ES432475A1 - Procedure for the preparation of new derivatives of bifenilo. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of new derivatives of bifenilo. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES432475A1 ES432475A1 ES432475A ES432475A ES432475A1 ES 432475 A1 ES432475 A1 ES 432475A1 ES 432475 A ES432475 A ES 432475A ES 432475 A ES432475 A ES 432475A ES 432475 A1 ES432475 A1 ES 432475A1
- Authority
- ES
- Spain
- Prior art keywords
- radical
- general formula
- formula
- group
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002360 preparation method Methods 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- -1 alkali metal salt Chemical class 0.000 abstract 2
- 150000007529 inorganic bases Chemical class 0.000 abstract 2
- 150000007530 organic bases Chemical class 0.000 abstract 2
- WDJHALXBUFZDSR-UHFFFAOYSA-N Acetoacetic acid Natural products CC(=O)CC(O)=O WDJHALXBUFZDSR-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical class C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000001640 fractional crystallisation Methods 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
- C07C245/12—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom
- C07C245/14—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5407—Acyclic saturated phosphonium compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedure for the preparation of new biphenyl derivatives of the general formula I, **(See formula)** wherein the radical signifies a halogen atom and the radical B signifies the hydroxy group, an alkoxy or aralkoxy group or a group of the formula (see formula), in which R3 and R4, which may be the same or different from each other, represent hydrogen atoms, the carboxymethyl radical, a lower alcohol radical or a phenyl radical optionally substituted by a hydroxy or methyl group, and, in the case of that B means the hydroxy group, of its salts with organic or inorganic bases, characterized in that for the preparation of compounds of the general formula I, in which B means the hydroxy group, an alkoxy or aralkoxy radical, a compound of the general formula II **(See formula)** in which the radical has the meanings indicated above and Hal means a halogen atom, firstly with an alkali metal salt of an acetoacetic acid ester to form a compound of the general formula III. **(See formula)** wherein the radical R7 signifies an alcoholic or aralkoxy radical, in a solvent, and then the β-keto-carboxylic acid ester of the general formula III is cleaved by strong alkalis to form a compound of the formula I; and the eventually obtained racemates are split by fractional crystallization of their salts with optically active bases into their two optically active individual components, and if desired, compounds obtained from the general formula I, in which B means the alkoxy group, or are saponified to form compounds of the general formula I, in which B represents the hydroxy group, and if desired, compounds obtained from the general formula I, in which B is the hydroxy group, are transformed according to methods customary in their esters or in its salts by means of organic or inorganic bases or, if desired, for the preparation of compounds of the general formula I, in which B means the radical (see formula), a compound of the general formula I in which B represents an alkoxy group or a halogen atom, is reacted with a primary or secondary amine at elevated temperatures. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19732300402 DE2300402A1 (en) | 1973-01-05 | 1973-01-05 | Antiphlogistic butyric acid derivs - 3-(halo-substd.-4-biphenylyl)-butyric acid derivs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES432475A1 true ES432475A1 (en) | 1976-11-01 |
Family
ID=5868340
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES432475A Expired ES432475A1 (en) | 1973-01-05 | 1974-11-30 | Procedure for the preparation of new derivatives of bifenilo. (Machine-translation by Google Translate, not legally binding) |
Country Status (5)
| Country | Link |
|---|---|
| BG (1) | BG21848A3 (en) |
| CS (1) | CS165397B2 (en) |
| DE (1) | DE2300402A1 (en) |
| ES (1) | ES432475A1 (en) |
| HU (1) | HU169142B (en) |
-
1973
- 1973-01-05 DE DE19732300402 patent/DE2300402A1/en active Pending
- 1973-08-15 HU HUTO000975 patent/HU169142B/hu unknown
- 1973-08-16 CS CS491473A patent/CS165397B2/cs unknown
-
1974
- 1974-09-14 BG BG2768174A patent/BG21848A3/xx unknown
- 1974-11-30 ES ES432475A patent/ES432475A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| HU169142B (en) | 1976-09-28 |
| CS165397B2 (en) | 1975-12-22 |
| BG21848A3 (en) | 1976-09-20 |
| DE2300402A1 (en) | 1974-07-18 |
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