ES461837A1 - Procedimiento para la preparacion de derivados de prostano. - Google Patents
Procedimiento para la preparacion de derivados de prostano.Info
- Publication number
- ES461837A1 ES461837A1 ES461837A ES461837A ES461837A1 ES 461837 A1 ES461837 A1 ES 461837A1 ES 461837 A ES461837 A ES 461837A ES 461837 A ES461837 A ES 461837A ES 461837 A1 ES461837 A1 ES 461837A1
- Authority
- ES
- Spain
- Prior art keywords
- cis
- alpha
- prostane derivatives
- inhibiting
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- UKVVPDHLUHAJNZ-PMACEKPBSA-N prostane Chemical class CCCCCCCC[C@H]1CCC[C@@H]1CCCCCCC UKVVPDHLUHAJNZ-PMACEKPBSA-N 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- 238000001311 chemical methods and process Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 210000004211 gastric acid Anatomy 0.000 abstract 1
- 230000029860 luteolysis Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Procedimiento para la preparación de derivados de fórmula general: (Fórmula I) En la que R1 es un radical hidroximetilo, n es 1 o 2, X es un radical etileno o trans-vinileno, Y es un enlace directo, un radical alquilenoxi C1-5 en el que el átomo de oxígeno está enlazado a R2, o un radical alquileno C1-5, y R2 es un radical fenilo opcionalmente sustituido por átomos de halógeno o radicales alquilo C1-5, alcoxi o halógeno-alquilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB34969/75A GB1516414A (en) | 1975-08-22 | 1975-08-22 | Prostane derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES461837A1 true ES461837A1 (es) | 1978-05-16 |
Family
ID=10372250
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES450866A Expired ES450866A1 (es) | 1975-08-22 | 1976-08-20 | Procedimiento para la preparacion de derivados de prostano. |
| ES461837A Expired ES461837A1 (es) | 1975-08-22 | 1977-08-23 | Procedimiento para la preparacion de derivados de prostano. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES450866A Expired ES450866A1 (es) | 1975-08-22 | 1976-08-20 | Procedimiento para la preparacion de derivados de prostano. |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US4241215A (es) |
| JP (1) | JPS5225746A (es) |
| AR (1) | AR211276A1 (es) |
| AT (1) | AT353431B (es) |
| AU (1) | AU510107B2 (es) |
| BE (1) | BE845404A (es) |
| CA (1) | CA1088932A (es) |
| DD (1) | DD125481A5 (es) |
| DE (1) | DE2637384A1 (es) |
| DK (1) | DK372376A (es) |
| ES (2) | ES450866A1 (es) |
| FI (1) | FI762386A (es) |
| FR (1) | FR2322587A1 (es) |
| GB (1) | GB1516414A (es) |
| IE (1) | IE43930B1 (es) |
| IL (1) | IL50213A0 (es) |
| IN (1) | IN144651B (es) |
| NL (1) | NL7609223A (es) |
| NO (1) | NO762708L (es) |
| SE (1) | SE424860B (es) |
| ZA (1) | ZA764646B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1582853A (en) * | 1977-06-16 | 1981-01-14 | Ici Ltd | Prostane derivatives |
| FR2399999A1 (fr) * | 1977-08-12 | 1979-03-09 | Ici Ltd | Carbamates ou esters de derives du 4-prostene-1-ol et composition pharmaceutique ou veterinaire les contenant |
| JPS5686083A (en) * | 1979-12-13 | 1981-07-13 | Trio Kenwood Corp | Controlling device for motor |
| JPS59148588A (ja) * | 1983-02-10 | 1984-08-25 | Fuji Photo Film Co Ltd | 電動機の速度制御装置 |
| CA2269853A1 (en) | 1996-11-12 | 1998-05-22 | Paul W. Zinke | Use of cis-.delta.4 analogs of prostaglandins as ocular hypotensives |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2317019A1 (de) * | 1972-04-27 | 1973-11-08 | Upjohn Co | Neue 4,5-didehydro-prostaglandine |
| DD118856A5 (es) * | 1972-11-08 | 1976-03-20 | ||
| US4032561A (en) * | 1975-05-27 | 1977-06-28 | The Upjohn Company | 17-Phenyl-18,19,20-trinor-cis-4,5-didehydro-PGF1.sub.α compounds |
-
1975
- 1975-08-22 GB GB34969/75A patent/GB1516414A/en not_active Expired
-
1976
- 1976-07-30 IE IE1696/76A patent/IE43930B1/en unknown
- 1976-08-02 ZA ZA764646A patent/ZA764646B/xx unknown
- 1976-08-04 IN IN1390/CAL/76A patent/IN144651B/en unknown
- 1976-08-04 NO NO762708A patent/NO762708L/no unknown
- 1976-08-04 AU AU16545/76A patent/AU510107B2/en not_active Expired
- 1976-08-06 IL IL50213A patent/IL50213A0/xx unknown
- 1976-08-11 US US05/713,505 patent/US4241215A/en not_active Expired - Lifetime
- 1976-08-18 DK DK372376A patent/DK372376A/da unknown
- 1976-08-19 DE DE19762637384 patent/DE2637384A1/de not_active Ceased
- 1976-08-19 NL NL7609223A patent/NL7609223A/xx not_active Application Discontinuation
- 1976-08-19 CA CA259,466A patent/CA1088932A/en not_active Expired
- 1976-08-19 SE SE7609235A patent/SE424860B/xx unknown
- 1976-08-20 AR AR264397A patent/AR211276A1/es active
- 1976-08-20 AT AT620076A patent/AT353431B/de not_active IP Right Cessation
- 1976-08-20 FI FI762386A patent/FI762386A/fi not_active Application Discontinuation
- 1976-08-20 ES ES450866A patent/ES450866A1/es not_active Expired
- 1976-08-20 FR FR7625397A patent/FR2322587A1/fr active Granted
- 1976-08-20 BE BE169985A patent/BE845404A/xx unknown
- 1976-08-20 DD DD194423A patent/DD125481A5/xx unknown
- 1976-08-23 JP JP51100474A patent/JPS5225746A/ja active Pending
-
1977
- 1977-08-23 ES ES461837A patent/ES461837A1/es not_active Expired
-
1979
- 1979-11-19 US US06/095,306 patent/US4306095A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU1654576A (en) | 1978-02-09 |
| IN144651B (es) | 1978-06-03 |
| GB1516414A (en) | 1978-07-05 |
| BE845404A (fr) | 1977-02-21 |
| SE424860B (sv) | 1982-08-16 |
| FR2322587A1 (fr) | 1977-04-01 |
| ATA620076A (de) | 1979-04-15 |
| SE7609235L (sv) | 1977-02-23 |
| ES450866A1 (es) | 1977-12-01 |
| US4241215A (en) | 1980-12-23 |
| DE2637384A1 (de) | 1977-03-03 |
| AR211276A1 (es) | 1977-11-15 |
| DK372376A (da) | 1977-02-23 |
| DD125481A5 (es) | 1977-04-20 |
| US4306095A (en) | 1981-12-15 |
| IE43930B1 (en) | 1981-07-01 |
| NL7609223A (nl) | 1977-02-24 |
| AT353431B (de) | 1979-11-12 |
| IL50213A0 (en) | 1976-10-31 |
| FR2322587B1 (es) | 1980-03-28 |
| JPS5225746A (en) | 1977-02-25 |
| FI762386A (es) | 1977-02-23 |
| CA1088932A (en) | 1980-11-04 |
| IE43930L (en) | 1977-02-22 |
| NO762708L (es) | 1977-02-23 |
| AU510107B2 (en) | 1980-06-05 |
| ZA764646B (en) | 1977-07-27 |
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