ES486845A1 - Un procedimiento para la preparacion de un isomero optica- mente activo del acido 2-(1-halonaft-2-iloxi) propionico - Google Patents
Un procedimiento para la preparacion de un isomero optica- mente activo del acido 2-(1-halonaft-2-iloxi) propionicoInfo
- Publication number
- ES486845A1 ES486845A1 ES486845A ES486845A ES486845A1 ES 486845 A1 ES486845 A1 ES 486845A1 ES 486845 A ES486845 A ES 486845A ES 486845 A ES486845 A ES 486845A ES 486845 A1 ES486845 A1 ES 486845A1
- Authority
- ES
- Spain
- Prior art keywords
- salts
- halonapth
- yloxy
- derivatives
- optical isomers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003839 salts Chemical class 0.000 title abstract 2
- 230000003287 optical effect Effects 0.000 title 1
- 150000004672 propanoic acids Chemical class 0.000 title 1
- 235000019260 propionic acid Nutrition 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000001741 anti-phlogistic effect Effects 0.000 abstract 1
- 230000001139 anti-pruritic effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 239000003908 antipruritic agent Substances 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 230000003480 fibrinolytic effect Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002349 hydroxyamino group Chemical group [H]ON([H])[*] 0.000 abstract 1
- 230000000444 normolipidemic effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un procedimiento para la preparación de un isómero ópticamente activo del ácido 2-(1- halonaft-2-iloxi) propiónico, de la fórmula general **fórmula general** en dónde R presenta un hidroxilo, un alcoxilo (C1-4), un aralcoxilo, un ácido oxipropilsulfónico o una sal respectiva, un grupo amínico primario, un mono (C1-4) alquil- amino, un di (C1-4) alquilamino o hidroxiamino y X representa un átomo de flúor, cloro, bromo o yodo, y sus sales y derivados, que constituye la materia activa en la composición de agentes antiflogisticos, analgésicos, anti-agregantes, antipruríticos, fibrinolíticos o normolipidémicos caracterizado porque cuando en la fórmula general R representa un grupo hidroxi) comprende: a) separar un isómero opticamente activo de una mezcla racémica de ácido 2-(1-halonaft-2- iloxi)propiónico; b) separar un isómero ópticamente activo de una mezcla racémica de ácido 2-(naft-2- iloxi)propiónico y halogenar el ácido en la posición 1 del anillonaftalénico o c) halogenar por medio de unintermediario diazo el ácido d o l 2-(1-aminonaft-2-iloxi) propiónico obtenido mediante resolución de ácido d l 2-(1-aminonaft-2-iloxi) propiónico o mediante reducción del ácido d o l 2-(1-nitronaft-2-iloxi) propiónico obtenido mediante resolución del ácido d l 2-(1-nitronaft-2-iloxi) propiónico
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT09665/78A IT1109006B (it) | 1978-12-14 | 1978-12-14 | Acidi 2 i alogeno naft 2 ilossi propionoici forme otticamente attive e forme racemiche loro derivati e procedimenti di fabbricazione relativi |
Publications (1)
Publication Number | Publication Date |
---|---|
ES486845A1 true ES486845A1 (es) | 1980-10-01 |
Family
ID=11132975
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES486845A Expired ES486845A1 (es) | 1978-12-14 | 1979-12-13 | Un procedimiento para la preparacion de un isomero optica- mente activo del acido 2-(1-halonaft-2-iloxi) propionico |
Country Status (11)
Country | Link |
---|---|
JP (1) | JPS55122735A (es) |
BE (1) | BE880596A (es) |
CA (1) | CA1151664A (es) |
CH (1) | CH644577A5 (es) |
DE (1) | DE2949106A1 (es) |
ES (1) | ES486845A1 (es) |
FR (1) | FR2444023A1 (es) |
GB (1) | GB2047234A (es) |
IT (1) | IT1109006B (es) |
NL (1) | NL7909052A (es) |
SE (1) | SE7910284L (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3722778A1 (de) * | 1987-07-09 | 1989-03-09 | Raschig Ag | Polyalkylenglykol-naphthyl-3-sulfopropyl- diether und deren salze, verfahren zur herstellung dieser verbindungen und ihre verwendung als netzmittel in der galvanotechnik |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE790363A (fr) * | 1971-10-21 | 1973-02-15 | Menarini Sas | Acides (1-halogeno-2-naphtyloxy)-acetiques, composes relatifs alpha-substitues, leurs derives et leurs procedes de preparation |
-
1978
- 1978-12-14 IT IT09665/78A patent/IT1109006B/it active
-
1979
- 1979-02-12 CA CA000341734A patent/CA1151664A/en not_active Expired
- 1979-12-06 DE DE19792949106 patent/DE2949106A1/de not_active Withdrawn
- 1979-12-10 GB GB7942537A patent/GB2047234A/en not_active Withdrawn
- 1979-12-11 CH CH1097879A patent/CH644577A5/it not_active IP Right Cessation
- 1979-12-13 SE SE7910284A patent/SE7910284L/xx not_active Application Discontinuation
- 1979-12-13 ES ES486845A patent/ES486845A1/es not_active Expired
- 1979-12-13 BE BE0/198548A patent/BE880596A/fr not_active IP Right Cessation
- 1979-12-14 FR FR7930763A patent/FR2444023A1/fr active Granted
- 1979-12-14 JP JP16167779A patent/JPS55122735A/ja active Pending
- 1979-12-14 NL NL7909052A patent/NL7909052A/nl not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CH644577A5 (it) | 1984-08-15 |
IT7809665A0 (it) | 1978-12-14 |
BE880596A (fr) | 1980-04-01 |
FR2444023A1 (fr) | 1980-07-11 |
JPS55122735A (en) | 1980-09-20 |
FR2444023B1 (es) | 1985-02-01 |
CA1151664A (en) | 1983-08-09 |
NL7909052A (nl) | 1980-06-17 |
DE2949106A1 (de) | 1980-06-26 |
SE7910284L (sv) | 1980-06-15 |
IT1109006B (it) | 1985-12-16 |
GB2047234A (en) | 1980-11-26 |
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