ES416106A1 - Procedimiento para la preparacion de n-(heteroaril-metil)- 6,14-endoeteno-7a-hidroxialcohil-tetrahidro-nororipavinas y tebainas. - Google Patents

Procedimiento para la preparacion de n-(heteroaril-metil)- 6,14-endoeteno-7a-hidroxialcohil-tetrahidro-nororipavinas y tebainas.

Info

Publication number: ES416106A1
Authority: ES; Spain
Prior art keywords: methyl; salts; northebaines; nororipavines; endoetheno
Prior art date: 1972-06-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES416106A

Other languages

English (en)

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

CH Boehringer Sohn AG and Co KG

Original Assignee

CH Boehringer Sohn AG and Co KG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1972-06-21

Filing date

1973-06-20

Publication date

1976-02-16

1973-06-20 Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG

1974-04-05 Priority to ES425011A priority Critical patent/ES425011A1/es

1974-04-05 Priority to ES425012A priority patent/ES425012A1/es

1974-04-05 Priority to ES425013A priority patent/ES425013A1/es

1976-02-16 Publication of ES416106A1 publication Critical patent/ES416106A1/es

Status Expired legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
- C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Plant Substances (AREA)
Plural Heterocyclic Compounds (AREA)

ES416106A 1972-06-21 1973-06-20 Procedimiento para la preparacion de n-(heteroaril-metil)- 6,14-endoeteno-7a-hidroxialcohil-tetrahidro-nororipavinas y tebainas. Expired ES416106A1 (es)

Priority Applications (3)

Application Number	Priority Date	Filing Date	Title
ES425011A ES425011A1 (es)	1972-06-21	1974-04-05	Procedimiento para la preparacion de n-(heteroaril-metil)- 6,14-endoetno-7 a-hidrovialcohil-tetrahidro-nororipavinas y tebainas.
ES425012A ES425012A1 (es)	1972-06-21	1974-04-05	Procedimiento para la preparacion de n-(heteroanil-metil)- 6,14-endoetano-7 a-hidoriaecohil-tetrahidro-nororizavinas y tebainas.
ES425013A ES425013A1 (es)	1972-06-21	1974-04-05	Procedimiento para la preparacion de n-(heteroaril-metil)- 6,14-endoetno-7 a-hidrovialcohil-tetrahidro-nororipavinas y tebainas.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE2230154A DE2230154A1 (de)	1972-06-21	1972-06-21	N-(heteroaryl-methyl)-6,14-endoaetheno7alpha-hydroxyalkyl-tetrahydro-nororipavine und -thebaine, deren hydrierungsprodukte und saeureadditionssalze sowie verfahren zu deren herstellung

Publications (1)

Publication Number	Publication Date
ES416106A1 true ES416106A1 (es)	1976-02-16

Family

ID=5848276

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
ES416106A Expired ES416106A1 (es)	1972-06-21	1973-06-20	Procedimiento para la preparacion de n-(heteroaril-metil)- 6,14-endoeteno-7a-hidroxialcohil-tetrahidro-nororipavinas y tebainas.
ES425015A Expired ES425015A1 (es)	1972-06-21	1974-04-05	Procedimiento para la preparacion de n-(heteroaril-metil)- 6,14-endoeteno-7alfa-hidroxialcohil - tetrahidro - nororipa-vinas y tebainas.
ES425010A Expired ES425010A1 (es)	1972-06-21	1974-04-05	Procedimiento para la preparacion de n-(heteroaril-metil)- 6,14-endoetno-7 a-hidrovialcohil-tetrahidro-nororipavinas y tebainas.

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
ES425015A Expired ES425015A1 (es)	1972-06-21	1974-04-05	Procedimiento para la preparacion de n-(heteroaril-metil)- 6,14-endoeteno-7alfa-hidroxialcohil - tetrahidro - nororipa-vinas y tebainas.
ES425010A Expired ES425010A1 (es)	1972-06-21	1974-04-05	Procedimiento para la preparacion de n-(heteroaril-metil)- 6,14-endoetno-7 a-hidrovialcohil-tetrahidro-nororipavinas y tebainas.

Country Status (14)

Country	Link
US (1)	US3931189A (es)
JP (1)	JPS5614673B2 (es)
AT (7)	AT329198B (es)
BE (1)	BE801271A (es)
CH (7)	CH585752A5 (es)
DE (1)	DE2230154A1 (es)
DK (1)	DK141629C (es)
ES (3)	ES416106A1 (es)
FI (1)	FI57261C (es)
FR (1)	FR2189066B1 (es)
GB (1)	GB1431385A (es)
NL (1)	NL7308555A (es)
NO (1)	NO139050C (es)
SE (1)	SE412235B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4232026A (en) *	1978-07-20	1980-11-04	Merck & Co., Inc.	Diazaditwistanes, and pharmaceutical compositions for treating pain in warm blooded animals containing them
JPS60119848A (ja) *	1983-11-30	1985-06-27	三井建設株式会社	繊維補強コンクリ−ト並びにその施工法
JPS62298530A (ja) *	1986-06-16	1987-12-25	Otsuka Pharmaceut Co Ltd	坐薬用医薬組成物
CN1233645C (zh) *	2001-09-14	2005-12-28	中国人民解放军军事医学科学院毒物药物研究所	新的东罂粟碱衍生物及其医药用途
CN1939920B (zh) *	2005-09-29	2011-08-31	中国人民解放军军事医学科学院毒物药物研究所	东罂粟碱类化合物及其医药用途
WO2010014229A1 (en)	2008-07-30	2010-02-04	Purdue Pharma L.P.	Buprenorphine analogs
JP2021104932A (ja) *	2018-03-30	2021-07-26	日本ケミファ株式会社	モルヒナン誘導体の製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3474101A (en) *	1960-09-05	1969-10-21	Reckitt & Sons Ltd	Thebaine and oripavine derivatives
US3285914A (en) *	1964-06-11	1966-11-15	Smith Kline French Lab	3-n-substituted derivatives of oripavine and thebaine
GB1136764A (en) *	1965-08-13	1968-12-18	Reckitt & Sons Ltd	Derivatives of thebaine and oripavine
GB1146272A (en) *	1966-01-17	1969-03-26	Reckitt & Sons Ltd	Novel thebaine and oripavine derivatives
GB1223445A (en) *	1968-07-18	1971-02-24	Reckitt & Colmann Prod Ltd	Improvements in or relating to derivatives of morphine, their salts, and processes for their preparation
DE2107989A1 (de) *	1971-02-19	1972-09-07	Boehringer Sohn Ingelheim	N-(Furyl-methy])-morphinane, deren Säureadditionssalze sowie Verfahren zu deren Herstellung

1972
- 1972-06-21 DE DE2230154A patent/DE2230154A1/de not_active Withdrawn
1973
- 1973-06-06 AT AT462374*7A patent/AT329198B/de not_active IP Right Cessation
- 1973-06-06 AT AT462174*7A patent/AT328101B/de not_active IP Right Cessation
- 1973-06-06 AT AT461874*7A patent/AT328098B/de not_active IP Right Cessation
- 1973-06-06 AT AT461974*7A patent/AT328099B/de not_active IP Right Cessation
- 1973-06-06 AT AT462274*7A patent/AT327409B/de not_active IP Right Cessation
- 1973-06-06 AT AT462074*7A patent/AT328100B/de not_active IP Right Cessation
- 1973-06-06 AT AT494473A patent/AT325219B/de not_active IP Right Cessation
- 1973-06-13 US US05/369,500 patent/US3931189A/en not_active Expired - Lifetime
- 1973-06-18 CH CH1460976A patent/CH585752A5/xx not_active IP Right Cessation
- 1973-06-18 CH CH1461076A patent/CH585753A5/xx not_active IP Right Cessation
- 1973-06-18 CH CH881573A patent/CH585751A5/xx not_active IP Right Cessation
- 1973-06-18 CH CH1460776A patent/CH586224A5/xx not_active IP Right Cessation
- 1973-06-18 CH CH1460876A patent/CH594672A5/xx not_active IP Right Cessation
- 1973-06-18 CH CH1460676A patent/CH587264A5/xx not_active IP Right Cessation
- 1973-06-18 CH CH1461176A patent/CH594673A5/xx not_active IP Right Cessation
- 1973-06-20 ES ES416106A patent/ES416106A1/es not_active Expired
- 1973-06-20 GB GB2934673A patent/GB1431385A/en not_active Expired
- 1973-06-20 FI FI1989/73A patent/FI57261C/fi active
- 1973-06-20 JP JP6969173A patent/JPS5614673B2/ja not_active Expired
- 1973-06-20 NO NO2561/73A patent/NO139050C/no unknown
- 1973-06-20 SE SE7308709A patent/SE412235B/xx unknown
- 1973-06-20 DK DK341273A patent/DK141629C/da active
- 1973-06-20 NL NL7308555A patent/NL7308555A/xx not_active Application Discontinuation
- 1973-06-21 FR FR7322738A patent/FR2189066B1/fr not_active Expired
- 1973-06-21 BE BE132576A patent/BE801271A/xx unknown
1974
- 1974-04-05 ES ES425015A patent/ES425015A1/es not_active Expired
- 1974-04-05 ES ES425010A patent/ES425010A1/es not_active Expired

Also Published As

Publication number	Publication date
SE412235B (sv)	1980-02-25
ATA462374A (de)	1975-07-15
FR2189066B1 (es)	1976-12-31
ATA461974A (de)	1975-05-15
AT329198B (de)	1976-04-26
NO139050B (no)	1978-09-18
DE2230154A1 (de)	1974-01-17
DK141629C (da)	1980-09-29
AT328100B (de)	1976-03-10
CH594672A5 (es)	1978-01-13
AT327409B (de)	1976-01-26
ATA461874A (de)	1975-05-15
AT328098B (de)	1976-03-10
ATA462174A (de)	1975-05-15
GB1431385A (en)	1976-04-07
AT325219B (de)	1975-10-10
BE801271A (fr)	1973-12-21
FI57261C (fi)	1980-07-10
JPS4954390A (es)	1974-05-27
ES425015A1 (es)	1976-07-01
FR2189066A1 (es)	1974-01-25
AT328101B (de)	1976-03-10
CH585753A5 (es)	1977-03-15
ATA462074A (de)	1975-05-15
NL7308555A (es)	1973-12-27
FI57261B (fi)	1980-03-31
AU5721173A (en)	1975-01-09
US3931189A (en)	1976-01-06
DK141629B (da)	1980-05-12
NO139050C (no)	1979-01-03
CH585751A5 (es)	1977-03-15
JPS5614673B2 (es)	1981-04-06
CH587264A5 (es)	1977-04-29
ATA462274A (de)	1975-04-15
AT328099B (de)	1976-03-10
CH585752A5 (es)	1977-03-15
ES425010A1 (es)	1976-06-16
CH586224A5 (es)	1977-03-31
CH594673A5 (es)	1978-01-13

Publication	Publication Date	Title
ES452763A1 (es)	1977-10-01	Procedimiento para la preparacion de nuevos 2-tetrahidrofur-furil-6, 7-benzomorfanos disustituidos en 5, 9-beta.
ES431510A1 (es)	1976-11-01	Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos.
ES440079A1 (es)	1977-02-16	Procedimiento para preparar nuevos derivados del acido 3- quinoleincarboxilico.
IE41528L (en)	1975-04-27	Furfuryl-benzomorphane derivatives.
IE36326B1 (en)	1976-10-13	Diamines
ES462006A1 (es)	1978-06-16	Procedimiento para la obtencion de nuevas feniletilaminas.
ES439927A1 (es)	1977-06-01	Procedimiento para la obtencion de 7-metoxi-6-tiatetracicli-nas.
ES395482A1 (es)	1973-12-16	Procedimiento para la preparacion de compuestos de nafti- lalcohilaminas.
ES425010A1 (es)	1976-06-16	Procedimiento para la preparacion de n-(heteroaril-metil)- 6,14-endoetno-7 a-hidrovialcohil-tetrahidro-nororipavinas y tebainas.
ES424307A1 (es)	1976-07-01	Procedimiento para la preparacion de n-(heteroarilmetil)-7-alfa - acil - 6,14-endoeteno - tetrahidronororipavinas y te-bainas.
ES450897A1 (es)	1977-12-01	Procedimiento para la preparacion de n-(r-tetrahidrofurfu- ril)-noroximorfona y n-(s-tetrahidrofurfuril)-noroximorfona.
ES390163A1 (es)	1973-07-01	Procedimiento para la preparacion de amino-derivados de los acidos pirazolo (3,4-b) piridina-5-carboxilicos.
IE38320L (en)	1974-03-14	Nor-morphines and nor-codeines