ES8205190A1 - Un procedimiento para la preparacion del acido 3,7,11,15-tetrametil-2,4,6,10-14-hexadecapentaenoico. - Google Patents
Un procedimiento para la preparacion del acido 3,7,11,15-tetrametil-2,4,6,10-14-hexadecapentaenoico.Info
- Publication number
- ES8205190A1 ES8205190A1 ES501124A ES501124A ES8205190A1 ES 8205190 A1 ES8205190 A1 ES 8205190A1 ES 501124 A ES501124 A ES 501124A ES 501124 A ES501124 A ES 501124A ES 8205190 A1 ES8205190 A1 ES 8205190A1
- Authority
- ES
- Spain
- Prior art keywords
- tetramethyl
- hexadecapentaenoic acid
- hexadecapentaenoic
- acid
- keratinisation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- UUBHZHZSIKRVIV-KCXSXWJSSA-N (2e,6e,10e)-3,7,11,15-tetramethylhexadeca-2,4,6,10,14-pentaenoic acid Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\C=C\C(\C)=C\C(O)=O UUBHZHZSIKRVIV-KCXSXWJSSA-N 0.000 title abstract 2
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000004494 ethyl ester group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/03—Monocarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
- C07C69/587—Monocarboxylic acid esters having at least two carbon-to-carbon double bonds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DEL ACIDO 3,7,11,15-TETRAMETIL-2,4,6,10,14-HEXADECAPENTAENOICO Y SUS SALES FISIOLOGICAMENTE COMPATIBLES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (I), EN LA QUE R ES HIDROGENO O METILO Y "M" VALE 0 O 1, CON LA CONDICION DE QUE CUANDO R ES HIDROGENO "M" ES 1 Y VICEVERSA, CON UN REACTIVO DE WITTIG,DERIVADO DE UN COMPUESTO DE FORMULA (II), EN LA QUE X ES UN HALOGENO, R1 ES ALQUILO INFERIOR Y "N" VALE 0 O 1, SIENDO N+M = 1; SEGUIDA DE LA REACCION DE HIDROLISIS DEL COMPUESTO OBTENIDO, EN PRESENCIA DE UNA BASE. ESTE COMPUESTO TIENE APLICACIONES FARMACOLOGICAS COMO AGENTE CANCERIGENO Y PARA EL TRATAMIENTO DE ENFERMEDADES DE LA PIEL CON QUERATINIZACION.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4455880A JPS56140949A (en) | 1980-04-07 | 1980-04-07 | 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenic acid |
JP10442080A JPS5731615A (en) | 1980-07-31 | 1980-07-31 | Remedy for skin disease with keratinization |
Publications (2)
Publication Number | Publication Date |
---|---|
ES501124A0 ES501124A0 (es) | 1982-06-01 |
ES8205190A1 true ES8205190A1 (es) | 1982-06-01 |
Family
ID=26384501
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES501124A Expired ES8205190A1 (es) | 1980-04-07 | 1981-04-06 | Un procedimiento para la preparacion del acido 3,7,11,15-tetrametil-2,4,6,10-14-hexadecapentaenoico. |
ES509913A Granted ES509913A0 (es) | 1980-04-07 | 1982-02-25 | Un procedimiento para la preparacion del acido 3,7,11,15-tetrametil-2,4,6,10,14-hexadecapentaenoico. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES509913A Granted ES509913A0 (es) | 1980-04-07 | 1982-02-25 | Un procedimiento para la preparacion del acido 3,7,11,15-tetrametil-2,4,6,10,14-hexadecapentaenoico. |
Country Status (11)
Country | Link |
---|---|
AU (1) | AU537402B2 (es) |
CA (1) | CA1179370A (es) |
CH (1) | CH646682A5 (es) |
DE (1) | DE3113149A1 (es) |
DK (1) | DK158457C (es) |
ES (2) | ES8205190A1 (es) |
FR (1) | FR2479807A1 (es) |
GB (1) | GB2073750B (es) |
IT (1) | IT1194141B (es) |
NL (1) | NL191744C (es) |
SE (1) | SE447243B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56140949A (en) * | 1980-04-07 | 1981-11-04 | Eisai Co Ltd | 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenic acid |
JPS57106638A (en) * | 1980-12-24 | 1982-07-02 | Eisai Co Ltd | Conjugated polyprenylcarboxylic acid and its derivative |
EP0059258B1 (en) * | 1980-12-24 | 1984-05-30 | Eisai Co., Ltd. | Pharmaceutical preparations comprising polyprenyl compounds, especially as anti-cancer agents, and pharmaceutical compositions for the prevention and treatment of cancer and skin diseases |
JPS58164508A (ja) * | 1982-03-26 | 1983-09-29 | Eisai Co Ltd | イソプレニルカルボン酸含有外用組成物 |
JPS5973516A (ja) * | 1982-10-21 | 1984-04-25 | Eisai Co Ltd | 抗炎症剤 |
JPS6160612A (ja) * | 1984-08-31 | 1986-03-28 | Eisai Co Ltd | 制癌効果増強剤 |
IL107587A (en) * | 1993-11-12 | 1998-08-16 | Univ Ramot | Farnesyl geranyl or geranyl-geranyl derivatives pharmaceutical compositions containing them and methods for their preparation |
DE60142038D1 (de) | 2000-04-24 | 2010-06-17 | Kowa Co | Aktivatoren des peroxisome proliferator-activated rezeptors |
CN116041172A (zh) * | 2023-02-01 | 2023-05-02 | 宝鸡文理学院 | 一种神经酸的制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2171497A5 (en) * | 1972-02-02 | 1973-09-21 | Rhone Poulenc Sa | 1,5-dimethyl-1,5-hexadienylidene sulphone derivs - - intermediates for terpenes |
JPS52131507A (en) * | 1976-04-24 | 1977-11-04 | Sankyo Co Ltd | Polyprenyl derivatives |
-
1981
- 1981-04-01 NL NL8101630A patent/NL191744C/xx not_active IP Right Cessation
- 1981-04-01 DE DE19813113149 patent/DE3113149A1/de active Granted
- 1981-04-01 GB GB8110160A patent/GB2073750B/en not_active Expired
- 1981-04-03 SE SE8102161A patent/SE447243B/sv not_active IP Right Cessation
- 1981-04-06 ES ES501124A patent/ES8205190A1/es not_active Expired
- 1981-04-06 FR FR8106874A patent/FR2479807A1/fr active Granted
- 1981-04-06 CA CA000374715A patent/CA1179370A/en not_active Expired
- 1981-04-06 CH CH231781A patent/CH646682A5/fr not_active IP Right Cessation
- 1981-04-06 DK DK155081A patent/DK158457C/da not_active IP Right Cessation
- 1981-04-07 IT IT20967/81A patent/IT1194141B/it active
- 1981-04-07 AU AU69159/81A patent/AU537402B2/en not_active Ceased
-
1982
- 1982-02-25 ES ES509913A patent/ES509913A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
DE3113149A1 (de) | 1982-01-28 |
GB2073750B (en) | 1984-02-22 |
CA1179370A (en) | 1984-12-11 |
ES501124A0 (es) | 1982-06-01 |
AU537402B2 (en) | 1984-06-21 |
DK158457C (da) | 1990-10-08 |
NL8101630A (nl) | 1981-11-02 |
FR2479807A1 (fr) | 1981-10-09 |
GB2073750A (en) | 1981-10-21 |
NL191744B (nl) | 1996-02-01 |
AU6915981A (en) | 1981-10-15 |
FR2479807B1 (es) | 1984-07-20 |
SE447243B (sv) | 1986-11-03 |
ES8304058A1 (es) | 1983-02-16 |
DE3113149C2 (es) | 1988-11-10 |
DK158457B (da) | 1990-05-21 |
DK155081A (da) | 1981-10-08 |
SE8102161L (sv) | 1981-10-08 |
ES509913A0 (es) | 1983-02-16 |
CH646682A5 (fr) | 1984-12-14 |
IT1194141B (it) | 1988-09-14 |
IT8120967A0 (it) | 1981-04-07 |
NL191744C (nl) | 1996-06-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20000301 |