ES421133A1 - 1-phenoxy-2-hydroxy-3-chromonyloxy-propane derivatives - Google Patents

1-phenoxy-2-hydroxy-3-chromonyloxy-propane derivatives

Info

Publication number
ES421133A1
ES421133A1 ES421133A ES421133A ES421133A1 ES 421133 A1 ES421133 A1 ES 421133A1 ES 421133 A ES421133 A ES 421133A ES 421133 A ES421133 A ES 421133A ES 421133 A1 ES421133 A1 ES 421133A1
Authority
ES
Spain
Prior art keywords
group
see formula
formula
chloride
toluenesulfonyl chloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES421133A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc
Publication of ES421133A1 publication Critical patent/ES421133A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A process for preparing 1- (substituted phenoxy) -2-hydroxy-3- [2- (5-1H-tetrazolyl) -chromyloxy] -propanes having the formula **(See formula)** wherein each of R1 and R2 is selected from the group consisting of hydrogen, halogen, nitro, cyano, C 1 -C 4 -alkoxy, and C 1 -C 4 -alkoxy, the method of which comprises: reacting with ammonia a compound having the formula **(See formula)** wherein R3 is an alcoholic group of 1 to 4 carbon atoms and R1 and R2 have the same meaning as defined above, in a solvent selected from the group consisting of ethanol, chloroform, methanol, and a chloroform/methanol mixture, to obtain the corresponding amide, **(See formula)** dehydrate the amide with a reagent selected from the group consisting of p-toluenesulfonyl chloride/pyridine, p-toluenesulfonyl chloride/lutidine, and p-toluenesulfonyl chloride/collidine in dimethylformamide, to obtain the corresponding nitrile in which the hydroxyl group in position 2 it is protected by a formyl group, **(See formula)** reacting the nitrile with sodium azide and ammonium chloride or lithium chloride in the presence of a second solvent selected from the group consisting of dimethylformamide, dimethyl sulfoxide and dimethylacetamide, to obtain the corresponding tetrazole salt, **(See formula)** wherein X is selected from the group consisting of sodium, lithium, or ammonia; and, acidifying the tetrazole salt and making the hydroxyl group in position 2 formylated with a dilute mineral acid to obtain the compound. (Machine-translation by Google Translate, not legally binding)
ES421133A 1972-12-05 1973-12-04 1-phenoxy-2-hydroxy-3-chromonyloxy-propane derivatives Expired ES421133A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5611772A GB1457254A (en) 1972-12-05 1972-12-05 1-phenoxy-2-hydroxy-3-chromonyloxy-propane derivatives

Publications (1)

Publication Number Publication Date
ES421133A1 true ES421133A1 (en) 1976-04-16

Family

ID=10475767

Family Applications (1)

Application Number Title Priority Date Filing Date
ES421133A Expired ES421133A1 (en) 1972-12-05 1973-12-04 1-phenoxy-2-hydroxy-3-chromonyloxy-propane derivatives

Country Status (16)

Country Link
JP (2) JPS533392B2 (en)
AR (1) AR199426A1 (en)
AU (1) AU460893B2 (en)
BE (1) BE808190A (en)
CA (1) CA1016178A (en)
CH (1) CH585749A5 (en)
DE (1) DE2360355C3 (en)
ES (1) ES421133A1 (en)
FR (1) FR2208674B1 (en)
GB (1) GB1457254A (en)
HU (1) HU166457B (en)
IL (1) IL43761A (en)
NL (1) NL179056C (en)
NO (1) NO138661C (en)
SE (3) SE404605B (en)
ZA (1) ZA739197B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5811141U (en) * 1981-07-14 1983-01-24 本田技研工業株式会社 brake disc
JPS5834235U (en) * 1981-08-28 1983-03-05 カシオ計算機株式会社 Movable contact piece of push button switch
US5659051A (en) * 1993-07-13 1997-08-19 Sumitomo Chemical Company, Limited Process of producing 2-cyano-4-oxo-4H-benzopyran compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3965122A (en) * 1970-12-30 1976-06-22 Fujisawa Pharmaceutical Co., Ltd. Chromone compounds and preparation thereof

Also Published As

Publication number Publication date
NL179056C (en) 1986-07-01
NL7316575A (en) 1974-06-07
JPS50111219A (en) 1975-09-01
CA1016178A (en) 1977-08-23
AU460893B2 (en) 1975-05-08
JPS533392B2 (en) 1978-02-06
DE2360355B2 (en) 1978-10-12
CH585749A5 (en) 1977-03-15
IL43761A0 (en) 1974-03-14
BE808190A (en) 1974-03-29
IL43761A (en) 1977-10-31
NO138661C (en) 1978-10-18
NO138661B (en) 1978-07-10
AU6313373A (en) 1975-05-08
AR199426A1 (en) 1974-08-30
SE404605B (en) 1978-10-16
DE2360355A1 (en) 1974-06-20
DE2360355C3 (en) 1979-06-07
SE7700663L (en) 1977-01-21
HU166457B (en) 1975-03-28
ZA739197B (en) 1974-10-30
JPS5336016B2 (en) 1978-09-30
SE7700664L (en) 1977-01-21
SE408420B (en) 1979-06-11
FR2208674B1 (en) 1977-01-28
NL179056B (en) 1986-02-03
GB1457254A (en) 1976-12-01
SE408421B (en) 1979-06-11
JPS4993367A (en) 1974-09-05
FR2208674A1 (en) 1974-06-28

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