ES529276A0 - Procedimiento para producir la totalidad o parte de las subunidades a y b de la toxina del colera - Google Patents
Procedimiento para producir la totalidad o parte de las subunidades a y b de la toxina del coleraInfo
- Publication number
- ES529276A0 ES529276A0 ES529276A ES529276A ES529276A0 ES 529276 A0 ES529276 A0 ES 529276A0 ES 529276 A ES529276 A ES 529276A ES 529276 A ES529276 A ES 529276A ES 529276 A0 ES529276 A0 ES 529276A0
- Authority
- ES
- Spain
- Prior art keywords
- colera
- subunits
- toxin
- procedure
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003053 toxin Substances 0.000 title 1
- 231100000765 toxin Toxicity 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/848—Escherichia
- Y10S435/849—Escherichia coli
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/909—Vibrio
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/381,083 US4666837A (en) | 1982-05-24 | 1982-05-24 | DNA sequences, recombinant DNA molecules and processes for producing the A and B subunits of cholera toxin and preparations containing so-obtained subunit or subunits |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8504460A1 ES8504460A1 (es) | 1985-05-01 |
ES529276A0 true ES529276A0 (es) | 1985-05-01 |
Family
ID=23503587
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES522566A Expired ES8504458A1 (es) | 1982-05-24 | 1983-05-20 | Procedimiento para producir la subunidad a la toxina del colera. |
ES529276A Granted ES529276A0 (es) | 1982-05-24 | 1984-01-30 | Procedimiento para producir la totalidad o parte de las subunidades a y b de la toxina del colera |
ES535809A Expired ES8506348A1 (es) | 1982-05-24 | 1984-09-11 | Procedimiento para producir la subunidad b de la toxina del colera |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES522566A Expired ES8504458A1 (es) | 1982-05-24 | 1983-05-20 | Procedimiento para producir la subunidad a la toxina del colera. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES535809A Expired ES8506348A1 (es) | 1982-05-24 | 1984-09-11 | Procedimiento para producir la subunidad b de la toxina del colera |
Country Status (10)
Country | Link |
---|---|
US (1) | US4666837A (es) |
EP (1) | EP0095452A3 (es) |
JP (1) | JPS58222033A (es) |
AU (1) | AU1348083A (es) |
CA (1) | CA1212640A (es) |
DK (1) | DK211483A (es) |
ES (3) | ES8504458A1 (es) |
GR (1) | GR79261B (es) |
PT (1) | PT76726B (es) |
ZA (1) | ZA833662B (es) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5399494A (en) * | 1983-03-04 | 1995-03-21 | The University Of Maryland System | Vibrio cholerae strain CVD103Hgr, method of making same, and vaccines derived therefrom |
US4935364A (en) * | 1983-03-04 | 1990-06-19 | Swiss Serum And Vaccine Institute Berne | Method of isolating restriction fragment deletions in vibrio cholerae and products thereof |
US5470729A (en) * | 1983-03-04 | 1995-11-28 | University Of Maryland At Baltimore | Method of isolating restriction fragment deletions in Vibrio cholerae, and products thereof |
US5882653A (en) * | 1983-03-04 | 1999-03-16 | The University Of Maryland System | Vibrio cholerae 01 (CVD111) and non-01 (CVD112 and CVD112RM) serogroup vaccine strains, methods of making same and products thereof |
US4882278A (en) * | 1983-04-29 | 1989-11-21 | President And Fellows Of Harvard College | Non-toxinogenic vibrio cholerae mutants |
GB8333131D0 (en) * | 1983-12-12 | 1984-01-18 | Glaxo Group Ltd | Microbiological process |
AU589114B2 (en) * | 1984-02-01 | 1989-10-05 | Enterovax Limited | Genetically engineered bacteria useful as a vaccine |
US6022950A (en) * | 1984-06-07 | 2000-02-08 | Seragen, Inc. | Hybrid molecules having translocation region and cell-binding region |
US5668255A (en) * | 1984-06-07 | 1997-09-16 | Seragen, Inc. | Hybrid molecules having translocation region and cell-binding region |
US4808700A (en) * | 1984-07-09 | 1989-02-28 | Praxis Biologics, Inc. | Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers |
CA1340372C (en) * | 1984-07-09 | 1999-02-02 | John D. Clements | Production of e. coli lt-b enterotoxin subunit |
US5308835A (en) * | 1984-07-09 | 1994-05-03 | Praxis Biologics, Inc. | Production of the E. coli LT-B enterotoxin subunit |
ATE243754T1 (de) * | 1987-05-21 | 2003-07-15 | Micromet Ag | Multifunktionelle proteine mit vorbestimmter zielsetzung |
US5258498A (en) * | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
US5091513A (en) * | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
US5132405A (en) * | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
US6043057A (en) * | 1988-09-16 | 2000-03-28 | Vitec Aktiebolag | Recombinant systems for expression of the cholera B-sub-unit with the aid of foreign promoters and/or leader peptides |
SE462285B (sv) * | 1988-09-16 | 1990-05-28 | Jan Roland Holmgren | Expression av koleratoxinets bindande subenhet med hjaelp av fraemmande promotor- och/eller ledarpeptidstrukturer |
FR2636842B1 (fr) * | 1988-09-27 | 1994-06-10 | Liege Universite Etat | Proteine de fusion d'une sequence derivee de la sous-unite b de la toxine cholerique et d'un antigene heterologue doue de proprietes immunogenes, compositions de vaccins les contenant et acides nucleiques recombinants contenant une sequence de nucleotides codant pour ladite proteine de fusion |
US20040014068A1 (en) * | 1988-10-05 | 2004-01-22 | Whatman, Inc. | Solid medium and method for DNA storage |
US5985327A (en) * | 1988-10-05 | 1999-11-16 | Flinders Technologies Pty. Ltd. | Solid medium and method for DNA storage |
CA2071969A1 (en) * | 1989-12-22 | 1991-06-23 | John R. Murphy | Hybrid molecules having translocation region and cell-binding region |
IL101715A (en) * | 1991-05-02 | 2005-06-19 | Amgen Inc | Recombinant dna-derived cholera toxin subunit analogs |
IT1253009B (it) * | 1991-12-31 | 1995-07-10 | Sclavo Ricerca S R L | Mutanti immunogenici detossificati della tossina colerica e della tossina lt, loro preparazione ed uso per la preparazione di vaccini |
GB9513371D0 (en) * | 1995-06-30 | 1995-09-06 | Biocine Spa | Immunogenic detoxified mutant toxins |
USH1985H1 (en) | 1992-01-09 | 2001-08-07 | The United States Of America As Represented By The Secretary Of The Navy | Method for detecting biological toxins |
JP3134907B2 (ja) * | 1993-06-15 | 2001-02-13 | 株式会社島津製作所 | コレラ菌検出用オリゴヌクレオチドおよびそれを用いた検出法 |
GB9326174D0 (en) * | 1993-12-22 | 1994-02-23 | Biocine Sclavo | Mucosal adjuvant |
PT814843E (pt) * | 1995-03-31 | 2004-04-30 | Xenova Res Ltd | Conjugados de hapteno-transportador para utilizacao na terapia de abuso de drogas |
US5840307A (en) * | 1995-03-31 | 1998-11-24 | Immulogic Pharmacuetical Corp. | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation |
US20020032316A1 (en) * | 1995-03-31 | 2002-03-14 | Cantab Pharmaceuticals Research Limited | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same |
US6818222B1 (en) | 1997-03-21 | 2004-11-16 | Chiron Corporation | Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants |
US7097845B2 (en) | 1997-04-23 | 2006-08-29 | Jacob Sten Petersen | Combinations of antigen and mucosal binding component for inducing specific immunological tolerance |
US6232082B1 (en) | 1998-12-01 | 2001-05-15 | Nabi | Hapten-carrier conjugates for treating and preventing nicotine addiction |
US20030162733A1 (en) * | 2000-11-27 | 2003-08-28 | Haynes Joel R. | Nucleic acid adjuvants |
JP2004529906A (ja) | 2001-03-19 | 2004-09-30 | イオマイ コーポレイシヨン | 経皮的免疫賦活 |
US20060099229A1 (en) * | 2004-11-05 | 2006-05-11 | Universiti Sains Malaysia | Vibrio cholerae strains VCUSM1 and VCUSM4, method of producing same, and vaccine derivatives thereof |
WO2014044690A1 (en) | 2012-09-18 | 2014-03-27 | Valneva Austria Gmbh | Improved vaccines |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4366246A (en) * | 1977-11-08 | 1982-12-28 | Genentech, Inc. | Method for microbial polypeptide expression |
US4264737A (en) * | 1978-09-21 | 1981-04-28 | President And Fellows Of Harvard College | Method of making genetically stable mutants of vibrio cholerae |
US4332892A (en) * | 1979-01-15 | 1982-06-01 | President And Fellows Of Harvard College | Protein synthesis |
US4328209A (en) * | 1979-04-11 | 1982-05-04 | Board Of Regents, The University Of Texas System | Cholera vaccine |
US4293652A (en) * | 1979-05-25 | 1981-10-06 | Cetus Corporation | Method for synthesizing DNA sequentially |
US4338397A (en) * | 1980-04-11 | 1982-07-06 | President And Fellows Of Harvard College | Mature protein synthesis |
-
1982
- 1982-05-24 US US06/381,083 patent/US4666837A/en not_active Expired - Lifetime
-
1983
- 1983-04-13 AU AU13480/83A patent/AU1348083A/en not_active Abandoned
- 1983-05-11 DK DK211483A patent/DK211483A/da not_active Application Discontinuation
- 1983-05-18 EP EP83870048A patent/EP0095452A3/en not_active Withdrawn
- 1983-05-19 PT PT76726A patent/PT76726B/pt unknown
- 1983-05-20 ES ES522566A patent/ES8504458A1/es not_active Expired
- 1983-05-20 ZA ZA833662A patent/ZA833662B/xx unknown
- 1983-05-20 CA CA000428654A patent/CA1212640A/en not_active Expired
- 1983-05-23 JP JP58091416A patent/JPS58222033A/ja active Pending
- 1983-05-23 GR GR71430A patent/GR79261B/el unknown
-
1984
- 1984-01-30 ES ES529276A patent/ES529276A0/es active Granted
- 1984-09-11 ES ES535809A patent/ES8506348A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS58222033A (ja) | 1983-12-23 |
EP0095452A3 (en) | 1985-10-02 |
AU1348083A (en) | 1983-12-01 |
GR79261B (es) | 1984-10-22 |
PT76726B (en) | 1985-12-27 |
ES8504460A1 (es) | 1985-05-01 |
ES522566A0 (es) | 1985-04-16 |
ES535809A0 (es) | 1985-07-01 |
ES8504458A1 (es) | 1985-04-16 |
CA1212640A (en) | 1986-10-14 |
PT76726A (en) | 1983-06-01 |
ZA833662B (en) | 1984-03-28 |
ES8506348A1 (es) | 1985-07-01 |
DK211483D0 (da) | 1983-05-11 |
US4666837A (en) | 1987-05-19 |
DK211483A (da) | 1983-11-25 |
EP0095452A2 (fr) | 1983-11-30 |
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