ES480351A1 - Procedimiento para la obtencion de 1,4-dihidropiridinas ni- tro-sustituidas. - Google Patents
Procedimiento para la obtencion de 1,4-dihidropiridinas ni- tro-sustituidas.Info
- Publication number
- ES480351A1 ES480351A1 ES480351A ES480351A ES480351A1 ES 480351 A1 ES480351 A1 ES 480351A1 ES 480351 A ES480351 A ES 480351A ES 480351 A ES480351 A ES 480351A ES 480351 A1 ES480351 A1 ES 480351A1
- Authority
- ES
- Spain
- Prior art keywords
- dihydropyridines
- nitro
- manufacture
- medicaments containing
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Procedimiento para la obtención de 1,4- dihidropiridinas nitro-sustituidas de fórmula general I **(Fórmula)** donde R significa hidrógeno o un resto alquilo de cadena recta o ramificada que, en caso dado, puede estar interrumpido en la cadena alquilo por 1 a 2 átomos de oxígeno, o un resto arilo o aralquilo, R1 y R4 significan hidrógeno, un resto alquilo de cadena recta o ramificada, un resto arilo, un resto aralquilo o un resto heteroarilo, R2 significa hidrógeno, un grupo nitro o el grupo COR5, donde R5 bien significa un resto alquilo, arilo o aralquilo, o R5 significa el grupo OR6 representa un resto hidrocarburo de cadena recta, ramificada o cíclica, saturado o insaturado, que en caso dado está interrumpido por 1 a 2 átomos de oxígeno o de azufre en la cadena, o donde un átomo de hidrógeno puede estar sustituido por un grupo fenoxi o fenilo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19772752820 DE2752820A1 (de) | 1977-11-26 | 1977-11-26 | Neue nitrosubstituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
ES480351A1 true ES480351A1 (es) | 1979-12-01 |
Family
ID=6024688
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES475379A Expired ES475379A1 (es) | 1977-11-26 | 1978-11-24 | Procedimiento para la obtencion de 1,4-dihidropiridinas ni- tro-sustituidas |
ES480350A Expired ES480350A1 (es) | 1977-11-26 | 1979-05-08 | Procedimiento para la obtencion de 1,4-dihidropiridinasnitrosustituidas. |
ES480351A Expired ES480351A1 (es) | 1977-11-26 | 1979-05-08 | Procedimiento para la obtencion de 1,4-dihidropiridinas ni- tro-sustituidas. |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES475379A Expired ES475379A1 (es) | 1977-11-26 | 1978-11-24 | Procedimiento para la obtencion de 1,4-dihidropiridinas ni- tro-sustituidas |
ES480350A Expired ES480350A1 (es) | 1977-11-26 | 1979-05-08 | Procedimiento para la obtencion de 1,4-dihidropiridinasnitrosustituidas. |
Country Status (7)
Country | Link |
---|---|
US (1) | US4248873A (es) |
EP (1) | EP0002208B1 (es) |
JP (1) | JPS5481279A (es) |
AT (1) | AT368492B (es) |
DE (2) | DE2752820A1 (es) |
ES (3) | ES475379A1 (es) |
IT (1) | IT1100185B (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL57416A (en) * | 1978-05-30 | 1983-03-31 | Smith Kline French Lab | Nitro compounds,processes for preparing them and compositions containing them |
US4405624A (en) * | 1978-05-30 | 1983-09-20 | Smith Kline & French Laboratories Limited | Nitro-substituted dihydropyrroles and tetrahydropyridines, compositions, compounds, and medicinal use |
DE3206671A1 (de) * | 1982-02-25 | 1983-09-01 | Bayer Ag, 5090 Leverkusen | Dihydropyridine mit positiv inotroper wirkung, neue verbindungen, ihre verwendung in arzneimitteln und verfahren zu ihrer herstellung |
NZ201395A (en) * | 1981-07-30 | 1987-02-20 | Bayer Ag | Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines |
DE3130041A1 (de) * | 1981-07-30 | 1983-02-17 | Bayer Ag, 5090 Leverkusen | Dihydropyridine mit positiv inotroper wirkung, neue verbindungen, ihre verwendung in arzneimitteln und verfahren zu ihrer herstellung |
DE3319956A1 (de) * | 1983-06-01 | 1984-12-06 | Bayer Ag, 5090 Leverkusen | 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
DE3326384A1 (de) * | 1983-07-22 | 1985-01-31 | Bayer Ag, 5090 Leverkusen | 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
FR2554109A1 (fr) * | 1983-11-01 | 1985-05-03 | Sandoz Sa | Nouveaux derives de la 1,4-dihydropyridine, leur preparation et leur utilisation en therapeutique comme medicaments |
DE3420784A1 (de) * | 1984-06-04 | 1985-12-05 | Bayer Ag, 5090 Leverkusen | 3-nitro-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
DE3445852A1 (de) * | 1984-12-15 | 1986-06-19 | Bayer Ag, 5090 Leverkusen | Dihydropyridin-carbonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
DE3447170A1 (de) * | 1984-12-22 | 1986-07-03 | Bayer Ag, 5090 Leverkusen | Mischung unterschiedlicher dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
DE3447169A1 (de) * | 1984-12-22 | 1986-07-03 | Bayer Ag, 5090 Leverkusen | Optisch aktive nitrodihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln |
DE3501855A1 (de) * | 1985-01-22 | 1986-07-24 | Bayer Ag, 5090 Leverkusen | 5-aryl-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
DE3517473A1 (de) * | 1985-05-15 | 1986-11-20 | Bayer Ag, 5090 Leverkusen | Pyrimidinyl-dihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln |
US4771057A (en) * | 1986-02-03 | 1988-09-13 | University Of Alberta | Reduced pyridyl derivatives with cardiovascular regulating properties |
US4868181A (en) * | 1986-08-04 | 1989-09-19 | E. I. Du Pont De Nemours And Company | 1,4-dihydropyridine derivatives with calcium agonist and alpha1 -antagonist activity |
NO881411L (no) * | 1987-04-14 | 1988-10-17 | Bayer Ag | Substituerte pyrroler. |
DE3724909A1 (de) * | 1987-07-28 | 1989-02-09 | Bayer Ag | Neue substituierte nitro-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung |
DE3732380A1 (de) * | 1987-09-25 | 1989-04-06 | Bayer Ag | Dihydropyridinether, verfahren zu ihrer herstellung und ihre verwendung |
MY104933A (en) * | 1987-09-30 | 1994-07-30 | Pfizer Ltd | Platelet activating factor antagonists |
DE3737340A1 (de) * | 1987-11-04 | 1989-05-24 | Bayer Ag | Neue fluormethoxyphenyl-dihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln |
DE3737341A1 (de) * | 1987-11-04 | 1989-05-18 | Bayer Ag | Neue fluormethoxyphenyl-dihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln |
DE3800785A1 (de) * | 1988-01-09 | 1989-07-20 | Hoechst Ag | Substituierte 7-(pyridazin-5-yl)-3,5-dihydroxyheptan(en)- saeuren, ihre entsprechenden (delta)-lactone bzw. derivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte |
DE4011105A1 (de) * | 1990-04-06 | 1991-10-10 | Bayer Ag | Neue 4-chinolyl-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
US5204472A (en) * | 1990-04-06 | 1993-04-20 | Bayer Aktiengesellschaft | Quinoline and isoquinoline intermediates |
US5254692A (en) * | 1990-04-06 | 1993-10-19 | Bayer Aktiengesellschaft | 2,6-dialkyl-4-(benzothiazol- or benzoxazol-7-yl)-1,4-dihydropyridines |
US5166148A (en) * | 1990-07-09 | 1992-11-24 | The Du Pont Merck Pharmaceutical Company | 2-amino-1,4-dihydropyridine derivatives with calcium agonist and alpha1 -antagonist activity |
DE4134760A1 (de) * | 1991-10-22 | 1993-07-08 | Bayer Ag | Aryl-chinolyl-substituierte 1,4-dihydropyridin-dicarbonsaeurederivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
DE4202526A1 (de) * | 1992-01-30 | 1993-08-05 | Bayer Ag | Neue 4-cinnolinyl- und 4-naphthyridinyl-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
DE4313691A1 (de) * | 1993-04-27 | 1994-11-03 | Bayer Ag | 2,6-Disubstituierte 4-Chinolyl-dihydropyridine |
DE4313690A1 (de) * | 1993-04-27 | 1994-11-03 | Bayer Ag | Kondensierte Chinolyl-dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln |
DE4313692A1 (de) * | 1993-04-27 | 1994-11-03 | Bayer Ag | 3-Chinolyl substituierte Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln |
DE4313697A1 (de) * | 1993-04-27 | 1994-11-03 | Bayer Ag | Chinolyl-dihydropyridinester, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln |
WO2014027329A1 (en) | 2012-08-16 | 2014-02-20 | Ecole Polytechnique Federale De Lausanne (Epfl) | Method and apparatus for low complexity spectral analysis of bio-signals |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2310747A1 (de) * | 1973-03-03 | 1974-09-12 | Bayer Ag | Verfahren zur herstellung von neuen amino-3,4-dihydropyridinen und ihre verwendung als arzneimittel |
-
1977
- 1977-11-26 DE DE19772752820 patent/DE2752820A1/de not_active Withdrawn
-
1978
- 1978-11-06 US US05/958,239 patent/US4248873A/en not_active Expired - Lifetime
- 1978-11-16 DE DE7878101379T patent/DE2860529D1/de not_active Expired
- 1978-11-16 EP EP78101379A patent/EP0002208B1/de not_active Expired
- 1978-11-24 ES ES475379A patent/ES475379A1/es not_active Expired
- 1978-11-24 AT AT0841778A patent/AT368492B/de not_active IP Right Cessation
- 1978-11-24 IT IT30192/78A patent/IT1100185B/it active
- 1978-11-27 JP JP14543278A patent/JPS5481279A/ja active Granted
-
1979
- 1979-05-08 ES ES480350A patent/ES480350A1/es not_active Expired
- 1979-05-08 ES ES480351A patent/ES480351A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ATA841778A (de) | 1982-02-15 |
ES475379A1 (es) | 1979-10-16 |
ES480350A1 (es) | 1980-01-01 |
IT1100185B (it) | 1985-09-28 |
IT7830192A0 (it) | 1978-11-24 |
DE2860529D1 (en) | 1981-04-09 |
JPS5481279A (en) | 1979-06-28 |
EP0002208A1 (de) | 1979-06-13 |
US4248873A (en) | 1981-02-03 |
DE2752820A1 (de) | 1979-05-31 |
JPS6132308B2 (es) | 1986-07-25 |
EP0002208B1 (de) | 1981-03-11 |
AT368492B (de) | 1982-10-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19960603 |