ES8201126A1 - Prepn. of 2:amino 5:nitro benzophenone(s) - by reaction of 4:nitro benzanilide with benzoyl halide and hydrolysis - Google Patents

Prepn. of 2:amino 5:nitro benzophenone(s) - by reaction of 4:nitro benzanilide with benzoyl halide and hydrolysis

Info

Publication number
ES8201126A1
ES8201126A1 ES500078A ES500078A ES8201126A1 ES 8201126 A1 ES8201126 A1 ES 8201126A1 ES 500078 A ES500078 A ES 500078A ES 500078 A ES500078 A ES 500078A ES 8201126 A1 ES8201126 A1 ES 8201126A1
Authority
ES
Spain
Prior art keywords
nitro
hydrolysis
benzanilide
amino
benzophenone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES500078A
Other languages
Spanish (es)
Other versions
ES500078A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre SA
Original Assignee
Pierre Fabre SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre SA filed Critical Pierre Fabre SA
Publication of ES500078A0 publication Critical patent/ES500078A0/en
Publication of ES8201126A1 publication Critical patent/ES8201126A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

2-amino-5-nitro benzophenone derivs. of formula (I) (where X= H or halogen), are prepd. by treatment of a 4-nitro benzanilide (II) with a benzoyl halide (II) in the presence of a Lewis acid catalyst, followed by acid hydrolysis. The pref. Lewis acid is zinc chloride and the preferred hydrolysis medium is a mixt. of acetic acid, sulphuric acid and water. (I) is an intermediate for medicaments such as nitrazepam, chlorazepam, flunitrazepam and 2-benzoyl-4-nitro glycylanilides. This process gives good yields of pure prod. and is simple to carry out.
ES500078A 1980-02-14 1981-02-14 Prepn. of 2:amino 5:nitro benzophenone(s) - by reaction of 4:nitro benzanilide with benzoyl halide and hydrolysis Expired ES8201126A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8003266A FR2476070A1 (en) 1980-02-14 1980-02-14 Prepn. of 2:amino 5:nitro benzophenone(s) - by reaction of 4:nitro benzanilide with benzoyl halide and hydrolysis

Publications (2)

Publication Number Publication Date
ES500078A0 ES500078A0 (en) 1981-12-16
ES8201126A1 true ES8201126A1 (en) 1981-12-16

Family

ID=9238582

Family Applications (1)

Application Number Title Priority Date Filing Date
ES500078A Expired ES8201126A1 (en) 1980-02-14 1981-02-14 Prepn. of 2:amino 5:nitro benzophenone(s) - by reaction of 4:nitro benzanilide with benzoyl halide and hydrolysis

Country Status (3)

Country Link
ES (1) ES8201126A1 (en)
FR (1) FR2476070A1 (en)
IT (1) IT1170707B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103613548A (en) * 2013-12-10 2014-03-05 沈阳药科大学 Synthesis process of nizofenone fumarate

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD74798A (en) *
AT275502B (en) * 1966-02-22 1969-10-27 Richter Gedeon Vegyeszet Process for the preparation of substituted 2-aminobenzophenones

Also Published As

Publication number Publication date
IT8147772A1 (en) 1982-08-12
IT8147772A0 (en) 1981-02-12
IT1170707B (en) 1987-06-03
ES500078A0 (en) 1981-12-16
FR2476070B1 (en) 1983-12-09
FR2476070A1 (en) 1981-08-21

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603