ES8200372A1 - Procedimiento para la preparacion de compuestos lefemicos. - Google Patents
Procedimiento para la preparacion de compuestos lefemicos.Info
- Publication number
- ES8200372A1 ES8200372A1 ES490163A ES490163A ES8200372A1 ES 8200372 A1 ES8200372 A1 ES 8200372A1 ES 490163 A ES490163 A ES 490163A ES 490163 A ES490163 A ES 490163A ES 8200372 A1 ES8200372 A1 ES 8200372A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- alkyl
- optionally
- membered heterocycle
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS CEFEMICOS DE FORMULA (I), DONDE N ES 0 O 1; R1 ES HIDROGENO O ALCOXI U R2 ES UN GRUPO AZIDO O UN RADICAL -SR3, DONDE R3 ES UN HETEROCICLO DE 5 O 6 MIEMBROS, CON EL QUE PUEDE ESTAR CONDENSADO UN NUCLEO BENCENICO O ALCOHILO. SE HACEN REACCIONAR COMPUESTOS CEFEMICOS DE FORMULA (II) CON AZIDAS, PREFERENTEMENTE AZIDAS DE METALES ALCALINOS. SE REALIZA EN SOLUCION OCUOSA O EN MEZCLAS CON AGUAS Y DISOLVENTES MISCIBLES TAL COMO ACETONA. LA TEMPERATURA DE REACCION DEBE ESTAR ENTRE 50 Y 80C. LOS COMPUESTOS PREPARADOS SE PUEDEN TRANSFORMAR EN UNA SAL OBTENIDA DEL ACIDO CARBOXILICO LIBRE, EN UNA SAL OBTENIDA DE ESTER O BIEN SAPONIFICANDO UN ESTER, EL ACIDO CARBOXILICO SE TRANSFORMA EN UNA SAL. EXISTE OTRO PROCEDIMIENTO PARTIENDO DE COMPUESTOS CEFEMICOS DE FORMULAS (III) EN FORMA DE SUS SALES O ESTERES. SE UTILIZAN PARA COMBATIR INFECCIOSOS GRAM-POSITIVOS Y SOBRE TODO GRAM-NEGATIVOS Y SON EFICACES FRENTE A ESTAFILOCOCOS FORMADORES DE PENICILINAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19792914327 DE2914327A1 (de) | 1979-04-09 | 1979-04-09 | Cephemderivate und verfahren zu ihrer herstellung |
Publications (2)
Publication Number | Publication Date |
---|---|
ES490163A0 ES490163A0 (es) | 1981-10-16 |
ES8200372A1 true ES8200372A1 (es) | 1981-10-16 |
Family
ID=6067880
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES490163A Expired ES8200372A1 (es) | 1979-04-09 | 1980-04-01 | Procedimiento para la preparacion de compuestos lefemicos. |
ES497635A Expired ES8200693A1 (es) | 1979-04-09 | 1980-12-11 | Procedimiento para la preparacion de compuestos cefemicos |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES497635A Expired ES8200693A1 (es) | 1979-04-09 | 1980-12-11 | Procedimiento para la preparacion de compuestos cefemicos |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0017238B1 (es) |
JP (1) | JPS55141490A (es) |
AT (1) | ATE2793T1 (es) |
CA (1) | CA1151151A (es) |
DE (2) | DE2914327A1 (es) |
ES (2) | ES8200372A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE53429B1 (en) * | 1981-08-03 | 1988-11-09 | Fujisawa Pharmaceutical Co | New cephem compounds and processes for preparation thereof |
US4499088A (en) * | 1983-01-04 | 1985-02-12 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
JPS60190783A (ja) * | 1983-12-21 | 1985-09-28 | Sumitomo Seiyaku Kk | セフエム系化合物 |
US4761409A (en) * | 1984-08-16 | 1988-08-02 | Sumitomo Pharmaceuticals Company, Limited | Cephem derivatives |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1399086A (en) * | 1971-05-14 | 1975-06-25 | Glaxo Lab Ltd | Cephalosporin compounds |
DE2822860A1 (de) * | 1978-05-26 | 1979-11-29 | Hoechst Ag | Cephemderivate und verfahren zu ihrer herstellung |
-
1979
- 1979-04-09 DE DE19792914327 patent/DE2914327A1/de not_active Withdrawn
-
1980
- 1980-04-01 ES ES490163A patent/ES8200372A1/es not_active Expired
- 1980-04-03 AT AT80101800T patent/ATE2793T1/de not_active IP Right Cessation
- 1980-04-03 DE DE8080101800T patent/DE3062318D1/de not_active Expired
- 1980-04-03 EP EP80101800A patent/EP0017238B1/de not_active Expired
- 1980-04-08 CA CA000349333A patent/CA1151151A/en not_active Expired
- 1980-04-09 JP JP4578580A patent/JPS55141490A/ja active Pending
- 1980-12-11 ES ES497635A patent/ES8200693A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DE3062318D1 (en) | 1983-04-21 |
ES490163A0 (es) | 1981-10-16 |
EP0017238A1 (de) | 1980-10-15 |
ES497635A0 (es) | 1981-11-01 |
EP0017238B1 (de) | 1983-03-16 |
ES8200693A1 (es) | 1981-11-01 |
ATE2793T1 (de) | 1983-04-15 |
CA1151151A (en) | 1983-08-02 |
JPS55141490A (en) | 1980-11-05 |
DE2914327A1 (de) | 1980-10-30 |
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