ES440054A1 - A procedure for the preparation of cephalosporins. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

A procedure for the preparation of structure cephalosporins **(See formula)** where R is selected from the group consisting of hydrogen, C1 -C4 -alkyl and from the following groups: cyano-methyl, thienyl-methyl, furyl-methyl, naphthyl-methyl, phenyl-methyl, phenoxy-methyl, phenyl-isopropyl, phenoxy-isopropyl, pyridyl-4-thiomethyl, tetrazolyl-1-methyl; R1 is selected from the group consisting of: hydroxyl, alkoxy with 1 to 4 carbon atoms, trichloro-ethoxy, benzyloxy, p-methoxybenzyloxy, p-nitrobenzyloxy, benzydryloxy, triphenyl-methoxy, phenyloxy, p-halo-phenyloxy; Z is chosen from the group consisting of hydrogen, hydroxyl, -O-alkyl, -O-CO-alkyl and from the radicals -Br, -I, -NH3, -NH2, -O-COCH3, -O-CO-NH2 and mononuclear nitrogenous S heterocyclic ring, characterized in that a compound of the structure is reacted: **(See formula)** in which R, R1 and Z have the meaning indicated above, with iodine in an appropriate aqueous solvent at a temperature between 5ºC and 80ºC, in the presence of heavy metal oxides or with free radical initiators, under the influence of light or heat, for obtain an intermediate structure compound: **(See formula)** in which R, R1 and Z have the aforementioned meaning, whose intermediate (II) is reacted, in an appropriate solvent, with a compound chosen from the group consisting of inorganic or organic bases to finally obtain the compound of structure (III), which is isolated and purified in a known way. (Machine-translation by Google Translate, not legally binding)