ES466205A1 - 3-substituted 1,2,4-triazines and their preparation - Google Patents

3-substituted 1,2,4-triazines and their preparation

Info

Publication number
ES466205A1
ES466205A1 ES466205A ES466205A ES466205A1 ES 466205 A1 ES466205 A1 ES 466205A1 ES 466205 A ES466205 A ES 466205A ES 466205 A ES466205 A ES 466205A ES 466205 A1 ES466205 A1 ES 466205A1
Authority
ES
Spain
Prior art keywords
group
naphthyl
triazines
phenyl
phenyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES466205A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dow Chemical Co
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/761,177 external-priority patent/US4071684A/en
Priority claimed from US05/803,927 external-priority patent/US4263295A/en
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of ES466205A1 publication Critical patent/ES466205A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e

Abstract

A nitrile is reacted with a 2-aminoethylhydrazine in the presence of transition metal salts or of elemental sulphur as catalyst. The new 3-diarylethyl-tetrahydro-1,2,4-triazines thus obtained, of formula < IMAGE > in which m = 0, n = 1, R is a hydrogen atom or a methyl or acetyl group, R1 is a hydrogen atom or a methyl group, A and B independently represent a naphthyl, 1,3-benzodioxol-5-yl or phenyl group or a phenyl group substituted by one or two fragments chosen from the following: lower alkyl, lower alkoxy, halo and naphthyl, provided that A is not a phenyl group when B is a phenyl or naphthyl group, and their pharmaceutically acceptable salts can be used as anxiolytic medicaments.
ES466205A 1977-01-21 1978-01-20 3-substituted 1,2,4-triazines and their preparation Expired ES466205A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/761,177 US4071684A (en) 1977-01-21 1977-01-21 Process for producing 3-substituted 1,2,4-triazines
US05/803,927 US4263295A (en) 1977-06-06 1977-06-06 Psychoactive 3-(1-2-diarylethyl)-1,4,5,6-tetrahydro-1,2,4-triazines and their method of use

Publications (1)

Publication Number Publication Date
ES466205A1 true ES466205A1 (en) 1979-06-01

Family

ID=27116938

Family Applications (1)

Application Number Title Priority Date Filing Date
ES466205A Expired ES466205A1 (en) 1977-01-21 1978-01-20 3-substituted 1,2,4-triazines and their preparation

Country Status (13)

Country Link
JP (1) JPS5395987A (en)
AT (1) AT360032B (en)
CH (1) CH639080A5 (en)
DE (1) DE2800385A1 (en)
DK (1) DK152755C (en)
ES (1) ES466205A1 (en)
FR (1) FR2378019A1 (en)
GB (1) GB1576579A (en)
IE (1) IE46246B1 (en)
IT (1) IT1111157B (en)
NL (1) NL7800535A (en)
NO (1) NO159529C (en)
SE (1) SE447380B (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3428635A (en) * 1966-12-05 1969-02-18 Dow Chemical Co Substituted 1,4,5,6 - tetrahydro - as - triazines and a method for their production
US3497509A (en) * 1966-12-05 1970-02-24 Dow Chemical Co Imino ester method for producing 1,4,5,6-tetrahydro-as-triazine
US3471486A (en) * 1967-10-23 1969-10-07 Dow Chemical Co 3-aralkyl-as-triazines

Also Published As

Publication number Publication date
JPS5395987A (en) 1978-08-22
FR2378019A1 (en) 1978-08-18
CH639080A5 (en) 1983-10-31
IE780115L (en) 1978-07-21
AT360032B (en) 1980-12-10
DE2800385A1 (en) 1978-07-27
IT7819422A0 (en) 1978-01-19
NO780201L (en) 1978-07-24
IT1111157B (en) 1986-01-13
NO159529C (en) 1989-01-11
DK23078A (en) 1978-07-22
DK152755C (en) 1988-10-03
DK152755B (en) 1988-05-09
NL7800535A (en) 1978-07-25
GB1576579A (en) 1980-10-08
FR2378019B1 (en) 1980-08-22
IE46246B1 (en) 1983-04-06
JPS6241227B2 (en) 1987-09-02
ATA44378A (en) 1980-05-15
SE447380B (en) 1986-11-10
DE2800385C2 (en) 1989-01-26
SE7800737L (en) 1978-07-22
NO159529B (en) 1988-10-03

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990503