ES439141A1 - Alkenylxanthines and their conversion to hydroxyalkylxanthines - Google Patents

Alkenylxanthines and their conversion to hydroxyalkylxanthines

Info

Publication number
ES439141A1
ES439141A1 ES439141A ES439141A ES439141A1 ES 439141 A1 ES439141 A1 ES 439141A1 ES 439141 A ES439141 A ES 439141A ES 439141 A ES439141 A ES 439141A ES 439141 A1 ES439141 A1 ES 439141A1
Authority
ES
Spain
Prior art keywords
atoms
prepared
radicals
alkenylxanthines
monoalkenyldialkylxanthines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES439141A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/485,869 external-priority patent/US4108995A/en
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES439141A1 publication Critical patent/ES439141A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/10—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 3 and 7, e.g. theobromine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)

Abstract

In the process there are prepared novel monoalkenyldialkylxanthines of the general formula I < IMAGE > One of the radicals R<1>, R<2> and R<3> is ( omega -1)-alken-1-yl having 4 to 8 C atoms, which does not have a branch in the ( omega -1)-position. The two other radicals are alkyl having 1 to 12 C atoms. According to the invention, a 1-halo-C4-C8-alkene having a terminal double bond, but not one containing a tertiary C atom, is reacted with an appropriate alkali metal salt of a dialkylxanthine. Haloalkenes having an unbranched carbon chain are preferably employed. Monoalkenyldialkylxanthines of the formula I may expediently be prepared in which one of the two alkyl radicals has 2 to 12 C atoms. The alkenylxanthines prepared are useful as starting substances for the preparation of therapeutically utilisable hydroxyalkylxanthine compounds, of which e.g. 1-(5'-hydroxyhexyl)theobromine is distinguished by promotion of the circulation.
ES439141A 1974-07-05 1975-07-04 Alkenylxanthines and their conversion to hydroxyalkylxanthines Expired ES439141A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48587074A 1974-07-05 1974-07-05
US05/485,869 US4108995A (en) 1973-07-11 1974-07-05 Hydroxyhexyl-alkylxanthines and pharmaceutical compositions containing hydroxyhexyl-alkylxanthines

Publications (1)

Publication Number Publication Date
ES439141A1 true ES439141A1 (en) 1977-02-16

Family

ID=27048497

Family Applications (1)

Application Number Title Priority Date Filing Date
ES439141A Expired ES439141A1 (en) 1974-07-05 1975-07-04 Alkenylxanthines and their conversion to hydroxyalkylxanthines

Country Status (14)

Country Link
JP (1) JPS5250800B2 (en)
AR (1) AR210330A1 (en)
AT (1) AT339917B (en)
CA (1) CA1062710A (en)
CH (2) CH622519A5 (en)
DK (1) DK140214B (en)
ES (1) ES439141A1 (en)
FI (1) FI59249C (en)
FR (1) FR2277089A1 (en)
GB (1) GB1500039A (en)
LU (1) LU72897A1 (en)
NL (1) NL166476C (en)
NO (1) NO143224C (en)
SE (2) SE420097B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU197569B (en) * 1984-01-12 1989-04-28 Sandoz Ag Process for producing 8alpha-acylaminoergoline derivatives and pharmaceuticals comprising such compounds
DE3525801A1 (en) * 1985-07-19 1987-01-22 Hoechst Ag TERTIA HYDROXYALKYLXANTHINE, METHOD FOR THE PRODUCTION THEREOF, THE MEDICINAL PRODUCT CONTAINING IT AND THEIR USE
EP0570831A2 (en) * 1992-05-20 1993-11-24 Hoechst Aktiengesellschaft Use of Xanthinderivatives for treatment of cerebral nerve dammages after disruption of the blood circulation

Also Published As

Publication number Publication date
CA1062710A (en) 1979-09-18
SE427183B (en) 1983-03-14
GB1500039A (en) 1978-02-08
NO752423L (en) 1976-01-06
SE7507726L (en) 1976-01-07
FI59249C (en) 1981-07-10
FR2277089A1 (en) 1976-01-30
JPS5134194A (en) 1976-03-23
NO143224B (en) 1980-09-22
ATA517275A (en) 1977-03-15
SE420097B (en) 1981-09-14
LU72897A1 (en) 1976-05-31
FR2277089B1 (en) 1978-03-17
NL7507976A (en) 1976-01-07
AU8275575A (en) 1977-01-06
NL166476B (en) 1981-03-16
JPS5250800B2 (en) 1977-12-27
DK140214B (en) 1979-07-09
DK301775A (en) 1976-01-06
FI59249B (en) 1981-03-31
AT339917B (en) 1977-11-10
NL166476C (en) 1981-08-17
AR210330A1 (en) 1977-07-29
CH622519A5 (en) 1981-04-15
DK140214C (en) 1979-12-03
CH622018A5 (en) 1981-03-13
SE7807853L (en) 1978-07-14
FI751958A (en) 1976-01-06
NO143224C (en) 1981-01-02

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