ES479931A1 - Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them. - Google Patents
Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them.Info
- Publication number
- ES479931A1 ES479931A1 ES479931A ES479931A ES479931A1 ES 479931 A1 ES479931 A1 ES 479931A1 ES 479931 A ES479931 A ES 479931A ES 479931 A ES479931 A ES 479931A ES 479931 A1 ES479931 A1 ES 479931A1
- Authority
- ES
- Spain
- Prior art keywords
- substituted amino
- pyridine derivatives
- alkyl
- hydrogen
- processes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A class of substituted amino pyridine derivatives are of value in the treatment of diabetes. Some of the compounds also possess hypolipidaemic activity. The compounds are represented by the formula (I): < CHEM > wherein R<3> is hydrogen, alkyl or an acidic function R<2> is hydrogen or alkyl R<4> and R<5> are hydrogen, alkyl or halogen Z is hydrogen, phenyl, alkyl or aralkyl Alk is alkylene and x is 0 or 1 R<1> is optionally substituted phenyl or naphthyl. Most of the compounds of formula (I) are novel.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3305577 | 1977-08-06 | ||
GB1940678 | 1978-05-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES479931A1 true ES479931A1 (en) | 1979-12-01 |
Family
ID=26254035
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES472384A Expired ES472384A1 (en) | 1977-08-06 | 1978-08-04 | Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them. |
ES479932A Expired ES479932A1 (en) | 1977-08-06 | 1979-04-25 | Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them. |
ES479933A Expired ES479933A1 (en) | 1977-08-06 | 1979-04-25 | Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them. |
ES479931A Expired ES479931A1 (en) | 1977-08-06 | 1979-04-25 | Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them. |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES472384A Expired ES472384A1 (en) | 1977-08-06 | 1978-08-04 | Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them. |
ES479932A Expired ES479932A1 (en) | 1977-08-06 | 1979-04-25 | Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them. |
ES479933A Expired ES479933A1 (en) | 1977-08-06 | 1979-04-25 | Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0000816A1 (en) |
JP (1) | JPS5441881A (en) |
AU (1) | AU3862078A (en) |
DK (1) | DK346278A (en) |
ES (4) | ES472384A1 (en) |
IL (1) | IL55242A0 (en) |
IT (1) | IT1106623B (en) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1160229A (en) * | 1979-03-13 | 1984-01-10 | Pieter T. Haken | Pyridyliminomethylbenzene derivatives |
DE3066911D1 (en) * | 1979-04-21 | 1984-04-19 | Beecham Group Plc | Dihydropyridine derivatives, processes for their preparation and pharmaceutical compositions containing them |
JPS5938653B2 (en) * | 1980-05-30 | 1984-09-18 | 日本ビクター株式会社 | How to make needles with electrodes |
JPS5798143A (en) * | 1980-12-05 | 1982-06-18 | Victor Co Of Japan Ltd | Base body of detection type for variation in electrostatic capacity value |
DE3124673A1 (en) * | 1981-06-24 | 1983-01-13 | Bayer Ag, 5090 Leverkusen | SUBSITUATED 2-AMINO-PYRIDINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE IN MEDICINAL PRODUCTS AND THE PRODUCTION THEREOF |
US4552960A (en) * | 1983-06-20 | 1985-11-12 | Eli Lilly And Company | Fungicidal amines |
US4774251A (en) * | 1984-06-18 | 1988-09-27 | Eli Lilly And Company | Method of inhibiting aromatase |
US4855308A (en) * | 1987-12-04 | 1989-08-08 | Warner-Lambert Company | Method of treating senile cognitive decline with N'-substituted aminopyridine adrenergic agents |
US4931457B1 (en) * | 1989-06-28 | 1993-11-16 | Hoechst-Roussel Pharmaceuticals Incorporated | Naphthylamino-and naphthyloxy-pyridineamin compounds useful as topical antiinflammatory agents for the treatment of skin disorders |
AU630877B2 (en) * | 1989-07-28 | 1992-11-12 | Ah N. Fah | Improved automatic plant watering and feeding system |
FR2668770A1 (en) * | 1990-11-07 | 1992-05-07 | Nyco Sa | HETEROCYCLIC AMINO ACID ESTERS AND THEIR DERIVATIVES, AND THEIR APPLICATION AS ANTI-OXIDIZING ADDITIVES FOR HIGH TEMPERATURE LUBRICATING OILS. |
GB9514160D0 (en) * | 1994-07-25 | 1995-09-13 | Zeneca Ltd | Aromatic compounds |
GB9420557D0 (en) * | 1994-10-12 | 1994-11-30 | Zeneca Ltd | Aromatic compounds |
TW502026B (en) * | 1995-06-20 | 2002-09-11 | Zeneca Ltd | Aromatic compounds useful as antagonists of e-type prostaglandins, processes for the preparation thereof, pharmaceutical compositions comprising the compounds, and intermediates |
TW434240B (en) * | 1995-06-20 | 2001-05-16 | Zeneca Ltd | Aromatic compounds, preparation thereof and pharmaceutical composition comprising same |
US5834468A (en) * | 1995-07-07 | 1998-11-10 | Zeneca Limited | Substituted aryl and heteroaryl compounds as E-type prostaglandin antagonists |
DE19845406C2 (en) * | 1998-10-02 | 2001-10-18 | Aventis Pharma Gmbh | Substituted 1,3-diaryl-2-pyridin-2-yl-3- (pyridin-2-ylamino) propanol derivatives, process for their preparation, medicaments containing these compounds and their use |
IL146006A0 (en) * | 1999-05-17 | 2002-07-25 | Novo Nordisk As | Glucagon antagonists/inverse agonists |
US6503949B1 (en) | 1999-05-17 | 2003-01-07 | Noro Nordisk A/S | Glucagon antagonists/inverse agonists |
JP2004510707A (en) * | 2000-08-08 | 2004-04-08 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | Neuroprotective 2-pyridinamine compositions and related methods |
WO2006105023A1 (en) * | 2005-03-28 | 2006-10-05 | Boehringer Ingelheim International Gmbh | Pyridine derivatives useful as inhibitors of pkc-theta |
WO2009003861A1 (en) | 2007-07-02 | 2009-01-08 | F. Hoffmann-La Roche Ag | Imidazole derivatives as ccr2 receptor antagonists |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2784138A (en) * | 1953-03-07 | 1957-03-05 | Bayer Ag | Fungicidal compositions of nu-arylhydroxyarylmethylamines |
DE1119274B (en) * | 1954-03-19 | 1961-12-14 | Raschig Gmbh Dr F | Process for the preparation of 2-amino-4-alkyl-pyridines |
NL132603C (en) * | 1964-08-29 | |||
DE1670522C3 (en) * | 1966-05-12 | 1978-08-31 | Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt | New Benzylaminopyridines |
GB1188154A (en) * | 1966-05-28 | 1970-04-15 | Egyt Gyogyszervegyeszeti Gyar | New Pyridine Derivatives and process for their preparation |
US3450707A (en) * | 1966-12-13 | 1969-06-17 | Sterling Drug Inc | Certain 2-anilino-pyridine derivatives |
US3535328A (en) * | 1967-09-01 | 1970-10-20 | Exxon Research Engineering Co | Certain substituted aminothioethoxy pyridines |
FR2050940A5 (en) * | 1969-06-30 | 1971-04-02 | Rhone Poulenc Sa | |
DE2141418A1 (en) * | 1970-08-18 | 1972-03-09 | Roemmers S.A. Industrial Comercial Y Financiera, Buenos Aires | Aniline derivatives of nicotinic acid and their salts |
FR2155922A2 (en) * | 1971-10-15 | 1973-05-25 | Aries Robert | Organophosphorus pesticides - stabilized by amino- or aminoalkyl-pyridines |
DE2230392A1 (en) * | 1972-06-22 | 1974-01-31 | Cassella Farbwerke Mainkur Ag | SUBSTITUTED PYRIDINE COMPOUNDS AND PROCESS FOR THEIR PRODUCTION |
GB1405308A (en) * | 1972-12-13 | 1975-09-10 | Basf Ag | Amino-pytidines as coupling components for azo dyes |
FR2288798A1 (en) * | 1974-10-24 | 1976-05-21 | Popescu Francine | Bright zinc electroplating bath - contg pyridine deriv and soluble organic polymer |
DE2605467A1 (en) * | 1976-02-12 | 1977-08-18 | Basf Ag | PYRIDINE COMPOUNDS |
-
1978
- 1978-07-25 EP EP78300190A patent/EP0000816A1/en not_active Withdrawn
- 1978-07-28 IL IL55242A patent/IL55242A0/en unknown
- 1978-08-03 AU AU38620/78A patent/AU3862078A/en active Pending
- 1978-08-04 ES ES472384A patent/ES472384A1/en not_active Expired
- 1978-08-04 IT IT50601/78A patent/IT1106623B/en active
- 1978-08-04 DK DK346278A patent/DK346278A/en unknown
- 1978-08-07 JP JP9604778A patent/JPS5441881A/en active Pending
-
1979
- 1979-04-25 ES ES479932A patent/ES479932A1/en not_active Expired
- 1979-04-25 ES ES479933A patent/ES479933A1/en not_active Expired
- 1979-04-25 ES ES479931A patent/ES479931A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES479933A1 (en) | 1979-12-01 |
IT1106623B (en) | 1985-11-11 |
IT7850601A0 (en) | 1978-08-04 |
ES479932A1 (en) | 1979-12-01 |
JPS5441881A (en) | 1979-04-03 |
AU3862078A (en) | 1980-02-07 |
EP0000816A1 (en) | 1979-02-21 |
DK346278A (en) | 1979-02-07 |
ES472384A1 (en) | 1979-10-01 |
IL55242A0 (en) | 1978-09-29 |
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