ES8202809A1 - Un procedimiento para la preparacion de espiro (ciclohexano-1,1'(3'h)-isobenzofuranos) - Google Patents
Un procedimiento para la preparacion de espiro (ciclohexano-1,1'(3'h)-isobenzofuranos)Info
- Publication number
- ES8202809A1 ES8202809A1 ES501418A ES501418A ES8202809A1 ES 8202809 A1 ES8202809 A1 ES 8202809A1 ES 501418 A ES501418 A ES 501418A ES 501418 A ES501418 A ES 501418A ES 8202809 A1 ES8202809 A1 ES 8202809A1
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- loweralkyl
- chem
- isobenzofuran
- cyclohexane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Furan Compounds (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE ESPIRO (CILOEHEXANO-1''1 (3''H) ISOBENZOFURANOS). CONSISTE EN ESCINDIR Y CICLISAR CONCOSMITANTEMENTE UN COMPUESTO (I) PARA OBTENER EL COMPUESTO (II), EL CUAL SE HACE REACCIONAR CON UN REACTIVO METALICO (III). SE OBTIENE EL COMPUESTO (IV) QUE SE REDUCE AL COMPUESTO (V). OPCIONALMENTE SE OBTIENEN LAS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/073,055 US4263317A (en) | 1979-09-06 | 1979-09-06 | Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8202809A1 true ES8202809A1 (es) | 1982-03-01 |
ES501418A0 ES501418A0 (es) | 1982-03-01 |
Family
ID=22111440
Family Applications (8)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES494690A Granted ES494690A0 (es) | 1979-09-06 | 1980-09-01 | Un procedimiento para la preparacion de espiro (ciclohexano-1.1'(3'h)-isobenzofuranos) |
ES501423A Granted ES501423A0 (es) | 1979-09-06 | 1981-04-15 | Un procedimiento para la preparacion de espiro (ciclohexano-1,1'(3'h)-isobenzofuranos) |
ES501418A Granted ES501418A0 (es) | 1979-09-06 | 1981-04-15 | Un procedimiento para la preparacion de espiro (ciclohexano-1,1'(3'h)-isobenzofuranos) |
ES501419A Granted ES501419A0 (es) | 1979-09-06 | 1981-04-15 | Un procedimiento para la preparacion de espiro (ciclohexano-1,1'(3'h)-isobenzoeuranos) |
ES501422A Expired ES8202810A1 (es) | 1979-09-06 | 1981-04-15 | Un procedimiento para la preparacion de espiro(ciclohexano- 1,1'(3'h)-isobenzofuranos) |
ES501420A Expired ES8203082A1 (es) | 1979-09-06 | 1981-04-15 | Un procedimiento para la preparacion de espiro (ciclohexano-1,1'(3'h)-isobenzofuranos) |
ES501424A Granted ES501424A0 (es) | 1979-09-06 | 1981-04-15 | Un procedimiento para la preparacion de espiro (ciclohexano-1,1'(3'h)-isobenzofuranos) |
ES501421A Granted ES501421A0 (es) | 1979-09-06 | 1981-04-15 | Un procedimiento para la preparacion de espiro (ciclohexano-1,1'(3'h)-isobenzofuranos) |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES494690A Granted ES494690A0 (es) | 1979-09-06 | 1980-09-01 | Un procedimiento para la preparacion de espiro (ciclohexano-1.1'(3'h)-isobenzofuranos) |
ES501423A Granted ES501423A0 (es) | 1979-09-06 | 1981-04-15 | Un procedimiento para la preparacion de espiro (ciclohexano-1,1'(3'h)-isobenzofuranos) |
Family Applications After (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES501419A Granted ES501419A0 (es) | 1979-09-06 | 1981-04-15 | Un procedimiento para la preparacion de espiro (ciclohexano-1,1'(3'h)-isobenzoeuranos) |
ES501422A Expired ES8202810A1 (es) | 1979-09-06 | 1981-04-15 | Un procedimiento para la preparacion de espiro(ciclohexano- 1,1'(3'h)-isobenzofuranos) |
ES501420A Expired ES8203082A1 (es) | 1979-09-06 | 1981-04-15 | Un procedimiento para la preparacion de espiro (ciclohexano-1,1'(3'h)-isobenzofuranos) |
ES501424A Granted ES501424A0 (es) | 1979-09-06 | 1981-04-15 | Un procedimiento para la preparacion de espiro (ciclohexano-1,1'(3'h)-isobenzofuranos) |
ES501421A Granted ES501421A0 (es) | 1979-09-06 | 1981-04-15 | Un procedimiento para la preparacion de espiro (ciclohexano-1,1'(3'h)-isobenzofuranos) |
Country Status (4)
Country | Link |
---|---|
US (1) | US4263317A (es) |
EP (1) | EP0027522A1 (es) |
JP (1) | JPS5645469A (es) |
ES (8) | ES494690A0 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4301292A (en) * | 1979-09-06 | 1981-11-17 | Hoechst-Roussel Pharmaceuticals, Incorporated | 1-[2-(4,5-Dihydro-4,4-dialkyl-2-oxazolyl)phenyl]-4-(dialkylamino)cyclohexanol |
US4288623A (en) * | 1979-09-06 | 1981-09-08 | Hoechst-Roussel Pharmaceuticals Inc. | 1-Aryl-4-amino-cyclohexan-1-ols |
US4313959A (en) * | 1981-04-27 | 1982-02-02 | Hoechst-Roussel Pharmaceuticals Inc. | (Arylmethyl)phenyl-aminocyclohexanols, cyclohexenes and intermediates thereof |
US4404221A (en) * | 1981-10-19 | 1983-09-13 | Hoechst-Roussel Pharmaceuticals Inc. | 2'-Substituted-spiro[benzofuran-2(3H),1'-cyclohexanes] and its pharmaceutical use |
US4517311A (en) * | 1981-10-19 | 1985-05-14 | Hoechst-Roussel Pharmaceuticals Inc. | 2'-Substituted-spiro[benzofuran-2(3H),1'-cycloalkanes] and their analgesic and anti-depressant compositions |
US4594435A (en) * | 1982-09-13 | 1986-06-10 | Hoechst-Roussel Pharmaceuticals, Inc. | Intermediates for 2'-substituted-spiro[benzofuran-2(3H),1'-cycloalkanes] |
US5173499A (en) * | 1988-04-15 | 1992-12-22 | T Cell Sciences, Inc. | Compounds which inhibit complement and/or suppress immune activity |
US5506247A (en) * | 1988-04-15 | 1996-04-09 | T Cell Sciences, Inc. | Compounds that inhibit complement and/or suppress immune activity |
US5366986A (en) * | 1988-04-15 | 1994-11-22 | T Cell Sciences, Inc. | Compounds which inhibit complement and/or suppress immune activity |
US4981980A (en) * | 1989-09-14 | 1991-01-01 | Merck & Co., Inc. | Drug for treating manic depression |
US5239110A (en) * | 1992-12-30 | 1993-08-24 | Sterling Winthrop, Inc. | Phenylcyclohexanol derivatives as agents for treating CNS disorders |
DE19962866A1 (de) | 1999-12-24 | 2001-07-05 | Effem Gmbh | Verfahren zum Herstellen gefüllter Nahrungsmittel-Hohlkörper |
US6453106B1 (en) | 2000-06-30 | 2002-09-17 | Ge-Act Communications, Inc. | Method and apparatus for a cable location and protection system |
SE0202133D0 (sv) * | 2002-07-08 | 2002-07-08 | Astrazeneca Ab | Novel compounds |
SE0302755D0 (sv) * | 2003-10-17 | 2003-10-17 | Astrazeneca Ab | Novel compounds |
US20070021498A1 (en) * | 2004-10-14 | 2007-01-25 | Nafizal Hossain | Novel tricyclic spiroderivatives as modulators of chemokine receptor activity |
SE0302811D0 (sv) * | 2003-10-23 | 2003-10-23 | Astrazeneca Ab | Novel compounds |
SE0303090D0 (sv) * | 2003-11-20 | 2003-11-20 | Astrazeneca Ab | Novel compounds |
SE0303280D0 (sv) * | 2003-12-05 | 2003-12-05 | Astrazeneca Ab | Novel compounds |
SE0303541D0 (sv) * | 2003-12-22 | 2003-12-22 | Astrazeneca Ab | New compounds |
BRPI0714463A2 (pt) * | 2006-07-19 | 2013-04-02 | Astrazeneca Ab | compostos de espiropiperidina tricÍclicos, sua sÍntese e seus usos como moduladores de atividade receptora de quimiocina |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3962259A (en) * | 1973-12-12 | 1976-06-08 | American Hoechst Corporation | 1,3-Dihydrospiro[isobenzofuran]s and derivatives thereof |
US3959475A (en) * | 1973-12-12 | 1976-05-25 | American Hoechst Corporation | Substituted 1,3-dihydrospiro(isobenzofuran)s |
US4031224A (en) * | 1976-04-29 | 1977-06-21 | American Hoechst Corporation | 1,3-Dihydro-heteroarylspiro (isobenzofuran)s |
-
1979
- 1979-09-06 US US06/073,055 patent/US4263317A/en not_active Expired - Lifetime
-
1980
- 1980-08-26 EP EP80105048A patent/EP0027522A1/en not_active Withdrawn
- 1980-09-01 ES ES494690A patent/ES494690A0/es active Granted
- 1980-09-06 JP JP12297280A patent/JPS5645469A/ja active Pending
-
1981
- 1981-04-15 ES ES501423A patent/ES501423A0/es active Granted
- 1981-04-15 ES ES501418A patent/ES501418A0/es active Granted
- 1981-04-15 ES ES501419A patent/ES501419A0/es active Granted
- 1981-04-15 ES ES501422A patent/ES8202810A1/es not_active Expired
- 1981-04-15 ES ES501420A patent/ES8203082A1/es not_active Expired
- 1981-04-15 ES ES501424A patent/ES501424A0/es active Granted
- 1981-04-15 ES ES501421A patent/ES501421A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
ES8203083A1 (es) | 1982-02-16 |
ES8203084A1 (es) | 1982-02-16 |
ES501423A0 (es) | 1982-02-16 |
ES501422A0 (es) | 1982-03-01 |
US4263317A (en) | 1981-04-21 |
ES8106512A1 (es) | 1981-07-16 |
ES501420A0 (es) | 1982-02-16 |
EP0027522A1 (en) | 1981-04-29 |
ES8203872A1 (es) | 1982-04-01 |
ES8203085A1 (es) | 1982-02-16 |
JPS5645469A (en) | 1981-04-25 |
ES8203082A1 (es) | 1982-02-16 |
ES501421A0 (es) | 1982-02-16 |
ES8202810A1 (es) | 1982-03-01 |
ES501424A0 (es) | 1982-02-16 |
ES494690A0 (es) | 1981-07-16 |
ES501418A0 (es) | 1982-03-01 |
ES501419A0 (es) | 1982-04-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8202809A1 (es) | Un procedimiento para la preparacion de espiro (ciclohexano-1,1'(3'h)-isobenzofuranos) | |
TW341565B (en) | Indole derivatives processes and intermediates for their preparation and pharmaceutical compositions containing them | |
HU906402D0 (en) | Process for producing tricyclic carbapeneme derivatives an pharmaceutical preparatives containing these compounds as active substance | |
AU636351B2 (en) | N-heteroaryl-purin-6-amines, a process for their preparation and their use as medicaments | |
AU626740B2 (en) | Aminocarbonylcarbamates related to physostigmine, a process for their preparation and their use as medicaments | |
ES8601915A1 (es) | Un procedimiento para preparar derivados de piridazinona | |
HU199766B (en) | Process for producing new bicyclic compounds of 5-lipoxygenaze inhibiting activity and pharmaceutical compositions containing them | |
ES8504682A1 (es) | Un procedimiento para la preparacion de compuestos nitro alifaticos | |
LV10235B (en) | New esters, method of preparation thereof, pharmaceutical composition and method of treatment | |
EP0397511A3 (en) | Novel cephalosporin compounds and processes for preparation thereof | |
EA199700287A1 (ru) | Бензамиды для лечения нейродегенеративных заболеваний | |
HUT61018A (en) | Process for producing 3-/1-thiazolidinylbutyl-4-piperazinyl/1-h-indazole derivatives and pharmaceutical compositions comprising such compounds as active ingredient | |
DE3362260D1 (en) | (-)-15-deoxyspergualin, a process for the preparation of the same, and a pharmaceutical composition containing the same | |
ES8506716A1 (es) | Un metodo de preparar espiro (indolo (1, 7-ab) (1, 5)-benzodiazepin-2, 4'-piperidinas) | |
ES8207505A1 (es) | Procedimiento para la preparacion de derivados de fenoxi- aminopropanol substituidos | |
ES8608488A1 (es) | Un metodo para preparar nuevas 1-aminoalquil-amino-4-arilo- xipiperidinas sustituidas | |
IL65213A (en) | 1,4-benzoxazine derivatives,cyclopent(b)(1,4)oxazine derivatives,their preparation and pharmaceutical compositions containing them | |
CA1261341A (en) | SPIRO[BENZOFURANE-2(3H),1'-CYCLOHEPTANES]; METHOD AND INTERMEDIATE PRODUCTS FOR PREPARING THEM; THEIR USE AS MEDICINES | |
AU3375893A (en) | Intermediates of n-hydroxy-dibenz(b,e)oxepin-alkylamines and -alkanoic acid amides, related heterocyclic analogues, a process for their preparation and their use as medicaments | |
JO1757B1 (en) | New vehicles | |
TW226996B (en) | Novel isatin and oxindole derivatives which are acetylcholinesterase inhibitors, a process and intermediates for preparing said derivatives and a pharmaceutical composition thereof |