ES8102137A1 - Procedimiento para la obtencion de vinil-3 cefalosporinas - Google Patents
Procedimiento para la obtencion de vinil-3 cefalosporinasInfo
- Publication number
- ES8102137A1 ES8102137A1 ES491688A ES491688A ES8102137A1 ES 8102137 A1 ES8102137 A1 ES 8102137A1 ES 491688 A ES491688 A ES 491688A ES 491688 A ES491688 A ES 491688A ES 8102137 A1 ES8102137 A1 ES 8102137A1
- Authority
- ES
- Spain
- Prior art keywords
- radical
- hydrogen
- protective
- cephalosporins
- vinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE VINIL-3 CEFALOSPORINA, QUE RESPONDE A LAS FORMULAS GENERALES (I) Y (II), Y SUS SALES, DONDE R1 REPRESENTA DIVERSOS TIPOS RADICALES; R2 ES UN ATOMO DE HIDROGENO, UN RADICAL FACILMENTE ELIMINABLE POR VIA ENZIMATICA; R3, R1 ELEVADO A O, R2 ELEVADO A O Y R REPRESENTAN DIVERSOS TIPOS DE RADICALES. SEGUN LA COMBINACION DE RADICALES R1, R2, R3 Y EL VALOR DE N, LOS PRODUCTOS DE FORMULA GENERAL (I) SE OBTIENEN POR DIFERENTES PROCEDIMIENTOS. UNO DE ELLOS CONSISTE EN HACER REACCIONAR UN ACIDO REPRESENTADO POR (III) CON UN COMPUESTO DE FORMULA (I), EN LA QU R1 ES UN ATOMO DE HIDROGENO; POSTERIORMENTE TIENE LUGAR LA REDUCCION DEL OXIDO OBTENIDO. LAS CEFALOSPORINAS DE LA FORMULA GENERAL (II) SE OBTIENE A PARTIR DE LOS PRODUCTOS (I), SEGUN DIVERSAS REACCIONES DE ACUERDO CON EL VALOR DE LOS RADICALES. UN PROCEDIMIENTO DE OBTENCION CONSISTE EN HACER REACCIONAR UN TIOLESTER DE FORMULA (IV) CON UNA AMINO-7 CEFALOSPORINA DE FORMULA GENERAL (I), EN LA QUE R1 ES UN ATOMO DE HIDROGENO; R1 ELEVADO A 1 REPRESENTA UN RADICAL DE FORMULA GENERAL (II). ESTOS COMPUESTOS PRESENTAN PROPIEDADES ANTIBACTERIANAS. *FORMULA*
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7913097A FR2457297A1 (fr) | 1979-05-23 | 1979-05-23 | Nouvelles vinyl-3 cephalosporines, et leur preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
ES491688A0 ES491688A0 (es) | 1980-12-16 |
ES8102137A1 true ES8102137A1 (es) | 1980-12-16 |
Family
ID=9225763
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES491689A Expired ES8203906A1 (es) | 1979-05-23 | 1980-05-21 | Procedimiento para la obtencion de cefalosporinas |
ES491688A Expired ES8102137A1 (es) | 1979-05-23 | 1980-05-21 | Procedimiento para la obtencion de vinil-3 cefalosporinas |
ES495236A Granted ES495236A0 (es) | 1979-05-23 | 1980-09-22 | Procedimiento para la obtencion de vinil-3 cefalosporinas |
ES495237A Granted ES495237A0 (es) | 1979-05-23 | 1980-09-22 | Procedimiento para la obtencion de vinil-3 cefalosporinas |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES491689A Expired ES8203906A1 (es) | 1979-05-23 | 1980-05-21 | Procedimiento para la obtencion de cefalosporinas |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES495236A Granted ES495236A0 (es) | 1979-05-23 | 1980-09-22 | Procedimiento para la obtencion de vinil-3 cefalosporinas |
ES495237A Granted ES495237A0 (es) | 1979-05-23 | 1980-09-22 | Procedimiento para la obtencion de vinil-3 cefalosporinas |
Country Status (32)
Country | Link |
---|---|
US (2) | US4365062A (es) |
JP (2) | JPS55154979A (es) |
AT (2) | AT368509B (es) |
AU (2) | AU532884B2 (es) |
BE (2) | BE883417A (es) |
CA (2) | CA1148141A (es) |
CH (2) | CH650000A5 (es) |
CS (1) | CS235508B2 (es) |
DD (2) | DD151169A5 (es) |
DE (2) | DE3019445A1 (es) |
DK (2) | DK222280A (es) |
ES (4) | ES8203906A1 (es) |
FI (2) | FI801642A (es) |
FR (1) | FR2457297A1 (es) |
GB (2) | GB2051061B (es) |
GR (2) | GR68436B (es) |
HU (2) | HU184759B (es) |
IE (2) | IE49813B1 (es) |
IL (2) | IL60140A (es) |
IT (2) | IT1140972B (es) |
LU (2) | LU82476A1 (es) |
NL (2) | NL8003024A (es) |
NO (2) | NO801503L (es) |
NZ (2) | NZ193800A (es) |
PH (2) | PH17310A (es) |
PL (3) | PL126671B1 (es) |
PT (2) | PT71277A (es) |
SE (2) | SE8003822L (es) |
SU (4) | SU965358A3 (es) |
YU (3) | YU136980A (es) |
ZA (2) | ZA803035B (es) |
ZW (1) | ZW12380A1 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2494276A2 (fr) * | 1980-11-20 | 1982-05-21 | Rhone Poulenc Ind | Nouvelles vinyl-3 cephalosporines, et leur preparation |
FR2511376A1 (fr) * | 1981-08-17 | 1983-02-18 | Rhone Poulenc Sante | Nouveaux derives de la cephalosporine et leur prepration |
FR2511372A1 (fr) * | 1981-08-17 | 1983-02-18 | Rhone Poulenc Sante | Nouveaux derives de la cephalosporine et leur preparation |
FR2531712A1 (fr) * | 1982-08-13 | 1984-02-17 | Rhone Poulenc Sante | Nouveaux derives de la cephalosporine et leur preparation |
US4609730A (en) * | 1982-11-22 | 1986-09-02 | Fujisawa Pharmaceutical Co., Ltd. | 7-[substituted imino-2-(2-aminothiazol-4-yl)-acetamido]-3(2,2-dihalovinyl or ethynyl)-3-cephem-4-carboxylic acid (syn isomers), having antimicrobial activities |
US4520022A (en) * | 1983-01-28 | 1985-05-28 | Bristol-Myers Company | Substituted vinyl cephalosporins |
ZA84584B (en) * | 1983-01-28 | 1984-09-26 | Bristol Myers Co | Substituted vinyl cephalosporins |
JPS604883U (ja) * | 1983-06-24 | 1985-01-14 | 松下冷機株式会社 | 冷蔵庫等の冷却装置 |
US4708955A (en) * | 1985-06-24 | 1987-11-24 | Bristol-Myers Company | 3-(substituted)propenyl-7-aminothiazol-ylcephalosporanic acids and esters thereof |
US4874856A (en) * | 1985-06-24 | 1989-10-17 | Bristol-Myers Company | 3-(substituted)propenyl-7-(aminothiazolylacetamido) ceph-3-em-4-carboxylic acids and esters thereof |
MY127641A (en) * | 1995-10-12 | 2006-12-29 | Essential Therapeutics Inc | Cephalosporin antibiotics |
US6025352A (en) * | 1997-09-29 | 2000-02-15 | Microcide Pharmaceuticals, Inc. | Cephalosporin antibiotics |
US6030965A (en) * | 1997-09-30 | 2000-02-29 | Microcide Pharmaceuticals, Inc. | Cephalosporin antibiotics |
AU2002239076A1 (en) * | 2002-02-28 | 2003-09-09 | Lg Life Sciences Ltd. | Novel cephalosporin compounds and process for preparing the same |
CA2935651A1 (en) | 2007-10-09 | 2009-04-16 | Gladius Pharmaceuticals Corporation | Broad spectrum beta-lactamase inhibitors |
EP2968352B1 (en) | 2013-03-12 | 2018-09-26 | Gladius Pharmaceuticals Corporation | Derivatized 3-styryl-cephalosporins |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3769277A (en) * | 1970-01-23 | 1973-10-30 | Glaxo Lab Ltd | Preparation of delta3-4 carboxy cephalosporins having a 3-vinyl or substituted 3-vinyl group |
US3823139A (en) * | 1970-03-26 | 1974-07-09 | Glaxo Lab Ltd | Cephalosporins having a ypsilon-carbonyl group at position-3 |
US3674784A (en) * | 1970-07-27 | 1972-07-04 | Lilly Co Eli | 3-formyl cephalosporin sulfoxides |
US4065620A (en) * | 1971-06-14 | 1977-12-27 | Eli Lilly And Company | 3-(Substituted) vinyl cephalosporins |
US4144393A (en) * | 1973-12-21 | 1979-03-13 | Glaxo Laboratories Limited | 3-Acetoxymethyl cephalosporins having at position-7 a carboxy substituted α-etherified hydroxyiminoarylacetamido group |
DE2637176A1 (de) * | 1975-08-22 | 1977-03-03 | Ciba Geigy Ag | Carbonylmethylderivate |
JPS5285185A (en) * | 1976-01-05 | 1977-07-15 | Teijin Ltd | Preparation of 7-acylaminocephalosporanic acids |
JPS5289694A (en) * | 1976-01-23 | 1977-07-27 | Asahi Chem Ind Co Ltd | Novel cephalosporins |
US4094978A (en) * | 1976-07-29 | 1978-06-13 | Syntex (U.S.A.) Inc. | 3-propenyl derivatives of cephalosporin, compositions and their use |
US4255423A (en) * | 1977-07-27 | 1981-03-10 | Merck & Co., Inc. | Cephalosporin compounds |
EP0015240A1 (de) * | 1979-02-16 | 1980-09-03 | Ciba-Geigy Ag | Azacyclyl (thio) ureidoacetyl-Verbindungen und Verfahren zu ihrer Herstellung |
-
1979
- 1979-05-23 FR FR7913097A patent/FR2457297A1/fr active Granted
-
1980
- 1980-05-21 CA CA000352346A patent/CA1148141A/fr not_active Expired
- 1980-05-21 CS CS803544A patent/CS235508B2/cs unknown
- 1980-05-21 AU AU58593/80A patent/AU532884B2/en not_active Ceased
- 1980-05-21 DD DD80221268A patent/DD151169A5/de unknown
- 1980-05-21 NZ NZ193800A patent/NZ193800A/xx unknown
- 1980-05-21 IT IT22241/80A patent/IT1140972B/it active
- 1980-05-21 NO NO801503A patent/NO801503L/no unknown
- 1980-05-21 ES ES491689A patent/ES8203906A1/es not_active Expired
- 1980-05-21 DD DD80221267A patent/DD151064A5/de unknown
- 1980-05-21 DE DE19803019445 patent/DE3019445A1/de not_active Withdrawn
- 1980-05-21 NZ NZ193801A patent/NZ193801A/xx unknown
- 1980-05-21 YU YU01369/80A patent/YU136980A/xx unknown
- 1980-05-21 FI FI801642A patent/FI801642A/fi not_active Application Discontinuation
- 1980-05-21 DK DK222280A patent/DK222280A/da not_active Application Discontinuation
- 1980-05-21 US US06/152,153 patent/US4365062A/en not_active Expired - Lifetime
- 1980-05-21 PL PL1980229959A patent/PL126671B1/pl unknown
- 1980-05-21 ZW ZW123/80A patent/ZW12380A1/xx unknown
- 1980-05-21 AT AT0271080A patent/AT368509B/de not_active IP Right Cessation
- 1980-05-21 PL PL1980224390A patent/PL126491B1/pl unknown
- 1980-05-21 ES ES491688A patent/ES8102137A1/es not_active Expired
- 1980-05-21 GB GB8016726A patent/GB2051061B/en not_active Expired
- 1980-05-21 PT PT71277A patent/PT71277A/pt unknown
- 1980-05-21 FI FI801643A patent/FI801643A/fi not_active Application Discontinuation
- 1980-05-21 US US06/152,084 patent/US4307230A/en not_active Expired - Lifetime
- 1980-05-21 LU LU82476A patent/LU82476A1/fr unknown
- 1980-05-21 HU HU801279A patent/HU184759B/hu unknown
- 1980-05-21 DE DE19803019430 patent/DE3019430A1/de not_active Withdrawn
- 1980-05-21 PL PL1980224392A patent/PL122638B1/pl unknown
- 1980-05-21 ZA ZA00803035A patent/ZA803035B/xx unknown
- 1980-05-21 LU LU82478A patent/LU82478A1/fr unknown
- 1980-05-21 SU SU802928399A patent/SU965358A3/ru active
- 1980-05-21 ZA ZA00803036A patent/ZA803036B/xx unknown
- 1980-05-21 GR GR62017A patent/GR68436B/el unknown
- 1980-05-21 SE SE8003822A patent/SE8003822L/xx not_active Application Discontinuation
- 1980-05-21 IE IE1060/80A patent/IE49813B1/en unknown
- 1980-05-21 CH CH3990/80A patent/CH650000A5/fr not_active IP Right Cessation
- 1980-05-21 PT PT71278A patent/PT71278A/pt unknown
- 1980-05-21 BE BE0/200708A patent/BE883417A/fr not_active IP Right Cessation
- 1980-05-21 GR GR62016A patent/GR68428B/el unknown
- 1980-05-21 AU AU58594/80A patent/AU537785B2/en not_active Ceased
- 1980-05-21 CH CH399180A patent/CH645380A5/fr not_active IP Right Cessation
- 1980-05-21 SU SU802928400A patent/SU927118A3/ru active
- 1980-05-21 HU HU801280A patent/HU183143B/hu unknown
- 1980-05-21 BE BE0/200709A patent/BE883418A/fr not_active IP Right Cessation
- 1980-05-21 IT IT22242/80A patent/IT1140973B/it active
- 1980-05-21 CA CA000352335A patent/CA1149375A/fr not_active Expired
- 1980-05-21 GB GB8016725A patent/GB2052488B/en not_active Expired
- 1980-05-21 DK DK223180A patent/DK223180A/da not_active Application Discontinuation
- 1980-05-21 NO NO801504A patent/NO801504L/no unknown
- 1980-05-21 SE SE8003823A patent/SE8003823L/xx not_active Application Discontinuation
- 1980-05-21 IE IE1059/80A patent/IE49812B1/en unknown
- 1980-05-21 AT AT0271180A patent/AT370737B/de not_active IP Right Cessation
- 1980-05-21 YU YU01370/80A patent/YU137080A/xx unknown
- 1980-05-22 PH PH24058A patent/PH17310A/en unknown
- 1980-05-22 IL IL60140A patent/IL60140A/xx unknown
- 1980-05-22 IL IL60141A patent/IL60141A/xx unknown
- 1980-05-22 PH PH24057A patent/PH15916A/en unknown
- 1980-05-23 NL NL8003024A patent/NL8003024A/nl not_active Application Discontinuation
- 1980-05-23 JP JP6800780A patent/JPS55154979A/ja active Pending
- 1980-05-23 NL NL8003010A patent/NL8003010A/nl not_active Application Discontinuation
- 1980-05-23 JP JP6800680A patent/JPS55154978A/ja active Pending
- 1980-09-22 ES ES495236A patent/ES495236A0/es active Granted
- 1980-09-22 ES ES495237A patent/ES495237A0/es active Granted
-
1981
- 1981-01-19 SU SU813229954A patent/SU984411A3/ru active
- 1981-01-19 SU SU813229054A patent/SU988193A3/ru active
-
1983
- 1983-03-09 YU YU00561/83A patent/YU56183A/xx unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20010402 |