOALQUILO, M VALE 0-3 Y N VALE 0-2, DE MODO QUE M+N>0, Y X, R1 Y R2 PUENDEN SER VARIOS RADIALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN CLORURO DE ACIDO DE FORMULA R-COCI, EN LAS QUE R'' ES HIDROGENO O ALQUILO INERIOR Y LOS DEMAS SIMBOLOS TIENE EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), EN UN DISOLVENTE INERTE, EN PRESENCIA DE UNA BASE COMO ACEPTOR DE ACIDO Y A UNA TEMPERATURA ENTRE 0 Y 50 C., SEGUIDA DE LA AMIDFICACION POR REACCION CON UNA AMINA DE FORMULA R1,NHR2. ESTOS COMPUESTOS TIENE APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD SOBRE EL SISTEMA NERVIOSO CENTRAL.
ES505004A 1980-08-27 1981-08-26 Procedimiento de preparacion de amidas del acido 4-aminobu- tirico Expired ES8206445A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8018609A FR2489319A1 (fr) 1980-08-27 1980-08-27 Derives de l'acide amino-4 butyrique et les medicaments, actifs notamment sur le systeme nerveux central, en contenant

Publications (2)

Publication Number Publication Date
ES505004A0 ES505004A0 (es) 1982-08-16
ES8206445A1 true ES8206445A1 (es) 1982-08-16

Family

ID=9245433

Family Applications (1)

Application Number Title Priority Date Filing Date
ES505004A Expired ES8206445A1 (es) 1980-08-27 1981-08-26 Procedimiento de preparacion de amidas del acido 4-aminobu- tirico

Country Status (15)

Country Link
EP (1) EP0046707B1 (es)
JP (1) JPS5772949A (es)
AT (1) ATE21099T1 (es)
AU (1) AU547392B2 (es)
CA (1) CA1208230A (es)
DE (1) DE3175030D1 (es)
DK (1) DK378781A (es)
ES (1) ES8206445A1 (es)
FR (1) FR2489319A1 (es)
GR (1) GR75299B (es)
IE (1) IE52415B1 (es)
NO (1) NO156608C (es)
NZ (1) NZ198110A (es)
PT (1) PT73558B (es)
ZA (1) ZA815662B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340902C (en) * 1985-02-15 2000-02-22 Harold L. Kohn Amino acid derivative anticonvulsant
US5654301A (en) * 1985-02-15 1997-08-05 Research Corporation Technologies, Inc. Amino acid derivative anticonvulsant
US5378729A (en) * 1985-02-15 1995-01-03 Research Corporation Technologies, Inc. Amino acid derivative anticonvulsant
CA1320734C (en) * 1986-02-04 1993-07-27 Suntory Limited Pyrrolidineamide derivative of acylamino acid and pharmaceutical composition containing the same
US5198458A (en) * 1986-02-04 1993-03-30 Suntory Limited Pyrrolidineamide derivatives of acylamino acid and pharmaceutical composition containing the same
NZ222045A (en) * 1986-08-21 1989-10-27 Res Corp Technologies Inc From diamides up to tetrapeptides for use as anticanvulsants
US4992472A (en) * 1987-06-16 1991-02-12 The United States Of America As Represented By The Department Of Health And Human Services Chemical differentiating agents
US5770625A (en) * 1988-02-08 1998-06-23 The Trustees Of Columbia University In The City Of New York Butyryl-tyrosinyl spermine, analogs thereof and methods of preparing and using same
DE3915755A1 (de) * 1989-05-13 1990-11-29 Bayer Ag Fungizide mittel sowie substituierte aminosaeureamid-derivate und deren herstellung
DE3915756A1 (de) * 1989-05-13 1990-11-29 Bayer Ag Cyclopropanoylaminosaeureamid-derivate
JPH03506045A (ja) * 1989-05-19 1991-12-26 リサーチ・コーポレイション・テクノロジーズ・インコーポレイテッド アミノ酸誘導体抗けいれん薬
DE4102042A1 (de) * 1991-01-24 1992-07-30 Bayer Ag Substituierte aminosaeureamid-derivate deren herstellung und verwendung als fungizide
US5585358A (en) * 1993-07-06 1996-12-17 Yissum Research Development Corporation Of The Hebrew University Of Jerusalem Derivatives of valproic acid amides and 2-valproenoic acid amides, method of making and use thereof as anticonvulsant agents
US6037472A (en) * 1993-11-04 2000-03-14 Syntex (U.S.A.) Inc. Matrix metalloprotease inhibitors
IL114483A0 (en) * 1994-07-12 1995-11-27 Yissum Res Dev Co Glycinamide derivatives pharmaceutical compositions containing the same and methods utilizing the same
CA2378955A1 (en) * 1999-08-10 2001-02-15 Uab Research Foundation Use of gaba agonists for treatment of spastic disorders, convulsions, and epilepsy
CZ2004266A3 (cs) 2000-07-21 2005-02-16 Teva Pharmaceutical Industries, Ltd. Použití derivátů amidů kyseliny valproové a kyseliny 2-valproenové pro léčbu mánie při bipolární poruše
EP1604656A1 (en) 2004-06-09 2005-12-14 Schwarz Pharma Ag Novel use of peptide compounds for treating amyotrophic lateral sclerosis (ALS)
US7632836B2 (en) * 2006-11-30 2009-12-15 Cenerx Biopharma, Inc. Dialkylamino alkyl esters of pivagabine as medicaments for the treatment of central nervous system disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB732415A (en) * 1952-07-12 1955-06-22 Ruhrchemie Ag Process for the production of aroylated aminocarboxylic acids
US3022314A (en) * 1955-06-20 1962-02-20 Upjohn Co Alpha-phenyl-omega-amino-alkanamides
IE33790B1 (en) * 1968-06-04 1974-10-30 Beecham Group Ltd Derivatives of n-acylaminoacid amides

Also Published As

Publication number Publication date
NO156608B (no) 1987-07-13
ZA815662B (en) 1982-08-25
CA1208230A (en) 1986-07-22
JPS5772949A (en) 1982-05-07
IE811835L (en) 1982-02-27
ES505004A0 (es) 1982-08-16
EP0046707B1 (fr) 1986-07-30
DE3175030D1 (en) 1986-09-04
DK378781A (da) 1982-02-28
IE52415B1 (en) 1987-10-28
GR75299B (es) 1984-07-13
PT73558A (fr) 1981-09-01
NO156608C (no) 1987-10-21
AU547392B2 (en) 1985-10-17
NZ198110A (en) 1984-12-14
FR2489319A1 (fr) 1982-03-05
AU7425981A (en) 1982-03-04
FR2489319B1 (es) 1984-04-06
PT73558B (fr) 1982-11-03
NO812890L (no) 1982-03-01
ATE21099T1 (de) 1986-08-15
EP0046707A1 (fr) 1982-03-03

Similar Documents

Publication Publication Date Title
ES8206445A1 (es) Procedimiento de preparacion de amidas del acido 4-aminobu- tirico
ES450643A1 (es) Procedimiento para la preparacion de derivados de pirrolidi-na.
GB1138405A (en) Morpholine derivatives
MX3355E (es) Metodo de preparacion de malo-2-pirrolidinonas n-substituidas aciclicas aliciclicas y aromaticas
GB1398412A (en) Piperidine derivatives
ES8604543A1 (es) Procedimiento para la obtencion de derivados piperazinicos
ES435197A1 (es) Procedimiento para preparar derivados de triazina.
ES8507462A1 (es) Procedimiento para preparar sales de amina
GB1191609A (en) Use of Oxalic Acid Diamides as Stabilizers for Polyolefins
GB1304786A (es)
DE3060367D1 (en) Derivatives of 2-benzoyl-4-nitro anilides, their preparation and their use as medicines
ES456991A1 (es) Procedimiento para la preparacion de 1,2,3-tiadiazol-5-il- ureas.
GB1367968A (en) Substituted m-trifluoromethylphenylurea derivatives
ES8700658A1 (es) Un procedimiento para preparar compuestos relacionados con histargina
ES481125A1 (es) Un procedimiento para la preparacion de nuevos derivados de 2-oxohexahidroacepina,-piperidina o -pirrolidina.
ES8301963A1 (es) Un procedimiento para preparacion de nuevas piperidinoquinazolinas.
FR2494272B1 (es)
ES428672A1 (es) Procedimiento para la obtencion de diamino-benzofenonas.
GB1057742A (en) N-substituted octadecadienoic acid amides
GB1491390A (en) Production of an n-(substituted)piperazine compound
ES425197A1 (es) Procedimiento para la produccion de acidos penicilinicos cristalinos.
ES414821A3 (es) Un procedimiento para la preparacion de tioamidas de acido siringico 4-sustituido.
ES379188A3 (es) Un procedimiento de preparacion de derivados de adamantano.
ES277617A2 (es) Procedimiento para preparar amidas de ácido 0,0-di(fluoro-alkil)-ditiofosforilacéticos
ES472090A2 (es) Mejoras introducidas en el objeto de la patente principal n.451407 por:procedimiento para preparar derivados de amidoxi-ma