ES492056A0 - Un procedimiento para la produccion de un derivado diazo - Google Patents
Un procedimiento para la produccion de un derivado diazoInfo
- Publication number
- ES492056A0 ES492056A0 ES492056A ES492056A ES492056A0 ES 492056 A0 ES492056 A0 ES 492056A0 ES 492056 A ES492056 A ES 492056A ES 492056 A ES492056 A ES 492056A ES 492056 A0 ES492056 A0 ES 492056A0
- Authority
- ES
- Spain
- Prior art keywords
- procedure
- production
- diazo derivative
- diazo
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
- C07D477/04—Preparation by forming the ring or condensed ring systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/933,323 US4174316A (en) | 1978-08-14 | 1978-08-14 | 4-Iodomethylazetidin-2-one |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8104295A1 ES8104295A1 (es) | 1981-04-16 |
ES492056A0 true ES492056A0 (es) | 1981-04-16 |
Family
ID=25463739
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES480127A Expired ES480127A1 (es) | 1978-08-14 | 1979-04-30 | Un procedimiento para la preparacion de tienamicina. |
ES492056A Granted ES492056A0 (es) | 1978-08-14 | 1980-05-30 | Un procedimiento para la produccion de un derivado diazo |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES480127A Expired ES480127A1 (es) | 1978-08-14 | 1979-04-30 | Un procedimiento para la preparacion de tienamicina. |
Country Status (8)
Country | Link |
---|---|
US (1) | US4174316A (es) |
EP (1) | EP0007973B1 (es) |
JP (4) | JPS5527169A (es) |
DE (1) | DE2966598D1 (es) |
DK (1) | DK169971B1 (es) |
ES (2) | ES480127A1 (es) |
FI (1) | FI66001C (es) |
IE (1) | IE48728B1 (es) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4275207A (en) * | 1978-08-14 | 1981-06-23 | Merck & Co., Inc. | Process for preparing 7-(1-hydroxyethyl)-3-(2-aminoethylthio)-1-carbadethiaceph-3-em-3-carboxylic acid and intermediate therefor |
JPS55147284A (en) * | 1979-04-17 | 1980-11-17 | Sanraku Inc | Novel beta-lactam derivative and its preparation |
EP0018594B1 (en) * | 1979-04-27 | 1985-08-21 | Merck & Co. Inc. | Process for the preparation of 3-(1-hydroxyethyl)-azetidinones |
US4400323A (en) * | 1979-07-23 | 1983-08-23 | Merck & Co., Inc. | 3-[1-Hydroxyethyl]-4-carboxymethyl-azetidin-2-one |
PT71552B (en) * | 1979-07-23 | 1981-12-14 | Merck & Co Inc | Process for preparation of thienamycin and intermediates |
PT71553B (en) * | 1979-07-23 | 1981-12-14 | Merck & Co Inc | Process for the preparation of thienamycin and intermediates |
EP0028151A1 (en) * | 1979-10-29 | 1981-05-06 | Beecham Group Plc | Process for the preparation of antibiotics |
GR72296B (es) * | 1979-12-03 | 1983-10-18 | Merck & Co Inc | |
US4262010A (en) * | 1979-12-03 | 1981-04-14 | Merck & Co., Inc. | 6-(1-Hydroxyethyl)-2-(2-aminoethylthio)-1,1-disubstituted-1-carbadethiapen-2-em-3-carboxylic acids |
DE3167774D1 (en) * | 1980-02-28 | 1985-01-31 | Fujisawa Pharmaceutical Co | 4-substituted-2-oxoazetidine compounds, processes for their preparation, and their use for preparing antibiotics |
IE52147B1 (en) * | 1980-03-27 | 1987-07-08 | Merck & Co Inc | 4-(3-carboxy-2-oxopropyl)-azetidin-2-ones and process for their preparation |
US4309346A (en) * | 1980-03-27 | 1982-01-05 | Merck & Co., Inc. | Process for the preparation of 1-carbapenems and intermediates via trithioorthoacetates |
EP0037082B1 (en) * | 1980-03-27 | 1985-03-20 | Merck & Co. Inc. | Process for the preparation of 1-carbapenems and intermediates via silyl-substituted dithioacetals |
EP0038869A1 (en) * | 1980-04-30 | 1981-11-04 | Merck & Co. Inc. | Process for the preparation of 1-carbapenems, and intermediates for their preparation |
JPS56154484A (en) * | 1980-05-01 | 1981-11-30 | Merck & Co Inc | 1-carbapenems derived from-4azetidinone and manufacture of intermediate therefor |
JPS5777670A (en) * | 1980-10-31 | 1982-05-15 | Microbial Chem Res Found | Preparation of 2-azetidinone derivative |
JPS57123182A (en) * | 1980-12-18 | 1982-07-31 | Merck & Co Inc | 6- and 4-substituted-1-azabicyclo(3,1,2,0)heptane- 3,7-dione-2-carboxylate |
US4348325A (en) * | 1981-03-30 | 1982-09-07 | Merck & Co., Inc. | Methyl 3-azido-4-C-cyano-2,3,4,6-tetradeoxy-α-D-arabino-hexopyranoside |
EP0073451B1 (en) * | 1981-08-27 | 1987-05-13 | Fujisawa Pharmaceutical Co., Ltd. | Carbapenam compound and processes for the preparation thereof |
WO1983002614A1 (en) * | 1982-02-02 | 1983-08-04 | Takeda Chemical Industries Ltd | 5,6-cis-carbapenem-3-carboxylic acid derivatives and process for their preparation |
JPS5865291A (ja) * | 1981-10-14 | 1983-04-18 | Sankyo Co Ltd | カルバペネム−3−カルボン酸誘導体およびその製法 |
CA1190236A (en) * | 1981-10-23 | 1985-07-09 | Edward J.J. Grabowski | Antibiotic synthesis |
JPS58103391A (ja) * | 1981-12-11 | 1983-06-20 | Meiji Seika Kaisha Ltd | 1−オキサデチア−セフエム誘導体の製造法 |
US4683301A (en) * | 1982-04-08 | 1987-07-28 | Bristol-Myers Company | Carbapenem antibiotics |
US4710568A (en) * | 1982-04-09 | 1987-12-01 | Bristol-Myers Company | Carbapenem antibiotics |
US4642341A (en) * | 1982-04-09 | 1987-02-10 | Bristol-Myers Company | Carbapenem antibiotics |
US4640799A (en) * | 1982-06-18 | 1987-02-03 | Bristol-Myers Company | Carbapenem antibiotics |
US4536335A (en) * | 1982-06-18 | 1985-08-20 | Bristol-Myers Company | Carbapenem antibiotics |
US4665170A (en) * | 1982-06-18 | 1987-05-12 | Bristol-Myers Company | Carbapenem antibiotics |
US4746736A (en) * | 1982-09-28 | 1988-05-24 | Bristol-Myers Company | Carbapenem antibiotics |
US4732977A (en) * | 1982-09-28 | 1988-03-22 | Bristol Myers Company | Carbapenem antibiotics |
US4472576A (en) * | 1982-12-03 | 1984-09-18 | Merck & Co., Inc. | Processes for the production of antibiotic 1-oxadethiacephalosporins |
EP0117053A1 (en) * | 1983-02-10 | 1984-08-29 | Ajinomoto Co., Inc. | Azetidinone derivatives |
CA1220215A (en) * | 1983-03-07 | 1987-04-07 | Yasutsugu Ueda | Carbapenem intermediates |
EP0133670A3 (de) * | 1983-08-09 | 1985-12-18 | Bayer Ag | Verfahren zur Herstellung von 7-Acylamino-3-hydrocy-cephem-4-carbonsäuren und 7-Acylamino-3-hydroxy-1-de-thia-1-oxacephem-4-carbonsäuren |
JPS60260580A (ja) * | 1985-04-05 | 1985-12-23 | Sankyo Co Ltd | カルバペネム−3−カルボン酸誘導体およびその製造法 |
US4665171A (en) * | 1985-07-17 | 1987-05-12 | Harvard University | Process and intermediates for β-lactam antibiotics |
US4783453A (en) * | 1985-06-10 | 1988-11-08 | Merck & Co., Inc. | 2-aza-substituted 1-carbadethiapen-2-em-3-carboxylic acids |
US4833167A (en) * | 1985-06-10 | 1989-05-23 | Merck & Co., Inc. | 2-aza-substituted 1-carbadethiapen-2-em-3-carboxylic acids |
US4782051A (en) * | 1985-06-10 | 1988-11-01 | Merck & Co., Inc. | 2-aza-substituted 1-carbadethiapen-2-em-3 carboxylic acids |
US4892869A (en) * | 1985-06-10 | 1990-01-09 | Merck & Co., Inc. | 2-aza substituted-1-carbadethiapen-2-em-3-carboxylic acids |
US4751296A (en) * | 1986-08-06 | 1988-06-14 | University Of Notre Dame Du Lac | Process for 4-halomethyl-azetidinones by cyclization of O-acylhydroxamates |
JPS6345250A (ja) * | 1987-03-05 | 1988-02-26 | Sankyo Co Ltd | β−ラクタム化合物 |
JPS6354359A (ja) * | 1987-03-05 | 1988-03-08 | Sankyo Co Ltd | 4―カルボキシメチルアゼチジノン誘導体の製法 |
JP2503247B2 (ja) * | 1988-04-01 | 1996-06-05 | 三共株式会社 | アゼチジノン誘導体 |
US5051502A (en) * | 1990-06-06 | 1991-09-24 | University Of Notre Dame Du Lac | Rhodium catalyzed cyclization process for bicyclic β-lactams |
US5189158A (en) * | 1991-03-20 | 1993-02-23 | American Cyanamid Company | 4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them |
DE69329939T2 (de) * | 1992-04-28 | 2001-06-28 | Tanabe Seiyaku Co., Ltd. | Verfahrenzur Abspaltung von Silylschutzgruppen aus geschützten HO-Gruppen |
US5587474A (en) * | 1992-06-18 | 1996-12-24 | Tanabe Seiyaku Co., Ltd. | Method for removing the protecting group for carboxyl group |
US8420628B2 (en) * | 2005-05-06 | 2013-04-16 | Allergan, Inc. | Substituted beta-lactams |
US8202855B2 (en) | 2008-03-04 | 2012-06-19 | Allergan, Inc | Substituted beta-lactams |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4122086A (en) * | 1977-07-26 | 1978-10-24 | Smithkline Corporation | Isopenicillins |
JPS55147284A (en) * | 1979-04-17 | 1980-11-17 | Sanraku Inc | Novel beta-lactam derivative and its preparation |
-
1978
- 1978-08-14 US US05/933,323 patent/US4174316A/en not_active Expired - Lifetime
-
1979
- 1979-04-20 IE IE374/79A patent/IE48728B1/en not_active IP Right Cessation
- 1979-04-27 FI FI791378A patent/FI66001C/fi not_active IP Right Cessation
- 1979-04-30 ES ES480127A patent/ES480127A1/es not_active Expired
- 1979-05-01 DK DK178979A patent/DK169971B1/da not_active IP Right Cessation
- 1979-05-01 EP EP79101307A patent/EP0007973B1/en not_active Expired
- 1979-05-01 DE DE7979101307T patent/DE2966598D1/de not_active Expired
- 1979-05-02 JP JP5353279A patent/JPS5527169A/ja active Granted
-
1980
- 1980-05-30 ES ES492056A patent/ES492056A0/es active Granted
-
1988
- 1988-08-24 JP JP63208472A patent/JPS6479182A/ja active Granted
-
1990
- 1990-11-30 JP JP2336948A patent/JPH03184954A/ja active Granted
- 1990-11-30 JP JP2336947A patent/JPH0780884B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPS5527169A (en) | 1980-02-27 |
EP0007973B1 (en) | 1984-02-01 |
JPH0248556B2 (es) | 1990-10-25 |
IE48728B1 (en) | 1985-05-01 |
FI66001C (fi) | 1984-08-10 |
DK178979A (da) | 1980-02-15 |
ES480127A1 (es) | 1980-09-01 |
JPH05384B2 (es) | 1993-01-05 |
US4174316A (en) | 1979-11-13 |
JPH03184979A (ja) | 1991-08-12 |
DK169971B1 (da) | 1995-04-18 |
FI791378A (fi) | 1980-02-15 |
DE2966598D1 (en) | 1984-03-08 |
EP0007973A1 (en) | 1980-02-20 |
FI66001B (fi) | 1984-04-30 |
JPH03184954A (ja) | 1991-08-12 |
JPS6479182A (en) | 1989-03-24 |
ES8104295A1 (es) | 1981-04-16 |
JPH0780884B2 (ja) | 1995-08-30 |
IE790374L (en) | 1980-02-14 |
JPH0353313B2 (es) | 1991-08-14 |
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