ES455918A1 - Procedimiento para preparar derivados de cefalosporina. - Google Patents

Procedimiento para preparar derivados de cefalosporina.

Info

Publication number
ES455918A1
ES455918A1 ES455918A ES455918A ES455918A1 ES 455918 A1 ES455918 A1 ES 455918A1 ES 455918 A ES455918 A ES 455918A ES 455918 A ES455918 A ES 455918A ES 455918 A1 ES455918 A1 ES 455918A1
Authority
ES
Spain
Prior art keywords
cephalosporin antibiotics
compounds
primary
useful
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES455918A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB6010/76A external-priority patent/GB1572993A/en
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Publication of ES455918A1 publication Critical patent/ES455918A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedimiento para preparar derivados de cefalosporina de fórmula general: **(Fórmula)** (donde R es un grupo alcohilo primario o secundario que contiene 1 a 4 átomos de carbono), caracterizado porque (A) se hace reaccionar ácido (6R,7R)-3-carbamoiloximetil-7-[(Z)-2-(fur-2-il)-2-metoxiiminoacetamido]cef-3-em-4-carboxílico (es decir, cefuroxima), o una sal del mismo, con un haloéster de fórmula: X.CH2.O.CO.R (donde R es como se ha definido antes, y X es halógeno).
ES455918A 1976-02-16 1977-02-15 Procedimiento para preparar derivados de cefalosporina. Expired ES455918A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB6010/76A GB1572993A (en) 1976-02-16 1976-02-16 Ester derivatives of cefuroxime
GB2730076 1976-06-30

Publications (1)

Publication Number Publication Date
ES455918A1 true ES455918A1 (es) 1978-01-01

Family

ID=26240323

Family Applications (1)

Application Number Title Priority Date Filing Date
ES455918A Expired ES455918A1 (es) 1976-02-16 1977-02-15 Procedimiento para preparar derivados de cefalosporina.

Country Status (14)

Country Link
US (1) US4446317A (es)
JP (1) JPS52100493A (es)
AT (1) AT358726B (es)
CA (1) CA1093549A (es)
CH (1) CH629814A5 (es)
DE (1) DE2706360A1 (es)
DK (1) DK63777A (es)
ES (1) ES455918A1 (es)
FR (1) FR2340951A1 (es)
IE (1) IE44698B1 (es)
IL (1) IL51451A (es)
NL (1) NL7701567A (es)
SE (1) SE432255B (es)
YU (1) YU41077A (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1598568A (en) * 1977-04-19 1981-09-23 Glaxo Lab Ltd Esters of(6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid
GB8400024D0 (en) * 1984-01-03 1984-02-08 Glaxo Group Ltd Cephalosporin antibiotics
GB8524001D0 (en) * 1985-09-30 1985-11-06 Glaxo Group Ltd Pharmaceutical composition
SE9804002D0 (sv) * 1998-11-23 1998-11-23 Astra Ab New manufacturing process

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1453049A (en) * 1973-08-21 1976-10-20 Glaxo Lab Ltd Cephalosporing antibiotics
US3974153A (en) * 1971-05-14 1976-08-10 Glaxo Laboratories Limited 7-Hydrocarbonoxy imino-acetamido-3-carbamoyloxy methylceph-3-em-4 carboxylic acids
GB1406113A (en) * 1972-10-05 1975-09-17 Leo Pharm Prod Ltd Process for the preparation of cephalosporin estets
PL98296B1 (pl) * 1973-02-07 1978-04-29 Politechnika Gdanskapo Sposob otrzymywania estrow acetoksymetylowych cefalosporyn
US3962227A (en) * 1973-02-23 1976-06-08 Eli Lilly And Company 3-halo cephalosporins
DK674674A (es) * 1973-12-21 1975-09-08 Glaxo Lab Ltd
CA1094545A (en) * 1976-02-16 1981-01-27 Michael Gregson Cephalosporin antibiotics

Also Published As

Publication number Publication date
ATA100577A (de) 1980-02-15
CH629814A5 (de) 1982-05-14
IL51451A (en) 1980-12-31
NL7701567A (nl) 1977-08-18
JPS52100493A (en) 1977-08-23
FR2340951A1 (fr) 1977-09-09
IE44698B1 (en) 1982-02-24
DE2706360A1 (de) 1977-08-18
SE7701667L (sv) 1977-08-17
IL51451A0 (en) 1977-04-29
DK63777A (da) 1977-08-17
YU41077A (en) 1982-06-30
CA1093549A (en) 1981-01-13
FR2340951B1 (es) 1981-11-06
US4446317A (en) 1984-05-01
SE432255B (sv) 1984-03-26
IE44698L (en) 1977-08-16
AT358726B (de) 1980-09-25

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19981103