ES422465A1 - Preparation of 2-alkylaminoalkyl 6-methyl-7-nitro- 1,2,3,4-tetrahydroquinolines - Google Patents

Preparation of 2-alkylaminoalkyl 6-methyl-7-nitro- 1,2,3,4-tetrahydroquinolines

Info

Publication number
ES422465A1
ES422465A1 ES422465A ES422465A ES422465A1 ES 422465 A1 ES422465 A1 ES 422465A1 ES 422465 A ES422465 A ES 422465A ES 422465 A ES422465 A ES 422465A ES 422465 A1 ES422465 A1 ES 422465A1
Authority
ES
Spain
Prior art keywords
nitro
formula
tetrahydroquinolines
methyl
alkylaminoalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES422465A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp
Original Assignee
Pfizer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp filed Critical Pfizer Corp
Publication of ES422465A1 publication Critical patent/ES422465A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C07D215/28—Alcohols; Ethers thereof with halogen atoms or nitro radicals in positions 5, 6 or 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals

Abstract

Procedure to prepare 2-aminoalkyl-6-methyl-7-nitro-1,2,3,4-tetrahydroquinolines, of general formula: **(See formula)** where R is a lower alkyl group, such as an alkyl group with up to 6 carbon atoms, and n is 1 or 2; characterized by comprising nitrating a compound of the formula: **(See formula)** wherein Ac is an acyl group, to form the 7-nitro derivative thereof; and hydrolyzing the latter, in the presence of an acid, to separate the acyl groups, a compound of formula (I) being isolated as a product. (Machine-translation by Google Translate, not legally binding)
ES422465A 1973-01-20 1974-01-19 Preparation of 2-alkylaminoalkyl 6-methyl-7-nitro- 1,2,3,4-tetrahydroquinolines Expired ES422465A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB306873A GB1397387A (en) 1973-01-20 1973-01-20 Preparation of 2-alkylaminoalkyl 6-methyl-7-nitro- 1,2,3,4-tetrahydroquinolines

Publications (1)

Publication Number Publication Date
ES422465A1 true ES422465A1 (en) 1976-05-01

Family

ID=9751399

Family Applications (1)

Application Number Title Priority Date Filing Date
ES422465A Expired ES422465A1 (en) 1973-01-20 1974-01-19 Preparation of 2-alkylaminoalkyl 6-methyl-7-nitro- 1,2,3,4-tetrahydroquinolines

Country Status (5)

Country Link
JP (1) JPS5429510B2 (en)
CH (1) CH590843A5 (en)
ES (1) ES422465A1 (en)
GB (1) GB1397387A (en)
NL (1) NL159378B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5056535A (en) * 1973-09-21 1975-05-17
JPS50160739A (en) * 1974-06-18 1975-12-26
JPS51138828A (en) * 1975-05-26 1976-11-30 Fujikura Ltd Method of manufacturing separator for battery
FR2393815A1 (en) * 1977-06-07 1979-01-05 Solvay PROCESS FOR THE AQUEOUS SUSPENSION POLYMERIZATION OF VINYL CHLORIDE
DE19935692A1 (en) * 1999-07-29 2001-02-01 Merck Patent Gmbh Nitriding in a static micromixer

Also Published As

Publication number Publication date
JPS5429510B2 (en) 1979-09-25
JPS5012092A (en) 1975-02-07
GB1397387A (en) 1975-06-11
NL7400700A (en) 1974-07-23
NL159378B (en) 1979-02-15
CH590843A5 (en) 1977-08-31

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