ES480190A1 - Procedimiento para la preparacion de compuestos antihiper- tensivos. - Google Patents
Procedimiento para la preparacion de compuestos antihiper- tensivos.Info
- Publication number
- ES480190A1 ES480190A1 ES480190A ES480190A ES480190A1 ES 480190 A1 ES480190 A1 ES 480190A1 ES 480190 A ES480190 A ES 480190A ES 480190 A ES480190 A ES 480190A ES 480190 A1 ES480190 A1 ES 480190A1
- Authority
- ES
- Spain
- Prior art keywords
- alkoxy
- alkyl
- phenyl
- halo
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
Procedimiento para la preparación de compuesto anti-hipertensivos de la fórmula II **fórmula** en que X es cloro o trifluorometilo, en que R es: (a) piridinilo, (b) triazinilo © pirazinilo (d) triazinilo, piraminilo o pirimidinilo sustituido por uno o dos triluorometil, alquilo, acloxi, dialquilamino, alquiltio o halo, en que halo es flúor, bromo o cloro, en que alquilo es de uno a tres átomos de carbono y en que alcoxi es de uno a tres átomos de carbono (f) halopiridinilo de uno a cuatro átomos halo (g) halopiridinilo de menos de cuatro átomos halo sustituido por uno o dos trifluorometilo, alquilo, alcoxi, dialquilamino o alquiltio, **fórmula** en que R1 es fenilo, fenilo sustituido con uno o dos halo, alcoxi, alquilo, trifluorometilo o alquilfenilsulfonilo, en que alquilo, alcoxi y halo son como se ha definido arriba o (i) - SO2R2, en que R2 es dialquilamino, fenilo, fenilo sustituido con uno o dos halo, alquilo , alcoxi o trifulorometilfenilo, en que alquilo, alcoxi y halo son como se ha definido arriba, caracterizado porque se hace reaccionar un compuesto de la fórmula **fórmula** en que X es como se define arriba, con la amina cíclica seleccionada **fórmula** o alternativamente haciendo reaccionar el compuesto de la fórmula **fórmula** en que X es como se define arriba, con el correspondiente cloruro de R2-sulfonilo o R1- isocianato.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/903,082 US4167567A (en) | 1978-05-05 | 1978-05-05 | Antihypertensive 4-aminoquinolines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES480190A1 true ES480190A1 (es) | 1980-02-01 |
Family
ID=25416910
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES480190A Expired ES480190A1 (es) | 1978-05-05 | 1979-05-03 | Procedimiento para la preparacion de compuestos antihiper- tensivos. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4167567A (es) |
| JP (1) | JPS54145683A (es) |
| AU (1) | AU522635B2 (es) |
| BE (1) | BE876039A (es) |
| CA (1) | CA1082707A (es) |
| CH (1) | CH642964A5 (es) |
| DE (1) | DE2914492A1 (es) |
| ES (1) | ES480190A1 (es) |
| FR (1) | FR2424913A1 (es) |
| GB (1) | GB2021567B (es) |
| HK (1) | HK60085A (es) |
| IT (1) | IT1192349B (es) |
| NL (1) | NL7902907A (es) |
| SE (1) | SE440352B (es) |
| SG (1) | SG38285G (es) |
| ZA (1) | ZA791809B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8424979D0 (en) * | 1984-10-03 | 1984-11-07 | Wyeth John & Brother Ltd | Benzenesulphonamide derivatives |
| PH22302A (en) * | 1985-02-11 | 1988-07-22 | Fujisawa Pharmaceutical Co | Piperidine compounds |
| GB8505430D0 (en) * | 1985-03-02 | 1985-04-03 | Wyeth John & Brother Ltd | Benzamide derivatives |
| WO1986005489A1 (en) * | 1985-03-13 | 1986-09-25 | The Upjohn Company | Process for 4-amino quinolines |
| US5212182A (en) * | 1990-10-03 | 1993-05-18 | American Home Products Corpooration | Substituted quinolinyl- and naphthalenylbenzamides or benzylamines and related compounds useful as analgesics |
| US5438064A (en) * | 1991-12-23 | 1995-08-01 | American Home Products Corporation | Derivatives of 4-anilinoquinoline-3-carboxamide as analgesic agents |
| IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
| GB9516709D0 (en) * | 1995-08-15 | 1995-10-18 | Zeneca Ltd | Medicament |
| GB9602166D0 (en) * | 1996-02-02 | 1996-04-03 | Zeneca Ltd | Aminoheterocyclic derivatives |
| WO1997028128A1 (en) | 1996-02-02 | 1997-08-07 | Zeneca Limited | Heterocyclic compounds useful as pharmaceutical agents |
| ATE230399T1 (de) * | 1996-08-14 | 2003-01-15 | Astrazeneca Ab | Substituierte pyrimidinderivate und ihre pharmazeutische anwendung |
| UA56197C2 (uk) * | 1996-11-08 | 2003-05-15 | Зенека Лімітед | Гетероциклічні похідні |
| AU5999698A (en) | 1997-02-13 | 1998-09-08 | Zeneca Limited | Heterocyclic compounds useful as oxido-squalene cyclase inhibitors |
| US6391880B1 (en) | 1997-02-13 | 2002-05-21 | Zeneca Limited | Heterocyclic compounds useful as oxido-squalene cyclase inhibitors |
| GB9715895D0 (en) | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic compounds |
| US5922203A (en) * | 1997-10-07 | 1999-07-13 | Hydranautics | Amine monomers and their use in preparing interfacially synthesized membranes for reverse osmosis and nanofiltration |
| GB9902989D0 (en) | 1999-02-11 | 1999-03-31 | Zeneca Ltd | Heterocyclic derivatives |
| US6464873B1 (en) | 1999-06-15 | 2002-10-15 | Hydranautics | Interfacially polymerized, bipiperidine-polyamide membranes for reverse osmosis and/or nanofiltration and process for making the same |
| US7842696B2 (en) * | 2007-06-21 | 2010-11-30 | Forest Laboratories Holdings Limited | Piperazine derivatives as inhibitors of stearoyl-CoA desaturase |
| US9795928B2 (en) | 2014-06-24 | 2017-10-24 | Nano And Advanced Materials Institute Limited | Stepwise interfacial polymerization technique with different reagent solution designs to prepare hollow fiber nanofiltration membrane composites |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3362956A (en) * | 1965-08-19 | 1968-01-09 | Sterling Drug Inc | 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines |
| BE754586A (fr) * | 1969-08-08 | 1971-02-08 | Upjohn Co | Preparations pharmaceutiques a base de p-(4-quinolylamino) benzamide etleur utilisation |
| ZA742410B (en) * | 1973-05-04 | 1975-04-30 | Upjohn Co | A new chemical process for preparing 2-,3-and 4-(4-quinolyl)-aminobenzamides |
| ZA743269B (en) * | 1973-06-15 | 1975-05-28 | Upjohn Co | Anti-hypertensive compounds |
| US4025629A (en) * | 1974-01-07 | 1977-05-24 | The Upjohn Company | P-(trifluoromethylquinolylamino)benzamides, pharmaceutical dosage forms and method of treatment |
-
1978
- 1978-05-05 US US05/903,082 patent/US4167567A/en not_active Expired - Lifetime
-
1979
- 1979-03-29 CA CA324,413A patent/CA1082707A/en not_active Expired
- 1979-04-10 DE DE19792914492 patent/DE2914492A1/de not_active Ceased
- 1979-04-12 NL NL7902907A patent/NL7902907A/xx not_active Application Discontinuation
- 1979-04-17 ZA ZA791809A patent/ZA791809B/xx unknown
- 1979-04-23 IT IT22086/79A patent/IT1192349B/it active
- 1979-04-26 GB GB7914583A patent/GB2021567B/en not_active Expired
- 1979-05-02 JP JP5356479A patent/JPS54145683A/ja active Pending
- 1979-05-02 SE SE7903820A patent/SE440352B/sv not_active IP Right Cessation
- 1979-05-02 AU AU46676/79A patent/AU522635B2/en not_active Ceased
- 1979-05-03 ES ES480190A patent/ES480190A1/es not_active Expired
- 1979-05-04 BE BE0/194991A patent/BE876039A/xx not_active IP Right Cessation
- 1979-05-04 CH CH422879A patent/CH642964A5/de not_active IP Right Cessation
- 1979-05-04 FR FR7911265A patent/FR2424913A1/fr active Granted
-
1985
- 1985-05-23 SG SG382/85A patent/SG38285G/en unknown
- 1985-08-08 HK HK600/85A patent/HK60085A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE7903820L (sv) | 1979-11-06 |
| BE876039A (fr) | 1979-11-05 |
| FR2424913A1 (fr) | 1979-11-30 |
| IT1192349B (it) | 1988-03-31 |
| CH642964A5 (de) | 1984-05-15 |
| AU522635B2 (en) | 1982-06-17 |
| IT7922086A0 (it) | 1979-04-23 |
| NL7902907A (nl) | 1979-11-07 |
| ZA791809B (en) | 1980-05-28 |
| AU4667679A (en) | 1979-11-08 |
| GB2021567B (en) | 1982-09-02 |
| DE2914492A1 (de) | 1979-11-08 |
| JPS54145683A (en) | 1979-11-14 |
| US4167567A (en) | 1979-09-11 |
| FR2424913B1 (es) | 1983-05-20 |
| CA1082707A (en) | 1980-07-29 |
| SE440352B (sv) | 1985-07-29 |
| HK60085A (en) | 1985-08-16 |
| GB2021567A (en) | 1979-12-05 |
| SG38285G (en) | 1985-11-15 |
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