ES454085A1 - Procedimiento para la preparacion de n-(r-tetrahidrofurfu- ril)-noroximorfona y n-(s-tetrahidrofurfuril)-noroximorfona nuevas. - Google Patents

Procedimiento para la preparacion de n-(r-tetrahidrofurfu- ril)-noroximorfona y n-(s-tetrahidrofurfuril)-noroximorfona nuevas.

Info

Publication number: ES454085A1
Authority: ES; Spain
Prior art keywords: tetrahydrofurfuril; noroximorphone; translation; preparation; machine
Prior art date: 1975-08-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES454085A

Other languages

English (en)

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

CH Boehringer Sohn AG and Co KG

Original Assignee

CH Boehringer Sohn AG and Co KG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-08-27

Filing date

1976-12-09

Publication date

1977-11-16

1976-12-09 Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG

1977-11-16 Publication of ES454085A1 publication Critical patent/ES454085A1/es

Status Expired legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pain & Pain Management (AREA)
Addiction (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

ES454085A 1975-08-27 1976-12-09 Procedimiento para la preparacion de n-(r-tetrahidrofurfu- ril)-noroximorfona y n-(s-tetrahidrofurfuril)-noroximorfona nuevas. Expired ES454085A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19752538075 DE2538075A1 (de)	1975-08-27	1975-08-27	N-tetrahydrofurfuryl-noroxymorphone, deren saeureadditionssalze, diese enthaltende arzneimittel sowie verfahren zu ihrer herstellung

Publications (1)

Publication Number	Publication Date
ES454085A1 true ES454085A1 (es)	1977-11-16

Family

ID=5954931

Family Applications (5)

Application Number	Title	Priority Date	Filing Date
ES450897A Expired ES450897A1 (es)	1975-08-27	1976-08-21	Procedimiento para la preparacion de n-(r-tetrahidrofurfu- ril)-noroximorfona y n-(s-tetrahidrofurfuril)-noroximorfona.
ES454086A Expired ES454086A1 (es)	1975-08-27	1976-12-09	Procedimiento para la preparacion de n-(r-tetrahidrofurfu- ril)-noroximorfona y n-(s-tetrahidrofurfuril)-norosimorfona nuevas.
ES454087A Expired ES454087A2 (es)	1975-08-27	1976-12-09	Procedimiento para la preparacion de n-(r-tetrahidrofurfu- ril)-noroximorfona y n-(s-tetrahidrofurfuril)-noroximorfona nuevas.
ES454084A Expired ES454084A1 (es)	1975-08-27	1976-12-09	Procedimiento para la preparmacion de n-(r-tetrahidrofurfu- ril)-noroximorfona y n-(s-tetrahidrofurfuril)-noroximorfona nuevas.
ES454085A Expired ES454085A1 (es)	1975-08-27	1976-12-09	Procedimiento para la preparacion de n-(r-tetrahidrofurfu- ril)-noroximorfona y n-(s-tetrahidrofurfuril)-noroximorfona nuevas.

Family Applications Before (4)

Application Number	Title	Priority Date	Filing Date
ES450897A Expired ES450897A1 (es)	1975-08-27	1976-08-21	Procedimiento para la preparacion de n-(r-tetrahidrofurfu- ril)-noroximorfona y n-(s-tetrahidrofurfuril)-noroximorfona.
ES454086A Expired ES454086A1 (es)	1975-08-27	1976-12-09	Procedimiento para la preparacion de n-(r-tetrahidrofurfu- ril)-noroximorfona y n-(s-tetrahidrofurfuril)-norosimorfona nuevas.
ES454087A Expired ES454087A2 (es)	1975-08-27	1976-12-09	Procedimiento para la preparacion de n-(r-tetrahidrofurfu- ril)-noroximorfona y n-(s-tetrahidrofurfuril)-noroximorfona nuevas.
ES454084A Expired ES454084A1 (es)	1975-08-27	1976-12-09	Procedimiento para la preparmacion de n-(r-tetrahidrofurfu- ril)-noroximorfona y n-(s-tetrahidrofurfuril)-noroximorfona nuevas.

Country Status (33)

Country	Link
US (1)	US4100288A (es)
JP (1)	JPS5231100A (es)
AT (1)	AT350737B (es)
AU (1)	AU499926B2 (es)
BE (1)	BE845563A (es)
BG (2)	BG27545A3 (es)
CA (1)	CA1068266A (es)
CH (5)	CH622521A5 (es)
CS (2)	CS192599B2 (es)
DD (1)	DD127145A5 (es)
DE (1)	DE2538075A1 (es)
DK (1)	DK143278C (es)
ES (5)	ES450897A1 (es)
FI (1)	FI762430A (es)
FR (1)	FR2321888A1 (es)
GB (1)	GB1519719A (es)
GR (1)	GR61158B (es)
HU (1)	HU176929B (es)
IE (1)	IE44069B1 (es)
IL (1)	IL50355A (es)
LU (1)	LU75667A1 (es)
MX (1)	MX4133E (es)
NL (1)	NL7609485A (es)
NO (1)	NO145793C (es)
NZ (1)	NZ181864A (es)
PH (1)	PH13780A (es)
PL (2)	PL110724B1 (es)
PT (1)	PT65521B (es)
RO (1)	RO69457A (es)
SE (1)	SE7609495L (es)
SU (2)	SU612631A3 (es)
YU (1)	YU208176A (es)
ZA (1)	ZA765120B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4272541A (en) *	1978-06-02	1981-06-09	Miles Laboratories, Inc.	7,8 and 7-8 Substituted 4,5α-epoxymorphinan-6-one compounds, and methods of treating pain and drug dependence with them
US4272540A (en) *	1979-04-24	1981-06-09	Sisa, Incorporated	14-Methoxymorphinan-6-one compounds and therapeutic methods of treating pain and drug dependence with them
DE3220831A1 (de) *	1982-06-03	1983-12-08	Boehringer Ingelheim KG, 6507 Ingelheim	N-(2-methoxyethyl)-noroxymorphon, dessen saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung
AU2007240680B2 (en) *	2006-04-21	2013-05-02	Nektar Therapeutics	Stereoselective reduction of a morphinone
ES2708726T3 (es) *	2010-07-08	2019-04-10	Alkermes Pharma Ireland Ltd	Proceso para la síntesis de morfinanos sustituidos
US9211293B2 (en)	2011-12-15	2015-12-15	Alkermes Pharma Ireland Limited	Opioid agonist antagonist combinations
US9656961B2 (en)	2013-05-24	2017-05-23	Alkermes Pharma Ireland Limited	Methods for treating depressive symptoms
CA2911231C (en)	2013-05-24	2021-12-07	Alkermes Pharma Ireland Limited	Morphan and morphinan analogues, and methods of use
CA3091826A1 (en) *	2018-02-23	2019-08-29	Rhodes Technologies	Novel opioid compounds and uses thereof
EP4243768A1 (en)	2020-11-12	2023-09-20	Alkermes Pharma Ireland Limited	Immediate release multilayer tablet

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH446370A (de)	1964-03-05	1967-11-15	Hoffmann La Roche	Verfahren zur Herstellung von Phenanthren-Derivaten
DE2238839A1 (de) *	1972-08-07	1974-02-14	Boehringer Sohn Ingelheim	Neue morphinon-derivate, deren saeureadditionssalze, verfahren zu ihrer herstellung sowie ihre verwendung zur herstellung von arzneimitteln

1975
- 1975-08-27 DE DE19752538075 patent/DE2538075A1/de not_active Withdrawn
1976
- 1976-07-28 AT AT553976A patent/AT350737B/de not_active IP Right Cessation
- 1976-08-12 PH PH18780A patent/PH13780A/en unknown
- 1976-08-13 US US05/714,045 patent/US4100288A/en not_active Expired - Lifetime
- 1976-08-13 RO RO7687297A patent/RO69457A/ro unknown
- 1976-08-21 ES ES450897A patent/ES450897A1/es not_active Expired
- 1976-08-23 SU SU762389512A patent/SU612631A3/ru active
- 1976-08-24 FI FI762430A patent/FI762430A/fi not_active Application Discontinuation
- 1976-08-25 BG BG7634062A patent/BG27545A3/xx unknown
- 1976-08-25 CS CS778646A patent/CS192599B2/cs unknown
- 1976-08-25 IL IL50355A patent/IL50355A/xx unknown
- 1976-08-25 DD DD194461A patent/DD127145A5/xx unknown
- 1976-08-25 CS CS765528A patent/CS192564B2/cs unknown
- 1976-08-25 BG BG7634743A patent/BG27546A4/xx unknown
- 1976-08-25 CH CH1079676A patent/CH622521A5/de not_active IP Right Cessation
- 1976-08-26 DK DK386876A patent/DK143278C/da active
- 1976-08-26 SE SE7609495A patent/SE7609495L/xx not_active Application Discontinuation
- 1976-08-26 IE IE1911/76A patent/IE44069B1/en unknown
- 1976-08-26 NL NL7609485A patent/NL7609485A/xx not_active Application Discontinuation
- 1976-08-26 PT PT65521A patent/PT65521B/pt unknown
- 1976-08-26 ZA ZA00765120A patent/ZA765120B/xx unknown
- 1976-08-26 GR GR51547A patent/GR61158B/el unknown
- 1976-08-26 AU AU17201/76A patent/AU499926B2/en not_active Expired
- 1976-08-26 PL PL1976213963A patent/PL110724B1/pl unknown
- 1976-08-26 LU LU75667A patent/LU75667A1/xx unknown
- 1976-08-26 NO NO762932A patent/NO145793C/no unknown
- 1976-08-26 HU HU76BO1629A patent/HU176929B/hu unknown
- 1976-08-26 CA CA259,909A patent/CA1068266A/en not_active Expired
- 1976-08-26 JP JP51102168A patent/JPS5231100A/ja active Pending
- 1976-08-26 YU YU02081/76A patent/YU208176A/xx unknown
- 1976-08-26 MX MX764858U patent/MX4133E/es unknown
- 1976-08-26 BE BE170118A patent/BE845563A/xx unknown
- 1976-08-26 PL PL1976192020A patent/PL109091B1/pl unknown
- 1976-08-26 GB GB35603/76A patent/GB1519719A/en not_active Expired
- 1976-08-26 NZ NZ181864A patent/NZ181864A/xx unknown
- 1976-08-27 FR FR7625985A patent/FR2321888A1/fr active Granted
- 1976-12-09 ES ES454086A patent/ES454086A1/es not_active Expired
- 1976-12-09 ES ES454087A patent/ES454087A2/es not_active Expired
- 1976-12-09 ES ES454084A patent/ES454084A1/es not_active Expired
- 1976-12-09 ES ES454085A patent/ES454085A1/es not_active Expired
1977
- 1977-05-31 SU SU772485952A patent/SU638262A3/ru active
1980
- 1980-09-18 CH CH699680A patent/CH624117A5/de not_active IP Right Cessation
- 1980-09-18 CH CH699580A patent/CH624116A5/de not_active IP Right Cessation
- 1980-09-18 CH CH699380A patent/CH624114A5/de not_active IP Right Cessation
- 1980-09-18 CH CH699480A patent/CH624115A5/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
FR2321888B1 (es)	1980-01-11
NO145793C (no)	1982-06-02
ZA765120B (en)	1978-05-30
CH624117A5 (es)	1981-07-15
FR2321888A1 (fr)	1977-03-25
PT65521A (de)	1976-09-01
DK143278C (da)	1981-12-07
BG27546A4 (en)	1979-11-12
NO762932L (es)	1977-03-01
IE44069L (en)	1977-02-27
PL109091B1 (en)	1980-05-31
PT65521B (de)	1978-07-04
PH13780A (en)	1980-09-26
ES450897A1 (es)	1977-12-01
CS192599B2 (en)	1979-08-31
DD127145A5 (es)	1977-09-07
CH624114A5 (es)	1981-07-15
GR61158B (en)	1978-09-30
DK386876A (da)	1977-02-28
RO69457A (ro)	1981-04-30
BE845563A (fr)	1977-02-28
CH624115A5 (es)	1981-07-15
NO145793B (no)	1982-02-22
PL192020A1 (pl)	1979-03-12
MX4133E (es)	1982-01-06
FI762430A (es)	1977-02-28
BG27545A3 (en)	1979-11-12
YU208176A (en)	1982-08-31
ES454086A1 (es)	1977-11-16
SE7609495L (sv)	1977-02-28
IL50355A0 (en)	1976-10-31
SU612631A3 (ru)	1978-06-25
AU499926B2 (en)	1979-05-03
SU638262A3 (ru)	1978-12-15
AU1720176A (en)	1978-03-02
ES454084A1 (es)	1977-11-16
CS192564B2 (en)	1979-08-31
ATA553976A (de)	1978-11-15
JPS5231100A (en)	1977-03-09
ES454087A2 (es)	1977-11-16
PL110724B1 (en)	1980-07-31
GB1519719A (en)	1978-08-02
DK143278B (da)	1981-08-03
US4100288A (en)	1978-07-11
IE44069B1 (en)	1981-08-12
CA1068266A (en)	1979-12-18
CH622521A5 (es)	1981-04-15
CH624116A5 (es)	1981-07-15
LU75667A1 (es)	1977-09-13
IL50355A (en)	1979-11-30
AT350737B (de)	1979-06-11
HU176929B (hu)	1981-06-28
NL7609485A (nl)	1977-03-01
DE2538075A1 (de)	1977-03-17
NZ181864A (en)	1978-06-20

Publication	Publication Date	Title
BE848712A (fr)	1977-05-24	Compositions d'acides carboxyliques,
ES454085A1 (es)	1977-11-16	Procedimiento para la preparacion de n-(r-tetrahidrofurfu- ril)-noroximorfona y n-(s-tetrahidrofurfuril)-noroximorfona nuevas.
ES455691A1 (es)	1978-01-01	Procedimiento para la produccion de derivados de piperacina.
SE7411243L (es)	1975-05-02
SE431205B (sv)	1984-01-23	Forfarande for framstellning av estrar av 3-aminometylen-6,7-dimetoxi-2-metyl-4-oxo-1,2,3,4-tetrahydro-1-kinolinkarboxylsyra
ES446187A1 (es)	1977-10-01	Un metodo de preparar nuevos compuestos de oxima-eter.
ES386969A1 (es)	1973-04-16	Un metodo para preparar una amidinourea.
ES458389A1 (es)	1978-02-16	Procedimiento para preparar derivados de prostaglandina.
SE427276B (sv)	1983-03-21	Forfarande for framstellning av d-homosteroider
JPS5285163A (en)	1977-07-15	Preparation of malenimide derivatives
ES433723A1 (es)	1976-11-16	Procedimiento de obtencion de un derivado de 2-pirrolidi- nona.
ES429817A1 (es)	1976-09-01	Procedimiento para preparar derivados del acido tricloro- acetamido-6 penicilanico.
JPS51138664A (en)	1976-11-30	Process for preparing 4-exo-hydroxy-endo-tri cyclo 95.2.2.02,6)-undeca-8-ene
JPS5219681A (en)	1977-02-15	Preparation of thiouridine derivatives
ES428011A1 (es)	1976-07-16	Procedimiento para la preparacion de 2-amino-3,5-dibromo- bencilamina.
ES413391A1 (es)	1976-01-16	Procedimiento de preparacion de n-(aminoalcohil terciario)-2-alcoxi-benzamidas.
ES429857A1 (es)	1976-09-01	Procedimiento para preparar derivados del acido monoclora- cetamido-7 desacetoxi-3 cefalosporanico.
JPS51138698A (en)	1976-11-30	Process preparing 2-cycloalkylthioadenine s
ES427954A1 (es)	1976-09-01	Procedimiento para la preparacion de 2-amino - n - ciclohe-xil-3,5-dibromo - n - metil-bencilamina.
ES458425A1 (es)	1978-03-16	Un procedimiento para la preparacion de nuevos derivados de 3-cianopiridinas.
ES403885A1 (es)	1975-05-01	Un procedimiento de preparacion de derivados sustituidos enn' de la n-(trimetoxi-3,4,5) cinamoil-piperazina.
ES457552A1 (es)	1978-03-16	Procedimiento para la preparacion de aminoalcoxi-cicloalca- nos.
JPS51136643A (en)	1976-11-26	Process for preparation of aromatic ester derivatives
ES457688A1 (es)	1978-02-01	Nuevo procedimiento de obtencion de sales acidas de adicion de 3-fenil-5-dietilamino-etil-1,2-4,-oxodiazol.
ES428270A1 (es)	1977-01-01	Procedimiento de preparacion del sec. butil-2-metil-1 nitro-5 imidazol.