ES438601A1 - Procedure for the obtaining of new diazepine derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Process for obtaining new diazepine derivatives of general formula I: ** (See formula) ** wherein R 1 signifies hydrogen or an alkyl group with 1 to 3 carbon atoms and R 2 and R 3 signify hydrogen, alkyl groups with 1 to 6 carbon atoms or hydroxyalkyl groups with 2 to 6 carbon atoms, dialkylaminoalkyl groups with a total of 4 to 7 carbon atoms, or aralkyl groups with 7 to 9 carbon atoms, the lower alkyl groups being able to R2 and R3 in the β or γ be linked directly or also through an oxygen atom, the imino group, an alkyloimino or hydroxyalkyloimino group with a maximum of 4 carbon atoms to a bivalent radical with a total of 10 carbon atoms and the A and B can be substituted by halogen up to the atomic number 35, alkyl or alkoxy groups, each having 1 to 6 carbon atoms, trifluoromethyl groups or nitro groups, as well as the 5-oxides and the addition salts of the compounds of the general formula I with inorganic and organic acids, characterized in that a compound of general formula II: ** (See formula) ** where Y means the amino group or a nitrogenous group transformable in situ therein by reduction or solvolysis, R1, R2 and R3 have the meanings indicated under formula I and rings A and B may be substituted as indicated therein, cyclized or it is subjected to a reduction or solvolysis under cyclising conditions and the reaction product obtained from the general formula I, if desired, is oxidized to its 5-oxide or, if desired, is transformed into an addition salt with an inorganic acid or organic (Machine-translation by Google Translate, not legally binding)