ES8105781A1 - Monacolin K derivatives - Google Patents

Monacolin K derivatives

Info

Publication number
ES8105781A1
ES8105781A1 ES493726A ES493726A ES8105781A1 ES 8105781 A1 ES8105781 A1 ES 8105781A1 ES 493726 A ES493726 A ES 493726A ES 493726 A ES493726 A ES 493726A ES 8105781 A1 ES8105781 A1 ES 8105781A1
Authority
ES
Spain
Prior art keywords
monacolin
salts
esters
prepared
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES493726A
Other languages
Spanish (es)
Other versions
ES493726A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP9581479A external-priority patent/JPS5621594A/en
Priority claimed from JP12346179A external-priority patent/JPS5646841A/en
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of ES493726A0 publication Critical patent/ES493726A0/en
Publication of ES8105781A1 publication Critical patent/ES8105781A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/46—Unsaturated compounds containing hydroxy or O-metal groups containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Abstract

Salts and esters of the parent acid corresponding to the lactone Monacolin K may be prepared by salification or esterification of Monacolin K or of a reactive derivative thereof and the salts may be prepared by cultivation of various fungi of the genus Monascus under appropriate conditions. These salts and esters have an activity greater than or comparable with that of Monacolin K itself in the inhibition of biosynthesis of cholesterol. They are, accordingly, valuable antihypercholesteraemic agents.
ES493726A 1979-07-27 1980-07-24 Monacolin K derivatives Expired ES8105781A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9581479A JPS5621594A (en) 1979-07-27 1979-07-27 Mb-530b carboxylic acid metal salt and its preparation
JP12346179A JPS5646841A (en) 1979-09-26 1979-09-26 Mb-530b carboxylic acid ester and its preparation

Publications (2)

Publication Number Publication Date
ES493726A0 ES493726A0 (en) 1981-06-16
ES8105781A1 true ES8105781A1 (en) 1981-06-16

Family

ID=26436995

Family Applications (1)

Application Number Title Priority Date Filing Date
ES493726A Expired ES8105781A1 (en) 1979-07-27 1980-07-24 Monacolin K derivatives

Country Status (16)

Country Link
AT (1) AT375334B (en)
AU (1) AU6083980A (en)
CH (1) CH647749A5 (en)
DD (1) DD153827A5 (en)
DE (1) DE3028284A1 (en)
DK (1) DK322380A (en)
ES (1) ES8105781A1 (en)
FI (1) FI71300C (en)
FR (1) FR2462417A1 (en)
GB (1) GB2055100A (en)
IT (1) IT1147763B (en)
NL (1) NL8004303A (en)
NO (1) NO156210C (en)
NZ (1) NZ194445A (en)
PL (1) PL225901A1 (en)
SE (1) SE445828B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1327360C (en) * 1983-11-14 1994-03-01 William F. Hoffman Oxo-analogs of mevinolin-like antihypercholesterolemic agents
EP0164049B1 (en) * 1984-06-04 1990-12-12 Merck & Co. Inc. Process for preparing hmg-coa reductase inhibtors with a 3,5-dihydroxypentanoate subunit
EP0204287A3 (en) * 1985-06-04 1987-07-01 Merck & Co. Inc. Process for the preparation of hmg-coa reductase inhibitors with a 3,5-dihydroxypentanoate subunit
USRE33033E (en) * 1985-07-05 1989-08-22 Merck & Co., Inc. Process for the preparation of HMG-CoA reductase inhibitors intermediates
US4611081A (en) * 1985-07-05 1986-09-09 Merck & Co., Inc. Process for the preparation of HMG-CoA reductase inhibitors intermediates
US7238348B2 (en) 1996-09-30 2007-07-03 Beijing Peking University Wbl Corporation Ltd. Method of treatment of osteoporosis with compositions of red rice fermentation products
US6046022A (en) 1996-09-30 2000-04-04 Peking University Methods and compositions employing red rice fermentation products
EP1089731A4 (en) * 1998-06-24 2003-06-18 Merck & Co Inc Compositions and methods for treating elevated blood cholesterol
SI20070A (en) 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. NOVEL SALTS OF INHIBITORS OF HMG-CoA REDUCTASE
US6806290B2 (en) 2000-06-09 2004-10-19 Lek Pharmaceuticals D.D. Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same
SK16982002A3 (en) * 2000-06-09 2003-04-01 Lek Pharmaceuticals D. D. Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same
CA2421018A1 (en) * 2000-09-06 2002-03-14 Merck & Co., Inc. Dihydroxy open-acid salt of simvastatin
SK242004A3 (en) 2001-06-13 2004-06-08 Ranbaxy Lab Ltd Methyl analogs of simvastatin as novel HMG-CoA reductase inhibitors
KR100379075B1 (en) 2002-03-07 2003-04-08 Jinis Biopharmaceuticals Co Method for producing low cholesterol animal food product and food product therefrom
US8158362B2 (en) 2005-03-30 2012-04-17 Decode Genetics Ehf. Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
CN101659923B (en) * 2008-08-26 2011-10-26 北京北大维信生物科技有限公司 Method for preparing open-loop lovastatin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2748825C2 (en) * 1976-11-02 1986-11-27 Sankyo Co., Ltd., Tokio/Tokyo Substituted 3,5-dihydroxyheptanoic acid derivatives and medicaments for hyperlipemia containing them
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b

Also Published As

Publication number Publication date
FI802357A (en) 1981-01-28
IT1147763B (en) 1986-11-26
FI71300C (en) 1986-12-19
AU6083980A (en) 1981-01-29
ATA392380A (en) 1983-12-15
DK322380A (en) 1981-01-28
DE3028284C2 (en) 1990-08-09
ES493726A0 (en) 1981-06-16
AT375334B (en) 1984-07-25
SE8005386L (en) 1981-01-28
DD153827A5 (en) 1982-02-03
FR2462417B1 (en) 1984-01-20
NL8004303A (en) 1981-01-29
FR2462417A1 (en) 1981-02-13
PL225901A1 (en) 1982-07-19
NO156210C (en) 1987-08-12
NO156210B (en) 1987-05-04
SE445828B (en) 1986-07-21
FI71300B (en) 1986-09-09
CH647749A5 (en) 1985-02-15
IT8068211A0 (en) 1980-07-28
NO802244L (en) 1981-01-28
DE3028284A1 (en) 1981-02-19
NZ194445A (en) 1984-07-06
GB2055100A (en) 1981-02-25

Similar Documents

Publication Publication Date Title
ES8105781A1 (en) Monacolin K derivatives
ES8105389A1 (en) Polyhydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-ethyl)-1-naphthylenyl-2-methylbutanoates, corresponding hydroxy acids, process for preparing and pharmaceutical compositions containing the same.
ES8107306A1 (en) A method for the production of antibiotic C-15003 P-3.
AU662430B2 (en) Derivatives of quinic acid and a process for their production
SE8102254L (en) ASSOCIATIONS WHICH INHIBIT CHOLESTEROL BIOSYNTHESIS AND PREPARATION THEREOF
JPS57122076A (en) Hypocholesterolemic fermentation product and manufacture
IE39397B1 (en) Emulsifiers derived from hydroxycarboxylic acids
AU547968B2 (en) Ml-236b derivatives i.e. alactone and the corresponding free hydroxy-carboxylic acid
FR2467199B1 (en)
GB1514389A (en) Glycerides with antibacterial properties
IE811096L (en) Esters of alkoxy-acylderivatives of carnitine
AU5482080A (en) Phthyalidyl esters of acetone adduct of epicillin
IE792294L (en) Process for the preparation of 2-ketogulonic acid.
ES8200639A1 (en) Cyclopropane-carboxylic acid esters, process for their preparation and their use.
AU5791080A (en) Oxirane carboxylic acid ester derivatives
IE781105L (en) Esters of alkyl-dioxo-pyrazolidine derivatives.
GB1513158A (en) Dry extracts of plants of the senecio genus
IE46106L (en) Reduction of 2,5-diketogluconic acid
GB1527825A (en) Preparation of stable clear substrate solutions for the analysis of ester hydrolases
GB1080679A (en) A hydrolysis product derived from meso-inositol hexa-nicotinate
AU517641B2 (en) 3-aryl-4-isotliazole carboxylic acids and 3-aryl-4 isoxazole carboxylic acids as plant growth regulants
JPS53142595A (en) Preparation of alpha-alanine by fermentation process
JPS5661377A (en) Optically active cephaloasporin analog