ES8205752A1 - Procedimiento para transformar la estructura de insulina quecristaliza de forma romboedrica - Google Patents
Procedimiento para transformar la estructura de insulina quecristaliza de forma romboedricaInfo
- Publication number
- ES8205752A1 ES8205752A1 ES494260A ES494260A ES8205752A1 ES 8205752 A1 ES8205752 A1 ES 8205752A1 ES 494260 A ES494260 A ES 494260A ES 494260 A ES494260 A ES 494260A ES 8205752 A1 ES8205752 A1 ES 8205752A1
- Authority
- ES
- Spain
- Prior art keywords
- suspension
- crystals
- preparation
- insulin crystals
- insulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C07K14/625—Extraction from natural sources
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
PROCEDIMIENTO DE TRANSFORMACION ESTRUCTURAL DE INSULINA CRISTALIZADA EN FORMA ROMBOEDRICA DE PORCINO, CON ESTRUCTURA 4-ZN, EN ROMBOEDROS CON ESTRUCTURA 2-ZN. LOS CRISTALES CON ESTRUCTUA 4ZN SE MANTIENEN EN UN MEDIO ACUOSO A UNA TEMPERATURA COMPRENDIDA ENTRE LA AMBIENTE Y LOS 45C. EL MEDIO ACUOSO DEBE CONTENER MENOS DEL 6 POR 100 DE CLORURO DE SODIO Y UN PH QUE OSCILE ENTRE 4,5 Y 6,0 MANTENIENDOSE ESTABLE POR ADICION DE UN TAMPON, HASTA QUE NO SE PUEDA DETECTAR EN LA MUESTRA NINGUN CRISTAL DE LA ESTRUCTUA 4-ZN. CUANDO SE TERMINA LA TRANSFORMACION SE DILUYE LA SUSPENSION CRISTALINA CON UNA SOLUCION DE DILUCION QUE CONTIENE UNA SUSTANCIA PARA AJUSTAR LA ISOTONIA, TAL COMO EL CLORURO DE SODIO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792933946 DE2933946A1 (de) | 1979-08-22 | 1979-08-22 | Insulinkristallsuspension und verfahren zu ihrer herstellung. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES494260A0 ES494260A0 (es) | 1982-08-01 |
| ES8205752A1 true ES8205752A1 (es) | 1982-08-01 |
Family
ID=6079022
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES494260A Expired ES8205752A1 (es) | 1979-08-22 | 1980-08-14 | Procedimiento para transformar la estructura de insulina quecristaliza de forma romboedrica |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0025868B1 (es) |
| JP (1) | JPS5632412A (es) |
| AT (1) | ATE1281T1 (es) |
| AU (1) | AU539091B2 (es) |
| CA (1) | CA1155439A (es) |
| DE (2) | DE2933946A1 (es) |
| DK (1) | DK149347C (es) |
| ES (1) | ES8205752A1 (es) |
| GR (1) | GR69915B (es) |
| IE (1) | IE50188B1 (es) |
| IL (1) | IL60889A (es) |
| ZA (1) | ZA805152B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5534488A (en) * | 1993-08-13 | 1996-07-09 | Eli Lilly And Company | Insulin formulation |
| YU18596A (sh) * | 1995-03-31 | 1998-07-10 | Eli Lilly And Company | Analogne formulacije monomernog insulina |
| DK0840748T3 (da) | 1995-07-25 | 2003-07-28 | Novartis Ag | Transformerende vækstfaktor betakrystaller |
| DE69806362T2 (de) * | 1997-03-20 | 2003-01-30 | Novo Nordisk As | Therapeutische pulverformulierung zur pulmonaren anwendung, welche kristallines insulin enthält |
| DE102009001969A1 (de) | 2009-03-30 | 2010-10-07 | Robert Bosch Gmbh | Sensormodul |
| US20220064213A1 (en) * | 2019-01-10 | 2022-03-03 | Biocon Limited | Preparative crystallization of recombinant human insulin |
-
1979
- 1979-08-22 DE DE19792933946 patent/DE2933946A1/de not_active Withdrawn
-
1980
- 1980-08-14 ES ES494260A patent/ES8205752A1/es not_active Expired
- 1980-08-16 AT AT80104879T patent/ATE1281T1/de not_active IP Right Cessation
- 1980-08-16 EP EP80104879A patent/EP0025868B1/de not_active Expired
- 1980-08-16 DE DE8080104879T patent/DE3060628D1/de not_active Expired
- 1980-08-20 GR GR62708A patent/GR69915B/el unknown
- 1980-08-21 CA CA000358705A patent/CA1155439A/en not_active Expired
- 1980-08-21 ZA ZA00805152A patent/ZA805152B/xx unknown
- 1980-08-21 AU AU61621/80A patent/AU539091B2/en not_active Ceased
- 1980-08-21 DK DK359380A patent/DK149347C/da not_active IP Right Cessation
- 1980-08-21 IE IE1762/80A patent/IE50188B1/en unknown
- 1980-08-21 IL IL60889A patent/IL60889A/xx unknown
- 1980-08-22 JP JP11487980A patent/JPS5632412A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU539091B2 (en) | 1984-09-13 |
| DE2933946A1 (de) | 1981-03-12 |
| IL60889A (en) | 1983-07-31 |
| CA1155439A (en) | 1983-10-18 |
| GR69915B (es) | 1982-07-21 |
| IL60889A0 (en) | 1980-10-26 |
| IE50188B1 (en) | 1986-03-05 |
| EP0025868B1 (de) | 1982-06-30 |
| DE3060628D1 (en) | 1982-08-19 |
| IE801762L (en) | 1981-03-22 |
| JPS5632412A (en) | 1981-04-01 |
| ES494260A0 (es) | 1982-08-01 |
| EP0025868A1 (de) | 1981-04-01 |
| DK149347B (da) | 1986-05-12 |
| ZA805152B (en) | 1981-08-26 |
| DK359380A (da) | 1981-02-23 |
| ATE1281T1 (de) | 1982-07-15 |
| AU6162180A (en) | 1981-04-09 |
| DK149347C (da) | 1986-10-20 |
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