ES548772A0 - Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos. - Google Patents

Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.

Info

Publication number
ES548772A0
ES548772A0 ES548772A ES548772A ES548772A0 ES 548772 A0 ES548772 A0 ES 548772A0 ES 548772 A ES548772 A ES 548772A ES 548772 A ES548772 A ES 548772A ES 548772 A0 ES548772 A0 ES 548772A0
Authority
ES
Spain
Prior art keywords
hydroxyphenoxialchyleneheterociclyl
procedure
preparation
carboxylic acids
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES548772A
Other languages
English (en)
Other versions
ES8707947A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of ES8707947A1 publication Critical patent/ES8707947A1/es
Publication of ES548772A0 publication Critical patent/ES548772A0/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D285/00Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01Five-membered rings
    • C07D285/02Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/121,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D275/00Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/58Two sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/041,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/101,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/16Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62Benzothiazoles
    • C07D277/68Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70Sulfur atoms
    • C07D277/74Sulfur atoms substituted by carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D285/00Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01Five-membered rings
    • C07D285/02Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/121,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/1251,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D285/00Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01Five-membered rings
    • C07D285/02Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/121,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/1251,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/40Oxygen atoms attached in positions 3 and 4, e.g. maltol

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ES548772A 1984-11-12 1985-11-11 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos. Expired ES8707947A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP23899184 1984-11-12
JP21932785 1985-10-01

Publications (2)

Publication Number Publication Date
ES8707947A1 ES8707947A1 (es) 1987-09-01
ES548772A0 true ES548772A0 (es) 1987-09-01

Family

ID=26523058

Family Applications (9)

Application Number Title Priority Date Filing Date
ES548772A Expired ES8707947A1 (es) 1984-11-12 1985-11-11 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556751A Expired ES8801235A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556749A Expired ES8801233A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556748A Expired ES8801232A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxolicas.
ES556752A Expired ES8801188A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556750A Expired ES8801234A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556747A Expired ES8801187A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556746A Expired ES8801231A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556753A Expired ES8801189A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.

Family Applications After (8)

Application Number Title Priority Date Filing Date
ES556751A Expired ES8801235A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556749A Expired ES8801233A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556748A Expired ES8801232A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxolicas.
ES556752A Expired ES8801188A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556750A Expired ES8801234A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556747A Expired ES8801187A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556746A Expired ES8801231A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556753A Expired ES8801189A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.

Country Status (8)

Country Link
US (2) US4855310A (es)
EP (1) EP0181779B1 (es)
KR (1) KR900004804B1 (es)
AT (1) ATE102930T1 (es)
CA (1) CA1269982A (es)
DE (1) DE3587777T2 (es)
ES (9) ES8707947A1 (es)
PH (1) PH22520A (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61186368A (ja) * 1985-02-14 1986-08-20 Kyorin Pharmaceut Co Ltd 新規な抗アレルギ−薬およびその製造方法
US5180730A (en) * 1985-07-22 1993-01-19 Yamanouchi Pharmaceutical Co., Ltd. Heterocyclic compounds
US4803211A (en) * 1985-07-22 1989-02-07 Yamanouchi Pharmaceutical Co., Ltd. Thiadizazole compounds as antagonists of SRS-A
US4942245A (en) * 1987-04-20 1990-07-17 Kyorin Pharmaceutical Co., Ltd. Benzimidazole Derivatives
JPH0667836B2 (ja) * 1989-03-01 1994-08-31 東洋紡績株式会社 アミド系化合物からなる抗アレルギー剤
US5102897A (en) * 1990-03-27 1992-04-07 Warner-Lambert Company 3,5-ditertiarybutyl-4-hydroxyphenyl, 1,3,4-thiadiazoles and oxadiazoles linked by carbon, oxygen, and sulfur residues
DE4035599A1 (de) * 1990-11-06 1992-05-07 Dresden Arzneimittel Neue 5-(phenoxyalkanoylamino)-uracile, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO1998046786A1 (en) * 1997-04-11 1998-10-22 Eli Lilly And Company Combinatorial libraries of peptidomimetic aminothioether acids
NZ512565A (en) * 1999-01-22 2003-12-19 Elan Pharm Inc Fused ring heteroaryl and heterocyclic compounds which inhibit leukocyte adhesion mediated by VLA-4
JP2002535314A (ja) * 1999-01-22 2002-10-22 エラン ファーマシューティカルズ,インコーポレイテッド Vla−4により媒介される白血球接着を阻害する化合物
ATE299490T1 (de) 1999-01-22 2005-07-15 Elan Pharm Inc Multizyklische verbindungen zur hemmung der durch vla-4 vermittelten leukozytenadhäsion
US6436904B1 (en) * 1999-01-25 2002-08-20 Elan Pharmaceuticals, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
AU3246600A (en) 1999-03-01 2000-09-21 Elan Pharmaceuticals, Inc. Alpha-aminoacetic acid derivatives useful as alpha 4 beta 7 receptor antagonists
US6552073B1 (en) * 2002-03-01 2003-04-22 Exonhit Therapeutics Sa Compounds and methods of treating cell proliferative diseases
TWI281470B (en) * 2002-05-24 2007-05-21 Elan Pharm Inc Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins
TW200307671A (en) * 2002-05-24 2003-12-16 Elan Pharm Inc Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins
CA2489355A1 (en) * 2002-06-13 2003-12-24 Qlt Inc. Methods of using isothiazole derivatives to treat cancer or inflammation
AU2006297220B8 (en) * 2005-09-29 2013-01-31 Elan Pharmaceuticals, Inc. Pyrimidinyl amide compounds which inhibit leukocyte adhesion mediated by VLA-4
CN101273035A (zh) 2005-09-29 2008-09-24 伊兰制药公司 抑制由vla-4介导的白细胞粘附的氨基甲酸酯化合物
KR20080100271A (ko) * 2006-02-27 2008-11-14 엘란 파마슈티칼스, 인크. Vla-4에 의해 매개되는 백혈구 부착을 억제하는 피리미디닐 술폰아미드 화합물
WO2010126914A1 (en) * 2009-04-27 2010-11-04 Elan Pharmaceuticals, Inc. Pyridinone antagonists of alpha-4 integrins
CA2782797C (en) 2009-10-02 2018-08-07 Avexxin As Anti inflammatory 2-oxothiazoles and 2 -oxooxazoles
JP6371312B2 (ja) 2013-01-29 2018-08-08 アヴェクシン エーエス 坑炎症および抗腫瘍2−オキソチアゾール化合物ならびに2−オキソチオフェン化合物
GB201413695D0 (en) 2014-08-01 2014-09-17 Avexxin As Compound
GB201604318D0 (en) 2016-03-14 2016-04-27 Avexxin As Combination therapy

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1546937A (en) * 1976-07-29 1979-05-31 Beecham Group Ltd 2,4-diaminopyrimidine derivatives
JPS591268B2 (ja) * 1978-10-18 1984-01-11 興和株式会社 チアジアゾ−ル誘導体
US4411905A (en) * 1979-09-04 1983-10-25 Richardson-Merrell Inc. Antisecretory 1,2,4-triazole-3-thiols
AU554388B2 (en) * 1981-06-15 1986-08-21 American Home Products Corporation Alpha-phenyl-2-(aza)benzothiazolylthioglycolic acid derivatives
DE3270324D1 (en) * 1982-01-22 1986-05-07 Basf Ag Aminothiadiazoles, process for their preparation and their use in combating unwanted plant growth
US4517188A (en) * 1983-05-09 1985-05-14 Mead Johnson & Company 1-Pyrimidinyloxy-3-hetaryl-alkylamino-2-propanols
US4672066A (en) * 1985-04-22 1987-06-09 Hoffmann-La Roche Inc. Derivatives of 4-acetyl-3-hydroxy-2-alkyl-phenoxycarboxylic acids
US4803211A (en) * 1985-07-22 1989-02-07 Yamanouchi Pharmaceutical Co., Ltd. Thiadizazole compounds as antagonists of SRS-A

Also Published As

Publication number Publication date
ES556749A0 (es) 1987-12-16
ATE102930T1 (de) 1994-04-15
CA1269982A (en) 1990-06-05
US4855310A (en) 1989-08-08
KR860004041A (ko) 1986-06-16
ES556752A0 (es) 1987-12-16
DE3587777T2 (de) 1994-06-23
ES8801189A1 (es) 1987-12-16
ES8707947A1 (es) 1987-09-01
ES556746A0 (es) 1987-12-16
DE3587777D1 (de) 1994-04-21
ES8801187A1 (es) 1987-12-16
PH22520A (en) 1988-10-17
ES8801235A1 (es) 1987-12-16
ES8801232A1 (es) 1987-12-16
ES8801231A1 (es) 1987-12-16
ES556750A0 (es) 1987-12-16
ES8801233A1 (es) 1987-12-16
ES556753A0 (es) 1987-12-16
EP0181779A1 (en) 1986-05-21
ES556748A0 (es) 1987-12-16
ES8801234A1 (es) 1987-12-16
EP0181779B1 (en) 1994-03-16
ES556747A0 (es) 1987-12-16
ES556751A0 (es) 1987-12-16
KR900004804B1 (ko) 1990-07-06
ES8801188A1 (es) 1987-12-16
US4908368A (en) 1990-03-13

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980202