ES448168A1 - Pyrimidines and in their preparation - Google Patents
Pyrimidines and in their preparationInfo
- Publication number
- ES448168A1 ES448168A1 ES448168A ES448168A ES448168A1 ES 448168 A1 ES448168 A1 ES 448168A1 ES 448168 A ES448168 A ES 448168A ES 448168 A ES448168 A ES 448168A ES 448168 A1 ES448168 A1 ES 448168A1
- Authority
- ES
- Spain
- Prior art keywords
- water
- formula
- solvent
- solution
- see formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A procedure for the preparation of new pyrimidine derivatives of the formula: **(See formula)** where R1 and R3 represent hydrogen atoms or alkyl groups of 1 to 4 carbon atoms, R2 and R4 represent hydrogen atoms, alkyl groups of 1 to 8 carbon atoms, dialkyl aminoalkyl or aryl, the groups (see formula) can also represent piperazinyl groups optionally substituted in the nitrogen at position 4 with a methyl, phenyl or benzyl group; whose procedure consists of: a) reacting the compounds of formula: **(See formula)** where R1, R2, R3 and R4 have the meaning given in formula (I), in a mixture of water and a water-miscible solvent, in a homogeneous phase, in a neutral or acidic medium and at a temperature between 0ºC and 50ºC, with a solution of bromine in water or in a solvent miscible with water or with a solution of an oxygenated derivative of bromine, b) neutralize the medium after the reaction, adding a solution of an alkaline hydroxide; c) extracting the obtained product, using a solvent insoluble in water; and d) evaporating said solvent. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7516088A FR2311776A1 (en) | 1975-05-23 | 1975-05-23 | 2,4-DIAMINO-5-CHLORO-6 PYRIMIDINES AND PROCESS FOR THEIR PREPARATION |
FR7516089A FR2311547A1 (en) | 1975-05-23 | 1975-05-23 | 2,4-Diamino 5-bromo 6-chloro pyrimidines - with antiulcer, antispasmodic, antiemetic psychotropic activity |
Publications (1)
Publication Number | Publication Date |
---|---|
ES448168A1 true ES448168A1 (en) | 1977-12-01 |
Family
ID=26218882
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES448168A Expired ES448168A1 (en) | 1975-05-23 | 1976-05-21 | Pyrimidines and in their preparation |
Country Status (10)
Country | Link |
---|---|
CA (1) | CA1068270A (en) |
CH (1) | CH602663A5 (en) |
DE (1) | DE2622639A1 (en) |
ES (1) | ES448168A1 (en) |
GB (1) | GB1554227A (en) |
IT (1) | IT1070500B (en) |
LU (1) | LU75002A1 (en) |
MX (1) | MX3527E (en) |
NL (1) | NL7605319A (en) |
PT (1) | PT65122B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0111440A1 (en) * | 1982-10-15 | 1984-06-20 | Ciba-Geigy Ag | 2-Aminopyrimidines, their production and use |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2257294B1 (en) * | 1973-07-06 | 1977-07-01 | Ugine Kuhlmann | |
CH512187A (en) * | 1969-02-14 | 1971-09-15 | Sandoz Ag | Herbicidal agent |
FR2173746B1 (en) * | 1972-03-01 | 1975-04-25 | Ugine Kuhlmann |
-
1976
- 1976-05-19 NL NL7605319A patent/NL7605319A/en not_active Application Discontinuation
- 1976-05-19 CH CH627176A patent/CH602663A5/xx not_active IP Right Cessation
- 1976-05-20 DE DE19762622639 patent/DE2622639A1/en not_active Ceased
- 1976-05-21 PT PT6512276A patent/PT65122B/en unknown
- 1976-05-21 GB GB2100276A patent/GB1554227A/en not_active Expired
- 1976-05-21 LU LU75002A patent/LU75002A1/xx unknown
- 1976-05-21 ES ES448168A patent/ES448168A1/en not_active Expired
- 1976-05-21 IT IT6824376A patent/IT1070500B/en active
- 1976-05-21 CA CA253,151A patent/CA1068270A/en not_active Expired
- 1976-05-31 MX MX10034476U patent/MX3527E/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA1068270A (en) | 1979-12-18 |
MX3527E (en) | 1981-01-27 |
LU75002A1 (en) | 1977-01-19 |
NL7605319A (en) | 1976-11-25 |
GB1554227A (en) | 1979-10-17 |
PT65122B (en) | 1977-10-11 |
DE2622639A1 (en) | 1976-12-09 |
PT65122A (en) | 1976-06-01 |
IT1070500B (en) | 1985-03-29 |
CH602663A5 (en) | 1978-07-31 |
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