ES544439A0 - Procedimiento para la preparacion de acidos a,w -dicarboxi- licos - Google Patents
Procedimiento para la preparacion de acidos a,w -dicarboxi- licosInfo
- Publication number
- ES544439A0 ES544439A0 ES544439A ES544439A ES544439A0 ES 544439 A0 ES544439 A0 ES 544439A0 ES 544439 A ES544439 A ES 544439A ES 544439 A ES544439 A ES 544439A ES 544439 A0 ES544439 A0 ES 544439A0
- Authority
- ES
- Spain
- Prior art keywords
- licos
- dicarboxy
- acids
- procedure
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/42—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/26—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms containing rings other than aromatic rings
- C07C55/28—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms containing rings other than aromatic rings monocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/32—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/34—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings containing more than one carboxyl group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/305—Saturated compounds containing more than one carboxyl group containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843423166 DE3423166A1 (de) | 1984-06-22 | 1984-06-22 | Alpha-, omega-dicarbonsaeuren, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES544439A0 true ES544439A0 (es) | 1986-02-01 |
| ES8604090A1 ES8604090A1 (es) | 1986-02-01 |
Family
ID=6238954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES544439A Expired ES8604090A1 (es) | 1984-06-22 | 1985-06-21 | Procedimiento para la preparacion de acidos a,w -dicarboxi- licos |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4711896A (es) |
| EP (1) | EP0185080B1 (es) |
| JP (1) | JPH0780807B2 (es) |
| AU (1) | AU4607185A (es) |
| CA (1) | CA1262552A (es) |
| DD (1) | DD240541A5 (es) |
| DE (2) | DE3423166A1 (es) |
| DK (1) | DK75986D0 (es) |
| ES (1) | ES8604090A1 (es) |
| FI (1) | FI860711A (es) |
| GR (1) | GR851509B (es) |
| HU (1) | HUT38892A (es) |
| IL (1) | IL75549A (es) |
| NO (1) | NO860661L (es) |
| PT (1) | PT80681B (es) |
| WO (1) | WO1986000298A1 (es) |
| ZA (1) | ZA854684B (es) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4876279A (en) * | 1986-05-05 | 1989-10-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| IL101708A (en) * | 1992-04-28 | 1996-08-04 | Senyorina Ltd | Anti-fattening drugs comprising amino acid derivatives |
| US5602164A (en) * | 1992-04-28 | 1997-02-11 | Senyorina Ltd. | Anti-obesity drugs |
| TW322493B (es) * | 1994-06-27 | 1997-12-11 | Shell Int Research | |
| US5648387A (en) * | 1995-03-24 | 1997-07-15 | Warner-Lambert Company | Carboxyalkylethers, formulations, and treatment of vascular diseases |
| IL119971A (en) | 1997-01-07 | 2003-02-12 | Yissum Res Dev Co | Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids |
| US20020037876A1 (en) * | 1998-06-25 | 2002-03-28 | Yissum Research Development Company Of Hebrew University Of Jerusalem | Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them |
| IL121165A0 (en) | 1997-06-26 | 1997-11-20 | Yissum Res Dev Co | Pharmaceutical compositions containing carboxylic acids and derivatives thereof |
| EP1204626B1 (en) | 1999-04-01 | 2008-01-16 | Esperion Therapeutics Inc. | Ether compounds, compositions, and uses thereof |
| US7304093B2 (en) * | 2000-10-11 | 2007-12-04 | Esperion Therapeutics, Inc. | Ketone compounds and compositions for cholesterol management and related uses |
| CA2425311C (en) | 2000-10-11 | 2011-06-14 | Esperion Therapeutics, Inc. | Ketone compounds and compositions for cholesterol management and related uses |
| JP2004532799A (ja) | 2000-10-11 | 2004-10-28 | エスペリオン セラピューティクス，インコーポレイテッド | コレステロール管理および関連用途のためのスルフィド化合物およびジスルフィド化合物ならびにそれらを含む組成物 |
| CA2425678A1 (en) | 2000-10-11 | 2002-04-18 | Jean-Louis H. Dasseux | Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses |
| AU2002213137A1 (en) | 2000-10-11 | 2002-04-22 | Esperion Therapeutics, Inc. | Ether compounds and compositions for cholesterol management and related uses |
| US20040122091A1 (en) * | 2000-10-11 | 2004-06-24 | Esperion Therapeutics, Inc. | Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses |
| US20050020694A1 (en) * | 2001-10-11 | 2005-01-27 | Dasseux Jean-Louis Henri | Sulfide and disulfide compounds and compositions for cholesterol management and related uses |
| US20040192771A1 (en) * | 2001-10-11 | 2004-09-30 | Dasseux Jean-Louis Henri | Ether compounds and compositions for cholesterol management and related uses |
| US20040204502A1 (en) * | 2001-10-11 | 2004-10-14 | Dasseux Jean-Louis Henri | Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses |
| MXPA04009831A (es) * | 2002-04-10 | 2004-12-07 | Esperion Therapeutics Inc | Imitaciones de la coenzima-a de acilo, composiciones de las mismas y metodos de manejo del colesterol y usos relacionados. |
| US20050101565A1 (en) * | 2002-07-03 | 2005-05-12 | Esperion Therapeutics, Inc. | Pharmaceutical compositions and methods for treating, preventing, and managing cholesterol, dyslipidemia, and related disorders |
| US20040048910A1 (en) * | 2002-08-22 | 2004-03-11 | Bove Susan Elizabeth | Method of treating osteoarthritis |
| MX349134B (es) | 2003-01-23 | 2017-07-12 | Esperion Therapeutics Inc | Compuestos de hidroxilo y composiciones para el manejo del colesterol y usos relacionados. |
| WO2005002557A1 (en) * | 2003-07-03 | 2005-01-13 | Warner-Lambert Company Llc | Pharmaceutical compositions including an ether and selective cox-2 inhibitor and uses thereof |
| WO2005046662A2 (en) * | 2003-11-07 | 2005-05-26 | Jj Pharma, Inc. | Hdl-boosting combination therapy complexes |
| US20050192347A1 (en) * | 2003-12-23 | 2005-09-01 | Dasseux Jean-Louis H. | Urea and thiourea compounds and compositions for cholesterol management and related uses |
| WO2005068412A1 (en) | 2003-12-24 | 2005-07-28 | Esperion Therapeutics, Inc. | Ketone compounds and compositions for cholesterol management and related uses |
| EP1699448A4 (en) * | 2003-12-30 | 2010-11-03 | Syndromex Ltd | PROCESS FOR DELIVERY OF 3,3,14,14 TETRAMETHYL HEXADECANE 1,16 DIOIC ACID |
| MXJL06000070A (es) * | 2004-06-09 | 2007-04-10 | Avanir Pharmaceuticals | Pequenas moleculas para el tratamiento de hipercolesterolemia y enfermedades relacionadas. |
| JP2008509228A (ja) * | 2004-06-09 | 2008-03-27 | アバニール・ファーマシューティカルズ | 高コレステロール血症の治療のための逆コレステロール輸送のメディエイタ |
| PE20050986A1 (es) * | 2004-06-09 | 2006-02-03 | Avanir Pharmaceuticals | Derivados heterociclicos mediadores del transporte inverso de colesterol |
| EP1838296B1 (en) * | 2004-10-20 | 2012-08-08 | Resverlogix Corp. | Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases |
| EP2314295B1 (en) * | 2005-07-29 | 2015-01-28 | Resverlogix, Inc | Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices |
| US8053440B2 (en) * | 2007-02-01 | 2011-11-08 | Resverlogix Corporation | Compounds for the prevention and treatment of cardiovascular diseases |
| IL181577A0 (en) * | 2007-02-26 | 2007-07-04 | Jacob Bar Tana | Combination therapy composition and methods for the treatment of cardiovascular disorders and immune-related disorders |
| EP2431043A1 (en) | 2007-05-23 | 2012-03-21 | Amcol International Corporation | Cholesterol-interacting layered phyllosilicates for suppressing gastrointestinal cholesterol absorption |
| PT2346837E (pt) | 2008-06-26 | 2015-04-02 | Resverlogix Corp | Métodos de preparação de derivados de quinazolinona |
| ES2542835T3 (es) | 2009-01-08 | 2015-08-12 | Resverlogix Corporation | Compuestos para la prevención y el tratamiento de enfermedades cardiovasculares |
| BRPI1009315B8 (pt) | 2009-03-18 | 2021-05-25 | Resverlogix Corp | composto anti-flamatórios e suas composições farmacêuticas |
| TR201818390T4 (tr) | 2009-04-22 | 2019-01-21 | Resverlogix Corp | Yeni̇ anti̇-i̇nflamatuvar ajanlar |
| ES2670576T3 (es) | 2009-09-03 | 2018-05-31 | Pfizer Vaccines Llc | Vacuna de PCSK9 |
| CA2812109A1 (en) | 2010-09-20 | 2012-03-29 | Kareus Therapeutics, Sa | Methods and compositions for treatment of diabetes and dyslipidemia |
| WO2012131504A1 (en) | 2011-03-02 | 2012-10-04 | Pfizer Inc. | Pcsk9 vaccine |
| PL2773354T3 (pl) | 2011-11-01 | 2019-12-31 | Resverlogix Corp. | Doustna formulacja o natychmiastowym uwalnianiu dla podstawowych chinazolinów |
| WO2013084237A1 (en) | 2011-12-08 | 2013-06-13 | Syndromex Ltd. | Deuterated tetramethyl dioic acids, compositions comprising them and uses thereof |
| WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
| US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
| CA2895905A1 (en) | 2012-12-21 | 2014-06-26 | Zenith Epigenetics Corp. | Novel heterocyclic compounds as bromodomain inhibitors |
| WO2015123291A1 (en) | 2014-02-11 | 2015-08-20 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Pcsk9 vaccine and methods of using the same |
| US10111885B2 (en) | 2015-03-13 | 2018-10-30 | Resverlogix Corp. | Compositions and therapeutic methods for the treatment of complement-associated diseases |
| EP3267989A4 (en) | 2015-03-13 | 2018-11-07 | Esperion Therapeutics, Inc. | Fixed dose combinations and formulations comprising etc1002 and ezetimibe and methods of treating or reducing the risk of cardiovascular disease |
| MA41793A (fr) | 2015-03-16 | 2018-01-23 | Esperion Therapeutics Inc | Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire |
| CN107118098B (zh) * | 2016-02-25 | 2020-07-14 | 中国科学院上海药物研究所 | 一类脂肪酸类化合物、其制备方法及其用途 |
| US10512624B2 (en) | 2016-11-30 | 2019-12-24 | Syndromex Ltd. | Long-chain amphipathic dicarboxylic acids for treatment of diabetes type-1 |
| BR112021025964A2 (pt) | 2019-06-21 | 2022-05-24 | Esperion Therapeutics Inc | Formas de sal de ácido bempedoico e métodos para uso das mesmas |
| WO2021021563A1 (en) | 2019-07-26 | 2021-02-04 | Espervita Therapeutics, Inc. | Functionalized long-chain hydrocarbon mono- and di-carboxylic acids useful for the prevention or treatment of disease |
| WO2022159808A2 (en) * | 2021-01-25 | 2022-07-28 | Espervita Therapeutics, Inc. | Functionalized long-chain hydrocarbon mono- and di-carboxylic acids and derivatives thereof, and their use for the prevention or treatment of disease |
| US11730712B2 (en) | 2021-01-25 | 2023-08-22 | Espervita Therapeutics, Inc. | Functionalized long-chain hydrocarbon mono- and di-carboxylic acids and derivatives thereof, and their use for the prevention or treatment of disease |
| CN115887435A (zh) * | 2021-09-23 | 2023-04-04 | 博骥源（上海）生物医药有限公司 | 长链类化合物及其用途 |
| CN115894220A (zh) * | 2021-09-23 | 2023-04-04 | 中国科学院上海药物研究所 | 一类作用于acly的长链类化合物、其制备方法及其用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1210786B (de) * | 1962-12-17 | 1966-02-17 | Shell Int Research | Verfahren zur Herstellung von p-Phenylen-bis (3, 3'-isovaleriansaeure) und 3-Phenylisovalerian-saeure |
| GB1556660A (en) * | 1975-10-07 | 1979-11-28 | Akzo Nv | Di-carboxylic acid derivatives |
| IL64542A0 (en) * | 1981-12-15 | 1982-03-31 | Yissum Res Dev Co | Long-chain alpha,omega-dicarboxylic acids and derivatives thereof and pharmaceutical compositions containing them |
-
1984
- 1984-06-22 DE DE19843423166 patent/DE3423166A1/de not_active Withdrawn
-
1985
- 1985-06-15 WO PCT/EP1985/000288 patent/WO1986000298A1/de active IP Right Grant
- 1985-06-15 US US06/840,563 patent/US4711896A/en not_active Expired - Lifetime
- 1985-06-15 JP JP60503069A patent/JPH0780807B2/ja not_active Expired - Fee Related
- 1985-06-15 AU AU46071/85A patent/AU4607185A/en not_active Abandoned
- 1985-06-15 HU HU853002A patent/HUT38892A/hu unknown
- 1985-06-15 DE DE8585903247T patent/DE3574130D1/de not_active Expired
- 1985-06-15 EP EP85903247A patent/EP0185080B1/de not_active Expired
- 1985-06-18 IL IL75549A patent/IL75549A/xx not_active IP Right Cessation
- 1985-06-19 DD DD85277529A patent/DD240541A5/de unknown
- 1985-06-20 GR GR851509A patent/GR851509B/el unknown
- 1985-06-21 ZA ZA854684A patent/ZA854684B/xx unknown
- 1985-06-21 CA CA000484907A patent/CA1262552A/en not_active Expired
- 1985-06-21 PT PT80681A patent/PT80681B/pt not_active IP Right Cessation
- 1985-06-21 ES ES544439A patent/ES8604090A1/es not_active Expired
-
1986
- 1986-02-17 FI FI860711A patent/FI860711A/fi not_active Application Discontinuation
- 1986-02-18 DK DK75986A patent/DK75986D0/da not_active Application Discontinuation
- 1986-02-21 NO NO860661A patent/NO860661L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT80681A (de) | 1985-07-01 |
| CA1262552A (en) | 1989-10-31 |
| FI860711A0 (fi) | 1986-02-17 |
| DK75986A (da) | 1986-02-18 |
| PT80681B (de) | 1987-05-08 |
| EP0185080B1 (de) | 1989-11-08 |
| ZA854684B (en) | 1986-02-26 |
| WO1986000298A1 (en) | 1986-01-16 |
| EP0185080A1 (es) | 1986-06-25 |
| JPH0780807B2 (ja) | 1995-08-30 |
| DK75986D0 (da) | 1986-02-18 |
| DE3574130D1 (en) | 1989-12-14 |
| AU4607185A (en) | 1986-01-24 |
| HUT38892A (en) | 1986-07-28 |
| JPS61502537A (ja) | 1986-11-06 |
| NO860661L (no) | 1986-02-21 |
| IL75549A (en) | 1989-03-31 |
| DE3423166A1 (de) | 1986-01-02 |
| DD240541A5 (de) | 1986-11-05 |
| GR851509B (es) | 1985-06-25 |
| IL75549A0 (en) | 1985-10-31 |
| FI860711A (fi) | 1986-02-17 |
| US4711896A (en) | 1987-12-08 |
| ES8604090A1 (es) | 1986-02-01 |
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