ES475157A1 - New derivative of benzensulfonamido and benzencarboxyamido * method of its production and drug composition containing these - Google Patents

New derivative of benzensulfonamido and benzencarboxyamido * method of its production and drug composition containing these

Info

Publication number
ES475157A1
ES475157A1 ES475157A ES475157A ES475157A1 ES 475157 A1 ES475157 A1 ES 475157A1 ES 475157 A ES475157 A ES 475157A ES 475157 A ES475157 A ES 475157A ES 475157 A1 ES475157 A1 ES 475157A1
Authority
ES
Spain
Prior art keywords
group
hydrogen
alkyl
general formula
benzensulfonamido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES475157A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allen and Hanburys Ltd
Original Assignee
Allen and Hanburys Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB4419/77A external-priority patent/GB1593651A/en
Application filed by Allen and Hanburys Ltd filed Critical Allen and Hanburys Ltd
Publication of ES475157A1 publication Critical patent/ES475157A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The novel benzenesulphonamide and benzamide derivatives of the general formula: < IMAGE > in which R1 represents a halogen atom or the group NR2R3 R2 and R3, which can be identical or different, represent hydrogen or straight-chain or branched (C1-C6)-alkyl, or where R2 and R3, together with the nitrogen atom, can form a 5- or 6-membered heterocyclic ring which can contain a further heteroatom from the group O, N or S, or where R2 represents hydrogen and R3 represents the group R4CO or R4SO2, in which R4 has the meaning hydrogen or (C1-4)-alkyl R5 represents hydrogen or one or more halogen atoms or hydroxy- or (C1-4)-alkoxy groups X represents CH2, O or the group NR6, in which NR6 has the meaning hydrogen or (C1-4)-alkyl, and Y represents SO2NH2 or CONH2, and the acid addition salts with organic or inorganic acids thereof are suitable for the treatment of cardiovascular disorders, such as hypertension. These compounds are prepared by reductive alkylation of a compound of the general formula: < IMAGE > with a ketone of the general formula:
ES475157A 1977-02-03 1978-11-16 New derivative of benzensulfonamido and benzencarboxyamido * method of its production and drug composition containing these Expired ES475157A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB4419/77A GB1593651A (en) 1977-02-03 1977-02-03 Amides
GB442077 1977-02-03

Publications (1)

Publication Number Publication Date
ES475157A1 true ES475157A1 (en) 1979-05-01

Family

ID=26239110

Family Applications (2)

Application Number Title Priority Date Filing Date
ES466587A Expired ES466587A1 (en) 1977-02-03 1978-02-02 New derivative of benzensulfonamido and benzencarboxyamido * method of its production and drug composition containing these
ES475157A Expired ES475157A1 (en) 1977-02-03 1978-11-16 New derivative of benzensulfonamido and benzencarboxyamido * method of its production and drug composition containing these

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES466587A Expired ES466587A1 (en) 1977-02-03 1978-02-02 New derivative of benzensulfonamido and benzencarboxyamido * method of its production and drug composition containing these

Country Status (10)

Country Link
JP (1) JPS6011898B2 (en)
AU (1) AU521707B2 (en)
CH (1) CH642057A5 (en)
DE (1) DE2803688A1 (en)
DK (1) DK31578A (en)
ES (2) ES466587A1 (en)
FR (1) FR2379515A1 (en)
NL (1) NL7801216A (en)
NZ (1) NZ186310A (en)
SE (1) SE7800930L (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1147342A (en) * 1977-10-12 1983-05-31 Kazuo Imai Process of producing novel phenylethanolamine derivatives
JPS5553262A (en) * 1978-10-17 1980-04-18 Yamanouchi Pharmaceut Co Ltd Phenylethanolamine derivative
EP0028105B1 (en) * 1979-10-25 1983-01-19 Beecham Group Plc Secondary amines, their preparation and use in pharmaceutical compositions
PH25150A (en) * 1986-06-05 1991-03-13 Ciba Geigy Ag Novel pharmaceutical preparation for topical application
US4906634A (en) * 1988-03-08 1990-03-06 Schering A.G. Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents
AU2737295A (en) * 1994-06-09 1996-01-04 Glaxo Group Limited Phenethanolamine derivatives and their use as atypical beta-adrenoceptor agonists
ZA964425B (en) * 1995-07-05 1996-12-09 De Beers Ind Diamond Mounting of cutter picks
AU715233B2 (en) 1996-01-10 2000-01-20 Asahi Kasei Kogyo Kabushiki Kaisha Novel tricyclic compounds and drug compositions containing the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1266058A (en) * 1969-07-08 1972-03-08
US3860647A (en) * 1973-08-20 1975-01-14 Smithkline Corp {60 -Aminomethyl-4-hydroxy-3-sulfamyl-benzyl alcohols and 4-hydroxy-3-sulfamyl phenethylamines
LU74760A1 (en) * 1975-04-17 1977-02-04

Also Published As

Publication number Publication date
DE2803688A1 (en) 1978-08-10
NZ186310A (en) 1979-10-25
AU3273178A (en) 1979-08-02
DK31578A (en) 1978-08-04
NL7801216A (en) 1978-08-07
SE7800930L (en) 1978-08-04
ES466587A1 (en) 1979-01-16
FR2379515A1 (en) 1978-09-01
CH642057A5 (en) 1984-03-30
JPS53111029A (en) 1978-09-28
FR2379515B1 (en) 1981-07-31
AU521707B2 (en) 1982-04-29
JPS6011898B2 (en) 1985-03-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980202