ES467430A1 - Procedimiento para la obtencion de esteres de acidos andros-tazdien-17-carboxilicos. - Google Patents

Procedimiento para la obtencion de esteres de acidos andros-tazdien-17-carboxilicos.

Info

Publication number
ES467430A1
ES467430A1 ES467430A ES467430A ES467430A1 ES 467430 A1 ES467430 A1 ES 467430A1 ES 467430 A ES467430 A ES 467430A ES 467430 A ES467430 A ES 467430A ES 467430 A1 ES467430 A1 ES 467430A1
Authority
ES
Spain
Prior art keywords
androstadiene
carboxylic acid
novel
acid esters
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES467430A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES467430A1 publication Critical patent/ES467430A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedimiento para la obtención de ésteres de ácidos androstadien-17-carboxílicos de fórmula: **(Fórmula 01)** donde R'' significa un grupo hidroxi libre o esterificado con un ácido carboxílico con un máximo de 7 átomos de carbono, R''` significa un grupo metilo en la posición alfa o beta o el grupo metileno y R'' junto con R''` significa el grupo 16 alfa, 17 alfa-dihidroxiacetonido **(Fórmula 02)**
ES467430A 1976-02-24 1978-03-01 Procedimiento para la obtencion de esteres de acidos andros-tazdien-17-carboxilicos. Expired ES467430A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH225376A CH628355A5 (de) 1976-02-24 1976-02-24 Verfahren zur herstellung neuer androstadien-17beta-carbonsaeuren und ihrer ester und salze.

Publications (1)

Publication Number Publication Date
ES467430A1 true ES467430A1 (es) 1979-08-16

Family

ID=4229445

Family Applications (5)

Application Number Title Priority Date Filing Date
ES456134A Expired ES456134A1 (es) 1976-02-24 1977-02-22 Procedimiento para la obtencion de esteres de acidos andros-tadien-17-carboxilicos.
ES467430A Expired ES467430A1 (es) 1976-02-24 1978-03-01 Procedimiento para la obtencion de esteres de acidos andros-tazdien-17-carboxilicos.
ES467432A Expired ES467432A1 (es) 1976-02-24 1978-03-01 Procedimiento para la obtencion de esteres de acidos andros-tadien-17-carboxilicos.
ES467433A Expired ES467433A1 (es) 1976-02-24 1978-03-01 Procedimiento para la obtencion de esteres de acidos andros-tadien-17-carboxilicos
ES467434A Expired ES467434A1 (es) 1976-02-24 1978-03-01 Procedimiento para la obtencion de esteres de acidos andros-tadien-17-carboxilicos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES456134A Expired ES456134A1 (es) 1976-02-24 1977-02-22 Procedimiento para la obtencion de esteres de acidos andros-tadien-17-carboxilicos.

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES467432A Expired ES467432A1 (es) 1976-02-24 1978-03-01 Procedimiento para la obtencion de esteres de acidos andros-tadien-17-carboxilicos.
ES467433A Expired ES467433A1 (es) 1976-02-24 1978-03-01 Procedimiento para la obtencion de esteres de acidos andros-tadien-17-carboxilicos
ES467434A Expired ES467434A1 (es) 1976-02-24 1978-03-01 Procedimiento para la obtencion de esteres de acidos andros-tadien-17-carboxilicos.

Country Status (26)

Country Link
US (1) US4285937A (es)
JP (1) JPS52102264A (es)
AT (1) AT361141B (es)
AU (1) AU513559B2 (es)
BE (1) BE851725A (es)
CA (1) CA1084483A (es)
CH (4) CH628355A5 (es)
CY (1) CY1198A (es)
DD (1) DD145918A5 (es)
DE (1) DE2707336A1 (es)
DK (1) DK153493C (es)
ES (5) ES456134A1 (es)
FR (2) FR2342302A1 (es)
GB (1) GB1578243A (es)
HK (1) HK57483A (es)
HU (1) HU176762B (es)
IE (1) IE45023B1 (es)
IL (2) IL51519A (es)
KE (1) KE3300A (es)
MX (1) MX9203366A (es)
MY (1) MY8500017A (es)
NL (1) NL7701886A (es)
NZ (1) NZ183418A (es)
SE (1) SE436572B (es)
SG (1) SG37383G (es)
ZA (1) ZA771087B (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4188385A (en) * 1978-04-05 1980-02-12 Syntex (U.S.A.) Inc. Thioetianic acid derivatives
PT69411A (en) * 1978-04-05 1979-04-01 Syntex Inc 4-halo etianic acids and derivatives thereof
US4198403A (en) * 1978-04-05 1980-04-15 Syntex (U.S.A.) Inc. 17 Beta-thiocarboxylic acid esters of 4-halo-3-oxoandrost-4-enes
DE3024008C2 (de) * 1980-06-24 1982-04-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von 17α-Hydroxy-etiocarbonsäuren
US4607028A (en) * 1983-08-18 1986-08-19 Ciba-Geigy Corporation Novel carboxylic acid esters
SE8306370D0 (sv) * 1983-11-18 1983-11-18 Draco Ab Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions
IL78144A0 (en) * 1985-04-04 1986-07-31 Draco Ab Novel androstane-17beta-carboxylic acid esters
SE8501693D0 (sv) * 1985-04-04 1985-04-04 Draco Ab Novel 16,17-acetalsubstituted androstane-17beta-carboxylic acid esters
WO1990015816A1 (en) * 1989-06-16 1990-12-27 The Upjohn Company Suramin type compounds and angiostatic steroids to inhibit angiogenesis
US6596260B1 (en) 1993-08-27 2003-07-22 Novartis Corporation Aerosol container and a method for storage and administration of a predetermined amount of a pharmaceutically active aerosol
US5646136A (en) * 1994-01-04 1997-07-08 Duke University Methods of inhibiting angiogenesis and tumor growth, and treating ophthalmologic conditions with angiostatic and therapeutic steroids
US5981517A (en) * 1996-05-09 1999-11-09 Soft Drugs, Inc. Androstene derivatives
GB0015876D0 (en) * 2000-06-28 2000-08-23 Novartis Ag Organic compounds
AR032471A1 (es) * 2000-08-05 2003-11-12 Glaxo Group Ltd Derivado de androstano y solvatos del mismo, su uso para la fabricacion de medicamentos, composiciones farmaceuticas que los comprenden, procesos para preparar tales derivados, intermediarios utiles en la preparacion de tales derivados, procesos para preparar tales intermediarios, y compuestos inter
US6750210B2 (en) * 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6858596B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6858593B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6777400B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6777399B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6787532B2 (en) * 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
GB0019172D0 (en) * 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
UA77656C2 (en) * 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
CA2445839A1 (en) * 2001-04-30 2002-11-07 Glaxo Group Limited Anti-inflammatory 17.beta.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.alpha
US20050175545A1 (en) * 2002-02-04 2005-08-11 Keith Biggadike Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist
GB0202635D0 (en) * 2002-02-05 2002-03-20 Glaxo Wellcome Mfg Pte Ltd Formulation containing novel anti-inflammatory androstane derivative
GB2389530B (en) * 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
KR20060032596A (ko) * 2003-06-19 2006-04-17 니콜라스 에스. 보도 국부 또는 다른 국소 투여를 위한 연성 항염증스테로이드의 활성 및/또는 작용기간의 증진
DE602004008083T2 (de) * 2003-06-19 2008-04-24 Nicholas S. Gainsville Bodor Verstärkung der aktivität und/oder wirkdauer von ausgewählten entzündungshemmenden steroiden
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
AU2006305620A1 (en) * 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Compositions of phosphodiesterase type IV inhibitors
US7687484B2 (en) * 2006-05-25 2010-03-30 Bodor Nicholas S Transporter enhanced corticosteroid activity
US7691811B2 (en) * 2006-05-25 2010-04-06 Bodor Nicholas S Transporter-enhanced corticosteroid activity and methods and compositions for treating dry eye
GB0615108D0 (en) * 2006-07-28 2006-09-06 Glaxo Group Ltd Novel formulations
US8227027B2 (en) 2007-12-07 2012-07-24 Presspart Gmbh & Co. Kg Method for applying a polymer coating to an internal surface of a container
EP2111861A1 (en) 2008-04-21 2009-10-28 Ranbaxy Laboratories Limited Compositions of phosphodiesterase type IV inhibitors
US8835410B2 (en) 2011-05-10 2014-09-16 Bodor Laboratories, Inc. Treatment of eyelid dermatitis
CN111100176A (zh) * 2019-12-20 2020-05-05 重庆华邦胜凯制药有限公司 一种化合物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3636010A (en) * 1968-12-23 1972-01-18 Ciba Geigy Corp Esters of steroid-17-carboxylic acids
GB1384372A (en) * 1971-01-20 1975-02-19 Glaxo Lab Ltd Dereivatives of 17alpha-hydroxyandrost-4-ene-17beta-carboxylic acids
GB1438940A (en) * 1972-07-19 1976-06-09 Glaxo Lab Ltd 17beta-haloalkoxycarbonyl-17alpha-oxysteroids
GB1514476A (en) * 1974-08-30 1978-06-14 Glaxo Lab Ltd Alkyl and haloalkyl androst-4-ene and androsta-1,4-diene-17beta-carboxylates
US4093721A (en) * 1974-08-30 1978-06-06 Glaxo Laboratories Limited Pharmaceutical compositions of 6α,9α-difluoro-androst-4-ene-17β-carboxylates and derivatives thereof

Also Published As

Publication number Publication date
BE851725A (fr) 1977-08-23
AU513559B2 (en) 1980-12-11
IL51519A0 (en) 1977-04-29
FR2369297B1 (es) 1981-03-06
DE2707336A1 (de) 1977-08-25
US4285937A (en) 1981-08-25
DK153493C (da) 1988-11-28
CA1084483A (en) 1980-08-26
FR2369297A1 (fr) 1978-05-26
SE436572B (sv) 1985-01-07
HK57483A (en) 1983-11-25
AU2257277A (en) 1978-08-31
JPS52102264A (en) 1977-08-27
ES467432A1 (es) 1979-08-16
DK79077A (da) 1977-08-25
IE45023B1 (en) 1982-06-02
ZA771087B (en) 1978-01-25
ATA119477A (de) 1980-07-15
GB1578243A (en) 1980-11-05
SE7701999L (sv) 1977-08-25
HU176762B (en) 1981-05-28
FR2342302A1 (fr) 1977-09-23
FR2342302B1 (es) 1981-01-09
IL51519A (en) 1983-03-31
DE2707336C2 (es) 1988-09-01
CH628641A5 (de) 1982-03-15
CH628356A5 (de) 1982-02-26
IE45023L (en) 1977-08-24
ES456134A1 (es) 1978-05-01
DD145918A5 (de) 1981-01-14
IL61512A0 (en) 1980-12-31
MY8500017A (en) 1985-12-31
NL7701886A (nl) 1977-08-26
SG37383G (en) 1984-02-17
AT361141B (de) 1981-02-25
NZ183418A (en) 1980-02-21
ES467433A1 (es) 1979-10-16
CH629824A5 (de) 1982-05-14
CH628355A5 (de) 1982-02-26
JPS6139959B2 (es) 1986-09-06
ES467434A1 (es) 1979-08-16
KE3300A (en) 1983-08-05
MX9203366A (es) 1992-09-01
CY1198A (en) 1983-12-31
DK153493B (da) 1988-07-18

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Legal Events

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PC1A Transfer granted