ES512706A0 - Procedimiento para preparar derivados de indol o de indolina. - Google Patents

Procedimiento para preparar derivados de indol o de indolina.

Info

Publication number: ES512706A0
Authority: ES; Spain
Prior art keywords: carbon atoms; alkyl; hydrogen; indolina; indol
Prior art date: 1980-06-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

ES512706A

Other languages

English (en)

Other versions

ES8305327A1 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

May and Baker Ltd

Original Assignee

May and Baker Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-06-18

Filing date

1982-05-31

Publication date

1983-04-01

1982-05-31 Application filed by May and Baker Ltd filed Critical May and Baker Ltd

1983-04-01 Publication of ES8305327A1 publication Critical patent/ES8305327A1/es

1983-04-01 Publication of ES512706A0 publication Critical patent/ES512706A0/es

Status Granted legal-status Critical Current

Links

SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title abstract 3
125000004432 carbon atom Chemical group C* 0.000 abstract 8
125000000217 alkyl group Chemical group 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
201000001320 Atherosclerosis Diseases 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
125000003387 indolinyl group Chemical class N1(CCC2=CC=CC=C12)* 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5456—Arylalkanephosphonium compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Obesity (AREA)
Hematology (AREA)
Biochemistry (AREA)
Cardiology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Heart & Thoracic Surgery (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Plant Substances (AREA)

ES512706A 1980-06-18 1982-05-31 Procedimiento para preparar derivados de indol o de indolina. Granted ES512706A0 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB8019948		1980-06-18

Publications (2)

Publication Number	Publication Date
ES8305327A1 ES8305327A1 (es)	1983-04-01
ES512706A0 true ES512706A0 (es)	1983-04-01

Family

ID=10514138

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
ES503097A Expired ES8300091A1 (es)	1980-06-18	1981-06-16	Procedimiento para preparar derivados de indol o de indolina
ES512706A Granted ES512706A0 (es)	1980-06-18	1982-05-31	Procedimiento para preparar derivados de indol o de indolina.
ES512704A Expired ES8303332A1 (es)	1980-06-18	1982-05-31	Procedimiento para preparar derivados de indol o de indolina.
ES512705A Granted ES512705A0 (es)	1980-06-18	1982-05-31	Procedimiento para preparar derivados de indol o de indolina.

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
ES503097A Expired ES8300091A1 (es)	1980-06-18	1981-06-16	Procedimiento para preparar derivados de indol o de indolina

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
ES512704A Expired ES8303332A1 (es)	1980-06-18	1982-05-31	Procedimiento para preparar derivados de indol o de indolina.
ES512705A Granted ES512705A0 (es)	1980-06-18	1982-05-31	Procedimiento para preparar derivados de indol o de indolina.

Country Status (22)

Country	Link
US (1)	US4493843A (es)
EP (1)	EP0042298B1 (es)
JP (1)	JPS5728048A (es)
KR (1)	KR850001470B1 (es)
AT (1)	ATE9329T1 (es)
AU (1)	AU539678B2 (es)
CA (1)	CA1149811A (es)
DE (1)	DE3165998D1 (es)
DK (1)	DK264281A (es)
ES (4)	ES8300091A1 (es)
FI (1)	FI811889L (es)
GB (1)	GB2078736B (es)
GR (1)	GR75701B (es)
HK (2)	HK92684A (es)
HU (1)	HU183480B (es)
IE (1)	IE52102B1 (es)
IL (1)	IL63110A (es)
MY (2)	MY8500975A (es)
NZ (1)	NZ197441A (es)
PH (1)	PH16357A (es)
SG (2)	SG68984G (es)
ZA (1)	ZA814057B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MXPA01001995A (es)	1998-08-26	2004-07-30	Aventis Pharma Ltd	Aza-biciclos que modulan la inhibicion de adhesion celular.
WO2001044184A1 (en) *	1999-12-16	2001-06-21	Eli Lilly And Company	Synthesis of indole-containing spla2 inhibitors
WO2003099789A1 (en)	2002-05-22	2003-12-04	Errant Gene Therapeutics, Llc.	Histone deacetylase inhibitors based on alphachalcogenmethylcarbonyl compounds
DE602005012380D1 (de) *	2004-03-15	2009-03-05	Lilly Co Eli	4-(5-(aminomethyl)-indol-1-ylmethyl)benzamidderivate und verwandte verbindungen als opioidrezeptorantagonisten zur behandlung von fettleibigkeit
JP6217561B2 (ja) *	2014-08-21	2017-10-25	信越化学工業株式会社	新規オニウム塩化合物及びレジスト組成物並びにパターン形成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3076814A (en) *	1954-04-28	1963-02-05	Upjohn Co	Novel process for the preparation of tryptophols and to novel compounds produced therein
DE2237361A1 (de) *	1972-07-29	1974-02-14	Boehringer Mannheim Gmbh	(5-indolyloxy)-essigsaeure-derivate und verfahren zur herstellung derselben
US3992392A (en) *	1973-04-27	1976-11-16	The Ohio State University Research Foundation	Synthesis of indoles from anilines and intermediates therein
US3901899A (en) *	1973-04-27	1975-08-26	Univ Ohio State Res Found	Synthesis of indoles from anilines and intermediates therein
US3950343A (en) *	1973-11-06	1976-04-13	Ayerst, Mckenna And Harrison Ltd.	Pyrroloisoquinoline derivatives
US4070470A (en) *	1974-06-24	1978-01-24	Otsuka Pharmaceutical Co., Ltd.	Platelet aggregation inhibiting carbostyrils, their compositions and method of use
DE2909779A1 (de) *	1979-03-13	1980-09-18	Thomae Gmbh Dr K	Neue indolderivate, deren herstellung und deren verwendung als arzneimittel

1981
- 1981-06-16 NZ NZ197441A patent/NZ197441A/en unknown
- 1981-06-16 DK DK264281A patent/DK264281A/da not_active Application Discontinuation
- 1981-06-16 AT AT81302699T patent/ATE9329T1/de not_active IP Right Cessation
- 1981-06-16 AU AU71864/81A patent/AU539678B2/en not_active Ceased
- 1981-06-16 GB GB8118439A patent/GB2078736B/en not_active Expired
- 1981-06-16 ES ES503097A patent/ES8300091A1/es not_active Expired
- 1981-06-16 ZA ZA814057A patent/ZA814057B/xx unknown
- 1981-06-16 FI FI811889A patent/FI811889L/fi not_active Application Discontinuation
- 1981-06-16 KR KR1019810002197A patent/KR850001470B1/ko active
- 1981-06-16 DE DE8181302699T patent/DE3165998D1/de not_active Expired
- 1981-06-16 HU HU811777A patent/HU183480B/hu unknown
- 1981-06-16 EP EP81302699A patent/EP0042298B1/en not_active Expired
- 1981-06-17 CA CA000380032A patent/CA1149811A/en not_active Expired
- 1981-06-17 IE IE1344/81A patent/IE52102B1/en unknown
- 1981-06-17 IL IL63110A patent/IL63110A/xx unknown
- 1981-06-17 GR GR65248A patent/GR75701B/el unknown
- 1981-06-17 PH PH25767A patent/PH16357A/en unknown
- 1981-06-18 JP JP9453481A patent/JPS5728048A/ja active Pending
1982
- 1982-05-21 US US06/380,838 patent/US4493843A/en not_active Expired - Fee Related
- 1982-05-31 ES ES512706A patent/ES512706A0/es active Granted
- 1982-05-31 ES ES512704A patent/ES8303332A1/es not_active Expired
- 1982-05-31 ES ES512705A patent/ES512705A0/es active Granted
1984
- 1984-09-25 SG SG689/84A patent/SG68984G/en unknown
- 1984-11-22 HK HK926/84A patent/HK92684A/xx unknown
1985
- 1985-10-05 SG SG730/85A patent/SG73085G/en unknown
- 1985-11-21 HK HK924/85A patent/HK92485A/xx unknown
- 1985-12-30 MY MY975/85A patent/MY8500975A/xx unknown
1986
- 1986-12-30 MY MY409/86A patent/MY8600409A/xx unknown

Also Published As

Publication number	Publication date
GR75701B (es)	1984-08-02
SG73085G (en)	1986-05-02
ES512704A0 (es)	1983-02-01
ES503097A0 (es)	1982-10-01
ATE9329T1 (de)	1984-09-15
ES8305327A1 (es)	1983-04-01
CA1149811A (en)	1983-07-12
HK92485A (en)	1985-11-29
ES8303333A1 (es)	1983-02-01
ES512705A0 (es)	1983-02-01
ES8300091A1 (es)	1982-10-01
IE811344L (en)	1981-12-18
AU539678B2 (en)	1984-10-11
US4493843A (en)	1985-01-15
EP0042298A1 (en)	1981-12-23
GB2078736B (en)	1984-03-07
DK264281A (da)	1981-12-19
MY8600409A (en)	1986-12-31
SG68984G (en)	1985-03-15
KR850001470B1 (ko)	1985-10-10
ZA814057B (en)	1982-07-28
GB2078736A (en)	1982-01-13
PH16357A (en)	1983-09-05
JPS5728048A (en)	1982-02-15
KR830006205A (ko)	1983-09-20
FI811889L (fi)	1981-12-19
AU7186481A (en)	1981-12-24
NZ197441A (en)	1984-11-09
IE52102B1 (en)	1987-06-24
DE3165998D1 (de)	1984-10-18
EP0042298B1 (en)	1984-09-12
ES8303332A1 (es)	1983-02-01
HK92684A (en)	1984-11-30
HU183480B (en)	1984-05-28
IL63110A (en)	1986-10-31
MY8500975A (en)	1985-12-31

Publication	Publication Date	Title
JPS57171973A (en)	1982-10-22	Manufacture of 4-amino-chloroquinolines
SE8003815L (sv)	1980-11-24	Alkyl-ketohexopyranosid-derivat
FI800770A (fi)	1980-09-14	Nya indolderivater deras framstaellning och deras anvaendning saosom laekemedel
ES512704A0 (es)	1983-02-01	Procedimiento para preparar derivados de indol o de indolina.
SE7612613L (sv)	1977-05-13	Forfarande for framstellning av nya derivat av daunorubicin
ATE9790T1 (de)	1984-10-15	1,4-naphthochinonderivate und deren verwendung.
ES447751A1 (es)	1977-10-01	Procedimiento para preparar derivados de imidazolilquinazo- lina.
GR74870B (es)	1984-07-12
JPS55162789A (en)	1980-12-18	Dithiepinoopyrrole derivative
HUT50833A (en)	1990-03-28	Process for producing indolo/3,2-1-de/ /1,4/-oxazino/2,3,4-ij/ /1,5/-naphthyridine derivatives
ES424221A2 (es)	1976-05-16	Procedimiento de preparacion de nuevos oxazino (5,6,e) indoles sustituidos.
AU558025B2 (en)	1987-01-15	Dithiino(1,4)(2,3-6)pyrrole derivatives
ES483138A1 (es)	1980-09-01	Un procedimiento para la preparacion de derivados de tieno- tiacina