ES528761A0 - Procedimiento para preparar nuevos derivados de aminoacidos espirociclicos - Google Patents
Procedimiento para preparar nuevos derivados de aminoacidos espirociclicosInfo
- Publication number
- ES528761A0 ES528761A0 ES528761A ES528761A ES528761A0 ES 528761 A0 ES528761 A0 ES 528761A0 ES 528761 A ES528761 A ES 528761A ES 528761 A ES528761 A ES 528761A ES 528761 A0 ES528761 A0 ES 528761A0
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- denotes
- aryl
- denotes hydrogen
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19833300774 DE3300774A1 (de) | 1983-01-12 | 1983-01-12 | Neue spirocyclische aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue spirocyclische aminosaeuren als zwischenprodukte und verfahren zu deren herstellung |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8406880A1 ES8406880A1 (es) | 1984-09-01 |
ES528761A0 true ES528761A0 (es) | 1984-09-01 |
Family
ID=6188100
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES528761A Granted ES528761A0 (es) | 1983-01-12 | 1984-01-10 | Procedimiento para preparar nuevos derivados de aminoacidos espirociclicos |
ES530290A Expired ES8500905A1 (es) | 1983-01-12 | 1984-03-05 | Procedimiento para preparar derivados de aminoacidos espirociclicos. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES530290A Expired ES8500905A1 (es) | 1983-01-12 | 1984-03-05 | Procedimiento para preparar derivados de aminoacidos espirociclicos. |
Country Status (13)
Country | Link |
---|---|
US (1) | US4620012A (es) |
EP (1) | EP0116276B1 (es) |
JP (1) | JPH0759590B2 (es) |
KR (1) | KR910003185B1 (es) |
AT (1) | ATE39931T1 (es) |
AU (1) | AU575308B2 (es) |
DE (2) | DE3300774A1 (es) |
DK (1) | DK166586C (es) |
ES (2) | ES528761A0 (es) |
GR (1) | GR79158B (es) |
IE (1) | IE56544B1 (es) |
PT (1) | PT77943B (es) |
ZA (1) | ZA84213B (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3226768A1 (de) * | 1981-11-05 | 1983-05-26 | Hoechst Ag, 6230 Frankfurt | Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung |
GR78413B (es) * | 1981-12-29 | 1984-09-27 | Hoechst Ag | |
US5175306A (en) * | 1983-01-31 | 1992-12-29 | Hoechst Aktiengesellschaft | Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters |
DE3333455A1 (de) * | 1983-09-16 | 1985-04-11 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung n-alkylierter dipeptide und deren estern |
DE3413710A1 (de) * | 1984-04-12 | 1985-10-24 | Hoechst Ag, 6230 Frankfurt | Verfahren zur behandlung der herzinsuffizienz |
US5684016A (en) * | 1984-04-12 | 1997-11-04 | Hoechst Aktiengesellschaft | Method of treating cardiac insufficiency |
DE3431541A1 (de) * | 1984-08-28 | 1986-03-06 | Hoechst Ag, 6230 Frankfurt | Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung |
WO1986007064A1 (en) * | 1985-05-22 | 1986-12-04 | Takeda Chemical Industries, Ltd. | Piperidine derivatives |
US5231080A (en) * | 1985-10-15 | 1993-07-27 | Hoechst Aktiengesellschaft | Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease |
DE3610391A1 (de) * | 1986-03-27 | 1987-10-08 | Hoechst Ag | Verbindungen mit nootroper wirkung, diese enthaltende mittel und deren verwendung bei der behandlung und prophylaxe cognitiver dysfunktionen |
US5231084A (en) * | 1986-03-27 | 1993-07-27 | Hoechst Aktiengesellschaft | Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons |
CS277405B6 (en) * | 1986-06-12 | 1993-03-17 | Vyzk Ustav Farm Biochem Sp | Peptides with 1-amino-1-cycloalkane carboxylic acid |
DE3633496A1 (de) * | 1986-10-02 | 1988-04-14 | Hoechst Ag | Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln |
DE3639879A1 (de) * | 1986-11-21 | 1988-06-01 | Hoechst Ag | Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren, zwischenprodukte dieses verfahrens sowie ein verfahren zu deren herstellung |
DE3722007A1 (de) * | 1987-07-03 | 1989-01-12 | Hoechst Ag | Verfahren zur herstellung bicyclischer aminocarbonsaeuren, zwischenprodukte dieses verfahrens und deren verwendung |
HU904967D0 (en) * | 1988-04-22 | 1991-01-28 | Hoechst Ag | Process for producing new azabicyclo(3.3.o)octane-3-carboxylic acid-octylesther derivatives |
ES2227896T3 (es) * | 1997-12-16 | 2005-04-01 | Warner-Lambert Company Llc | Derivados de 1-aminometil-cicloalcanos sustituidos en 1 (=analogos de gabapentina), su preparacion y su uso en el tratamiento de trastornos neurologicos. |
EP1615886A1 (en) * | 2003-04-15 | 2006-01-18 | Warner-Lambert Company LLC | [c]-fused bicyclic proline derivatives and their use for treating arthritic conditions |
WO2004092132A1 (en) * | 2003-04-15 | 2004-10-28 | Warner-Lambert Company Llc | [b]-fused bicyclic proline derivatives and their use for treating arthritic conditions |
CN113372324A (zh) * | 2021-06-18 | 2021-09-10 | 山东大学苏州研究院 | 一种通过碘化锂催化合成螺环类化合物的方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
LU88621I2 (fr) * | 1980-10-23 | 1995-09-01 | Schering Corp | Sandopril |
DE3211397A1 (de) * | 1982-03-27 | 1983-11-10 | Hoechst Ag, 6230 Frankfurt | Spiro (4.(3+n))-2-aza-3-carbonsaeure-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung |
-
1983
- 1983-01-12 DE DE19833300774 patent/DE3300774A1/de not_active Withdrawn
-
1984
- 1984-01-09 AT AT84100130T patent/ATE39931T1/de not_active IP Right Cessation
- 1984-01-09 EP EP84100130A patent/EP0116276B1/de not_active Expired
- 1984-01-09 DE DE8484100130T patent/DE3476067D1/de not_active Expired
- 1984-01-10 GR GR73477A patent/GR79158B/el unknown
- 1984-01-10 US US06/569,758 patent/US4620012A/en not_active Expired - Lifetime
- 1984-01-10 KR KR1019840000070A patent/KR910003185B1/ko not_active IP Right Cessation
- 1984-01-10 ES ES528761A patent/ES528761A0/es active Granted
- 1984-01-11 AU AU23229/84A patent/AU575308B2/en not_active Ceased
- 1984-01-11 DK DK011984A patent/DK166586C/da active
- 1984-01-11 JP JP59002113A patent/JPH0759590B2/ja not_active Expired - Lifetime
- 1984-01-11 PT PT77943A patent/PT77943B/pt not_active IP Right Cessation
- 1984-01-11 IE IE48/84A patent/IE56544B1/en not_active IP Right Cessation
- 1984-01-11 ZA ZA84213A patent/ZA84213B/xx unknown
- 1984-03-05 ES ES530290A patent/ES8500905A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
US4620012A (en) | 1986-10-28 |
KR840007585A (ko) | 1984-12-08 |
DK166586B (da) | 1993-06-14 |
DK166586C (da) | 1993-11-08 |
DE3300774A1 (de) | 1984-07-12 |
AU575308B2 (en) | 1988-07-28 |
PT77943B (de) | 1986-05-30 |
EP0116276B1 (de) | 1989-01-11 |
ES8406880A1 (es) | 1984-09-01 |
IE840048L (en) | 1984-07-12 |
DK11984D0 (da) | 1984-01-11 |
KR910003185B1 (ko) | 1991-05-22 |
DK11984A (da) | 1984-07-13 |
EP0116276A3 (en) | 1985-11-27 |
JPH0759590B2 (ja) | 1995-06-28 |
ES530290A0 (es) | 1984-11-01 |
GR79158B (es) | 1984-10-02 |
DE3476067D1 (en) | 1989-02-16 |
ES8500905A1 (es) | 1984-11-01 |
ATE39931T1 (de) | 1989-01-15 |
EP0116276A2 (de) | 1984-08-22 |
AU2322984A (en) | 1984-07-19 |
PT77943A (de) | 1984-02-01 |
IE56544B1 (en) | 1991-08-28 |
JPS59134765A (ja) | 1984-08-02 |
ZA84213B (en) | 1984-08-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20041102 |